| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fedratinib (hydrochloride hydrate) perturbation in C32 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Fedratinib (hydrochloride hydrate)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.109657 |
| CD109 | CD109 molecule | 0.109187 |
| FN1 | fibronectin 1 | 0.0906483 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0855872 |
| CDC73 | cell division cycle 73 | 0.0698077 |
| ASPH | aspartate beta-hydroxylase | 0.0696471 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0661984 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0658116 |
| CALU | calumenin | 0.0618543 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0602163 |
| ACTG1 | actin gamma 1 | 0.0596772 |
| SRPK2 | SRSF protein kinase 2 | 0.0561195 |
| COPA | coatomer protein complex, subunit alpha | 0.0545527 |
| APP | amyloid beta (A4) precursor protein | 0.0518845 |
| NBAS | neuroblastoma amplified sequence | 0.050803 |
| ENO1 | enolase 1, (alpha) | 0.0507436 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0491306 |
| INSIG1 | insulin induced gene 1 | 0.0483452 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0479732 |
| FMNL2 | formin-like 2 | 0.0455621 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0453195 |
| OGA | O-GlcNAcase | 0.0441871 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0417889 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0413381 |
| SFTPA2 | surfactant protein A2 | 0.0408257 |
| PTK2 | protein tyrosine kinase 2 | 0.0397395 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0395787 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0394522 |
| AFDN | afadin, adherens junction formation factor | 0.0390066 |
| PGK1 | phosphoglycerate kinase 1 | 0.0388358 |
| GOLGA4 | golgin A4 | 0.0378746 |
| TPR | translocated promoter region, nuclear basket protein | 0.0373064 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0372971 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0363621 |
| WDR45B | WD repeat domain 45B | 0.0361883 |
| RBM33 | RNA binding motif protein 33 | 0.0361733 |
| CUL3 | cullin 3 | 0.035474 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0351501 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0349828 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0349214 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0339625 |
| HELZ | helicase with zinc finger | 0.0333075 |
| VMP1 | vacuole membrane protein 1 | 0.0327275 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0324226 |
| SPAG9 | sperm associated antigen 9 | 0.032232 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0321114 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.031971 |
| ARRDC3 | arrestin domain containing 3 | 0.0319326 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | 0.0313169 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0311775 |
| PCBP2 | poly(rC) binding protein 2 | 0.0309334 |
| ZNF292 | zinc finger protein 292 | 0.0305559 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0303554 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0302734 |
| SETD5 | SET domain containing 5 | 0.0302211 |
| CANX | calnexin | 0.029881 |
| COG5 | component of oligomeric golgi complex 5 | 0.0297841 |
| NAV2 | neuron navigator 2 | 0.029593 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.029588 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0292021 |
| FBXO7 | F-box protein 7 | 0.0291803 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | 0.0291473 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0288618 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.02858 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0285548 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.028172 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0275198 |
| NOS1AP | nitric oxide synthase 1 (neuronal) adaptor protein | 0.0274911 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0273628 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.027247 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0267912 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0266524 |
| ANO6 | anoctamin 6 | 0.0265606 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0265279 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.026508 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0261045 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0258337 |
| TPD52 | tumor protein D52 | 0.0258256 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0257143 |
| XPO1 | exportin 1 | 0.0255976 |
| PNPLA8 | patatin-like phospholipase domain containing 8 | 0.0254753 |
| NUP58 | nucleoporin 58 | 0.0254178 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0251366 |
| ZYX | zyxin | 0.025091 |
| GDF15 | growth differentiation factor 15 | 0.0249936 |
| RLF | rearranged L-myc fusion | 0.0249748 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0246448 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0246096 |
| MYO5A | myosin VA (heavy chain 12, myoxin) | 0.0243972 |
| FBXO42 | F-box protein 42 | 0.0243866 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0240134 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0240124 |
| LDHA | lactate dehydrogenase A | 0.0240062 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0237048 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0235428 |
| CAMSAP2 | calmodulin regulated spectrin-associated protein family, member 2 | 0.0234454 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | 0.0233173 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0232905 |
| ZNF654 | zinc finger protein 654 | 0.0232222 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0231715 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.253445 |
| VIM | vimentin | -0.140565 |
| MT2A | metallothionein 2A | -0.116209 |
| TMSB10 | thymosin beta 10 | -0.102035 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0920436 |
| RPLP1 | ribosomal protein, large, P1 | -0.063576 |
| FRMD4A | FERM domain containing 4A | -0.0604807 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0582521 |
| IER3 | immediate early response 3 | -0.0443855 |
| HLA-B | major histocompatibility complex, class I, B | -0.0437459 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0388414 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0385927 |
| S100A9 | S100 calcium binding protein A9 | -0.0383509 |
| DCT | dopachrome tautomerase | -0.0380593 |
| CALD1 | caldesmon 1 | -0.0374676 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0361357 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0356348 |
| GPC6 | glypican 6 | -0.0347341 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | -0.0343607 |
| TNNC1 | troponin C type 1 (slow) | -0.0342135 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0339087 |
| RPLP2 | ribosomal protein, large, P2 | -0.0322337 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0319491 |
| PCDH7 | protocadherin 7 | -0.0309518 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0307607 |
| LMNA | lamin A/C | -0.0305435 |
| S100A10 | S100 calcium binding protein A10 | -0.0304436 |
| GNAS | GNAS complex locus | -0.0294988 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0288944 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0288494 |
| EGR1 | early growth response 1 | -0.0281696 |
| RPS19 | ribosomal protein S19 | -0.0281231 |
| COL19A1 | collagen, type XIX, alpha 1 | -0.0280448 |
| FTL | ferritin, light polypeptide | -0.0278966 |
| RPS8 | ribosomal protein S8 | -0.0277666 |
| NAV3 | neuron navigator 3 | -0.0275642 |
| RPL35A | ribosomal protein L35a | -0.0275227 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0267435 |
| TAGLN2 | transgelin 2 | -0.0266101 |
| RPS29 | ribosomal protein S29 | -0.0238991 |
| RPL19 | ribosomal protein L19 | -0.0235923 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0232395 |
| RPS3 | ribosomal protein S3 | -0.0231762 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0226424 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0225783 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0222809 |
| RPL37A | ribosomal protein L37a | -0.0222161 |
| S100A6 | S100 calcium binding protein A6 | -0.0220837 |
| RPL34 | ribosomal protein L34 | -0.0218295 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0215961 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0215954 |
| OXR1 | oxidation resistance 1 | -0.021592 |
| OSMR | oncostatin M receptor | -0.0215737 |
| HMGB1 | high mobility group box 1 | -0.0212649 |
| MT1X | metallothionein 1X | -0.0197288 |
| RPS15 | ribosomal protein S15 | -0.0196875 |
| RPL36 | ribosomal protein L36 | -0.0196379 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0195611 |
| PTMA | prothymosin, alpha | -0.0195139 |
| RPS21 | ribosomal protein S21 | -0.019189 |
| RPL8 | ribosomal protein L8 | -0.0185554 |
| IFITM2 | interferon induced transmembrane protein 2 | -0.0178347 |
| RPL31 | ribosomal protein L31 | -0.017825 |
| RPS12 | ribosomal protein S12 | -0.0175923 |
| PFN1 | profilin 1 | -0.0173919 |
| RPS24 | ribosomal protein S24 | -0.0172631 |
| ICAM1 | intercellular adhesion molecule 1 | -0.017189 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -0.0170178 |
| RPL23 | ribosomal protein L23 | -0.016919 |
| RCAN1 | regulator of calcineurin 1 | -0.0168498 |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | -0.0166598 |
| RPL28 | ribosomal protein L28 | -0.0166535 |
| RPS5 | ribosomal protein S5 | -0.0165752 |
| RPS27A | ribosomal protein S27a | -0.016395 |
| GNB2 | guanine nucleotide binding protein (G protein), beta polypeptide 2 | -0.0162946 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0161626 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0159576 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0159504 |
| CLEC1B | C-type lectin domain family 1, member B | -0.015917 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0154882 |
| CD63 | CD63 molecule | -0.0154112 |
| RPL32 | ribosomal protein L32 | -0.0154033 |
| NRG1 | neuregulin 1 | -0.0153841 |
| RPS20 | ribosomal protein S20 | -0.0153496 |
| COX4I1 | cytochrome c oxidase subunit IV isoform 1 | -0.0153382 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | -0.0153269 |
| RPS6 | ribosomal protein S6 | -0.0152892 |
| RPL27 | ribosomal protein L27 | -0.0152217 |
| SCFD2 | sec1 family domain containing 2 | -0.0152151 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0151999 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0150167 |
| PTCHD4 | patched domain containing 4 | -0.0149755 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0148206 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0146849 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0146107 |
| RPL11 | ribosomal protein L11 | -0.0146039 |
| NLGN1 | neuroligin 1 | -0.0143468 |
| CUX1 | cut-like homeobox 1 | -0.0143139 |
| FOSL1 | FOS-like antigen 1 | -0.0143094 |
| ETV1 | ets variant 1 | -0.0141287 |
