FYN Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description FYN proto-oncogene, Src family tyrosine kinase|This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2534)
External Link http://www.ncbi.nlm.nih.gov/gene/2534
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Genes

409 interacting proteins for hub protein FYN from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
AATK apoptosis-associated tyrosine kinase
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACP1 acid phosphatase 1, soluble
ADAM15 ADAM metallopeptidase domain 15
ADD2 adducin 2 (beta)
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AIRE autoimmune regulator
AKAP6 A kinase (PRKA) anchor protein 6
ANXA6 annexin A6
APCS amyloid P component, serum
APOL5 apolipoprotein L, 5
APP amyloid beta (A4) precursor protein
ARHGAP32 Rho GTPase activating protein 32
ARHGAP33 Rho GTPase activating protein 33
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASB16 ankyrin repeat and SOCS box containing 16
ATXN1 ataxin 1
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCAR1 breast cancer anti-estrogen resistance 1
BCL3 B-cell CLL/lymphoma 3
BCR breakpoint cluster region
BMP8B bone morphogenetic protein 8b
BRCA2 breast cancer 2, early onset
BRPF3 bromodomain and PHD finger containing, 3
BTK Bruton agammaglobulinemia tyrosine kinase
C21ORF59 chromosome 21 open reading frame 59
C6 complement component 6
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAST calpastatin
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CAV3 caveolin 3
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBLC Cbl proto-oncogene C, E3 ubiquitin protein ligase
CCKBR cholecystokinin B receptor
CCR10 chemokine (C-C motif) receptor 10
CD19 CD19 molecule
CD2 CD2 molecule
CD226 CD226 molecule
CD244 CD244 molecule, natural killer cell receptor 2B4
CD247 CD247 molecule
CD2AP CD2-associated protein
CD300LB CD300 molecule-like family member b
CD300LF CD300 molecule-like family member f
CD36 CD36 molecule (thrombospondin receptor)
CD3D CD3d molecule, delta (CD3-TCR complex)
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD44 CD44 molecule (Indian blood group)
CD48 CD48 molecule
CD5 CD5 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
CDC27 cell division cycle 27
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDK5 cyclin-dependent kinase 5
CDK6 cyclin-dependent kinase 6
CDKL5 cyclin-dependent kinase-like 5
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CENPA centromere protein A
CEP152 centrosomal protein 152kDa
CHAF1A chromatin assembly factor 1, subunit A (p150)
CHN2 chimerin 2
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CKAP5 cytoskeleton associated protein 5
CLIC5 chloride intracellular channel 5
CLTC clathrin, heavy chain (Hc)
CNN1 calponin 1, basic, smooth muscle
CNN3 calponin 3, acidic
CNTFR ciliary neurotrophic factor receptor
CNTN1 contactin 1
CNTNAP1 contactin associated protein 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRMP1 collapsin response mediator protein 1
CSF1R colony stimulating factor 1 receptor
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSK c-src tyrosine kinase
CSMD2 CUB and Sushi multiple domains 2
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
CTNND2 catenin (cadherin-associated protein), delta 2
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila)
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCC DCC netrin 1 receptor
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
DKKL1 dickkopf-like 1
DLG2 discs, large homolog 2 (Drosophila)
DLG4 discs, large homolog 4 (Drosophila)
DLGAP1 discs, large (Drosophila) homolog-associated protein 1
DLGAP2 discs, large (Drosophila) homolog-associated protein 2
DLGAP3 discs, large (Drosophila) homolog-associated protein 3
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DLX4 distal-less homeobox 4
DNASE1L2 deoxyribonuclease I-like 2
DNM3 dynamin 3
DOCK1 dedicator of cytokinesis 1
DOCK3 dedicator of cytokinesis 3
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOK3 docking protein 3
DOK4 docking protein 4
DUSP15 dual specificity phosphatase 15
DYNLL1 dynein, light chain, LC8-type 1
DYNLT1 dynein, light chain, Tctex-type 1
EFNA1 ephrin-A1
EFNA2 ephrin-A2
EFNA3 ephrin-A3
EFNA4 ephrin-A4
EFNA5 ephrin-A5
EFS embryonal Fyn-associated substrate
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPHA3 EPH receptor A3
EPHA4 EPH receptor A4
EPHA8 EPH receptor A8
EPHB2 EPH receptor B2
EPHB3 EPH receptor B3
EPS15 epidermal growth factor receptor pathway substrate 15
ERBB3 erb-b2 receptor tyrosine kinase 3
EVL Enah/Vasp-like
EXTL3 exostosin-like glycosyltransferase 3
F2RL2 coagulation factor II (thrombin) receptor-like 2
FAM110A family with sequence similarity 110, member A
FANCA Fanconi anemia, complementation group A
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FGR FGR proto-oncogene, Src family tyrosine kinase
FLNA filamin A, alpha
FLNC filamin C, gamma
FLOT1 flotillin 1
FLOT2 flotillin 2
FLT1 fms-related tyrosine kinase 1
FNBP4 formin binding protein 4
FOXF2 forkhead box F2
FYB FYN binding protein
FYN FYN proto-oncogene, Src family tyrosine kinase
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
G6PD glucose-6-phosphate dehydrogenase
GAB2 GRB2-associated binding protein 2
GAB3 GRB2-associated binding protein 3
GAB4 GRB2-associated binding protein family, member 4
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAST gastrin
GCFC2 GC-rich sequence DNA-binding factor 2
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GNS glucosamine (N-acetyl)-6-sulfatase
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GP6 glycoprotein VI (platelet)
GPR45 G protein-coupled receptor 45
GPR63 G protein-coupled receptor 63
GRAP GRB2-related adaptor protein
GRB10 growth factor receptor-bound protein 10
GRB2 growth factor receptor-bound protein 2
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GSTZ1 glutathione S-transferase zeta 1
GTF2I general transcription factor IIi
GTF3A general transcription factor IIIA
GUCY2D guanylate cyclase 2D, membrane (retina-specific)
H3F3A H3 histone, family 3A
HCK HCK proto-oncogene, Src family tyrosine kinase
HCLS1 hematopoietic cell-specific Lyn substrate 1
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HDAC6 histone deacetylase 6
HEXA hexosaminidase A (alpha polypeptide)
HNRNPK heterogeneous nuclear ribonucleoprotein K
HNRNPR heterogeneous nuclear ribonucleoprotein R
HOXC8 homeobox C8
HRAS Harvey rat sarcoma viral oncogene homolog
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA4 heat shock 70kDa protein 4
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
IGF1R insulin-like growth factor 1 receptor
IL2RB interleukin 2 receptor, beta
IL3RA interleukin 3 receptor, alpha (low affinity)
IL7R interleukin 7 receptor
INSR insulin receptor
IRS1 insulin receptor substrate 1
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
ITCH itchy E3 ubiquitin protein ligase
ITGA6 integrin, alpha 6
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB4 integrin, beta 4
ITK IL2-inducible T-cell kinase
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
ITSN2 intersectin 2
JAK2 Janus kinase 2
JUP junction plakoglobin
KDR kinase insert domain receptor
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KMT2B lysine (K)-specific methyltransferase 2B
LAT linker for activation of T cells
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LDHA lactate dehydrogenase A
LDHB lactate dehydrogenase B
LPP LIM domain containing preferred translocation partner in lipoma
LPXN leupaxin
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LTBP2 latent transforming growth factor beta binding protein 2
LYN LYN proto-oncogene, Src family tyrosine kinase
MAG myelin associated glycoprotein
MAP2 microtubule-associated protein 2
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MAPK14 mitogen-activated protein kinase 14
MAPT microtubule-associated protein tau
MAX MYC associated factor X
MCAM melanoma cell adhesion molecule
MED14 mediator complex subunit 14
MED28 mediator complex subunit 28
MEPE matrix extracellular phosphoglycoprotein
MKI67 marker of proliferation Ki-67
MOS v-mos Moloney murine sarcoma viral oncogene homolog
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MST1R macrophage stimulating 1 receptor
MTA1 metastasis associated 1
MTA3 metastasis associated 1 family, member 3
MUSK muscle, skeletal, receptor tyrosine kinase
NBEA neurobeachin
NCAM1 neural cell adhesion molecule 1
NCK1 NCK adaptor protein 1
NCKAP5 NCK-associated protein 5
NCKIPSD NCK interacting protein with SH3 domain
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEK8 NIMA-related kinase 8
NELFB negative elongation factor complex member B
NFASC neurofascin
NFE2L2 nuclear factor, erythroid 2-like 2
NFS1 NFS1 cysteine desulfurase
NMT1 N-myristoyltransferase 1
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NPVF neuropeptide VF precursor
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR5A1 nuclear receptor subfamily 5, group A, member 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
ORC1 origin recognition complex, subunit 1
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PAX3 paired box 3
PAX7 paired box 7
PCDH8 protocadherin 8
PDE4D phosphodiesterase 4D, cAMP-specific
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDIA2 protein disulfide isomerase family A, member 2
PECAM1 platelet/endothelial cell adhesion molecule 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLAUR plasminogen activator, urokinase receptor
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLD2 phospholipase D2
PLXNA1 plexin A1
PLXNA2 plexin A2
PLXNA3 plexin A3
PLXNA4 plexin A4
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP1R3D protein phosphatase 1, regulatory subunit 3D
PRICKLE3 prickle homolog 3 (Drosophila)
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKCH protein kinase C, eta
PRKCQ protein kinase C, theta
PRKCZ protein kinase C, zeta
PROM1 prominin 1
PRX periaxin
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
PTPN5 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRA protein tyrosine phosphatase, receptor type, A
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRE protein tyrosine phosphatase, receptor type, E
PTPRF protein tyrosine phosphatase, receptor type, F
PTPRT protein tyrosine phosphatase, receptor type, T
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PXN paxillin
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RAVER1 ribonucleoprotein, PTB-binding 1
RIMS1 regulating synaptic membrane exocytosis 1
RIMS2 regulating synaptic membrane exocytosis 2
RIN3 Ras and Rab interactor 3
RP1L1 retinitis pigmentosa 1-like 1
RPL10 ribosomal protein L10
RPP38 ribonuclease P/MRP 38kDa subunit
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RRAS related RAS viral (r-ras) oncogene homolog
RTN4 reticulon 4
RUNX3 runt-related transcription factor 3
S100B S100 calcium binding protein B
SCARF2 scavenger receptor class F, member 2
SCN5A sodium channel, voltage gated, type V alpha subunit
SDC3 syndecan 3
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SEPN1 selenoprotein N, 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SF1 splicing factor 1
SF3B4 splicing factor 3b, subunit 4, 49kDa
SH2B2 SH2B adaptor protein 2
SH2D1A SH2 domain containing 1A
SH3BP2 SH3-domain binding protein 2
SH3KBP1 SH3-domain kinase binding protein 1
SHANK3 SH3 and multiple ankyrin repeat domains 3
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHC2 SHC (Src homology 2 domain containing) transforming protein 2
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SHC4 SHC (Src homology 2 domain containing) family, member 4
SHROOM2 shroom family member 2
SIGLEC10 sialic acid binding Ig-like lectin 10
SIT1 signaling threshold regulating transmembrane adaptor 1
SKAP1 src kinase associated phosphoprotein 1
SKAP2 src kinase associated phosphoprotein 2
SLAMF1 signaling lymphocytic activation molecule family member 1
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNX12 sorting nexin 12
SNX17 sorting nexin 17
SNX3 sorting nexin 3
SNX8 sorting nexin 8
SOCS1 suppressor of cytokine signaling 1
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
SP1 Sp1 transcription factor
SPHK1 sphingosine kinase 1
SPHK2 sphingosine kinase 2
SPN sialophorin
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK11 serine/threonine kinase 11
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
SYK spleen tyrosine kinase
SYNJ2 synaptojanin 2
TDRD1 tudor domain containing 1
TEK TEK tyrosine kinase, endothelial
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGOLN2 trans-golgi network protein 2
THY1 Thy-1 cell surface antigen
TMPO thymopoietin
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNK2 tyrosine kinase, non-receptor, 2
TOM1L1 target of myb1 (chicken)-like 1
TRAIP TRAF interacting protein
TRAT1 T cell receptor associated transmembrane adaptor 1
TRIM39 tripartite motif containing 39
TRIM69 tripartite motif containing 69
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TSKS testis-specific serine kinase substrate
TUBA1A tubulin, alpha 1a
TUBA1B tubulin, alpha 1b
TUBA3C tubulin, alpha 3c
TUBA4A tubulin, alpha 4a
TULP1 tubby like protein 1
TULP4 tubby like protein 4
TXK TXK tyrosine kinase
TYK2 tyrosine kinase 2
TYRO3 TYRO3 protein tyrosine kinase
TYROBP TYRO protein tyrosine kinase binding protein
UCK2 uridine-cytidine kinase 2
UNC119 unc-119 homolog (C. elegans)
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VCP valosin containing protein
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae)
WAS Wiskott-Aldrich syndrome
WASF1 WAS protein family, member 1
WASF2 WAS protein family, member 2
WASL Wiskott-Aldrich syndrome-like
WIPF1 WAS/WASL interacting protein family, member 1
WNK2 WNK lysine deficient protein kinase 2
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
YES1 YES proto-oncogene 1, Src family tyrosine kinase
YTHDC1 YTH domain containing 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZBTB33 zinc finger and BTB domain containing 33