| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | furin (paired basic amino acid cleaving enzyme)|This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] (NCBI Entrez Gene Database, 5045) |
| External Link | https://ncbi.nlm.nih.gov/gene/5045 |
| Similar Terms | |
| Downloads & Tools |
498 genes differentially expressed following the FURIN gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CD9 | CD9 molecule | 0.0162004 |
| COQ8A | coenzyme Q8A | 0.0151656 |
| NNMT | nicotinamide N-methyltransferase | 0.0146961 |
| MT1E | metallothionein 1E | 0.013202 |
| MMP7 | matrix metallopeptidase 7 | 0.0123328 |
| ZBTB18 | zinc finger and BTB domain containing 18 | 0.0123063 |
| CLU | clusterin | 0.012142 |
| LY96 | lymphocyte antigen 96 | 0.0120948 |
| IL7R | interleukin 7 receptor | 0.0119481 |
| PLXNB2 | plexin B2 | 0.0118571 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | 0.0117819 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0116637 |
| ADIRF | adipogenesis regulatory factor | 0.0116525 |
| AREG | amphiregulin | 0.0115493 |
| LDOC1 | leucine zipper, down-regulated in cancer 1 | 0.0115301 |
| MT1X | metallothionein 1X | 0.0115158 |
| CFB | complement factor B | 0.0114125 |
| LY6E | lymphocyte antigen 6 complex, locus E | 0.0114121 |
| KRT19 | keratin 19, type I | 0.0114079 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.0111541 |
| TNFAIP6 | tumor necrosis factor, alpha-induced protein 6 | 0.0109608 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.0108963 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0108009 |
| MT1G | metallothionein 1G | 0.0107758 |
| LXN | latexin | 0.0105661 |
| MT1F | metallothionein 1F | 0.0104692 |
| PDLIM4 | PDZ and LIM domain 4 | 0.0104471 |
| ASS1 | argininosuccinate synthase 1 | 0.0104259 |
| MB | myoglobin | 0.0101803 |
| HIST1H2BK | histone cluster 1, H2bk | 0.0101452 |
| TNNI2 | troponin I type 2 (skeletal, fast) | 0.0101181 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 | 0.0100858 |
| GPNMB | glycoprotein (transmembrane) nmb | 0.0100743 |
| KRT7 | keratin 7, type II | 0.00989218 |
| TST | thiosulfate sulfurtransferase (rhodanese) | 0.00987681 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | 0.00985891 |
| IFI30 | interferon, gamma-inducible protein 30 | 0.00981636 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.00979395 |
| WDR13 | WD repeat domain 13 | 0.00966306 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.00964586 |
| WDR45 | WD repeat domain 45 | 0.00961789 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.00960936 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | 0.00960543 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.00950251 |
| RAP1GAP2 | RAP1 GTPase activating protein 2 | 0.00943915 |
| LRRC17 | leucine rich repeat containing 17 | 0.00943777 |
| PDGFRL | platelet-derived growth factor receptor-like | 0.00939435 |
| EXT1 | exostosin glycosyltransferase 1 | 0.00937651 |
| PLIN2 | perilipin 2 | 0.00926469 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.00923758 |
| KRT18 | keratin 18, type I | 0.00923029 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.00921754 |
| CRISP3 | cysteine-rich secretory protein 3 | 0.00921573 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | 0.00917584 |
| TSPAN4 | tetraspanin 4 | 0.00917169 |
| MT1M | metallothionein 1M | 0.00916446 |
| SERPING1 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | 0.00914904 |
| TAX1BP3 | Tax1 (human T-cell leukemia virus type I) binding protein 3 | 0.0091425 |
| SPON2 | spondin 2, extracellular matrix protein | 0.0091026 |
| PENK | proenkephalin | 0.00908336 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.00907657 |
| TRIB2 | tribbles pseudokinase 2 | 0.00907433 |
| HSPA1A | heat shock 70kDa protein 1A | 0.00907231 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 | 0.00907151 |
| TNNT1 | troponin T type 1 (skeletal, slow) | 0.00906991 |
| ACTA1 | actin, alpha 1, skeletal muscle | 0.00905079 |
| STC2 | stanniocalcin 2 | 0.00901412 |
| IFITM2 | interferon induced transmembrane protein 2 | 0.00889756 |
| JCHAIN | joining chain of multimeric IgA and IgM | 0.00884868 |
| ACP5 | acid phosphatase 5, tartrate resistant | 0.00884701 |
| LSP1 | lymphocyte-specific protein 1 | 0.00882849 |
| NENF | neudesin neurotrophic factor | 0.00882248 |
| FOLR1 | folate receptor 1 (adult) | 0.00878737 |
| PDGFD | platelet derived growth factor D | 0.00878313 |
| S100A6 | S100 calcium binding protein A6 | 0.00876298 |
| GAS6 | growth arrest-specific 6 | 0.00872094 |
| TMEM176B | transmembrane protein 176B | 0.00871512 |
| FPR1 | formyl peptide receptor 1 | 0.00870455 |
| IGFBP4 | insulin-like growth factor binding protein 4 | 0.00861131 |
| C10ORF10 | chromosome 10 open reading frame 10 | 0.00857815 |
| GMPR | guanosine monophosphate reductase | 0.00857403 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 0.00855532 |
| ANPEP | alanyl (membrane) aminopeptidase | 0.00853839 |
| CTSZ | cathepsin Z | 0.00846607 |
| S100A8 | S100 calcium binding protein A8 | 0.00843539 |
| HPN | hepsin | 0.00842561 |
| ACOT9 | acyl-CoA thioesterase 9 | 0.00838994 |
| GALC | galactosylceramidase | 0.00838964 |
| BCL2L1 | BCL2-like 1 | 0.00832086 |
| UROD | uroporphyrinogen decarboxylase | 0.00823099 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.00815478 |
| CSRP1 | cysteine and glycine-rich protein 1 | 0.00813635 |
| MT1H | metallothionein 1H | 0.00807341 |
| MT1HL1 | metallothionein 1H-like 1 | 0.0080702 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.00806451 |
| RAP1GAP | RAP1 GTPase activating protein | 0.00806273 |
| METTL7A | methyltransferase like 7A | 0.00800184 |
| MMP3 | matrix metallopeptidase 3 | 0.00799375 |
| KEAP1 | kelch-like ECH-associated protein 1 | 0.00798216 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0079659 |
| CPB1 | carboxypeptidase B1 (tissue) | 0.00793329 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | 0.00792117 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | 0.00792086 |
| QPRT | quinolinate phosphoribosyltransferase | 0.00789148 |
| IDO1 | indoleamine 2,3-dioxygenase 1 | 0.00785748 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.00784408 |
| MYBPC1 | myosin binding protein C, slow type | 0.00782461 |
| ADI1 | acireductone dioxygenase 1 | 0.0078197 |
| CCN3 | cellular communication network factor 3 | 0.00777003 |
| AK1 | adenylate kinase 1 | 0.0077597 |
| SDC4 | syndecan 4 | 0.00774951 |
| NCF1C | neutrophil cytosolic factor 1C pseudogene | 0.00774553 |
| LTF | lactotransferrin | 0.00768789 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.00767085 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.00765833 |
| IRF7 | interferon regulatory factor 7 | 0.00765313 |
| TPSAB1 | tryptase alpha/beta 1 | 0.00764582 |
| RABAC1 | Rab acceptor 1 (prenylated) | 0.00764153 |
| PFKM | phosphofructokinase, muscle | 0.00764096 |
| SAMSN1 | SAM domain, SH3 domain and nuclear localization signals 1 | 0.00762171 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.00755537 |
| CAMK1 | calcium/calmodulin-dependent protein kinase I | 0.00754202 |
| TNNC1 | troponin C type 1 (slow) | 0.00752554 |
| ORAI3 | ORAI calcium release-activated calcium modulator 3 | 0.00752038 |
| LINC00094 | long intergenic non-protein coding RNA 94 | 0.00745777 |
| RGS4 | regulator of G-protein signaling 4 | 0.00744865 |
| S100A4 | S100 calcium binding protein A4 | 0.00744006 |
| MCUB | mitochondrial calcium uniporter dominant negative subunit beta | 0.00741076 |
| COPS7A | COP9 signalosome subunit 7A | 0.00739903 |
| OLFM4 | olfactomedin 4 | 0.00738594 |
| CTSD | cathepsin D | 0.00736164 |
| KRAS | Kirsten rat sarcoma viral oncogene homolog | 0.00734251 |
| TMEM176A | transmembrane protein 176A | 0.00733729 |
| ZBTB16 | zinc finger and BTB domain containing 16 | 0.00730026 |
| RGS16 | regulator of G-protein signaling 16 | 0.00728705 |
| RARRES2 | retinoic acid receptor responder (tazarotene induced) 2 | 0.00727581 |
| MYL2 | myosin, light chain 2, regulatory, cardiac, slow | 0.00723996 |
| VPREB1 | pre-B lymphocyte 1 | 0.0072288 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | 0.00722355 |
| ANXA4 | annexin A4 | 0.00722334 |
| TMPRSS4 | transmembrane protease, serine 4 | 0.00721092 |
| HSPA2 | heat shock 70kDa protein 2 | 0.00720186 |
| CTBP2 | C-terminal binding protein 2 | 0.00713159 |
| MYL6B | myosin, light chain 6B, alkali, smooth muscle and non-muscle | 0.00713131 |
| BCAT2 | branched chain amino-acid transaminase 2, mitochondrial | 0.007129 |
| COMP | cartilage oligomeric matrix protein | 0.00711808 |
| HCFC1R1 | host cell factor C1 regulator 1 (XPO1 dependent) | 0.00711328 |
| CX3CR1 | chemokine (C-X3-C motif) receptor 1 | 0.0071128 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.00710576 |
| NADK | NAD kinase | 0.00710351 |
| APOD | apolipoprotein D | 0.00708343 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | 0.00705759 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.00702815 |
| CAMKK2 | calcium/calmodulin-dependent protein kinase kinase 2, beta | 0.00701896 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 | 0.00699908 |
| SLC27A3 | solute carrier family 27 (fatty acid transporter), member 3 | 0.00698726 |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | 0.00698365 |
| MYBPC2 | myosin binding protein C, fast type | 0.00697468 |
| SIRT3 | sirtuin 3 | 0.00697418 |
| CCNG2 | cyclin G2 | 0.00696626 |
| PYCARD | PYD and CARD domain containing | 0.00696492 |
| HIST1H2BD | histone cluster 1, H2bd | 0.00695821 |
| CLCN4 | chloride channel, voltage-sensitive 4 | 0.00693951 |
| MDK | midkine (neurite growth-promoting factor 2) | 0.00692336 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.00689714 |
| RRAGC | Ras-related GTP binding C | 0.00688182 |
| GPX1 | glutathione peroxidase 1 | 0.00687502 |
| SYT1 | synaptotagmin I | 0.00687306 |
| NUDCD3 | NudC domain containing 3 | 0.00686502 |
| BTF3P11 | basic transcription factor 3 pseudogene 11 | 0.00685872 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.00685613 |
| CTSF | cathepsin F | 0.00685287 |
| RNF19B | ring finger protein 19B | 0.00683741 |
| INHBA | inhibin, beta A | 0.00682791 |
| VPREB3 | pre-B lymphocyte 3 | 0.00680655 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | 0.00677102 |
| HIST1H2AC | histone cluster 1, H2ac | 0.00676376 |
| CDKN2C | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | 0.00676336 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | 0.0067581 |
| VGLL4 | vestigial-like family member 4 | 0.0067565 |
| PF4 | platelet factor 4 | 0.00675497 |
| MPST | mercaptopyruvate sulfurtransferase | 0.00673227 |
| KIAA0930 | KIAA0930 | 0.00672823 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.00672319 |
| HMGN3 | high mobility group nucleosomal binding domain 3 | 0.00671006 |
| C4BPA | complement component 4 binding protein, alpha | 0.00669969 |
| RARRES3 | retinoic acid receptor responder (tazarotene induced) 3 | 0.0066978 |
| MT3 | metallothionein 3 | 0.00669727 |
| IRF9 | interferon regulatory factor 9 | 0.00667887 |
| PLK2 | polo-like kinase 2 | 0.00666884 |
| ELOB | elongin B | 0.00666832 |
| VTCN1 | V-set domain containing T cell activation inhibitor 1 | 0.00666763 |
| CCP110 | centriolar coiled coil protein 110kDa | 0.00666486 |
| SECTM1 | secreted and transmembrane 1 | 0.00665297 |
| AGRN | agrin | 0.00664058 |
| CASP1 | caspase 1, apoptosis-related cysteine peptidase | 0.00664018 |
| S100A13 | S100 calcium binding protein A13 | 0.00663123 |
| MYH2 | myosin, heavy chain 2, skeletal muscle, adult | 0.00661749 |
| CDC20 | cell division cycle 20 | 0.0066029 |
| RFTN1 | raftlin, lipid raft linker 1 | 0.00659835 |
| KRT14 | keratin 14, type I | 0.00659509 |
| AHR | aryl hydrocarbon receptor | 0.00659013 |
| KLHL41 | kelch-like family member 41 | 0.00655813 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.00653841 |
| CD63 | CD63 molecule | 0.00651424 |
| PKM | pyruvate kinase, muscle | 0.00651318 |
| ELN | elastin | 0.00650754 |
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | 0.00650683 |
| GALE | UDP-galactose-4-epimerase | 0.00649818 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | 0.00649293 |
| PXDC1 | PX domain containing 1 | 0.00648125 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.00647332 |
| CPA3 | carboxypeptidase A3 (mast cell) | 0.00645095 |
| CLEC4A | C-type lectin domain family 4, member A | 0.0064436 |
| RPA3 | replication protein A3, 14kDa | 0.00642728 |
| ALDH1L1 | aldehyde dehydrogenase 1 family, member L1 | 0.00642244 |
| SLC38A1 | solute carrier family 38, member 1 | 0.00642155 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.00641777 |
| PRDX2 | peroxiredoxin 2 | 0.00641641 |
| MYL1 | myosin, light chain 1, alkali; skeletal, fast | 0.00641463 |
| DNALI1 | dynein, axonemal, light intermediate chain 1 | 0.00640524 |
| RYR1 | ryanodine receptor 1 (skeletal) | 0.00638236 |
| TRIM8 | tripartite motif containing 8 | 0.00636357 |
| SLCO4C1 | solute carrier organic anion transporter family, member 4C1 | 0.00635486 |
| AGT | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | 0.00633805 |
| MFGE8 | milk fat globule-EGF factor 8 protein | 0.00632472 |
| TNNT3 | troponin T type 3 (skeletal, fast) | 0.00632351 |
| LRRC15 | leucine rich repeat containing 15 | 0.00632074 |
| FAM107A | family with sequence similarity 107, member A | 0.00631998 |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B | 0.00631273 |
| IFI35 | interferon-induced protein 35 | 0.00630784 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | 0.00630575 |
| S100A11 | S100 calcium binding protein A11 | 0.00630544 |
| TCEAL4 | transcription elongation factor A (SII)-like 4 | 0.00630241 |
| PLSCR1 | phospholipid scramblase 1 | 0.00628785 |
| CASP4 | caspase 4, apoptosis-related cysteine peptidase | 0.00627985 |
| GBAP1 | glucosidase, beta, acid pseudogene 1 | 0.0062748 |
| PLEKHM1 | pleckstrin homology domain containing, family M (with RUN domain) member 1 | 0.00626156 |
| MSRB1 | methionine sulfoxide reductase B1 | 0.00625681 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 0.00625202 |
| PEG10 | paternally expressed 10 | 0.00624648 |
| ZDHHC4 | zinc finger, DHHC-type containing 4 | 0.00624252 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.00623017 |
| RNPS1 | RNA binding protein S1, serine-rich domain | 0.00622757 |
| IGLL1 | immunoglobulin lambda-like polypeptide 1 | 0.00622141 |
| WDTC1 | WD and tetratricopeptide repeats 1 | 0.00621328 |
| PPIE | peptidylprolyl isomerase E (cyclophilin E) | 0.0061838 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 0.00618024 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CHP1 | calcineurin-like EF-hand protein 1 | -0.0191246 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | -0.0176388 |
| PRAME | preferentially expressed antigen in melanoma | -0.0113186 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -0.0112956 |
| KLK10 | kallikrein-related peptidase 10 | -0.0108562 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -0.0107973 |
| ME2 | malic enzyme 2, NAD(+)-dependent, mitochondrial | -0.0101932 |
| TSPAN7 | tetraspanin 7 | -0.0101746 |
| GNAS | GNAS complex locus | -0.0101732 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | -0.00983519 |
| RAB4A | RAB4A, member RAS oncogene family | -0.00975514 |
| ABLIM1 | actin binding LIM protein 1 | -0.00957041 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | -0.00946116 |
| ADAM28 | ADAM metallopeptidase domain 28 | -0.00921669 |
| SRSF1 | serine/arginine-rich splicing factor 1 | -0.00921181 |
| TNC | tenascin C | -0.00915385 |
| PTCH1 | patched 1 | -0.00914842 |
| LRP4 | low density lipoprotein receptor-related protein 4 | -0.00901064 |
| KLK11 | kallikrein-related peptidase 11 | -0.00897725 |
| BCHE | butyrylcholinesterase | -0.00884168 |
| CHD7 | chromodomain helicase DNA binding protein 7 | -0.00883966 |
| NRN1 | neuritin 1 | -0.00873115 |
| SCEL | sciellin | -0.00871147 |
| SSR3 | signal sequence receptor, gamma (translocon-associated protein gamma) | -0.00868733 |
| ACKR3 | atypical chemokine receptor 3 | -0.00845401 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | -0.00844051 |
| TPD52 | tumor protein D52 | -0.00843547 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | -0.00836981 |
| RPN2 | ribophorin II | -0.00833105 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.00824404 |
| HOPX | HOP homeobox | -0.0080734 |
| ASPH | aspartate beta-hydroxylase | -0.00806836 |
| PLK1 | polo-like kinase 1 | -0.00806093 |
| MCOLN1 | mucolipin 1 | -0.0080375 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.00802733 |
| ATXN1 | ataxin 1 | -0.00801525 |
| SORBS1 | sorbin and SH3 domain containing 1 | -0.00800936 |
| ITGA6 | integrin, alpha 6 | -0.00798488 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | -0.00797748 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta | -0.00797396 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.00793359 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | -0.00789784 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.00788701 |
| ZMYND11 | zinc finger, MYND-type containing 11 | -0.00788627 |
| DCTN4 | dynactin 4 (p62) | -0.00787345 |
| CTSG | cathepsin G | -0.00785104 |
| PHKA1 | phosphorylase kinase, alpha 1 (muscle) | -0.00783399 |
| CD200 | CD200 molecule | -0.00782935 |
| TPX2 | TPX2, microtubule-associated | -0.00776676 |
| KLK8 | kallikrein-related peptidase 8 | -0.00770423 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | -0.00770365 |
| PRKCQ | protein kinase C, theta | -0.00769608 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | -0.00767267 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.00763446 |
| NTS | neurotensin | -0.00756354 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.00756009 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | -0.00753485 |
| DMD | dystrophin | -0.0075184 |
| HAL | histidine ammonia-lyase | -0.00746389 |
| CCL14 | chemokine (C-C motif) ligand 14 | -0.00745148 |
| MECOM | MDS1 and EVI1 complex locus | -0.00744902 |
| DEFB1 | defensin, beta 1 | -0.00742117 |
| HLTF | helicase-like transcription factor | -0.00741969 |
| EIF5A | eukaryotic translation initiation factor 5A | -0.0073872 |
| MEF2C | myocyte enhancer factor 2C | -0.00736672 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.00735201 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.00732964 |
| SRSF6 | serine/arginine-rich splicing factor 6 | -0.00731479 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.00730403 |
| CERS6 | ceramide synthase 6 | -0.00724496 |
| LCP2 | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) | -0.00724267 |
| FOXF1 | forkhead box F1 | -0.00720625 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.00720512 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.00719892 |
| RPS5 | ribosomal protein S5 | -0.00718525 |
| RHCG | Rh family, C glycoprotein | -0.00716449 |
| RANBP9 | RAN binding protein 9 | -0.00715521 |
| RHOA | ras homolog family member A | -0.00714184 |
| PSMD10 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 | -0.00713975 |
| ERAP2 | endoplasmic reticulum aminopeptidase 2 | -0.00713294 |
| CD34 | CD34 molecule | -0.00711892 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | -0.00708463 |
| CDA | cytidine deaminase | -0.00705787 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.00703508 |
| MYO1B | myosin IB | -0.00701822 |
| ALDH18A1 | aldehyde dehydrogenase 18 family, member A1 | -0.00700871 |
| SULT2B1 | sulfotransferase family, cytosolic, 2B, member 1 | -0.00693625 |
| SELL | selectin L | -0.0069124 |
| KLK7 | kallikrein-related peptidase 7 | -0.00689643 |
| TFDP1 | transcription factor Dp-1 | -0.00689405 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | -0.00688863 |
| BAALC | brain and acute leukemia, cytoplasmic | -0.00688765 |
| RREB1 | ras responsive element binding protein 1 | -0.00686792 |
| ITM2A | integral membrane protein 2A | -0.00685334 |
| COL15A1 | collagen, type XV, alpha 1 | -0.00685176 |
| TRAF3 | TNF receptor-associated factor 3 | -0.00684937 |
| SRP72 | signal recognition particle 72kDa | -0.00677646 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | -0.00673849 |
| CS | citrate synthase | -0.00673543 |
| SERTAD2 | SERTA domain containing 2 | -0.0067279 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | -0.00672505 |
| GLTP | glycolipid transfer protein | -0.00671349 |
| DGAT1 | diacylglycerol O-acyltransferase 1 | -0.00669774 |
| PRKCH | protein kinase C, eta | -0.00669447 |
| RBBP4 | retinoblastoma binding protein 4 | -0.00667474 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | -0.00666729 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.00664911 |
| DDHD2 | DDHD domain containing 2 | -0.00664872 |
| EP400 | E1A binding protein p400 | -0.00662957 |
| B3GNT2 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 | -0.00662635 |
| ME1 | malic enzyme 1, NADP(+)-dependent, cytosolic | -0.00662508 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | -0.0066177 |
| TAF9B | TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa | -0.00661557 |
| LIG1 | ligase I, DNA, ATP-dependent | -0.00660839 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.00658146 |
| S100A7 | S100 calcium binding protein A7 | -0.00657026 |
| ATRN | attractin | -0.00656844 |
| SMARCA1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 | -0.00656023 |
| LIMD1 | LIM domains containing 1 | -0.00653529 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.00649405 |
| BTNL8 | butyrophilin-like 8 | -0.00647488 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.00645607 |
| SEPTIN6 | septin 6 | -0.00644287 |
| CCNA2 | cyclin A2 | -0.00643039 |
| ZNF750 | zinc finger protein 750 | -0.0064186 |
| ARHGAP15 | Rho GTPase activating protein 15 | -0.00641801 |
| TESC | tescalcin | -0.00641553 |
| ACTG2 | actin, gamma 2, smooth muscle, enteric | -0.00641318 |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 | -0.00640487 |
| PPP1CC | protein phosphatase 1, catalytic subunit, gamma isozyme | -0.00640122 |
| UGT2B17 | UDP glucuronosyltransferase 2 family, polypeptide B17 | -0.00639827 |
| BCLAF1 | BCL2-associated transcription factor 1 | -0.0063895 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.00638613 |
| MUC4 | mucin 4, cell surface associated | -0.00637471 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | -0.00637104 |
| ACOX2 | acyl-CoA oxidase 2, branched chain | -0.0063534 |
| ITIH5 | inter-alpha-trypsin inhibitor heavy chain family, member 5 | -0.0063527 |
| COG5 | component of oligomeric golgi complex 5 | -0.00635096 |
| IMMT | inner membrane protein, mitochondrial | -0.00633431 |
| VWA8 | von Willebrand factor A domain containing 8 | -0.0063293 |
| MTARC2 | mitochondrial amidoxime reducing component 2 | -0.00631661 |
| MALL | mal, T-cell differentiation protein-like | -0.00630734 |
| SHTN1 | shootin 1 | -0.00629216 |
| GTF2H2B | general transcription factor IIH, polypeptide 2B (pseudogene) | -0.00627911 |
| PTPN7 | protein tyrosine phosphatase, non-receptor type 7 | -0.00627825 |
| USP34 | ubiquitin specific peptidase 34 | -0.0062752 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.00627194 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.00627069 |
| SPRR1B | small proline-rich protein 1B | -0.0062622 |
| TCP1 | t-complex 1 | -0.00625451 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.00625278 |
| EIF4B | eukaryotic translation initiation factor 4B | -0.0062388 |
| SMAD5 | SMAD family member 5 | -0.00621198 |
| PDZD2 | PDZ domain containing 2 | -0.00620759 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | -0.00620716 |
| RIOX2 | ribosomal oxygenase 2 | -0.00620575 |
| FRS2 | fibroblast growth factor receptor substrate 2 | -0.0062025 |
| NPR3 | natriuretic peptide receptor 3 | -0.00620184 |
| AK4 | adenylate kinase 4 | -0.00619867 |
| KLK6 | kallikrein-related peptidase 6 | -0.00618905 |
| MCAM | melanoma cell adhesion molecule | -0.00618622 |
| PCDH9 | protocadherin 9 | -0.0061749 |
| PTHLH | parathyroid hormone-like hormone | -0.00617109 |
| AOC3 | amine oxidase, copper containing 3 | -0.00615346 |
| ACACA | acetyl-CoA carboxylase alpha | -0.00614741 |
| NINL | ninein-like | -0.00613509 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.00611856 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | -0.00608577 |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | -0.00607511 |
| PI3 | peptidase inhibitor 3, skin-derived | -0.00606544 |
| COX15 | cytochrome c oxidase assembly homolog 15 (yeast) | -0.00605394 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.00604437 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.00602011 |
| GANAB | glucosidase, alpha; neutral AB | -0.00601374 |
| TARS1 | threonyl-tRNA synthetase 1 | -0.0060114 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.00600906 |
| HOXB7 | homeobox B7 | -0.00600491 |
| PGAP1 | post-GPI attachment to proteins 1 | -0.00600182 |
| SPRR2B | small proline-rich protein 2B | -0.00599034 |
| IVL | involucrin | -0.00598492 |
| DEFB4A | defensin, beta 4A | -0.00597768 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.00597695 |
| IL36G | interleukin 36, gamma | -0.0059616 |
| RGCC | regulator of cell cycle | -0.00595087 |
| CPS1 | carbamoyl-phosphate synthase 1, mitochondrial | -0.00594852 |
| RAB25 | RAB25, member RAS oncogene family | -0.00594514 |
| CANX | calnexin | -0.00594281 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.00593118 |
| CAPRIN1 | cell cycle associated protein 1 | -0.0059202 |
| TGFA | transforming growth factor, alpha | -0.0059072 |
| TBC1D9B | TBC1 domain family, member 9B (with GRAM domain) | -0.00590652 |
| NFYA | nuclear transcription factor Y, alpha | -0.00590042 |
| GPATCH8 | G patch domain containing 8 | -0.00588507 |
| SPRY1 | sprouty homolog 1, antagonist of FGF signaling (Drosophila) | -0.00588414 |
| KRT2 | keratin 2, type II | -0.00587748 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.00587171 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.00584292 |
| HACD1 | 3-hydroxyacyl-CoA dehydratase 1 | -0.00582996 |
| KPNB1 | karyopherin (importin) beta 1 | -0.00582161 |
| FZD3 | frizzled class receptor 3 | -0.00582019 |
| ELAVL1 | ELAV like RNA binding protein 1 | -0.00580617 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.00579999 |
| MCC | mutated in colorectal cancers | -0.00579694 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.00579231 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | -0.0057801 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.00577423 |
| LAIR1 | leukocyte-associated immunoglobulin-like receptor 1 | -0.00577226 |
| FGFBP1 | fibroblast growth factor binding protein 1 | -0.00576987 |
| STOM | stomatin | -0.00575815 |
| NUP205 | nucleoporin 205kDa | -0.00575802 |
| CRYBG3 | beta-gamma crystallin domain containing 3 | -0.00575294 |
| VPS28 | vacuolar protein sorting 28 homolog (S. cerevisiae) | -0.00573824 |
| CPSF1 | cleavage and polyadenylation specific factor 1, 160kDa | -0.00571101 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | -0.00571053 |
| KIF14 | kinesin family member 14 | -0.00570543 |
| RCAN1 | regulator of calcineurin 1 | -0.00570417 |
| CHRNA3 | cholinergic receptor, nicotinic, alpha 3 (neuronal) | -0.00569734 |
| CALML5 | calmodulin-like 5 | -0.00569312 |
| ABCG2 | ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) | -0.0056832 |
| SLC25A3 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 | -0.00567946 |
| NCK1 | NCK adaptor protein 1 | -0.00567016 |
| PITX1 | paired-like homeodomain 1 | -0.00562447 |
| TLK1 | tousled-like kinase 1 | -0.00561516 |
| PAK1 | p21 protein (Cdc42/Rac)-activated kinase 1 | -0.00561495 |
| VDAC2 | voltage-dependent anion channel 2 | -0.00561483 |
| ZNF589 | zinc finger protein 589 | -0.00560171 |
| AQP4 | aquaporin 4 | -0.00559683 |
| WAC | WW domain containing adaptor with coiled-coil | -0.00558519 |
| ASF1A | anti-silencing function 1A histone chaperone | -0.00557867 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.00557245 |
| CCND2 | cyclin D2 | -0.00557154 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.00554938 |
| XIC | X chromosome inactivation center | -0.00554795 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | -0.00554282 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -0.00552777 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.00551994 |
| UPF2 | UPF2 regulator of nonsense transcripts homolog (yeast) | -0.00551916 |
| PNN | pinin, desmosome associated protein | -0.00551813 |
| RAB23 | RAB23, member RAS oncogene family | -0.00550524 |
| EDN3 | endothelin 3 | -0.00549829 |
| RBM5 | RNA binding motif protein 5 | -0.00549476 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.00548787 |
| TKTL1 | transketolase-like 1 | -0.00547107 |
| RGS10 | regulator of G-protein signaling 10 | -0.00546589 |
| C6ORF48 | chromosome 6 open reading frame 48 | -0.00545885 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -0.00545857 |
| RCN2 | reticulocalbin 2, EF-hand calcium binding domain | -0.00545372 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0054488 |
| GFI1 | growth factor independent 1 transcription repressor | -0.00544217 |
| CDK5R1 | cyclin-dependent kinase 5, regulatory subunit 1 (p35) | -0.00543418 |
