| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fedratinib (hydrochloride hydrate) perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Fedratinib (hydrochloride hydrate)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.132054 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.113385 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0994337 |
| ASPH | aspartate beta-hydroxylase | 0.0993509 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0893035 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0808985 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0802157 |
| APP | amyloid beta (A4) precursor protein | 0.0795385 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.077554 |
| CALU | calumenin | 0.0772791 |
| ACTG1 | actin gamma 1 | 0.0737829 |
| SPAG9 | sperm associated antigen 9 | 0.0727773 |
| SDC4 | syndecan 4 | 0.0699479 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0639819 |
| WDR43 | WD repeat domain 43 | 0.063011 |
| ATP13A3 | ATPase type 13A3 | 0.0628224 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0622643 |
| TPM3 | tropomyosin 3 | 0.0603456 |
| ARRDC3 | arrestin domain containing 3 | 0.0591465 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0589743 |
| SUCO | SUN domain containing ossification factor | 0.0587534 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0584704 |
| ANKRD11 | ankyrin repeat domain 11 | 0.058142 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.058134 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0574597 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0573613 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0568001 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0566538 |
| POTEF | POTE ankyrin domain family, member F | 0.0556418 |
| GOLGA4 | golgin A4 | 0.0538692 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0534931 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0529514 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0519423 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0516877 |
| PLK2 | polo-like kinase 2 | 0.0514738 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0500574 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0498343 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0495477 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0494241 |
| NAV2 | neuron navigator 2 | 0.0483566 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0472594 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0466401 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0464551 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0463486 |
| SET | SET nuclear proto-oncogene | 0.045409 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0453629 |
| UBQLN1 | ubiquilin 1 | 0.0453372 |
| COG5 | component of oligomeric golgi complex 5 | 0.043673 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0432544 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0432489 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0432425 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0431322 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0421056 |
| PTK2 | protein tyrosine kinase 2 | 0.0420229 |
| PCBP2 | poly(rC) binding protein 2 | 0.0416299 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0410364 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.040812 |
| COPA | coatomer protein complex, subunit alpha | 0.040794 |
| SEC24D | SEC24 family member D | 0.0407001 |
| SRPK2 | SRSF protein kinase 2 | 0.0405751 |
| SMAD3 | SMAD family member 3 | 0.0403846 |
| MSN | moesin | 0.0402659 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0401914 |
| CDK13 | cyclin-dependent kinase 13 | 0.0399466 |
| CALR | calreticulin | 0.0396475 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0396353 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0388873 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0388725 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.038386 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0382024 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0381379 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0379052 |
| FMNL2 | formin-like 2 | 0.0379049 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0378877 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0377633 |
| GOLGA2 | golgin A2 | 0.0374522 |
| SEPTIN9 | septin 9 | 0.0372742 |
| HELZ | helicase with zinc finger | 0.036158 |
| OGA | O-GlcNAcase | 0.0360936 |
| JAK1 | Janus kinase 1 | 0.0358846 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0356136 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0356115 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0352753 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0349599 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | 0.0344528 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | 0.0343416 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0343135 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0343052 |
| RBM39 | RNA binding motif protein 39 | 0.0341825 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | 0.0341554 |
| CANX | calnexin | 0.0338819 |
| CTBP2 | C-terminal binding protein 2 | 0.0338292 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0338025 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0330064 |
| GDF15 | growth differentiation factor 15 | 0.0328968 |
| GLG1 | golgi glycoprotein 1 | 0.032868 |
| FAR1 | fatty acyl CoA reductase 1 | 0.0328455 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0327027 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.032682 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0323481 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.144442 |
| FTL | ferritin, light polypeptide | -0.141678 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.139535 |
| TMSB10 | thymosin beta 10 | -0.138051 |
| CCL2 | chemokine (C-C motif) ligand 2 | -0.125228 |
| CD44 | CD44 molecule (Indian blood group) | -0.0857346 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0725414 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0693607 |
| GPC6 | glypican 6 | -0.0658432 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0621362 |
| VIM | vimentin | -0.0579948 |
| MX1 | MX dynamin-like GTPase 1 | -0.0577429 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.057166 |
| MT2A | metallothionein 2A | -0.056362 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0546908 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0522151 |
| GLIS3 | GLIS family zinc finger 3 | -0.0519886 |
| CP | ceruloplasmin (ferroxidase) | -0.0518021 |
| PFN1 | profilin 1 | -0.0506605 |
| S100A10 | S100 calcium binding protein A10 | -0.0495466 |
| RPL35A | ribosomal protein L35a | -0.0479918 |
| RNF213 | ring finger protein 213 | -0.0466642 |
| RPS6 | ribosomal protein S6 | -0.0461052 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0416431 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0416376 |
| IFI44L | interferon-induced protein 44-like | -0.0403673 |
| RPLP1 | ribosomal protein, large, P1 | -0.0398832 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0379703 |
| RPS8 | ribosomal protein S8 | -0.0365696 |
| RIGI | RNA sensor RIG-I | -0.0365203 |
| RPL12 | ribosomal protein L12 | -0.0358276 |
| SP100 | SP100 nuclear antigen | -0.0357206 |
| RPS19 | ribosomal protein S19 | -0.0353055 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0352609 |
| RPLP2 | ribosomal protein, large, P2 | -0.0347462 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0342724 |
| RPL28 | ribosomal protein L28 | -0.0338337 |
| RPS24 | ribosomal protein S24 | -0.0338135 |
| TUBA1B | tubulin, alpha 1b | -0.0333618 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0328313 |
| HMGB1 | high mobility group box 1 | -0.0327381 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0321777 |
| MAP1B | microtubule-associated protein 1B | -0.0321753 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0321347 |
| S100A11 | S100 calcium binding protein A11 | -0.031208 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0308143 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0294096 |
| CSF1 | colony stimulating factor 1 (macrophage) | -0.0293501 |
| RPL34 | ribosomal protein L34 | -0.0292922 |
| RPL35 | ribosomal protein L35 | -0.0290453 |
| RHEX | regulator of hemoglobinization and erythroid cell expansion | -0.0289937 |
| RRBP1 | ribosome binding protein 1 | -0.0284818 |
| OSMR | oncostatin M receptor | -0.0282762 |
| RPL9 | ribosomal protein L9 | -0.0273424 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0269358 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0266168 |
| LAP3 | leucine aminopeptidase 3 | -0.0256039 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0251318 |
| DIAPH3 | diaphanous-related formin 3 | -0.0251271 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.0248501 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0244335 |
| KYNU | kynureninase | -0.0244247 |
| RPS5 | ribosomal protein S5 | -0.024255 |
| PLSCR1 | phospholipid scramblase 1 | -0.0242367 |
| EGR1 | early growth response 1 | -0.0241002 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0237483 |
| TXNRD1 | thioredoxin reductase 1 | -0.0236142 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0233653 |
| RPS23 | ribosomal protein S23 | -0.0233273 |
| TAGLN2 | transgelin 2 | -0.0225564 |
| HMGA1 | high mobility group AT-hook 1 | -0.0225414 |
| S100A9 | S100 calcium binding protein A9 | -0.0223025 |
| RPL23 | ribosomal protein L23 | -0.0215676 |
| PTGR1 | prostaglandin reductase 1 | -0.0212651 |
| RPL36 | ribosomal protein L36 | -0.0208909 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0206209 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0206178 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0205162 |
| RPS25 | ribosomal protein S25 | -0.0201555 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0200182 |
| DGKI | diacylglycerol kinase, iota | -0.0199466 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0197984 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0197982 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0197465 |
| XAF1 | XIAP associated factor 1 | -0.0193859 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0192906 |
| MYADM | myeloid-associated differentiation marker | -0.0192344 |
| PKM | pyruvate kinase, muscle | -0.0191709 |
| SLC9A3R1 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 | -0.0190841 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0188996 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0188149 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0186521 |
| SERF2 | small EDRK-rich factor 2 | -0.0184675 |
| HLA-C | major histocompatibility complex, class I, C | -0.0184638 |
| TUBB | tubulin, beta class I | -0.0184562 |
| CYBA | cytochrome b-245, alpha polypeptide | -0.0183607 |
| G0S2 | G0/G1 switch 2 | -0.0183217 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0181043 |
| GBP1 | guanylate binding protein 1, interferon-inducible | -0.017944 |
| MKI67 | marker of proliferation Ki-67 | -0.0177811 |
