| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fedratinib (hydrochloride hydrate) perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Fedratinib (hydrochloride hydrate)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.170893 |
| ACTG1 | actin gamma 1 | 0.135943 |
| SDC4 | syndecan 4 | 0.117204 |
| NCOA3 | nuclear receptor coactivator 3 | 0.111826 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0967913 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 0.0962163 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0927458 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0915621 |
| VMP1 | vacuole membrane protein 1 | 0.0865766 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0783403 |
| KRT8 | keratin 8, type II | 0.0705829 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0681657 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0676235 |
| CLTC | clathrin, heavy chain (Hc) | 0.0651603 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 0.0651345 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0598542 |
| NDRG1 | N-myc downstream regulated 1 | 0.0565759 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.055475 |
| KIAA1217 | KIAA1217 | 0.0553751 |
| FAM13A | family with sequence similarity 13, member A | 0.0514873 |
| SERINC3 | serine incorporator 3 | 0.0508306 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0505192 |
| ENO1 | enolase 1, (alpha) | 0.0500928 |
| LDHA | lactate dehydrogenase A | 0.0493876 |
| B2M | beta-2-microglobulin | 0.0489661 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | 0.0483461 |
| INSIG1 | insulin induced gene 1 | 0.0482097 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0475765 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0473567 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0466573 |
| VCP | valosin containing protein | 0.0445686 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0436453 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0431682 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0428458 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0424522 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0424507 |
| MCL1 | myeloid cell leukemia 1 | 0.0417653 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0404935 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0391934 |
| G3BP2 | GTPase activating protein (SH3 domain) binding protein 2 | 0.0390713 |
| ANXA2 | annexin A2 | 0.0387713 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0384999 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0380745 |
| DSPP | dentin sialophosphoprotein | 0.0378379 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0374743 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0371769 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0368432 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0367085 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0356332 |
| SHROOM3 | shroom family member 3 | 0.0355525 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0350906 |
| YTHDC1 | YTH domain containing 1 | 0.0347368 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0345723 |
| EGFR | epidermal growth factor receptor | 0.0338861 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0338417 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0337873 |
| RBM39 | RNA binding motif protein 39 | 0.0328449 |
| MSMO1 | methylsterol monooxygenase 1 | 0.0322178 |
| TMSB4X | thymosin beta 4, X-linked | 0.0321897 |
| POTEF | POTE ankyrin domain family, member F | 0.0321491 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 0.0318165 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0313179 |
| TXNRD1 | thioredoxin reductase 1 | 0.0310738 |
| TMEM41B | transmembrane protein 41B | 0.0310596 |
| AREG | amphiregulin | 0.0310216 |
| ZNF841 | zinc finger protein 841 | 0.0309498 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0309149 |
| IPO7 | importin 7 | 0.0301849 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0301423 |
| MYO5B | myosin VB | 0.0300343 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0299438 |
| VEGFA | vascular endothelial growth factor A | 0.0295445 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0295295 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.028974 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0283882 |
| RAB14 | RAB14, member RAS oncogene family | 0.028237 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0280737 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0280175 |
| SYTL2 | synaptotagmin-like 2 | 0.0274196 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0271013 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0270677 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.026691 |
| CWC25 | CWC25 spliceosome-associated protein homolog (S. cerevisiae) | 0.0266865 |
| PGK1 | phosphoglycerate kinase 1 | 0.0266367 |
| TPM3 | tropomyosin 3 | 0.0262424 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0261954 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0261188 |
| SMYD3 | SET and MYND domain containing 3 | 0.0261081 |
| ANKRD36C | ankyrin repeat domain 36C | 0.0260364 |
| PPP1R9B | protein phosphatase 1, regulatory subunit 9B | 0.025804 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0256548 |
| PIP4K2B | phosphatidylinositol-5-phosphate 4-kinase, type II, beta | 0.0255997 |
| CYFIP1 | cytoplasmic FMR1 interacting protein 1 | 0.0255485 |
| RAB22A | RAB22A, member RAS oncogene family | 0.0255293 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0254542 |
| RAB6A | RAB6A, member RAS oncogene family | 0.025441 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0254272 |
| TAOK1 | TAO kinase 1 | 0.0254235 |
| DHX40 | DEAH (Asp-Glu-Ala-His) box polypeptide 40 | 0.0251952 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.025135 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPL23 | ribosomal protein L23 | -0.208165 |
| RPL19 | ribosomal protein L19 | -0.0814 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0537631 |
| TMSB10 | thymosin beta 10 | -0.048446 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0463479 |
| RPL35A | ribosomal protein L35a | -0.0437685 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0423819 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.0411795 |
| RPS19 | ribosomal protein S19 | -0.0350708 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0343642 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0333915 |
| BCAS1 | breast carcinoma amplified sequence 1 | -0.0331936 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0326001 |
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | -0.0322343 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0314138 |
| PRR11 | proline rich 11 | -0.0314017 |
| RPLP1 | ribosomal protein, large, P1 | -0.0297578 |
| HMGB1 | high mobility group box 1 | -0.0281509 |
| RPS12 | ribosomal protein S12 | -0.0279975 |
| S100A8 | S100 calcium binding protein A8 | -0.0270277 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.026869 |
| RPL35 | ribosomal protein L35 | -0.026707 |
| NF1 | neurofibromin 1 | -0.0264711 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0263223 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0256204 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0254126 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | -0.0250809 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.024901 |
| RPS17 | ribosomal protein S17 | -0.0245549 |
| RPL9 | ribosomal protein L9 | -0.0243085 |
| RPS8 | ribosomal protein S8 | -0.0242992 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0240321 |
| RPL7A | ribosomal protein L7a | -0.0236533 |
| ZNF609 | zinc finger protein 609 | -0.0234956 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0231647 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0230619 |
| SMC4 | structural maintenance of chromosomes 4 | -0.022821 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0228115 |
| RPS6 | ribosomal protein S6 | -0.0227085 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0215547 |
| GNAS | GNAS complex locus | -0.0213705 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0213055 |
| ANKRD30A | ankyrin repeat domain 30A | -0.0212786 |
| RPS29 | ribosomal protein S29 | -0.0212443 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0210442 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0209507 |
| RPL28 | ribosomal protein L28 | -0.0209463 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0209149 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0208241 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0207483 |
| RPS14 | ribosomal protein S14 | -0.0206726 |
| RPL8 | ribosomal protein L8 | -0.0203677 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.020229 |
| RPS25 | ribosomal protein S25 | -0.020099 |
| PRLR | prolactin receptor | -0.0198482 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0198192 |
| KLHL24 | kelch-like family member 24 | -0.019496 |
| PHIP | pleckstrin homology domain interacting protein | -0.0194389 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0193555 |
| PTMA | prothymosin, alpha | -0.0193355 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.019282 |
| S100A11 | S100 calcium binding protein A11 | -0.018873 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0188599 |
| ATP9A | ATPase, class II, type 9A | -0.0188396 |
| RPS5 | ribosomal protein S5 | -0.0187577 |
| TOX3 | TOX high mobility group box family member 3 | -0.0185716 |
| GATA3 | GATA binding protein 3 | -0.0184322 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0184099 |
| RPL32 | ribosomal protein L32 | -0.0182566 |
| PKP4 | plakophilin 4 | -0.0179568 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0179486 |
| PSMD5 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 | -0.0178861 |
| DYNLRB1 | dynein, light chain, roadblock-type 1 | -0.0178729 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.017697 |
| RPLP2 | ribosomal protein, large, P2 | -0.0176506 |
| RPS27 | ribosomal protein S27 | -0.0173828 |
| SIDT1 | SID1 transmembrane family, member 1 | -0.0173769 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.017376 |
| ARHGAP35 | Rho GTPase activating protein 35 | -0.0173032 |
| RPS20 | ribosomal protein S20 | -0.0172644 |
| PLEKHG4B | pleckstrin homology domain containing, family G (with RhoGef domain) member 4B | -0.0171477 |
| ZNF652 | zinc finger protein 652 | -0.0171122 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0169848 |
| NTN4 | netrin 4 | -0.0169777 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0169572 |
| RPS24 | ribosomal protein S24 | -0.0169255 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0167701 |
| RPL30 | ribosomal protein L30 | -0.0166536 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0165598 |
| TUBA1B | tubulin, alpha 1b | -0.0165054 |
| IL1RAPL2 | interleukin 1 receptor accessory protein-like 2 | -0.0164099 |
| TUBB | tubulin, beta class I | -0.0163454 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | -0.0163408 |
| TNS3 | tensin 3 | -0.0162813 |
| MAP4 | microtubule-associated protein 4 | -0.0162347 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0162116 |
| SPECC1L | sperm antigen with calponin homology and coiled-coil domains 1-like | -0.0161934 |
| TMC5 | transmembrane channel-like 5 | -0.0161086 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0160959 |
| DIAPH3 | diaphanous-related formin 3 | -0.0159661 |
