Fat digestion and absorption Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Fat is an important energy source from food. More than 95% of dietary fat is long-chain triacylglycerols (TAG), the remaining being phospholipids (4.5%) and sterols. In the small intestine lumen, dietary TAG is hydrolyzed to fatty acids (FA) and monoacylglycerols (MAG) by pancreatic lipase. These products are then emulsified with the help of phospholipids (PL) and bile acids (BA) present in bile to form micelles. Free FAs and MAGs are taken up by the enterocyte where they are rapidly resynthesized in endoplasmic reticulum (ER) to form TAG. PLs from the diet as well as bile - mainly LPA - too are absorbed by the enterocyte and are acylated to form phosphatidic acid (PA), which is also converted into TAG. Absorbed cholesterol (CL) is acylated to cholesterol esters (CE). Within the ER, TAG joins CE and apolipoprotein B (ApoB) to form chylomicrons that enter circulation through the lymph. (Kyoto Encyclopedia of Genes and Genomes, hsa04975)
External Link https://www.kegg.jp/entry/hsa04975
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Genes

43 proteins participating in the Fat digestion and absorption pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
APOA1 apolipoprotein A-I
APOA4 apolipoprotein A-IV
APOB apolipoprotein B
CD36 CD36 molecule (thrombospondin receptor)
CEL carboxyl ester lipase
CLPS colipase, pancreatic
DGAT1 diacylglycerol O-acyltransferase 1
DGAT2 diacylglycerol O-acyltransferase 2
FABP1 fatty acid binding protein 1, liver
FABP2 fatty acid binding protein 2, intestinal
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial
LIPF lipase, gastric
MOGAT2 monoacylglycerol O-acyltransferase 2
MOGAT3 monoacylglycerol O-acyltransferase 3
MTTP microsomal triglyceride transfer protein
NPC1L1 NPC1-like 1
PLA2G10 phospholipase A2, group X
PLA2G12A phospholipase A2, group XIIA
PLA2G12B phospholipase A2, group XIIB
PLA2G1B phospholipase A2, group IB (pancreas)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G2C phospholipase A2, group IIC
PLA2G2D phospholipase A2, group IID
PLA2G2E phospholipase A2, group IIE
PLA2G2F phospholipase A2, group IIF
PLA2G3 phospholipase A2, group III
PLA2G5 phospholipase A2, group V
PLPP1 phospholipid phosphatase 1
PLPP2 phospholipid phosphatase 2
PLPP3 phospholipid phosphatase 3
PNLIP pancreatic lipase
PNLIPRP1 pancreatic lipase-related protein 1
PNLIPRP2 pancreatic lipase-related protein 2
SCARB1 scavenger receptor class B, member 1
SLC27A1 solute carrier family 27 (fatty acid transporter), member 1
SLC27A4 solute carrier family 27 (fatty acid transporter), member 4
SOAT1 sterol O-acyltransferase 1
SOAT2 sterol O-acyltransferase 2