Fedratinib (hydrochloride hydrate)_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fedratinib (hydrochloride hydrate) perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fedratinib (hydrochloride hydrate)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AREG amphiregulin 0.23258
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.169464
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.125659
VMP1 vacuole membrane protein 1 0.0942753
PCBP2 poly(rC) binding protein 2 0.085855
EIF4A2 eukaryotic translation initiation factor 4A2 0.0834827
ANXA1 annexin A1 0.0754021
CCNL1 cyclin L1 0.074322
ASPH aspartate beta-hydroxylase 0.0699002
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0683685
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0656906
FXR1 fragile X mental retardation, autosomal homolog 1 0.0606652
ACTG1 actin gamma 1 0.058204
BIRC6 baculoviral IAP repeat containing 6 0.0578016
TMEM41B transmembrane protein 41B 0.0576104
TPM3 tropomyosin 3 0.0572947
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0566138
PUM2 pumilio RNA-binding family member 2 0.0563761
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.055956
IPO7 importin 7 0.0513335
RRM2 ribonucleotide reductase M2 0.0505335
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0488546
EEF2 eukaryotic translation elongation factor 2 0.0483066
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0478428
XPO1 exportin 1 0.0477561
TENM3 teneurin transmembrane protein 3 0.0476775
LDHA lactate dehydrogenase A 0.0467156
USP34 ubiquitin specific peptidase 34 0.0458109
GSK3B glycogen synthase kinase 3 beta 0.0457668
EIF4B eukaryotic translation initiation factor 4B 0.0418725
JMJD1C jumonji domain containing 1C 0.0417948
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0416041
KDM3A lysine (K)-specific demethylase 3A 0.0415702
KIF5B kinesin family member 5B 0.0414981
ENO1 enolase 1, (alpha) 0.0412869
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0412187
YAP1 Yes-associated protein 1 0.039575
CLDND1 claudin domain containing 1 0.0393324
NCAPD2 non-SMC condensin I complex, subunit D2 0.0391058
RTN4 reticulon 4 0.0384653
MEMO1 mediator of cell motility 1 0.0376435
ERRFI1 ERBB receptor feedback inhibitor 1 0.0375601
CPOX coproporphyrinogen oxidase 0.037186
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0368702
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0366588
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0366397
NEK7 NIMA-related kinase 7 0.0361923
MGAT4C MGAT4 family, member C 0.0358243
USP9X ubiquitin specific peptidase 9, X-linked 0.0357329
GASK1B golgi associated kinase 1B 0.0356996
YTHDC1 YTH domain containing 1 0.0353637
CEP192 centrosomal protein 192kDa 0.0351402
RICTOR RPTOR independent companion of MTOR, complex 2 0.0344687
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0340051
MMP12 matrix metallopeptidase 12 0.0338788
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0338229
ARRDC3 arrestin domain containing 3 0.0338181
BRWD1 bromodomain and WD repeat domain containing 1 0.0338031
CLTC clathrin, heavy chain (Hc) 0.0332055
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0330625
GPBP1 GC-rich promoter binding protein 1 0.0330613
ANKRD17 ankyrin repeat domain 17 0.0325783
PLK2 polo-like kinase 2 0.0321974
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0321191
NHSL1 NHS-like 1 0.0318578
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0318479
SMYD3 SET and MYND domain containing 3 0.0316756
ADAM9 ADAM metallopeptidase domain 9 0.0313047
PICALM phosphatidylinositol binding clathrin assembly protein 0.0312474
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0311779
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0311461
RAB6A RAB6A, member RAS oncogene family 0.031052
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0310497
CAMKMT calmodulin-lysine N-methyltransferase 0.0309753
UHMK1 U2AF homology motif (UHM) kinase 1 0.0309391
EXOC6B exocyst complex component 6B 0.0308477
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0307559
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0306507
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0300834
SETD5 SET domain containing 5 0.0298708
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0296491
MARCHF6 membrane associated ring-CH-type finger 6 0.0293588
ECT2 epithelial cell transforming 2 0.0292547
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0291719
WDR43 WD repeat domain 43 0.0291643
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0291065
SPATS2 spermatogenesis associated, serine-rich 2 0.0290919
CCNY cyclin Y 0.0290843
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0288892
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0286671
TM9SF3 transmembrane 9 superfamily member 3 0.0285894
POTEF POTE ankyrin domain family, member F 0.0282878
ARB2A ARB2 cotranscriptional regulator A 0.0282743
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0282601
FNIP1 folliculin interacting protein 1 0.0282147
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0277278
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0276376
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0275756
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.0275366
CCN2 cellular communication network factor 2 0.0275077

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.223107
TMSB10 thymosin beta 10 -0.195221
NLGN1 neuroligin 1 -0.14061
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.11232
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.100649
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0869471
PTMA prothymosin, alpha -0.0720527
FTL ferritin, light polypeptide -0.0718882
HMGA2 high mobility group AT-hook 2 -0.0675143
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0575787
RPLP1 ribosomal protein, large, P1 -0.0549653
RPL35A ribosomal protein L35a -0.0484743
CNRIP1 cannabinoid receptor interacting protein 1 -0.0471903
CCND1 cyclin D1 -0.0468521
RPS8 ribosomal protein S8 -0.0460971
HSPB1 heat shock 27kDa protein 1 -0.0452938
RPS24 ribosomal protein S24 -0.0445948
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0438309
RPS19 ribosomal protein S19 -0.043043
RPL23 ribosomal protein L23 -0.0428939
TPT1 tumor protein, translationally-controlled 1 -0.0390527
RPS23 ribosomal protein S23 -0.0380913
RPL34 ribosomal protein L34 -0.0365273
GCG glucagon -0.0360582
ZNF804A zinc finger protein 804A -0.0343549
CELF2 CUGBP, Elav-like family member 2 -0.0342591
S100A10 S100 calcium binding protein A10 -0.0334584
RPL19 ribosomal protein L19 -0.0318829
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0317694
BIRC3 baculoviral IAP repeat containing 3 -0.0314306
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0310893
RPL28 ribosomal protein L28 -0.0309958
RPS3 ribosomal protein S3 -0.0302037
DLC1 DLC1 Rho GTPase activating protein -0.0300128
RPL26 ribosomal protein L26 -0.0299827
RPL32 ribosomal protein L32 -0.029441
H1-0 H1.0 linker histone -0.0291106
HMGB1 high mobility group box 1 -0.0287871
RPL38 ribosomal protein L38 -0.0282736
RPL12 ribosomal protein L12 -0.0282419
RPL37A ribosomal protein L37a -0.0274144
RPLP2 ribosomal protein, large, P2 -0.0273434
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0272026
RPS5 ribosomal protein S5 -0.0268706
RIMS2 regulating synaptic membrane exocytosis 2 -0.0265283
RPL9 ribosomal protein L9 -0.026494
RPL36 ribosomal protein L36 -0.0264731
RPS25 ribosomal protein S25 -0.0264055
HMGA1 high mobility group AT-hook 1 -0.0262726
RPS13 ribosomal protein S13 -0.0262678
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.025912
TUBB tubulin, beta class I -0.0251507
PDIA3 protein disulfide isomerase family A, member 3 -0.024488
RPS21 ribosomal protein S21 -0.0243553
ATP5F1E ATP synthase F1 subunit epsilon -0.0238594
RPL35 ribosomal protein L35 -0.0236565
GNAS GNAS complex locus -0.0234941
RPS14 ribosomal protein S14 -0.0231093
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.022984
AKAP12 A kinase (PRKA) anchor protein 12 -0.0228656
RPS16 ribosomal protein S16 -0.0223072
CAVIN1 caveolae associated protein 1 -0.0221098
TUBA1B tubulin, alpha 1b -0.0220718
LRRC23 leucine rich repeat containing 23 -0.0220225
PDE4D phosphodiesterase 4D, cAMP-specific -0.0219678
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0212767
DIAPH2 diaphanous-related formin 2 -0.0211766
CALR calreticulin -0.0211744
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0211347
FUS FUS RNA binding protein -0.0209884
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0207636
RPL31 ribosomal protein L31 -0.020358
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0200695
RPS15 ribosomal protein S15 -0.0200436
RPS29 ribosomal protein S29 -0.0199065
RPS26 ribosomal protein S26 -0.0198646
RPS27 ribosomal protein S27 -0.0197423
RPS6 ribosomal protein S6 -0.0195515
RPL8 ribosomal protein L8 -0.0194705
PRH1 proline-rich protein HaeIII subfamily 1 -0.0194539
DEK DEK proto-oncogene -0.0193646
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0192065
TGM2 transglutaminase 2 -0.0189412
RPL11 ribosomal protein L11 -0.0189215
LOC102724023 ES1 protein homolog, mitochondrial -0.0188744
CSMD3 CUB and Sushi multiple domains 3 -0.0188606
SOD1 superoxide dismutase 1, soluble -0.0186216
RPLP0 ribosomal protein, large, P0 -0.018565
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0182562
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0182226
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0181583
ATG7 autophagy related 7 -0.0180829
TUBB4B tubulin, beta 4B class IVb -0.0177971
LDHB lactate dehydrogenase B -0.0177945
RPL27 ribosomal protein L27 -0.0177258
UBB ubiquitin B -0.0177159
RAI14 retinoic acid induced 14 -0.0176647
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0176267
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0176021
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0175411