FURIN Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description furin (paired basic amino acid cleaving enzyme)|This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] (NCBI Entrez Gene Database, 5045)
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Genes

307 genes differentially expressed following the FURIN gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ALPG alkaline phosphatase, germ cell 2.78719
EXTL1 exostosin-like glycosyltransferase 1 2.78719
CCR6 chemokine (C-C motif) receptor 6 2.78719
NR4A3 nuclear receptor subfamily 4, group A, member 3 2.78719
SAMD8 sterile alpha motif domain containing 8 2.78719
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 2.78719
NANOS3 nanos homolog 3 (Drosophila) 2.78719
CA9 carbonic anhydrase IX 2.78719
MTTP microsomal triglyceride transfer protein 2.78719
CLEC4D C-type lectin domain family 4, member D 2.78719
MEIOB meiosis specific with OB domains 2.78719
TTLL13 tubulin tyrosine ligase like 13 2.78719
GARIN6 golgi associated RAB2 interactor family member 6 2.78719
ACSS1 acyl-CoA synthetase short-chain family member 1 2.78719
SPAG8 sperm associated antigen 8 2.78719
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 2.78719
C17ORF107 chromosome 17 open reading frame 107 2.78719
SULT6B1 sulfotransferase family, cytosolic, 6B, member 1 2.78719
LAPTM5 lysosomal protein transmembrane 5 2.76925
TMEM151A transmembrane protein 151A 2.76925
TM4SF1 transmembrane 4 L six family member 1 2.76925
PCDHB7 protocadherin beta 7 2.76925
HES7 hes family bHLH transcription factor 7 2.76925
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 2.76925
CELA3B chymotrypsin-like elastase family, member 3B 2.76925
RCOR1 REST corepressor 1 2.76925
MYBPHL myosin binding protein H-like 2.76925
ENTHD1 ENTH domain containing 1 2.76925
ZNF208 zinc finger protein 208 2.76925
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 2.76925
SLC26A9 solute carrier family 26 (anion exchanger), member 9 2.76925
PCDHGB3 protocadherin gamma subfamily B, 3 2.76925
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2.76925
KCNU1 potassium channel, subfamily U, member 1 2.76925
INTS5 integrator complex subunit 5 2.76925
GRP gastrin-releasing peptide 2.76925
MRC1 mannose receptor, C type 1 2.76925
BMP3 bone morphogenetic protein 3 2.76925
PRDM13 PR domain containing 13 2.76925
KRT78 keratin 78, type II 2.76925
TBATA thymus, brain and testes associated 2.76925
EPCIP exosomal polycystin 1 interacting protein 2.76925
TCP11 t-complex 11, testis-specific 2.76925
F2 coagulation factor II (thrombin) 2.76925
OR1L8 olfactory receptor, family 1, subfamily L, member 8 2.76925
GIMAP8 GTPase, IMAP family member 8 2.76925
MFAP5 microfibrillar associated protein 5 2.76925
SOWAHB sosondowah ankyrin repeat domain family member B 2.76925
TLX3 T-cell leukemia homeobox 3 2.76925
PDZD9 PDZ domain containing 9 2.76925
SIX2 SIX homeobox 2 2.76925
GJA3 gap junction protein, alpha 3, 46kDa 2.76925
TYROBP TYRO protein tyrosine kinase binding protein 2.76925
CD300LF CD300 molecule-like family member f 2.76925
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.76925
OR6F1 olfactory receptor, family 6, subfamily F, member 1 2.76925
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 2.76925
FNDC9 fibronectin type III domain containing 9 2.76925
ADRB3 adrenoceptor beta 3 2.76925
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 2.76925
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 2.76925
ARX aristaless related homeobox 2.76925
SERTM2 serine rich and transmembrane domain containing 2 2.76925
H3C3 H3 clustered histone 3 2.76925
CFAP107 cilia and flagella associated protein 107 2.76925
ELOA2 elongin A2 2.76925
SLURP2 secreted LY6/PLAUR domain containing 2 2.76925
DERPC DERPC proline and glycine rich nuclear protein 2.76925
CCDC9B coiled-coil domain containing 9B 2.76925
ERVW-1 endogenous retrovirus group W, member 1 2.76925
HNRNPCL1 heterogeneous nuclear ribonucleoprotein C-like 1 2.76925
GATA3 GATA binding protein 3 2.76925
SCRT1 scratch family zinc finger 1 2.76925
SCN10A sodium channel, voltage gated, type X alpha subunit 2.76925
HPR haptoglobin-related protein 2.76925
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 2.76925
DMP1 dentin matrix acidic phosphoprotein 1 2.76925
ACTL10 actin-like 10 2.76925
KLF10 Kruppel-like factor 10 2.76925
TBX20 T-box 20 2.76925
BHLHA9 basic helix-loop-helix family, member a9 2.76925
TPTE transmembrane phosphatase with tensin homology 2.76925
TUBA4B tubulin, alpha 4b 2.76925
MOV10L1 Mov10 RISC complex RNA helicase like 1 2.76925
LRRC71 leucine rich repeat containing 71 2.76925
STARD6 StAR-related lipid transfer (START) domain containing 6 2.76925
CCR9 chemokine (C-C motif) receptor 9 2.76925
KLRF2 killer cell lectin-like receptor subfamily F, member 2 2.76925
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 2.76925
MYH13 myosin, heavy chain 13, skeletal muscle 2.76925
TMEM238L transmembrane protein 238 like 2.76925
PDK4 pyruvate dehydrogenase kinase, isozyme 4 2.76925
OR2V2 olfactory receptor, family 2, subfamily V, member 2 2.76925
ARR3 arrestin 3, retinal (X-arrestin) 2.76925
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) 2.76925
EFCAB9 EF-hand calcium binding domain 9 2.76925
CST7 cystatin F (leukocystatin) 2.76925
OR56A4 olfactory receptor, family 56, subfamily A, member 4 2.76925
NIM1K NIM1 serine/threonine protein kinase 2.76925
RSAD2 radical S-adenosyl methionine domain containing 2 2.76925
ZNF132 zinc finger protein 132 2.76925
CCL25 chemokine (C-C motif) ligand 25 2.76925
CCDC154 coiled-coil domain containing 154 2.76925
PCDHGB5 protocadherin gamma subfamily B, 5 2.76925
APOF apolipoprotein F 2.76925
TIGIT T cell immunoreceptor with Ig and ITIM domains 2.76925
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 2.76925
KRT17 keratin 17, type I 2.76925
TSPAN32 tetraspanin 32 2.76925
CYSLTR1 cysteinyl leukotriene receptor 1 2.76925
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 2.76925
LAMB4 laminin, beta 4 2.76925
ABI2 abl-interactor 2 2.76925
ABLIM3 actin binding LIM protein family, member 3 2.76925
FAIM2 Fas apoptotic inhibitory molecule 2 2.76925
OR13G1 olfactory receptor, family 13, subfamily G, member 1 2.76925
RGS8 regulator of G-protein signaling 8 2.76925
LHX2 LIM homeobox 2 2.76925
SLC38A3 solute carrier family 38, member 3 2.76925
PRSS37 protease, serine, 37 2.76925
DMRT1 doublesex and mab-3 related transcription factor 1 2.76925
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 2.76925
C8ORF89 chromosome 8 open reading frame 89 2.76925
RGCC regulator of cell cycle 2.76925
TEKT2 tektin 2 (testicular) 2.76925
PCDHGA4 protocadherin gamma subfamily A, 4 2.76925
CPA2 carboxypeptidase A2 (pancreatic) 2.76925
WFDC6 WAP four-disulfide core domain 6 2.76925
DBX2 developing brain homeobox 2 2.76925
ART1 ADP-ribosyltransferase 1 2.76925
GRM6 glutamate receptor, metabotropic 6 2.76925
PITX2 paired-like homeodomain 2 2.76925
ANXA2R annexin A2 receptor 2.76925
SLC34A3 solute carrier family 34 (type II sodium/phosphate cotransporter), member 3 2.76925
TMEM215 transmembrane protein 215 2.76925
WFDC11 WAP four-disulfide core domain 11 2.76925
DNAH8 dynein, axonemal, heavy chain 8 2.76925
OPN1LW opsin 1 (cone pigments), long-wave-sensitive 2.76925
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 2.76925
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.76925
NLRP6 NLR family, pyrin domain containing 6 2.76925
NLRP5 NLR family, pyrin domain containing 5 2.76925
CD80 CD80 molecule 2.76925
AMER3 APC membrane recruitment protein 3 2.76925
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 2.76925
SOST sclerostin 2.76925
HOXB7 homeobox B7 2.76925
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 2.76925
FGF10 fibroblast growth factor 10 2.76925
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 2.76925
PLGLB1 plasminogen-like B1 2.76925
APOL1 apolipoprotein L, 1 2.76925
TBXA2R thromboxane A2 receptor 2.69946
CCDC184 coiled-coil domain containing 184 2.69946
C2ORF72 chromosome 2 open reading frame 72 2.69946
SNRNP48 small nuclear ribonucleoprotein 48kDa (U11/U12) 2.56413
TPX2 TPX2, microtubule-associated 2.56202
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 2.55044
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 2.50148
TJAP1 tight junction associated protein 1 (peripheral) 2.41005
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 2.40219
PANO1 proapoptotic nucleolar protein 1 2.3809
GPR20 G protein-coupled receptor 20 2.34298
BTLA B and T lymphocyte associated 2.34298
CMBL carboxymethylenebutenolidase homolog (Pseudomonas) 2.32976
CAV1 caveolin 1, caveolae protein, 22kDa 2.32976
ALKBH1 alkB, alkylation repair homolog 1 (E. coli) 2.32509
SAFB scaffold attachment factor B 2.3207
EFHD1 EF-hand domain family, member D1 2.31909
PCDH10 protocadherin 10 2.30732
ATP5PD ATP synthase peripheral stalk subunit d 2.30732
PROM1 prominin 1 2.29701
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 2.28249
YAP1 Yes-associated protein 1 2.27267
H2AJ H2A.J histone 2.27267
CDHR3 cadherin-related family member 3 2.27267
COPG1 coatomer protein complex, subunit gamma 1 2.25286
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 2.23398
CENPX centromere protein X 2.22409
PPM1N protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative) 2.21958
PHF8 PHD finger protein 8 2.21319
COL11A1 collagen, type XI, alpha 1 2.20382
DZANK1 double zinc ribbon and ankyrin repeat domains 1 2.20382
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 2.19953
ACVR1 activin A receptor, type I 2.19899
PRPS2 phosphoribosyl pyrophosphate synthetase 2 2.18167
CST6 cystatin E/M 2.11603
PPP1R16A protein phosphatase 1, regulatory subunit 16A 2.0891
GSAP gamma-secretase activating protein 2.0891
A2ML1 alpha-2-macroglobulin-like 1 2.07728
DLAT dihydrolipoamide S-acetyltransferase 2.06555
C11ORF98 chromosome 11 open reading frame 98 2.06473
C1ORF159 chromosome 1 open reading frame 159 2.06374
SLC35B3 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3 2.0617
RBX1 ring-box 1, E3 ubiquitin protein ligase 2.05708
B4GAT1 beta-1,4-glucuronyltransferase 1 2.05529
CCND2 cyclin D2 2.03599
CPXM2 carboxypeptidase X (M14 family), member 2 2.02852
ZNF112 zinc finger protein 112 2.02644
CCDC149 coiled-coil domain containing 149 2.02577
LARP6 La ribonucleoprotein domain family, member 6 2.00647

decreased expression

Symbol Name Standardized Value
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -2.78719
PKP3 plakophilin 3 -2.78719
SUSD5 sushi domain containing 5 -2.78719
IFI35 interferon-induced protein 35 -2.78719
KIFC3 kinesin family member C3 -2.76925
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -2.76925
ZNF595 zinc finger protein 595 -2.76925
DLX4 distal-less homeobox 4 -2.76925
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.76925
GPER1 G protein-coupled estrogen receptor 1 -2.76925
CALHM2 calcium homeostasis modulator 2 -2.76925
OLIG1 oligodendrocyte transcription factor 1 -2.76925
ASB18 ankyrin repeat and SOCS box containing 18 -2.76925
CD302 CD302 molecule -2.76925
APH1A APH1A gamma secretase subunit -2.76925
NBPF10 neuroblastoma breakpoint family, member 10 -2.76925
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.76925
CPXM1 carboxypeptidase X (M14 family), member 1 -2.76925
DLG4 discs, large homolog 4 (Drosophila) -2.74343
FZD4 frizzled class receptor 4 -2.70542
SPX spexin hormone -2.65833
NMUR1 neuromedin U receptor 1 -2.65833
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 -2.65833
KLLN killin, p53-regulated DNA replication inhibitor -2.65833
CCER2 coiled-coil glutamate-rich protein 2 -2.65833
KLHL6 kelch-like family member 6 -2.65833
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 -2.65833
GMNC geminin coiled-coil domain containing -2.65833
MMP28 matrix metallopeptidase 28 -2.65833
C19ORF67 chromosome 19 open reading frame 67 -2.65833
AJM1 apical junction component 1 homolog -2.65833
AANAT aralkylamine N-acetyltransferase -2.65833
TMPRSS6 transmembrane protease, serine 6 -2.65833
HAL histidine ammonia-lyase -2.65833
TFEB transcription factor EB -2.65833
ADGRG1 adhesion G protein-coupled receptor G1 -2.65833
NR1I2 nuclear receptor subfamily 1, group I, member 2 -2.65833
PRB4 proline-rich protein BstNI subfamily 4 -2.65833
SYCP2 synaptonemal complex protein 2 -2.65833
LOX lysyl oxidase -2.65833
LOC124902436 talanin -2.65833
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 -2.65833
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 -2.65833
PGAM2 phosphoglycerate mutase 2 (muscle) -2.65833
GDNF glial cell derived neurotrophic factor -2.65833
C1QTNF12 C1q and TNF related 12 -2.65833
CRYBB2 crystallin, beta B2 -2.65833
PARP15 poly (ADP-ribose) polymerase family, member 15 -2.65833
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1 -2.65833
PRH2 proline-rich protein HaeIII subfamily 2 -2.65833
TBPL2 TATA box binding protein like 2 -2.65833
DCDC2B doublecortin domain containing 2B -2.65833
NPFFR1 neuropeptide FF receptor 1 -2.65833
SVOP SV2 related protein homolog (rat) -2.65833
GOLGA6A golgin A6 family, member A -2.65833
PTPN7 protein tyrosine phosphatase, non-receptor type 7 -2.65833
LYPD1 LY6/PLAUR domain containing 1 -2.56751
MEF2C myocyte enhancer factor 2C -2.56235
WDR53 WD repeat domain 53 -2.55044
PDLIM3 PDZ and LIM domain 3 -2.55044
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae) -2.52761
ADRA2B adrenoceptor alpha 2B -2.50005
JADE1 jade family PHD finger 1 -2.49189
DEF8 differentially expressed in FDCP 8 homolog (mouse) -2.46299
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 -2.43439
FOXO3 forkhead box O3 -2.39246
FSTL1 follistatin-like 1 -2.39059
FBRSL1 fibrosin-like 1 -2.38208
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -2.31759
FBLN7 fibulin 7 -2.31496
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 -2.31496
FAM234B family with sequence similarity 234 member B -2.2688
COPZ1 coatomer protein complex, subunit zeta 1 -2.2635
IAPP islet amyloid polypeptide -2.25332
ZNF408 zinc finger protein 408 -2.25332
GRM3 glutamate receptor, metabotropic 3 -2.25332
POU5F1B POU class 5 homeobox 1B -2.20382
FAM32A family with sequence similarity 32, member A -2.1997
PPP4R3A protein phosphatase 4 regulatory subunit 3A -2.19953
RBM4B RNA binding motif protein 4B -2.19899
CLEC16A C-type lectin domain family 16, member A -2.19259
PTPN23 protein tyrosine phosphatase, non-receptor type 23 -2.19253
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta -2.17897
ZNF286A zinc finger protein 286A -2.16258
TPBG trophoblast glycoprotein -2.14786
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme -2.13704
FTL ferritin, light polypeptide -2.10304
ADAM12 ADAM metallopeptidase domain 12 -2.10155
CECR2 cat eye syndrome chromosome region, candidate 2 -2.09986
NBPF9 neuroblastoma breakpoint family, member 9 -2.08833
RPL27A ribosomal protein L27a -2.08833
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -2.06608
GRK4 G protein-coupled receptor kinase 4 -2.06608
CHD4 chromodomain helicase DNA binding protein 4 -2.06473
DEDD death effector domain containing -2.06374
ACRBP acrosin binding protein -2.04941
TRABD2A TraB domain containing 2A -2.04941
LRRC8E leucine rich repeat containing 8 family, member E -2.04941
CAPN14 calpain 14 -2.04941
CCDC175 coiled-coil domain containing 175 -2.04941
RANGRF RAN guanine nucleotide release factor -2.0327
GNPAT glyceronephosphate O-acyltransferase -2.0287
GEMIN4 gem (nuclear organelle) associated protein 4 -2.02852
VSTM5 V-set and transmembrane domain containing 5 -2.02644
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit -2.02577
MSRA methionine sulfoxide reductase A -2.00647