Fc gamma R-mediated phagocytosis Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Phagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes take part in this process in higher organisms. After opsonization with antibodies (IgG), foreign extracellular materials are recognized by Fc gamma receptors. Cross-linking of Fc gamma receptors initiates a variety of signals mediated by tyrosine phosphorylation of multiple proteins, which lead through the actin cytoskeleton rearrangements and membrane remodeling to the formation of phagosomes. Nascent phagosomes undergo a process of maturation that involves fusion with lysosomes. The acquisition of lysosomal proteases and release of reactive oxygen species are crucial for digestion of engulfed materials in phagosomes. (Kyoto Encyclopedia of Genes and Genomes, hsa04666)
External Link https://www.kegg.jp/entry/hsa04666
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Genes

98 proteins participating in the Fc gamma R-mediated phagocytosis pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ACTR3C ARP3 actin-related protein 3 homolog C (yeast)
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
AMPH amphiphysin
ARF6 ADP-ribosylation factor 6
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa
ARPC4-TTLL3 ARPC4-TTLL3 readthrough
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
ARPC5L actin related protein 2/3 complex, subunit 5-like
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
BIN1 bridging integrator 1
CDC42 cell division cycle 42
CFL2 cofilin 2 (muscle)
CLSTN1 calsyntenin 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
DNM2 dynamin 2
DOCK1 dedicator of cytokinesis 1
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
GAB2 GRB2-associated binding protein 2
GSN gelsolin
HCK HCK proto-oncogene, Src family tyrosine kinase
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
INPPL1 inositol polyphosphate phosphatase-like 1
JMJD7-PLA2G4B JMJD7-PLA2G4B readthrough
LIMK1 LIM domain kinase 1
LIMK2 LIM domain kinase 2
LNCEGFL7OS lncRNA EGFL7 opposite strand
LOC102724971 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8
LOC124905743 low affinity immunoglobulin gamma Fc region receptor III-B
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MYO10 myosin X
NCF1 neutrophil cytosolic factor 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PKN1 protein kinase N1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLA2G4B phospholipase A2, group IVB (cytosolic)
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLA2G4D phospholipase A2, group IVD (cytosolic)
PLA2G4E phospholipase A2, group IVE
PLA2G4F phospholipase A2, group IVF
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLD2 phospholipase D2
PLPP1 phospholipid phosphatase 1
PLPP2 phospholipid phosphatase 2
PLPP3 phospholipid phosphatase 3
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKCG protein kinase C, gamma
PRKCSH protein kinase C substrate 80K-H
PTPRC protein tyrosine phosphatase, receptor type, C
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE3 ribonuclease, RNase A family, 3
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
SCIN scinderin
SPHK1 sphingosine kinase 1
SPHK2 sphingosine kinase 2
SPNS1 spinster homolog 1 (Drosophila)
SYK spleen tyrosine kinase
VASP vasodilator-stimulated phosphoprotein
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)
WAS Wiskott-Aldrich syndrome
WASF1 WAS protein family, member 1
WASF2 WAS protein family, member 2
WASF3 WAS protein family, member 3