Fanconi anemia pathway Gene Set

Dataset PID Pathways
Category structural or functional annotations
Type pathway
Description Interstrand cross links (ICL) of DNA can be induced by both endogenous and exogenous ligands. ICL if not repaired will lead to cell death. ICL repair pathway, also known as Fanconi anemia pathway is the cellular response to this type of DNA damage. (Pathway Ontology, PW_0001065)
External Link http://public.ndexbio.org/#/network/6befb873-6192-11e5-8ac5-06603eb7f303
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Genes

46 proteins participating in the Fanconi anemia pathway pathway from the PID Pathways dataset.

Symbol Name
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
ATRIP ATR interacting protein
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C17ORF70 chromosome 17 open reading frame 70
C19ORF40 chromosome 19 open reading frame 40
CHEK1 checkpoint kinase 1
FAN1 FANCD2/FANCI-associated nuclease 1
FANCA Fanconi anemia, complementation group A
FANCB Fanconi anemia, complementation group B
FANCC Fanconi anemia, complementation group C
FANCD2 Fanconi anemia, complementation group D2
FANCE Fanconi anemia, complementation group E
FANCF Fanconi anemia, complementation group F
FANCG Fanconi anemia, complementation group G
FANCI Fanconi anemia, complementation group I
FANCL Fanconi anemia, complementation group L
FANCM Fanconi anemia, complementation group M
FBXW11 F-box and WD repeat domain containing 11
H2AFX H2A histone family, member X
HES1 hes family bHLH transcription factor 1
HUS1 HUS1 checkpoint homolog (S. pombe)
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
NBN nibrin
PALB2 partner and localizer of BRCA2
RAD1 RAD1 checkpoint DNA exonuclease
RAD17 RAD17 homolog (S. pombe)
RAD50 RAD50 homolog (S. cerevisiae)
RAD9A RAD9 homolog A (S. pombe)
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RMI1 RecQ mediated genome instability 1
RPA1 replication protein A1, 70kDa
RPA2 replication protein A2, 32kDa
SSPO SCO-spondin
TOP3A topoisomerase (DNA) III alpha
TOPBP1 topoisomerase (DNA) II binding protein 1
UBE2T ubiquitin-conjugating enzyme E2T
USP1 ubiquitin specific peptidase 1
WDR48 WD repeat domain 48
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3