FRAT1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description frequently rearranged in advanced T-cell lymphomas 1|The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. [provided by RefSeq, Oct 2008] (NCBI Entrez Gene Database, 10023)
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Genes

316 genes differentially expressed following the FRAT1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TAS2R31 taste receptor, type 2, member 31 2.64051
IGFL2 IGF-like family member 2 2.64051
PTX4 pentraxin 4, long 2.64051
CD1C CD1c molecule 2.64051
PGAM4 phosphoglycerate mutase family member 4 2.64051
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2.64051
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 2.64051
OR5K1 olfactory receptor, family 5, subfamily K, member 1 2.64051
MBLAC1 metallo-beta-lactamase domain containing 1 2.64051
HES3 hes family bHLH transcription factor 3 2.64051
GPR52 G protein-coupled receptor 52 2.64051
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 2.64051
TAS2R30 taste receptor, type 2, member 30 2.64051
FAM3D family with sequence similarity 3, member D 2.64051
USH1G Usher syndrome 1G (autosomal recessive) 2.64051
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma 2.64051
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 2.64051
CFHR3 complement factor H-related 3 2.64051
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 2.64051
TMPRSS11F transmembrane protease, serine 11F 2.64051
IL4I1 interleukin 4 induced 1 2.64051
UNC13C unc-13 homolog C (C. elegans) 2.64051
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 2.64051
GMFG glia maturation factor, gamma 2.64051
CCDC38 coiled-coil domain containing 38 2.64051
DLL4 delta-like 4 (Drosophila) 2.64051
SLC44A4 solute carrier family 44, member 4 2.64051
FAM216B family with sequence similarity 216, member B 2.64051
GALR2 galanin receptor 2 2.64051
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 2.64051
PRR29 proline rich 29 2.64051
SPAG6 sperm associated antigen 6 2.64051
TDRD9 tudor domain containing 9 2.64051
PTGER3 prostaglandin E receptor 3 (subtype EP3) 2.64051
LILRB5 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5 2.64051
NFAM1 NFAT activating protein with ITAM motif 1 2.64051
OPRL1 opiate receptor-like 1 2.64051
ASPG asparaginase 2.64051
ZNF180 zinc finger protein 180 2.64051
UBE2U ubiquitin-conjugating enzyme E2U (putative) 2.64051
HAS1 hyaluronan synthase 1 2.64051
ADAMTSL5 ADAMTS-like 5 2.64051
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 2.64051
RAMP3 receptor (G protein-coupled) activity modifying protein 3 2.64051
CPED1 cadherin-like and PC-esterase domain containing 1 2.64051
SPMAP2L sperm microtubule associated protein 2 like 2.64051
OTOF otoferlin 2.64051
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 2.64051
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal 2.64051
STMN4 stathmin-like 4 2.64051
PDF peptide deformylase (mitochondrial) 2.64051
SMLR1 small leucine-rich protein 1 2.64051
ADRB1 adrenoceptor beta 1 2.64051
FOXC2 forkhead box C2 2.64051
FCMR Fc fragment of IgM receptor 2.64051
MRPL58 mitochondrial ribosomal protein L58 2.64051
PPP1R2B PPP1R2 family member B 2.64051
OR56B2 olfactory receptor family 56 subfamily B member 2 2.64051
LINC02268 long intergenic non-protein coding RNA 2268 2.64051
ANKRD42-DT ANKRD42 divergent transcript 2.64051
PNMA8C PNMA family member 8C 2.64051
RHEX regulator of hemoglobinization and erythroid cell expansion 2.64051
EZHIP EZH inhibitory protein 2.64051
ATP5MGL ATP synthase membrane subunit g like 2.64051
H2AJ H2A.J histone 2.64051
CPHXL2 cytoplasmic polyadenylated homeobox like 2 2.64051
ZNF441 zinc finger protein 441 2.64051
TSPAN8 tetraspanin 8 2.64051
RANBP3 RAN binding protein 3 2.64051
GZMM granzyme M (lymphocyte met-ase 1) 2.64051
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 2.64051
IL6 interleukin 6 2.64051
GOLGA7B golgin A7 family, member B 2.64051
SCN10A sodium channel, voltage gated, type X alpha subunit 2.64051
IRF8 interferon regulatory factor 8 2.64051
TMIE transmembrane inner ear 2.64051
PCDHB11 protocadherin beta 11 2.64051
ZAN zonadhesin (gene/pseudogene) 2.64051
PRR4 proline rich 4 (lacrimal) 2.64051
TSPAN1 tetraspanin 1 2.64051
OR51M1 olfactory receptor, family 51, subfamily M, member 1 2.64051
LEKR1 leucine, glutamate and lysine rich 1 2.64051
OSTN osteocrin 2.64051
CSAG3 CSAG family, member 3 2.64051
CNTN6 contactin 6 2.64051
MOV10L1 Mov10 RISC complex RNA helicase like 1 2.64051
MTMR11 myotubularin related protein 11 2.64051
CCR4 chemokine (C-C motif) receptor 4 2.64051
FOXD1 forkhead box D1 2.64051
RBP4 retinol binding protein 4, plasma 2.64051
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 2.64051
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 2.64051
GOLGA6A golgin A6 family, member A 2.64051
GOLGA6B golgin A6 family, member B 2.64051
ADAM2 ADAM metallopeptidase domain 2 2.64051
TCP11X2 t-complex 11 family, X-linked 2 2.64051
CLEC4G C-type lectin domain family 4, member G 2.64051
CD248 CD248 molecule, endosialin 2.64051
POU2AF1 POU class 2 associating factor 1 2.64051
CAGE1 cancer antigen 1 2.64051
PRM1 protamine 1 2.64051
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.64051
DES desmin 2.64051
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 2.64051
TFAP2D transcription factor AP-2 delta (activating enhancer binding protein 2 delta) 2.64051
NACA2 nascent polypeptide-associated complex alpha subunit 2 2.64051
MYF5 myogenic factor 5 2.64051
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.64051
RFPL1 ret finger protein-like 1 2.64051
TCAP titin-cap 2.64051
GCOM1 GRINL1A complex locus 1 2.64051
CRHR1 corticotropin releasing hormone receptor 1 2.64051
ANKRD20A1 ankyrin repeat domain 20 family, member A1 2.64051
LGALS12 lectin, galactoside-binding, soluble, 12 2.64051
EFCC1 EF-hand and coiled-coil domain containing 1 2.64051
CAPSL calcyphosine-like 2.64051
KLHL12 kelch-like family member 12 2.64051
RASA4 RAS p21 protein activator 4 2.64051
MEIS1 Meis homeobox 1 2.64051
IL24 interleukin 24 2.64051
CCNA1 cyclin A1 2.64051
ZNF831 zinc finger protein 831 2.64051
CLEC1A C-type lectin domain family 1, member A 2.64051
QRFP pyroglutamylated RFamide peptide 2.64051
KLK12 kallikrein-related peptidase 12 2.64051
C8G complement component 8, gamma polypeptide 2.64051
BSPH1 binder of sperm protein homolog 1 2.64051
ZC3H12D zinc finger CCCH-type containing 12D 2.64051
NT5C1A 5'-nucleotidase, cytosolic IA 2.64051
GPR62 G protein-coupled receptor 62 2.64051
IBSP integrin-binding sialoprotein 2.64051
BCL2L15 BCL2-like 15 2.64051
PSG3 pregnancy specific beta-1-glycoprotein 3 2.64051
GOLGA8R golgin A8 family, member R 2.64051
TMEM259 transmembrane protein 259 2.64051
AMPD1 adenosine monophosphate deaminase 1 2.64051
CARNS1 carnosine synthase 1 2.64051
AMDHD1 amidohydrolase domain containing 1 2.64051
OR10G3 olfactory receptor, family 10, subfamily G, member 3 2.64051
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) 2.64051
FRMPD1 FERM and PDZ domain containing 1 2.64051
ROM1 retinal outer segment membrane protein 1 2.64051
RNF148 ring finger protein 148 2.64051
MT1M metallothionein 1M 2.64051
F13A1 coagulation factor XIII, A1 polypeptide 2.64051
LRRC38 leucine rich repeat containing 38 2.64051
MSLN mesothelin 2.64051
FOXP3 forkhead box P3 2.64051
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 2.64051
DNAH8 dynein, axonemal, heavy chain 8 2.64051
MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B 2.64051
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 2.64051
PLEKHS1 pleckstrin homology domain containing, family S member 1 2.64051
AOC1 amine oxidase, copper containing 1 2.64051
IL12B interleukin 12B 2.64051
DMTN dematin actin binding protein 2.64051
ACSM1 acyl-CoA synthetase medium-chain family member 1 2.64051
ABRA actin binding Rho activating protein 2.64051
GCM2 glial cells missing homolog 2 (Drosophila) 2.64051
SP100 SP100 nuclear antigen 2.64051
C17ORF78 chromosome 17 open reading frame 78 2.64051
CARD9 caspase recruitment domain family, member 9 2.64051
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 2.64051
C9ORF50 chromosome 9 open reading frame 50 2.64051
PPIL3 peptidylprolyl isomerase (cyclophilin)-like 3 2.63219
BRINP1 bone morphogenetic protein/retinoic acid inducible neural-specific 1 2.57907
TXNRD1 thioredoxin reductase 1 2.56704
MED22 mediator complex subunit 22 2.56578
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 2.54762
CD8B CD8b molecule 2.53154
DUSP26 dual specificity phosphatase 26 (putative) 2.53154
PLCD1 phospholipase C, delta 1 2.3728
GLB1L2 galactosidase, beta 1-like 2 2.36884
LOXL4 lysyl oxidase-like 4 2.36659
EFCAB8 EF-hand calcium binding domain 8 2.36659
LOC122539214 Zinc finger protein LOC122539214 2.36659
ULK3 unc-51 like kinase 3 2.36064
COMMD8 COMM domain containing 8 2.36064
HID1 HID1 domain containing 2.36049
TOP1 topoisomerase (DNA) I 2.31963
UBE2G2 ubiquitin-conjugating enzyme E2G 2 2.26745
MAPK14 mitogen-activated protein kinase 14 2.25738
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 2.24505
HORMAD2 HORMA domain containing 2 2.23331
IL15 interleukin 15 2.23303
DCLRE1A DNA cross-link repair 1A 2.21758
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 2.21391
PGP phosphoglycolate phosphatase 2.2103
NKAIN3 Na+/K+ transporting ATPase interacting 3 2.20048
ARL17A ADP-ribosylation factor-like 17A 2.19936
MSH3 mutS homolog 3 2.19936
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 2.17972
CRY1 cryptochrome circadian clock 1 2.17517
FABP5 fatty acid binding protein 5 (psoriasis-associated) 2.15593
COL26A1 collagen, type XXVI, alpha 1 2.14236
HMSD histocompatibility (minor) serpin domain containing 2.10992
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 2.07981
RPRML reprimo-like 2.06686
RAD23B RAD23 homolog B (S. cerevisiae) 2.03388
DST dystonin 2.02062
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 2.01423
ZNF572 zinc finger protein 572 2.01045
PEX26 peroxisomal biogenesis factor 26 2.01045

decreased expression

Symbol Name Standardized Value
DUSP13B dual specificity phosphatase 13B -2.64051
CYB5R1 cytochrome b5 reductase 1 -2.64051
GPR55 G protein-coupled receptor 55 -2.64051
SPINK6 serine peptidase inhibitor, Kazal type 6 -2.64051
TNK1 tyrosine kinase, non-receptor, 1 -2.64051
DUSP15 dual specificity phosphatase 15 -2.64051
ACCS 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional) -2.64051
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 -2.64051
DPYS dihydropyrimidinase -2.64051
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 -2.64051
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 -2.64051
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit -2.64051
HERPUD2 HERPUD family member 2 -2.64051
ZNF324 zinc finger protein 324 -2.64051
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 -2.64051
HES2 hes family bHLH transcription factor 2 -2.64051
RAMP1 receptor (G protein-coupled) activity modifying protein 1 -2.64051
TMEM184A transmembrane protein 184A -2.64051
ZNF284 zinc finger protein 284 -2.64051
ZNF285 zinc finger protein 285 -2.64051
UPK3A uroplakin 3A -2.64051
TMT1B thiol methyltransferase 1B -2.64051
NPIPB12 nuclear pore complex interacting protein family member B12 -2.64051
SPAAR small regulatory polypeptide of amino acid response -2.64051
DEUP1 deuterosome assembly protein 1 -2.64051
GBA1 glucosylceramidase beta 1 -2.64051
FDXACB1 ferredoxin-fold anticodon binding domain containing 1 -2.64051
TMEM190 transmembrane protein 190 -2.64051
MROH5 maestro heat-like repeat family member 5 -2.64051
C3 complement component 3 -2.64051
SBSN suprabasin -2.64051
RUNX3 runt-related transcription factor 3 -2.64051
PDE1B phosphodiesterase 1B, calmodulin-dependent -2.64051
ZIC1 Zic family member 1 -2.64051
AKR1D1 aldo-keto reductase family 1, member D1 -2.64051
FGFRL1 fibroblast growth factor receptor-like 1 -2.64051
CLDN9 claudin 9 -2.64051
ZNF582 zinc finger protein 582 -2.64051
AFP alpha-fetoprotein -2.64051
GRK7 G protein-coupled receptor kinase 7 -2.64051
PCDH12 protocadherin 12 -2.64051
LPAR5 lysophosphatidic acid receptor 5 -2.64051
ZNF823 zinc finger protein 823 -2.64051
BAHCC1 BAH domain and coiled-coil containing 1 -2.64051
SHOX short stature homeobox -2.64051
TIGAR TP53 induced glycolysis regulatory phosphatase -2.64051
CSDC2 cold shock domain containing C2, RNA binding -2.64051
ECE2 endothelin converting enzyme 2 -2.64051
TMCC2 transmembrane and coiled-coil domain family 2 -2.64051
OLFML1 olfactomedin-like 1 -2.64051
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 -2.64051
RRH retinal pigment epithelium-derived rhodopsin homolog -2.64051
PLCD4 phospholipase C, delta 4 -2.64051
NPFFR1 neuropeptide FF receptor 1 -2.64051
SOX30 SRY (sex determining region Y)-box 30 -2.64051
TRAF3IP3 TRAF3 interacting protein 3 -2.64051
PF4V1 platelet factor 4 variant 1 -2.64051
CLPSL1 colipase-like 1 -2.64051
IL1A interleukin 1, alpha -2.64051
DKKL1 dickkopf-like 1 -2.64051
MMP3 matrix metallopeptidase 3 -2.64051
BHMT betaine--homocysteine S-methyltransferase -2.64051
ETNPPL ethanolamine-phosphate phospho-lyase -2.64051
IP6K3 inositol hexakisphosphate kinase 3 -2.64051
GTF2A1L general transcription factor IIA, 1-like -2.64051
PABIR3 PABIR family member 3 -2.58932
ADISSP adipose secreted signaling protein -2.55234
TXK TXK tyrosine kinase -2.54141
RPL10A ribosomal protein L10a -2.51953
RASA3 RAS p21 protein activator 3 -2.50168
CNTROB centrobin, centrosomal BRCA2 interacting protein -2.49724
HROB homologous recombination factor with OB-fold -2.49724
ART5 ADP-ribosyltransferase 5 -2.42396
THOC6 THO complex 6 -2.33503
CHRM5 cholinergic receptor, muscarinic 5 -2.32109
CSNK2A1 casein kinase 2, alpha 1 polypeptide -2.31419
IVNS1ABP influenza virus NS1A binding protein -2.27911
ZBTB44 zinc finger and BTB domain containing 44 -2.25757
LCMT1 leucine carboxyl methyltransferase 1 -2.25757
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) -2.24696
ERG v-ets avian erythroblastosis virus E26 oncogene homolog -2.24505
ZNF157 zinc finger protein 157 -2.2318
HLA-DOB major histocompatibility complex, class II, DO beta -2.21499
MCFD2 multiple coagulation factor deficiency 2 -2.20129
ZNF606 zinc finger protein 606 -2.19936
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.19936
PHLDB3 pleckstrin homology-like domain, family B, member 3 -2.18918
RPS28 ribosomal protein S28 -2.18643
ZC3H18 zinc finger CCCH-type containing 18 -2.18643
PFDN4 prefoldin subunit 4 -2.1857
LRRIQ1 leucine-rich repeats and IQ motif containing 1 -2.17972
RAB3A RAB3A, member RAS oncogene family -2.17208
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 -2.1403
ZNF777 zinc finger protein 777 -2.13403
TRNT1 tRNA nucleotidyl transferase, CCA-adding, 1 -2.12596
ZMYM5 zinc finger, MYM-type 5 -2.11223
PKD1L2 polycystic kidney disease 1-like 2 (gene/pseudogene) -2.10992
CSNK2A2 casein kinase 2, alpha prime polypeptide -2.10513
RAB2A RAB2A, member RAS oncogene family -2.10412
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 -2.08884
ZNF600 zinc finger protein 600 -2.07726
ATOSA atos homolog A -2.05401
TRIM61 tripartite motif containing 61 -2.0452
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 -2.04286
VCL vinculin -2.03282
ASF1B anti-silencing function 1B histone chaperone -2.02728
ZNF410 zinc finger protein 410 -2.01842
GPR158 G protein-coupled receptor 158 -2.01842
KPNA3 karyopherin alpha 3 (importin alpha 4) -2.01045
PDE3A phosphodiesterase 3A, cGMP-inhibited -2.00651
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B -2.00651
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) -2.00651
MRPL12 mitochondrial ribosomal protein L12 -2.00456