| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fedratinib (hydrochloride hydrate) perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Fedratinib (hydrochloride hydrate)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ACTG1 | actin gamma 1 | 0.251501 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.149759 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.146705 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.139706 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0959178 |
| SPAG9 | sperm associated antigen 9 | 0.0809971 |
| SMAD3 | SMAD family member 3 | 0.0788028 |
| PCBP2 | poly(rC) binding protein 2 | 0.0722678 |
| DSCAM | Down syndrome cell adhesion molecule | 0.071953 |
| ANXA2 | annexin A2 | 0.070682 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0696634 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0684849 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0653891 |
| GOLGA4 | golgin A4 | 0.0637202 |
| WDR43 | WD repeat domain 43 | 0.0636385 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0605474 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0605042 |
| NAV2 | neuron navigator 2 | 0.0594364 |
| FMNL2 | formin-like 2 | 0.0591578 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0589919 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0542675 |
| FLNB | filamin B, beta | 0.0540834 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0538704 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0534981 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0527265 |
| LDHA | lactate dehydrogenase A | 0.0516255 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0494131 |
| PGK1 | phosphoglycerate kinase 1 | 0.0489039 |
| VMP1 | vacuole membrane protein 1 | 0.0478771 |
| MSN | moesin | 0.0458583 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0457645 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0457513 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0451579 |
| OGA | O-GlcNAcase | 0.043577 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0433678 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.043222 |
| POTEF | POTE ankyrin domain family, member F | 0.0427195 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0423057 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0422047 |
| TPM3 | tropomyosin 3 | 0.0415745 |
| MCL1 | myeloid cell leukemia 1 | 0.0414169 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.0407618 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0405229 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0404335 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0404055 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0403354 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.0401141 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0389916 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0389281 |
| JMJD1C | jumonji domain containing 1C | 0.0382439 |
| SUCO | SUN domain containing ossification factor | 0.0376668 |
| RASA2 | RAS p21 protein activator 2 | 0.0376047 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0374003 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0370434 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0370126 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0365604 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0359556 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.035529 |
| RND3 | Rho family GTPase 3 | 0.0355285 |
| COPA | coatomer protein complex, subunit alpha | 0.0354792 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0342929 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0342899 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.034154 |
| ANO6 | anoctamin 6 | 0.0340488 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0340372 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0338314 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0330939 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0330436 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0329793 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0329554 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0327082 |
| ANXA1 | annexin A1 | 0.0325968 |
| WDR45B | WD repeat domain 45B | 0.0325873 |
| SBF2 | SET binding factor 2 | 0.0325684 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0324711 |
| SDC4 | syndecan 4 | 0.0323085 |
| RTN4 | reticulon 4 | 0.0320955 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0320052 |
| NBAS | neuroblastoma amplified sequence | 0.0319337 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.031825 |
| SRP54 | signal recognition particle 54kDa | 0.0317332 |
| DENND4A | DENN/MADD domain containing 4A | 0.0316385 |
| FBL | fibrillarin | 0.0315031 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0313808 |
| CLTC | clathrin, heavy chain (Hc) | 0.0313242 |
| TCIM | transcriptional and immune response regulator | 0.031205 |
| CALU | calumenin | 0.0309661 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0309402 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0309377 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.030702 |
| URI1 | URI1, prefoldin-like chaperone | 0.0305931 |
| NUP58 | nucleoporin 58 | 0.0305746 |
| MYOF | myoferlin | 0.0304427 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0301344 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0301053 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0298743 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0296945 |
| CCNY | cyclin Y | 0.0296175 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0293307 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.02911 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.235969 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.168969 |
| FTL | ferritin, light polypeptide | -0.121877 |
| RPS19 | ribosomal protein S19 | -0.115461 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.103721 |
| RPLP1 | ribosomal protein, large, P1 | -0.0874794 |
| VIM | vimentin | -0.0816925 |
| RPS6 | ribosomal protein S6 | -0.0793932 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0739419 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0703396 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0694403 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0675236 |
| MT2A | metallothionein 2A | -0.0663474 |
| RPS24 | ribosomal protein S24 | -0.0638597 |
| RPL35A | ribosomal protein L35a | -0.0609456 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0607033 |
| PTMA | prothymosin, alpha | -0.0551611 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.0508576 |
| RPL23 | ribosomal protein L23 | -0.0494728 |
| KYNU | kynureninase | -0.0487389 |
| KRT81 | keratin 81, type II | -0.0477737 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0469512 |
| RPLP2 | ribosomal protein, large, P2 | -0.0460811 |
| S100A10 | S100 calcium binding protein A10 | -0.0447351 |
| RPL28 | ribosomal protein L28 | -0.0444584 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0428206 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0404653 |
| RPS8 | ribosomal protein S8 | -0.0403507 |
| RPL19 | ribosomal protein L19 | -0.0393253 |
| RPL37A | ribosomal protein L37a | -0.0390249 |
| MAP1B | microtubule-associated protein 1B | -0.0383627 |
| RPS23 | ribosomal protein S23 | -0.0382633 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0381259 |
| RPS13 | ribosomal protein S13 | -0.0377024 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0366845 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0366641 |
| RPL26 | ribosomal protein L26 | -0.0340798 |
| TPM1 | tropomyosin 1 (alpha) | -0.033853 |
| RNF213 | ring finger protein 213 | -0.0333331 |
| RPS16 | ribosomal protein S16 | -0.0330223 |
| RPS29 | ribosomal protein S29 | -0.031909 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0318848 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0318616 |
| EGFR | epidermal growth factor receptor | -0.0317585 |
| OSMR | oncostatin M receptor | -0.0316251 |
| PDE10A | phosphodiesterase 10A | -0.0314206 |
| BICC1 | BicC family RNA binding protein 1 | -0.0308722 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0305251 |
| RPS11 | ribosomal protein S11 | -0.030335 |
| RPL12 | ribosomal protein L12 | -0.0302819 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0301999 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.0301659 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0298135 |
| RPL31 | ribosomal protein L31 | -0.0295871 |
| RPL9 | ribosomal protein L9 | -0.0293545 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0289022 |
| IER3 | immediate early response 3 | -0.0280338 |
| RPS17 | ribosomal protein S17 | -0.0275358 |
| RPL34 | ribosomal protein L34 | -0.0269623 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0269507 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0269327 |
| RPS5 | ribosomal protein S5 | -0.026828 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0255759 |
| SP100 | SP100 nuclear antigen | -0.0255035 |
| RPS20 | ribosomal protein S20 | -0.0253449 |
| RPL27 | ribosomal protein L27 | -0.0248842 |
| RPL32 | ribosomal protein L32 | -0.0248351 |
| UBB | ubiquitin B | -0.0248274 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | -0.0246705 |
| RPS3 | ribosomal protein S3 | -0.0242096 |
| NRG1 | neuregulin 1 | -0.024023 |
| EHBP1 | EH domain binding protein 1 | -0.0237582 |
| RPL38 | ribosomal protein L38 | -0.0234954 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.023228 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0232066 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0232058 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0231656 |
| HMGA1 | high mobility group AT-hook 1 | -0.0231559 |
| H1-0 | H1.0 linker histone | -0.0230986 |
| RPS14 | ribosomal protein S14 | -0.022796 |
| RPL35 | ribosomal protein L35 | -0.0225187 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0223813 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0223268 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0222881 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0221165 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0218536 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0214634 |
| PFN1 | profilin 1 | -0.0210426 |
| RPS12 | ribosomal protein S12 | -0.020925 |
| RPS25 | ribosomal protein S25 | -0.0208573 |
| RPL13A | ribosomal protein L13a | -0.0207433 |
| CP | ceruloplasmin (ferroxidase) | -0.0206333 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0205974 |
| TKT | transketolase | -0.0205575 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.020266 |
| RRBP1 | ribosome binding protein 1 | -0.0198386 |
| NRP1 | neuropilin 1 | -0.0193906 |
| KRT7 | keratin 7, type II | -0.0193773 |
| GABRB3 | gamma-aminobutyric acid (GABA) A receptor, beta 3 | -0.0186201 |
| GLIS3 | GLIS family zinc finger 3 | -0.0186189 |
