Fasciculation Gene Set
Dataset
CTD Gene-Disease Associations
Category
disease or phenotype associations
Type
disease
Description
Fasciculations are observed as small, local, involuntary muscle contractions (twitching) visible under the skin. Fasciculations result from increased irritability of an axon (which in turn is often a manifestation of disease of a motor neuron). This leads to sporadic discharges of all the muscle fibers controlled by the axon in isolation from other motor units. (Human Phenotype Ontology , HP_0002380 )
External Link
http://ctdbase.org/detail.go?type=disease&acc=MESH:D005207
Similar Terms
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Genes
15 genes/proteins associated with the disease Fasciculation from the curated CTD Gene-Disease Associations dataset.
Symbol
Name
Standardized Value
BCHE
butyrylcholinesterase
2.88009
CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)
1.72884
CHRNA4
cholinergic receptor, nicotinic, alpha 4 (neuronal)
1.70636
CHRNB4
cholinergic receptor, nicotinic, beta 4 (neuronal)
1.46832
CHRNA3
cholinergic receptor, nicotinic, alpha 3 (neuronal)
1.45352
HTR3A
5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
1.3231
CHRNA7
cholinergic receptor, nicotinic, alpha 7 (neuronal)
1.25245
FOS
FBJ murine osteosarcoma viral oncogene homolog
1.20848
TNF
tumor necrosis factor
1.19639
IL1B
interleukin 1, beta
1.18326
CHRM3
cholinergic receptor, muscarinic 3
1.05312
IL6
interleukin 6
1.03715
CHRM1
cholinergic receptor, muscarinic 1
1.02708
CASP3
caspase 3, apoptosis-related cysteine peptidase
1.02596
NOS2
nitric oxide synthase 2, inducible
1.01549
