| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fedratinib (hydrochloride hydrate) perturbation in H4 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Fedratinib (hydrochloride hydrate)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.157958 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.132286 |
| B2M | beta-2-microglobulin | 0.107682 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0955391 |
| CALU | calumenin | 0.0933164 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0929973 |
| CANX | calnexin | 0.0891831 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0828939 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0795832 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0769752 |
| HDAC9 | histone deacetylase 9 | 0.0724853 |
| STC1 | stanniocalcin 1 | 0.0651986 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0628752 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0625343 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.061343 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0599863 |
| LOX | lysyl oxidase | 0.0574423 |
| FNIP1 | folliculin interacting protein 1 | 0.0568011 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.054776 |
| COPA | coatomer protein complex, subunit alpha | 0.054434 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0541507 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0538615 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0523492 |
| FAM13A | family with sequence similarity 13, member A | 0.0518291 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0474053 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0463999 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0463256 |
| SRP54 | signal recognition particle 54kDa | 0.0450989 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0428181 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0423418 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0421877 |
| OGA | O-GlcNAcase | 0.0418501 |
| PCBP2 | poly(rC) binding protein 2 | 0.0415413 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.040504 |
| SDC4 | syndecan 4 | 0.040097 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0394189 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0393219 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0390503 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0387679 |
| ACTG1 | actin gamma 1 | 0.0380345 |
| RARS1 | arginyl-tRNA synthetase 1 | 0.0379857 |
| ZNF638 | zinc finger protein 638 | 0.037834 |
| MMP12 | matrix metallopeptidase 12 | 0.0374569 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0374417 |
| COL5A1 | collagen, type V, alpha 1 | 0.0367849 |
| LDHA | lactate dehydrogenase A | 0.036544 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0361767 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0358547 |
| TXNIP | thioredoxin interacting protein | 0.0353278 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0349177 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0347349 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | 0.034539 |
| ZNF841 | zinc finger protein 841 | 0.0345222 |
| FN1 | fibronectin 1 | 0.0342852 |
| ZNF146 | zinc finger protein 146 | 0.0342264 |
| GOLGA2 | golgin A2 | 0.034011 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0340085 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0339544 |
| POM121 | POM121 transmembrane nucleoporin | 0.0335634 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0334915 |
| DTNA | dystrobrevin, alpha | 0.0333478 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0333119 |
| HELZ | helicase with zinc finger | 0.0332367 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0328379 |
| WDR45B | WD repeat domain 45B | 0.0327357 |
| SEC24A | SEC24 family member A | 0.0323877 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.0318614 |
| SNX13 | sorting nexin 13 | 0.031597 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0311431 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0308671 |
| TMF1 | TATA element modulatory factor 1 | 0.0308577 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0301356 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | 0.0298851 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0294734 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0291808 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0289549 |
| SEC24D | SEC24 family member D | 0.0288 |
| SQSTM1 | sequestosome 1 | 0.0286112 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | 0.0286006 |
| LOXL2 | lysyl oxidase-like 2 | 0.0285931 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0283865 |
| VMP1 | vacuole membrane protein 1 | 0.0282856 |
| ZNF160 | zinc finger protein 160 | 0.0280076 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | 0.0280008 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.0278198 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.027658 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.0273162 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.027135 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0271301 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.027061 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0267757 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0266408 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0265942 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0265387 |
| NUP58 | nucleoporin 58 | 0.0258937 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0256621 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0256371 |
| EGFR | epidermal growth factor receptor | 0.0256143 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0255669 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.0255495 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FTL | ferritin, light polypeptide | -0.166098 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.116534 |
| TMSB10 | thymosin beta 10 | -0.110123 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0946831 |
| GLIS3 | GLIS family zinc finger 3 | -0.0914882 |
| MAP1B | microtubule-associated protein 1B | -0.0860778 |
| RPLP1 | ribosomal protein, large, P1 | -0.0776783 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0740328 |
| OSMR | oncostatin M receptor | -0.0698605 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0676844 |
| TXNRD1 | thioredoxin reductase 1 | -0.067403 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0630532 |
| RPS8 | ribosomal protein S8 | -0.0629643 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0623955 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0569075 |
| RPL28 | ribosomal protein L28 | -0.0541602 |
| CD44 | CD44 molecule (Indian blood group) | -0.0539584 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.05391 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.052427 |
| NLGN1 | neuroligin 1 | -0.0523052 |
| RPL35A | ribosomal protein L35a | -0.0513385 |
| SMAD3 | SMAD family member 3 | -0.0508086 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0491236 |
| TUBB | tubulin, beta class I | -0.0488733 |
| RPL36 | ribosomal protein L36 | -0.0468549 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0466164 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0462607 |
| RPL37A | ribosomal protein L37a | -0.0462498 |
| STK17A | serine/threonine kinase 17a | -0.0461801 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0460196 |
| RPLP2 | ribosomal protein, large, P2 | -0.045786 |
| RPL23 | ribosomal protein L23 | -0.0457182 |
| DST | dystonin | -0.0454023 |
| AHR | aryl hydrocarbon receptor | -0.0447114 |
| RPL34 | ribosomal protein L34 | -0.0439556 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0438899 |
| RPS19 | ribosomal protein S19 | -0.0434954 |
| TNS3 | tensin 3 | -0.0429438 |
| ACTN4 | actinin, alpha 4 | -0.0421926 |
| FLNA | filamin A, alpha | -0.0411512 |
| RPL19 | ribosomal protein L19 | -0.039277 |
| RTN4 | reticulon 4 | -0.0389065 |
| RPS24 | ribosomal protein S24 | -0.0387624 |
| IL6ST | interleukin 6 signal transducer | -0.0382729 |
| RPS6 | ribosomal protein S6 | -0.0366514 |
| RACK1 | receptor for activated C kinase 1 | -0.0354908 |
| ANXA2 | annexin A2 | -0.0350916 |
| LYPD6B | LY6/PLAUR domain containing 6B | -0.0340508 |
| PHF14 | PHD finger protein 14 | -0.0334547 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.033285 |
| RPL12 | ribosomal protein L12 | -0.0322278 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0322049 |
| VCL | vinculin | -0.0315559 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0310571 |
| RPS29 | ribosomal protein S29 | -0.0304795 |
| RPL9 | ribosomal protein L9 | -0.0303183 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0302508 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.0302172 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0301814 |
| PALLD | palladin, cytoskeletal associated protein | -0.0301053 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.0300588 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0300461 |
| S100A10 | S100 calcium binding protein A10 | -0.0299767 |
| YBX1 | Y box binding protein 1 | -0.0297928 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0293572 |
| ECE1 | endothelin converting enzyme 1 | -0.0284989 |
| RPL27A | ribosomal protein L27a | -0.0283863 |
| ELMO1 | engulfment and cell motility 1 | -0.0282657 |
| GNAS | GNAS complex locus | -0.0282049 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0279873 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | -0.0279186 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0277764 |
| FUS | FUS RNA binding protein | -0.0276693 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0276691 |
| S100A6 | S100 calcium binding protein A6 | -0.0272048 |
| HMGB1 | high mobility group box 1 | -0.0271905 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0271246 |
| RPL38 | ribosomal protein L38 | -0.027048 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0270468 |
| ASPH | aspartate beta-hydroxylase | -0.0267063 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0266513 |
| RPS21 | ribosomal protein S21 | -0.026424 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.026324 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0262642 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0260947 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0260513 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0257697 |
| RPL7 | ribosomal protein L7 | -0.0255538 |
| RPS20 | ribosomal protein S20 | -0.0255412 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0255268 |
| NAV1 | neuron navigator 1 | -0.0254311 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0254294 |
| TUSC3 | tumor suppressor candidate 3 | -0.0254288 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0254142 |
| PTCHD4 | patched domain containing 4 | -0.0250112 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0249013 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0248045 |
| NF1 | neurofibromin 1 | -0.0245267 |
| PTK2 | protein tyrosine kinase 2 | -0.0244273 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.023936 |
