FURIN Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description furin (paired basic amino acid cleaving enzyme)|This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] (NCBI Entrez Gene Database, 5045)
External Link http://www.ncbi.nlm.nih.gov/gene/5045
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Genes

67 interacting proteins for FURIN from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ADAM19 ADAM metallopeptidase domain 19
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4
ANTXR1 anthrax toxin receptor 1
ANTXR2 anthrax toxin receptor 2
AP2M1 adaptor-related protein complex 2, mu 1 subunit
BACE1 beta-site APP-cleaving enzyme 1
COL23A1 collagen, type XXIII, alpha 1
COL25A1 collagen, type XXV, alpha 1
CSNK2A1 casein kinase 2, alpha 1 polypeptide
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56
DSG3 desmoglein 3
EDA ectodysplasin A
EDN1 endothelin 1
EDN2 endothelin 2
ELAVL1 ELAV like RNA binding protein 1
F10 coagulation factor X
F2 coagulation factor II (thrombin)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
F9 coagulation factor IX
FBN1 fibrillin 1
FBN2 fibrillin 2
FBN3 fibrillin 3
FLNA filamin A, alpha
FLNC filamin C, gamma
GAS6 growth arrest-specific 6
GORASP2 golgi reassembly stacking protein 2, 55kDa
GPC3 glypican 3
HNF4A hepatocyte nuclear factor 4, alpha
ITM2C integral membrane protein 2C
LECT1 leukocyte cell derived chemotaxin 1
LRP1 low density lipoprotein receptor-related protein 1
MMP11 matrix metallopeptidase 11
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MMP24 matrix metallopeptidase 24 (membrane-inserted)
MMP25 matrix metallopeptidase 25
MST1R macrophage stimulating 1 receptor
MSTN myostatin
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NGF nerve growth factor (beta polypeptide)
NODAL nodal growth differentiation factor
NOTCH1 notch 1
NOTCH2 notch 2
NOTCH3 notch 3
NOTCH4 notch 4
PACS1 phosphofurin acidic cluster sorting protein 1
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PMCH pro-melanin-concentrating hormone
PRB4 proline-rich protein BstNI subfamily 4
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PROS1 protein S (alpha)
PROZ protein Z, vitamin K-dependent plasma glycoprotein
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8
SORCS1 sortilin-related VPS10 domain containing receptor 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TGFB1 transforming growth factor, beta 1
TGOLN2 trans-golgi network protein 2
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
UBC ubiquitin C
VWF von Willebrand factor
ZP3 zona pellucida glycoprotein 3 (sperm receptor)
ZP4 zona pellucida glycoprotein 4