| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/3005532 |
| Similar Terms | |
| Downloads & Tools |
197 proteins with high or low expression in FTI-277 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 1.7 |
| ZSCAN29 | zinc finger and SCAN domain containing 29 | 1.03 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | 0.97 |
| CENPE | centromere protein E, 312kDa | 0.87 |
| MRAS | muscle RAS oncogene homolog | 0.86 |
| CENPF | centromere protein F, 350/400kDa | 0.85 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.73 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.69 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | 0.56 |
| SLC4A2 | solute carrier family 4 (anion exchanger), member 2 | 0.53 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.51 |
| JUN | jun proto-oncogene | 0.51 |
| CPA4 | carboxypeptidase A4 | 0.48 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.47 |
| TMEM40 | transmembrane protein 40 | 0.46 |
| UNC13D | unc-13 homolog D (C. elegans) | 0.43 |
| ZNF226 | zinc finger protein 226 | 0.43 |
| CNTROB | centrobin, centrosomal BRCA2 interacting protein | 0.42 |
| ARHGAP23 | Rho GTPase activating protein 23 | 0.41 |
| ARL4A | ADP-ribosylation factor-like 4A | 0.4 |
| ZNF92 | zinc finger protein 92 | 0.4 |
| TAPT1 | transmembrane anterior posterior transformation 1 | 0.4 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.39 |
| GATD1 | glutamine amidotransferase class 1 domain containing 1 | 0.39 |
| CRYBG2 | crystallin beta-gamma domain containing 2 | 0.38 |
| PRDM16 | PR domain containing 16 | 0.38 |
| ANAPC11 | anaphase promoting complex subunit 11 | 0.37 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 0.37 |
| KLHL17 | kelch-like family member 17 | 0.37 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.36 |
| IFFO1 | intermediate filament family orphan 1 | 0.36 |
| ITGA7 | integrin, alpha 7 | 0.36 |
| KRAS | Kirsten rat sarcoma viral oncogene homolog | 0.36 |
| BDNF | brain-derived neurotrophic factor | 0.36 |
| RELT | RELT tumor necrosis factor receptor | 0.35 |
| CCN1 | cellular communication network factor 1 | 0.35 |
| PKNOX1 | PBX/knotted 1 homeobox 1 | 0.35 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | 0.35 |
| MISP | mitotic spindle positioning | 0.33 |
| HECW1 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 | 0.33 |
| RHOB | ras homolog family member B | 0.32 |
| ZNF696 | zinc finger protein 696 | 0.32 |
| MOSPD1 | motile sperm domain containing 1 | 0.31 |
| TJP1 | tight junction protein 1 | 0.3 |
| MOB3A | MOB kinase activator 3A | 0.3 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.3 |
| CYBA | cytochrome b-245, alpha polypeptide | 0.3 |
| WWC3 | WWC family member 3 | 0.3 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.29 |
| ERGIC2 | ERGIC and golgi 2 | 0.29 |
| SP100 | SP100 nuclear antigen | 0.29 |
| ZDHHC3 | zinc finger, DHHC-type containing 3 | 0.29 |
| FAM171A1 | family with sequence similarity 171, member A1 | 0.29 |
| CYTH1 | cytohesin 1 | 0.29 |
| ZNF185 | zinc finger protein 185 (LIM domain) | 0.28 |
| BAHD1 | bromo adjacent homology domain containing 1 | 0.28 |
| LYST | lysosomal trafficking regulator | 0.28 |
| B3GNT3 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 | 0.28 |
| RETREG1 | reticulophagy regulator 1 | 0.28 |
| NDUFB8 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa | 0.28 |
| ZG16B | zymogen granule protein 16B | 0.28 |
| COQ4 | coenzyme Q4 | 0.28 |
| ZC3HAV1L | zinc finger CCCH-type, antiviral 1-like | 0.28 |
| PHLDA3 | pleckstrin homology-like domain, family A, member 3 | 0.27 |
| L1CAM | L1 cell adhesion molecule | 0.27 |
| CERS4 | ceramide synthase 4 | 0.27 |
| DAPK2 | death-associated protein kinase 2 | 0.27 |
| GALNT5 | polypeptide N-acetylgalactosaminyltransferase 5 | 0.27 |
| TEAD2 | TEA domain family member 2 | 0.27 |
| CYTH3 | cytohesin 3 | 0.26 |
| PAH | phenylalanine hydroxylase | 0.26 |
| ZBTB7A | zinc finger and BTB domain containing 7A | 0.26 |
| SBSN | suprabasin | 0.26 |
| ZMAT3 | zinc finger, matrin-type 3 | 0.26 |
| NDUFA6 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa | 0.26 |
| ATP6V0A1 | ATPase, H+ transporting, lysosomal V0 subunit a1 | 0.26 |
| ZNF587B | zinc finger protein 587B | 0.26 |
| SEMA7A | semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) | 0.26 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.26 |
| TRIB1 | tribbles pseudokinase 1 | 0.26 |
| GMCL2 | germ cell-less 2, spermatogenesis associated | 0.26 |
| ZCCHC14 | zinc finger, CCHC domain containing 14 | 0.25 |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | 0.25 |
| PIN1 | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | 0.25 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.25 |
| ZFP62 | ZFP62 zinc finger protein | 0.25 |
| CIR1 | corepressor interacting with RBPJ, 1 | 0.25 |
| GVINP1 | GTPase, very large interferon inducible pseudogene 1 | 0.25 |
| CERK | ceramide kinase | 0.25 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.25 |
| IQCE | IQ motif containing E | 0.25 |
| TP53 | tumor protein p53 | 0.24 |
| EHD2 | EH-domain containing 2 | 0.24 |
| TMCO3 | transmembrane and coiled-coil domains 3 | 0.24 |
| BMP1 | bone morphogenetic protein 1 | 0.24 |
| S100A10 | S100 calcium binding protein A10 | 0.24 |
| ANKRD52 | ankyrin repeat domain 52 | 0.23 |
| AHCYL2 | adenosylhomocysteinase-like 2 | 0.23 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PLA2G12A | phospholipase A2, group XIIA | -1.19 |
| POF1B | premature ovarian failure, 1B | -1.17 |
| PIP | prolactin-induced protein | -1.16 |
| RUSC2 | RUN and SH3 domain containing 2 | -1.08 |
| PALM | paralemmin | -0.99 |
| FAM219A | family with sequence similarity 219, member A | -0.96 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.83 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -0.79 |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 | -0.77 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.76 |
| CRIP1 | cysteine-rich protein 1 (intestinal) | -0.76 |
| RAB28 | RAB28, member RAS oncogene family | -0.73 |
| ZDHHC2 | zinc finger, DHHC-type containing 2 | -0.72 |
| BORCS5 | BLOC-1 related complex subunit 5 | -0.65 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.65 |
| HHEX | hematopoietically expressed homeobox | -0.65 |
| GATA2 | GATA binding protein 2 | -0.64 |
| METTL26 | methyltransferase like 26 | -0.63 |
| SLC16A6 | solute carrier family 16, member 6 | -0.62 |
| CCDC90B | coiled-coil domain containing 90B | -0.57 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | -0.57 |
| ZNF526 | zinc finger protein 526 | -0.57 |
| AMOT | angiomotin | -0.55 |
| TTC9C | tetratricopeptide repeat domain 9C | -0.55 |
| NRP1 | neuropilin 1 | -0.55 |
| RPL26 | ribosomal protein L26 | -0.53 |
| SLC41A1 | solute carrier family 41 (magnesium transporter), member 1 | -0.52 |
| INTU | inturned planar cell polarity protein | -0.52 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.52 |
| RHOF | ras homolog family member F (in filopodia) | -0.52 |
| ADCY10 | adenylate cyclase 10 (soluble) | -0.51 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.51 |
| TET1 | tet methylcytosine dioxygenase 1 | -0.5 |
| YKT6 | YKT6 v-SNARE homolog (S. cerevisiae) | -0.5 |
| CMC1 | C-x(9)-C motif containing 1 | -0.5 |
| CRCP | CGRP receptor component | -0.49 |
| AFAP1L1 | actin filament associated protein 1-like 1 | -0.49 |
| TTC8 | tetratricopeptide repeat domain 8 | -0.49 |
| UBAP1 | ubiquitin associated protein 1 | -0.48 |
| NPRL3 | nitrogen permease regulator-like 3 (S. cerevisiae) | -0.47 |
| EPOP | elongin BC and polycomb repressive complex 2 associated protein | -0.47 |
| PRR14L | proline rich 14-like | -0.47 |
| CDON | cell adhesion associated, oncogene regulated | -0.47 |
| DENND4B | DENN/MADD domain containing 4B | -0.46 |
| TMEM64 | transmembrane protein 64 | -0.46 |
| C6ORF141 | chromosome 6 open reading frame 141 | -0.46 |
| KBTBD11 | kelch repeat and BTB (POZ) domain containing 11 | -0.45 |
| RHOQ | ras homolog family member Q | -0.45 |
| PALB2 | partner and localizer of BRCA2 | -0.44 |
| DZIP3 | DAZ interacting zinc finger protein 3 | -0.44 |
| AFG1L | AFG1 like ATPase | -0.44 |
| TRAF5 | TNF receptor-associated factor 5 | -0.44 |
| SLC49A4 | solute carrier family 49 member 4 | -0.43 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | -0.43 |
| DHX32 | DEAH (Asp-Glu-Ala-His) box polypeptide 32 | -0.43 |
| CNOT8 | CCR4-NOT transcription complex, subunit 8 | -0.42 |
| HBA1 | hemoglobin, alpha 1 | -0.42 |
| ADGRE2 | adhesion G protein-coupled receptor E2 | -0.42 |
| ZNF771 | zinc finger protein 771 | -0.42 |
| ACTN2 | actinin, alpha 2 | -0.41 |
| DNAH1 | dynein, axonemal, heavy chain 1 | -0.41 |
| ULK3 | unc-51 like kinase 3 | -0.4 |
| VGF | VGF nerve growth factor inducible | -0.4 |
| PALM3 | paralemmin 3 | -0.4 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | -0.4 |
| SPICE1 | spindle and centriole associated protein 1 | -0.4 |
| M1AP | meiosis 1 associated protein | -0.4 |
| TEDC1 | tubulin epsilon and delta complex 1 | -0.4 |
| PRMT2IP | PRMT2 interacting protein | -0.4 |
| GUCD1 | guanylyl cyclase domain containing 1 | -0.4 |
| PHKG2 | phosphorylase kinase, gamma 2 (testis) | -0.4 |
| TMEM231 | transmembrane protein 231 | -0.39 |
| RADX | RPA1 related single stranded DNA binding protein, X-linked | -0.39 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.39 |
| ZBED6 | zinc finger, BED-type containing 6 | -0.39 |
| JAG1 | jagged 1 | -0.39 |
| ZNF239 | zinc finger protein 239 | -0.39 |
| PLEKHH3 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 | -0.39 |
| TTLL5 | tubulin tyrosine ligase-like family member 5 | -0.38 |
| CCN3 | cellular communication network factor 3 | -0.38 |
| CCDC138 | coiled-coil domain containing 138 | -0.38 |
| FZD7 | frizzled class receptor 7 | -0.38 |
| BTBD3 | BTB (POZ) domain containing 3 | -0.37 |
| INPP5E | inositol polyphosphate-5-phosphatase, 72 kDa | -0.37 |
| ACY1 | aminoacylase 1 | -0.37 |
| SMIM12 | small integral membrane protein 12 | -0.37 |
| C2CD4C | C2 calcium-dependent domain containing 4C | -0.37 |
| BRCA2 | breast cancer 2, early onset | -0.37 |
| CENPI | centromere protein I | -0.36 |
| DCLRE1A | DNA cross-link repair 1A | -0.36 |
| UXT | ubiquitously-expressed, prefoldin-like chaperone | -0.36 |
| RHOD | ras homolog family member D | -0.36 |
| ZNF749 | zinc finger protein 749 | -0.36 |
| MSH5 | mutS homolog 5 | -0.36 |
| BCDIN3D | BCDIN3 domain containing | -0.36 |
| DPY30 | dpy-30 homolog (C. elegans) | -0.36 |
| SPATA33 | spermatogenesis associated 33 | -0.36 |
| SYNE4 | spectrin repeat containing, nuclear envelope family member 4 | -0.36 |
| PDP2 | pyruvate dehyrogenase phosphatase catalytic subunit 2 | -0.36 |
