FZD5 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description frizzled class receptor 5|Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7855)
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Genes

323 genes differentially expressed following the FZD5 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PCDHB14 protocadherin beta 14 2.79715
GRXCR1 glutaredoxin, cysteine rich 1 2.77944
TEX13B testis expressed 13B 2.77944
OR1A1 olfactory receptor, family 1, subfamily A, member 1 2.77944
CELA3B chymotrypsin-like elastase family, member 3B 2.77944
RAX retina and anterior neural fold homeobox 2.77944
SLC35G5 solute carrier family 35, member G5 2.77944
HORMAD1 HORMA domain containing 1 2.77944
BHLHE23 basic helix-loop-helix family, member e23 2.77944
PDZD9 PDZ domain containing 9 2.77944
NXPH3 neurexophilin 3 2.77944
NPPC natriuretic peptide C 2.77944
WDR87 WD repeat domain 87 2.77944
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 2.77944
COL19A1 collagen, type XIX, alpha 1 2.77944
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 2.77944
VCX2 variable charge, X-linked 2 2.77944
CLEC12A C-type lectin domain family 12, member A 2.77944
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 2.77944
ZNF503 zinc finger protein 503 2.77944
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 2.77944
MUC5B mucin 5B, oligomeric mucus/gel-forming 2.77944
APOA2 apolipoprotein A-II 2.77944
CCDC39 coiled-coil domain containing 39 2.77944
COPZ2 coatomer protein complex, subunit zeta 2 2.77944
GNG13 guanine nucleotide binding protein (G protein), gamma 13 2.77944
NPIPA7 nuclear pore complex interacting protein family, member A7 2.77944
GNRHR gonadotropin-releasing hormone receptor 2.77944
RNF133 ring finger protein 133 2.77944
C2ORF78 chromosome 2 open reading frame 78 2.77944
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 2.77944
EPHB3 EPH receptor B3 2.77944
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 2.77944
SPNS2 spinster homolog 2 (Drosophila) 2.77944
DMRTC1B DMRT-like family C1B 2.77944
SLC30A2 solute carrier family 30 (zinc transporter), member 2 2.77944
SLC30A4 solute carrier family 30 (zinc transporter), member 4 2.77944
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 2.77944
GYPB glycophorin B (MNS blood group) 2.77944
KCNRG potassium channel regulator 2.77944
CA6 carbonic anhydrase VI 2.77944
PTGFR prostaglandin F receptor (FP) 2.77944
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 2.77944
EPHB2 EPH receptor B2 2.77944
CD300LG CD300 molecule-like family member g 2.77944
SPATA31H1 SPATA31 subfamily H member 1 2.77944
RAX2 retina and anterior neural fold homeobox 2 2.77944
AANAT aralkylamine N-acetyltransferase 2.77944
CD300LF CD300 molecule-like family member f 2.77944
ALX4 ALX homeobox 4 2.77944
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic 2.77944
DNAAF1 dynein, axonemal, assembly factor 1 2.77944
PDF peptide deformylase (mitochondrial) 2.77944
MIOX myo-inositol oxygenase 2.77944
AVPR1B arginine vasopressin receptor 1B 2.77944
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 2.77944
CCDC198 coiled-coil domain containing 198 2.77944
CIMIP3 ciliary microtubule inner protein 3 2.77944
PRRT1B proline rich transmembrane protein 1B 2.77944
LOC124903372 uncharacterized LOC124903372 2.77944
ZNF593OS ZNF593 opposite strand 2.77944
SMIM35 small integral membrane protein 35 2.77944
LY6L lymphocyte antigen 6 family member L 2.77944
EZHIP EZH inhibitory protein 2.77944
H1-8 H1.8 linker histone 2.77944
OR56B2 olfactory receptor family 56 subfamily B member 2 2.77944
WNT16 wingless-type MMTV integration site family, member 16 2.77944
GCSAM germinal center-associated, signaling and motility 2.77944
AWAT1 acyl-CoA wax alcohol acyltransferase 1 2.77944
IL4 interleukin 4 2.77944
C10ORF67 chromosome 10 open reading frame 67 2.77944
CBLN3 cerebellin 3 precursor 2.77944
VMA21 VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) 2.77944
NXPE1 neurexophilin and PC-esterase domain family, member 1 2.77944
TEX101 testis expressed 101 2.77944
GGT6 gamma-glutamyltransferase 6 2.77944
FAP fibroblast activation protein, alpha 2.77944
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 2.77944
ARHGAP15 Rho GTPase activating protein 15 2.77944
KHDC1L KH homology domain containing 1-like 2.77944
ZNF705A zinc finger protein 705A 2.77944
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 2.77944
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 2.77944
PRDM7 PR domain containing 7 2.77944
NDP Norrie disease (pseudoglioma) 2.77944
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 2.77944
LRRC72 leucine rich repeat containing 72 2.77944
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 2.77944
EMCN endomucin 2.77944
NXNL1 nucleoredoxin-like 1 2.77944
CCDC27 coiled-coil domain containing 27 2.77944
TSPAN32 tetraspanin 32 2.77944
FOXE3 forkhead box E3 2.77944
IL19 interleukin 19 2.77944
RGCC regulator of cell cycle 2.77944
TBC1D21 TBC1 domain family, member 21 2.77944
TBC1D26 TBC1 domain family, member 26 2.77944
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 2.77944
PRRX1 paired related homeobox 1 2.77944
MAEL maelstrom spermatogenic transposon silencer 2.77944
VTCN1 V-set domain containing T cell activation inhibitor 1 2.77944
THBD thrombomodulin 2.77944
DAZAP1 DAZ associated protein 1 2.77944
GML glycosylphosphatidylinositol anchored molecule like 2.77944
CLEC4D C-type lectin domain family 4, member D 2.77944
AKNAD1 AKNA domain containing 1 2.77944
CST5 cystatin D 2.77944
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 2.77944
CT55 cancer/testis antigen 55 2.77944
NOG noggin 2.77944
KLHL8 kelch-like family member 8 2.77944
TMEM132D transmembrane protein 132D 2.77944
AQP7 aquaporin 7 2.77944
AQP6 aquaporin 6, kidney specific 2.77944
CPSF4L cleavage and polyadenylation specific factor 4-like 2.77944
DCAF12L2 DDB1 and CUL4 associated factor 12-like 2 2.77944
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 2.77944
LCN1 lipocalin 1 2.77944
SPINK9 serine peptidase inhibitor, Kazal type 9 2.77944
SIAH3 siah E3 ubiquitin protein ligase family member 3 2.77944
PROK1 prokineticin 1 2.77944
ZNF648 zinc finger protein 648 2.77944
NLRP3 NLR family, pyrin domain containing 3 2.77944
ASCL2 achaete-scute family bHLH transcription factor 2 2.77944
OR6B1 olfactory receptor, family 6, subfamily B, member 1 2.77944
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 2.77944
CNR2 cannabinoid receptor 2 (macrophage) 2.77944
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 2.77944
ANKRD30B ankyrin repeat domain 30B 2.77944
ACADL acyl-CoA dehydrogenase, long chain 2.77944
ZNF831 zinc finger protein 831 2.77944
NR2F1 nuclear receptor subfamily 2, group F, member 1 2.77944
CFI complement factor I 2.77944
CCDC83 coiled-coil domain containing 83 2.77944
EDN2 endothelin 2 2.77944
STOML3 stomatin (EPB72)-like 3 2.77944
GSC2 goosecoid homeobox 2 2.77944
MAGEA12 melanoma antigen family A12 2.77944
SST somatostatin 2.77944
XCR1 chemokine (C motif) receptor 1 2.77944
ZC3H11D zinc finger CCCH-type containing 11D 2.77944
ITGB7 integrin, beta 7 2.77944
PGM5 phosphoglucomutase 5 2.77944
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 2.77944
TAS2R41 taste receptor, type 2, member 41 2.77944
IP6K3 inositol hexakisphosphate kinase 3 2.77944
MMP10 matrix metallopeptidase 10 2.77944
IL33 interleukin 33 2.77944
PGR progesterone receptor 2.77944
NKPD1 NTPase, KAP family P-loop domain containing 1 2.77944
TMPRSS15 transmembrane protease, serine 15 2.77944
CENPF centromere protein F, 350/400kDa 2.75579
PADI4 peptidyl arginine deiminase, type IV 2.73141
PSPN persephin 2.73141
USP50 ubiquitin specific peptidase 50 2.73141
LAMA4 laminin, alpha 4 2.73141
PI4K2B phosphatidylinositol 4-kinase type 2 beta 2.73141
CCDC149 coiled-coil domain containing 149 2.70728
SLC67A1 solute carrier family 67 member 1 2.7072
FAM89B family with sequence similarity 89, member B 2.69767
QTRT1 queuine tRNA-ribosyltransferase 1 2.6683
ANO10 anoctamin 10 2.64781
PCDHGB6 protocadherin gamma subfamily B, 6 2.61205
CFAP44 cilia and flagella associated protein 44 2.53539
CLUL1 clusterin-like 1 (retinal) 2.51361
PHF11 PHD finger protein 11 2.46917
OSBPL10 oxysterol binding protein-like 10 2.43763
MBIP MAP3K12 binding inhibitory protein 1 2.42729
FAHD1 fumarylacetoacetate hydrolase domain containing 1 2.39813
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 2.35131
KCTD7 potassium channel tetramerization domain containing 7 2.33778
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 2.3267
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 2.3267
GCC2 GRIP and coiled-coil domain containing 2 2.30917
CLVS1 clavesin 1 2.30218
TTC21B tetratricopeptide repeat domain 21B 2.2991
MYRIP myosin VIIA and Rab interacting protein 2.29716
CST3 cystatin C 2.27605
HMOX1 heme oxygenase 1 2.27222
MOG myelin oligodendrocyte glycoprotein 2.25925
NLRC3 NLR family, CARD domain containing 3 2.25925
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2.22292
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 2.22292
MATN1 matrilin 1, cartilage matrix protein 2.19679
CFDP1 craniofacial development protein 1 2.17908
KIAA1549L KIAA1549-like 2.154
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 2.13504
SPP1 secreted phosphoprotein 1 2.13128
VWC2 von Willebrand factor C domain containing 2 2.12847
NFU1 NFU1 iron-sulfur cluster scaffold 2.12239
EP300 E1A binding protein p300 2.10921
VAMP5 vesicle-associated membrane protein 5 2.10234
TMSB10 thymosin beta 10 2.09821
ZMPSTE24 zinc metallopeptidase STE24 2.0852
SLBP stem-loop binding protein 2.07941
ZNF114 zinc finger protein 114 2.07941
ELP1 elongator acetyltransferase complex subunit 1 2.07715
SBDS Shwachman-Bodian-Diamond syndrome 2.0754
CEP55 centrosomal protein 55kDa 2.05272
MTMR1 myotubularin related protein 1 2.03952
CP ceruloplasmin (ferroxidase) 2.03651
GNG4 guanine nucleotide binding protein (G protein), gamma 4 2.03061
RELL1 RELT-like 1 2.03061
TVP23A trans-golgi network vesicle protein 23 homolog A (S. cerevisiae) 2.03014
FASTKD2 FAST kinase domains 2 2.02315
ZNF385A zinc finger protein 385A 2.02315
CEP85 centrosomal protein 85kDa 2.01612
COBL cordon-bleu WH2 repeat protein 2.01224

decreased expression

Symbol Name Standardized Value
FZD5 frizzled class receptor 5 -2.79715
AURKC aurora kinase C -2.77944
MSX1 msh homeobox 1 -2.77944
LOC105378220 macrophage receptor MARCO-like -2.77944
STEAP1B STEAP family member 1B -2.77944
TRIM58 tripartite motif containing 58 -2.77944
MST1R macrophage stimulating 1 receptor -2.77944
CRLF2 cytokine receptor-like factor 2 -2.77944
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) -2.77944
GSTO1 glutathione S-transferase omega 1 -2.77944
SPDYE6 speedy/RINGO cell cycle regulator family member E6 -2.77944
EPHA10 EPH receptor A10 -2.77944
SDR42E2 short chain dehydrogenase/reductase family 42E, member 2 -2.77944
FBXL6 F-box and leucine-rich repeat protein 6 -2.77944
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma -2.77944
ZNF26 zinc finger protein 26 -2.77944
CCDC171 coiled-coil domain containing 171 -2.77944
CALCR calcitonin receptor -2.77395
GPATCH11 G patch domain containing 11 -2.75579
NRSN1 neurensin 1 -2.73141
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 -2.73141
CLEC19A C-type lectin domain family 19, member A -2.73141
NCKAP1L NCK-associated protein 1-like -2.73141
UPB1 ureidopropionase, beta -2.73141
WDR93 WD repeat domain 93 -2.73141
CHRDL2 chordin-like 2 -2.73141
CD96 CD96 molecule -2.73141
LOX lysyl oxidase -2.73141
ZNF492 zinc finger protein 492 -2.73141
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 -2.73141
FGF23 fibroblast growth factor 23 -2.73141
ATOH7 atonal homolog 7 (Drosophila) -2.73141
TMPRSS11E transmembrane protease, serine 11E -2.73141
KCTD11 potassium channel tetramerization domain containing 11 -2.73141
BHLHA15 basic helix-loop-helix family, member a15 -2.73141
TEX46 testis expressed 46 -2.73141
LMNTD1 lamin tail domain containing 1 -2.73141
CNTN3 contactin 3 (plasmacytoma associated) -2.73141
FAM131C family with sequence similarity 131, member C -2.73141
RTN1 reticulon 1 -2.73141
AMN amnion associated transmembrane protein -2.73141
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 -2.73141
ZNF423 zinc finger protein 423 -2.73141
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 -2.73141
PLET1 placenta expressed transcript 1 -2.73141
ERAS ES cell expressed Ras -2.73141
ZFP28 ZFP28 zinc finger protein -2.73141
CLIP4 CAP-GLY domain containing linker protein family, member 4 -2.73141
AMIGO1 adhesion molecule with Ig-like domain 1 -2.73141
TMEM94 transmembrane protein 94 -2.69559
SSBP3 single stranded DNA binding protein 3 -2.66272
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) -2.61095
LAMP1 lysosomal-associated membrane protein 1 -2.60752
DKK2 dickkopf WNT signaling pathway inhibitor 2 -2.60406
DPY30 dpy-30 homolog (C. elegans) -2.59303
SLC22A31 solute carrier family 22, member 31 -2.54874
PCDHB4 protocadherin beta 4 -2.54874
CLK4 CDC-like kinase 4 -2.47914
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -2.46463
DAPK3 death-associated protein kinase 3 -2.44495
ANKS3 ankyrin repeat and sterile alpha motif domain containing 3 -2.44002
PACRG PARK2 co-regulated -2.43295
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -2.4248
OPCML opioid binding protein/cell adhesion molecule-like -2.40712
SMYD3 SET and MYND domain containing 3 -2.39811
TUSC3 tumor suppressor candidate 3 -2.39059
PCSK7 proprotein convertase subtilisin/kexin type 7 -2.37423
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 -2.37121
CLDN11 claudin 11 -2.36612
RBM28 RNA binding motif protein 28 -2.34004
WSB2 WD repeat and SOCS box containing 2 -2.33778
AFAP1 actin filament associated protein 1 -2.33083
DCLK2 doublecortin-like kinase 2 -2.32746
RNF44 ring finger protein 44 -2.32746
TINCR tissue differentiation-inducing non-protein coding RNA -2.32746
PSPH phosphoserine phosphatase -2.32691
RAB12 RAB12, member RAS oncogene family -2.3267
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 -2.30687
SRPX sushi-repeat containing protein, X-linked -2.30011
GFOD2 glucose-fructose oxidoreductase domain containing 2 -2.29937
BBS1 Bardet-Biedl syndrome 1 -2.29438
TMEM183A transmembrane protein 183A -2.27691
TUBB4B tubulin, beta 4B class IVb -2.27605
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -2.24939
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial -2.20874
PLK4 polo-like kinase 4 -2.20051
EGFL8 EGF-like-domain, multiple 8 -2.19722
ZNF585B zinc finger protein 585B -2.18464
POLR2G polymerase (RNA) II (DNA directed) polypeptide G -2.17908
CKMT1A creatine kinase, mitochondrial 1A -2.15901
SH2D5 SH2 domain containing 5 -2.15586
ZNF689 zinc finger protein 689 -2.15114
VILL villin-like -2.14994
BTBD1 BTB (POZ) domain containing 1 -2.13596
RPL14 ribosomal protein L14 -2.13596
SORBS2 sorbin and SH3 domain containing 2 -2.13374
ITPRIP inositol 1,4,5-trisphosphate receptor interacting protein -2.13374
ECHDC3 enoyl CoA hydratase domain containing 3 -2.12027
CORO2A coronin, actin binding protein, 2A -2.11063
IL11 interleukin 11 -2.10921
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase -2.10249
AKAP3 A kinase (PRKA) anchor protein 3 -2.10234
ELOVL6 ELOVL fatty acid elongase 6 -2.09006
PLAAT1 phospholipase A and acyltransferase 1 -2.07452
TGFA transforming growth factor, alpha -2.06119
ZNF600 zinc finger protein 600 -2.05914
BMPR1A bone morphogenetic protein receptor, type IA -2.02906
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -2.02315
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -2.01612
CFAP95 cilia and flagella associated protein 95 -2.01612
PRKCQ protein kinase C, theta -2.01612
AEBP1 AE binding protein 1 -2.01224
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa -2.01224
RPN1 ribophorin I -2.00314
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 -2.00222