Fedratinib (hydrochloride hydrate)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fedratinib (hydrochloride hydrate) perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fedratinib (hydrochloride hydrate)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.185474
NDRG1 N-myc downstream regulated 1 0.172187
AHNAK AHNAK nucleoprotein 0.140475
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.109144
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.106988
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0968797
LDHA lactate dehydrogenase A 0.0956872
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0794446
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0777517
SDC4 syndecan 4 0.0776382
PGK1 phosphoglycerate kinase 1 0.0701536
CANX calnexin 0.068384
ASPH aspartate beta-hydroxylase 0.0639862
EIF4B eukaryotic translation initiation factor 4B 0.0633321
EEF2 eukaryotic translation elongation factor 2 0.0597894
MYH9 myosin, heavy chain 9, non-muscle 0.0580993
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0565367
RAB6A RAB6A, member RAS oncogene family 0.0534192
PRELID2 PRELI domain containing 2 0.052572
ARRDC3 arrestin domain containing 3 0.0506912
PCBP2 poly(rC) binding protein 2 0.0504573
ENO1 enolase 1, (alpha) 0.0494083
OGA O-GlcNAcase 0.0492027
TTC3 tetratricopeptide repeat domain 3 0.0487076
ESYT2 extended synaptotagmin-like protein 2 0.0483634
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.048025
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0475473
CEP350 centrosomal protein 350kDa 0.0470054
PLAUR plasminogen activator, urokinase receptor 0.0466259
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0465426
SQSTM1 sequestosome 1 0.0464479
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0451955
UBA6 ubiquitin-like modifier activating enzyme 6 0.0434556
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0433694
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0431965
BIRC6 baculoviral IAP repeat containing 6 0.0429922
HDLBP high density lipoprotein binding protein 0.0426442
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0416715
PICALM phosphatidylinositol binding clathrin assembly protein 0.0411266
KDM2A lysine (K)-specific demethylase 2A 0.0405654
ZC3H11A zinc finger CCCH-type containing 11A 0.0403229
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0396086
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.039579
HOOK2 hook microtubule-tethering protein 2 0.0378858
EPN2 epsin 2 0.0377686
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0372851
ANKRD12 ankyrin repeat domain 12 0.0366245
DSPP dentin sialophosphoprotein 0.0365397
SUCO SUN domain containing ossification factor 0.0364889
CCDC47 coiled-coil domain containing 47 0.0362691
ARFGEF3 ARFGEF family member 3 0.0360446
LOC112694756 uncharaterized LOC112694756 0.0360418
ACTG1 actin gamma 1 0.0360172
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0359408
AKAP9 A kinase (PRKA) anchor protein 9 0.0352043
ZNF292 zinc finger protein 292 0.0351799
TBC1D22A TBC1 domain family, member 22A 0.0351443
UBA2 ubiquitin-like modifier activating enzyme 2 0.0348806
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0347168
ZNF638 zinc finger protein 638 0.0342013
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0338381
KDM3A lysine (K)-specific demethylase 3A 0.0336048
TXNIP thioredoxin interacting protein 0.0332274
DDIT4 DNA-damage-inducible transcript 4 0.033174
BTBD9 BTB (POZ) domain containing 9 0.0331299
CSDE1 cold shock domain containing E1, RNA-binding 0.0328962
INSIG2 insulin induced gene 2 0.0326571
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0325737
ERRFI1 ERBB receptor feedback inhibitor 1 0.0318161
COPA coatomer protein complex, subunit alpha 0.0312312
RNMT RNA (guanine-7-) methyltransferase 0.0308633
RARS1 arginyl-tRNA synthetase 1 0.0308211
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0301425
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0298282
KDM7A lysine (K)-specific demethylase 7A 0.0297728
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0297321
PHF3 PHD finger protein 3 0.029593
CORO1C coronin, actin binding protein, 1C 0.0294647
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.029447
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0293461
RUNX1 runt-related transcription factor 1 0.0286935
COG6 component of oligomeric golgi complex 6 0.0286382
SMYD3 SET and MYND domain containing 3 0.0284572
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0283851
UBXN7 UBX domain protein 7 0.0283532
USP34 ubiquitin specific peptidase 34 0.0283274
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0278379
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0277718
KRT8 keratin 8, type II 0.0277336
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0272496
XRN1 5'-3' exoribonuclease 1 0.0271728
INSIG1 insulin induced gene 1 0.0271436
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0268019
SCARB1 scavenger receptor class B, member 1 0.0267727
PAPOLA poly(A) polymerase alpha 0.0266276
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0265713
SEC23A Sec23 homolog A (S. cerevisiae) 0.0265532
CTBP2 C-terminal binding protein 2 0.0264231
FOXO3 forkhead box O3 0.0262464
AKAP10 A kinase (PRKA) anchor protein 10 0.0260359

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.147578
TMSB10 thymosin beta 10 -0.118718
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.102234
EGR1 early growth response 1 -0.0641249
TENM3 teneurin transmembrane protein 3 -0.0619985
RPL35A ribosomal protein L35a -0.0604964
RPS6 ribosomal protein S6 -0.0570329
S100A9 S100 calcium binding protein A9 -0.0513329
RPL34 ribosomal protein L34 -0.046227
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0449026
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0443311
RPLP1 ribosomal protein, large, P1 -0.0399842
RPS19 ribosomal protein S19 -0.0379709
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0373657
RPLP2 ribosomal protein, large, P2 -0.0370644
MKI67 marker of proliferation Ki-67 -0.0367519
RPL37A ribosomal protein L37a -0.0366987
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.036161
RPS24 ribosomal protein S24 -0.0353605
FAT1 FAT atypical cadherin 1 -0.0345484
TUBA1B tubulin, alpha 1b -0.0342518
VCL vinculin -0.0340666
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0339666
HMGA1 high mobility group AT-hook 1 -0.0339123
RPL12 ribosomal protein L12 -0.0333522
TPI1 triosephosphate isomerase 1 -0.0328967
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0328582
GNAS GNAS complex locus -0.0327837
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0324281
CARD16 caspase recruitment domain family, member 16 -0.0321417
NOP58 NOP58 ribonucleoprotein -0.0320052
RPS8 ribosomal protein S8 -0.03188
TOP1 topoisomerase (DNA) I -0.0311237
HMGB1 high mobility group box 1 -0.030817
PFN1 profilin 1 -0.0304726
SCFD2 sec1 family domain containing 2 -0.0304628
ZNF207 zinc finger protein 207 -0.0296323
RPS12 ribosomal protein S12 -0.0295381
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0295239
ABLIM1 actin binding LIM protein 1 -0.0293276
RAD51B RAD51 paralog B -0.0291674
RACK1 receptor for activated C kinase 1 -0.029001
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0289489
LPP LIM domain containing preferred translocation partner in lipoma -0.0287132
RPL32 ribosomal protein L32 -0.0286863
SERF2 small EDRK-rich factor 2 -0.0285325
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0282356
POTEF POTE ankyrin domain family, member F -0.0280327
SMC4 structural maintenance of chromosomes 4 -0.0274886
RTN4 reticulon 4 -0.027108
KIF5B kinesin family member 5B -0.0270811
RPL13A ribosomal protein L13a -0.026937
TBCA tubulin folding cofactor A -0.0267765
LOC102724023 ES1 protein homolog, mitochondrial -0.0265492
RPL19 ribosomal protein L19 -0.0263095
RPS3 ribosomal protein S3 -0.0261389
TUBB4B tubulin, beta 4B class IVb -0.0255123
RPL23 ribosomal protein L23 -0.0252848
RPS13 ribosomal protein S13 -0.025009
OLA1 Obg-like ATPase 1 -0.0248512
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0244941
SPIDR scaffolding protein involved in DNA repair -0.024327
TRA2B transformer 2 beta homolog (Drosophila) -0.0243142
HMGB2 high mobility group box 2 -0.0240887
RPL9 ribosomal protein L9 -0.0240156
RRBP1 ribosome binding protein 1 -0.0239441
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0238686
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.023768
YBX3 Y box binding protein 3 -0.0236318
NFIA nuclear factor I/A -0.0236106
SRRM2 serine/arginine repetitive matrix 2 -0.0234933
RBM39 RNA binding motif protein 39 -0.0234491
CENPF centromere protein F, 350/400kDa -0.0232881
RPS5 ribosomal protein S5 -0.0232136
RPL28 ribosomal protein L28 -0.0229673
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0229426
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0229176
RPS25 ribosomal protein S25 -0.0227327
NOP56 NOP56 ribonucleoprotein -0.0225957
ADNP activity-dependent neuroprotector homeobox -0.0225643
TUBB tubulin, beta class I -0.0224958
IFITM3 interferon induced transmembrane protein 3 -0.0224514
ACACA acetyl-CoA carboxylase alpha -0.022298
LDHB lactate dehydrogenase B -0.022247
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0220026
MYOF myoferlin -0.0219785
FTL ferritin, light polypeptide -0.0218142
RPL8 ribosomal protein L8 -0.0214323
GPHN gephyrin -0.0214021
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0212544
LSR lipolysis stimulated lipoprotein receptor -0.0211779
PRRC2B proline-rich coiled-coil 2B -0.0211332
ZFAND3 zinc finger, AN1-type domain 3 -0.0210758
RPS29 ribosomal protein S29 -0.0207475
DLG1 discs, large homolog 1 (Drosophila) -0.0207336
RPS10 ribosomal protein S10 -0.0205615
RPS27A ribosomal protein S27a -0.020527
SLC38A2 solute carrier family 38, member 2 -0.0205134
RPS23 ribosomal protein S23 -0.0204568
FUS FUS RNA binding protein -0.0202853