| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fedratinib (hydrochloride hydrate) perturbation in HEC-1-A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Fedratinib (hydrochloride hydrate)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ACTG1 | actin gamma 1 | 0.281119 |
| POTEF | POTE ankyrin domain family, member F | 0.136509 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0919182 |
| LDHA | lactate dehydrogenase A | 0.0773751 |
| B2M | beta-2-microglobulin | 0.0619535 |
| GOLGA4 | golgin A4 | 0.0619258 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0608054 |
| APP | amyloid beta (A4) precursor protein | 0.0607451 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0590827 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0584244 |
| SDC4 | syndecan 4 | 0.0577 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0573507 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0570476 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0561359 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0552274 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0542678 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0524949 |
| SET | SET nuclear proto-oncogene | 0.0513824 |
| PCBP2 | poly(rC) binding protein 2 | 0.0505119 |
| ASPH | aspartate beta-hydroxylase | 0.0488282 |
| MT2A | metallothionein 2A | 0.0478709 |
| SETD5 | SET domain containing 5 | 0.0478695 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0475326 |
| TPM4 | tropomyosin 4 | 0.0468931 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0468317 |
| FNIP1 | folliculin interacting protein 1 | 0.0458777 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.044438 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0422122 |
| SEPTIN9 | septin 9 | 0.0414637 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0413173 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0407476 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0400038 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.039851 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0396642 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0389511 |
| ENO1 | enolase 1, (alpha) | 0.0385057 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0379397 |
| TPM3 | tropomyosin 3 | 0.0366588 |
| SPAG9 | sperm associated antigen 9 | 0.0357595 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.035724 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0355598 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0352608 |
| GOLGB1 | golgin B1 | 0.0345425 |
| CCNL1 | cyclin L1 | 0.0344227 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0338421 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0337342 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0337163 |
| TMF1 | TATA element modulatory factor 1 | 0.0333394 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0330191 |
| NKTR | natural killer cell triggering receptor | 0.0329818 |
| FNBP1L | formin binding protein 1-like | 0.0329272 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0328948 |
| CALR | calreticulin | 0.0325652 |
| DIAPH1 | diaphanous-related formin 1 | 0.0324742 |
| VMP1 | vacuole membrane protein 1 | 0.0311905 |
| SETD2 | SET domain containing 2 | 0.030859 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0306905 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0305917 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0301594 |
| SMC5 | structural maintenance of chromosomes 5 | 0.0297721 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0293049 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0291172 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0290405 |
| YTHDC1 | YTH domain containing 1 | 0.0290124 |
| OGA | O-GlcNAcase | 0.0283906 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0278479 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0277346 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.027692 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0270671 |
| CREBRF | CREB3 regulatory factor | 0.0270102 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.026966 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.026901 |
| NDRG1 | N-myc downstream regulated 1 | 0.0265554 |
| NUP58 | nucleoporin 58 | 0.0262721 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0257341 |
| SFTPA2 | surfactant protein A2 | 0.0256373 |
| SSR1 | signal sequence receptor, alpha | 0.0255874 |
| ATP6V1A | ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A | 0.0251075 |
| DENND4A | DENN/MADD domain containing 4A | 0.0248846 |
| CANX | calnexin | 0.0248714 |
| ZNF638 | zinc finger protein 638 | 0.0243907 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0239632 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0239505 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0238792 |
| ANXA1 | annexin A1 | 0.0236547 |
| KIF1B | kinesin family member 1B | 0.0233796 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0230994 |
| PTK2 | protein tyrosine kinase 2 | 0.0230684 |
| KIF5C | kinesin family member 5C | 0.0230586 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0228858 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0226917 |
| TAOK1 | TAO kinase 1 | 0.0225846 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.022525 |
| VEGFA | vascular endothelial growth factor A | 0.0225191 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0224902 |
| KIDINS220 | kinase D-interacting substrate, 220kDa | 0.0223911 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.0222233 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0219511 |
| PTEN | phosphatase and tensin homolog | 0.0218805 |
| PGK1 | phosphoglycerate kinase 1 | 0.0218691 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.13479 |
| TMSB10 | thymosin beta 10 | -0.106608 |
| RHEX | regulator of hemoglobinization and erythroid cell expansion | -0.0993881 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0668496 |
| TXNRD1 | thioredoxin reductase 1 | -0.0639714 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0638367 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0630415 |
| SVIL | supervillin | -0.0624776 |
| RPS24 | ribosomal protein S24 | -0.0623404 |
| PRELID2 | PRELI domain containing 2 | -0.06199 |
| ITGB8 | integrin, beta 8 | -0.059901 |
| RPL35A | ribosomal protein L35a | -0.0568845 |
| HMGB1 | high mobility group box 1 | -0.0568673 |
| FHIT | fragile histidine triad | -0.0556186 |
| FTL | ferritin, light polypeptide | -0.0551422 |
| CCND1 | cyclin D1 | -0.0529843 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.052028 |
| S100A10 | S100 calcium binding protein A10 | -0.0519504 |
| RPLP1 | ribosomal protein, large, P1 | -0.0511682 |
| PAX8 | paired box 8 | -0.0497848 |
| WWOX | WW domain containing oxidoreductase | -0.0469949 |
| MACROD2 | MACRO domain containing 2 | -0.0461168 |
| RPL23 | ribosomal protein L23 | -0.0454313 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0446651 |
| DIAPH3 | diaphanous-related formin 3 | -0.0430211 |
| TUBB | tubulin, beta class I | -0.0428696 |
| DSCAML1 | Down syndrome cell adhesion molecule like 1 | -0.042545 |
| RPL34 | ribosomal protein L34 | -0.0410875 |
| TUBB4B | tubulin, beta 4B class IVb | -0.040006 |
| PLCB4 | phospholipase C, beta 4 | -0.0397227 |
| RPL35 | ribosomal protein L35 | -0.0380425 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0376214 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0374985 |
| MAP4 | microtubule-associated protein 4 | -0.0373841 |
| GNAS | GNAS complex locus | -0.037334 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0373261 |
| LAMB3 | laminin, beta 3 | -0.036764 |
| IER3 | immediate early response 3 | -0.0366853 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0353366 |
| RTN4 | reticulon 4 | -0.0350804 |
| CD44 | CD44 molecule (Indian blood group) | -0.0336003 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.03357 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0334381 |
| RPL38 | ribosomal protein L38 | -0.033212 |
| RPS8 | ribosomal protein S8 | -0.0325068 |
| MKI67 | marker of proliferation Ki-67 | -0.0325035 |
| RPLP2 | ribosomal protein, large, P2 | -0.032321 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0317986 |
| BICC1 | BicC family RNA binding protein 1 | -0.0315743 |
| ACTN4 | actinin, alpha 4 | -0.0315217 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0312187 |
| SUMF1 | sulfatase modifying factor 1 | -0.0307468 |
| ATG7 | autophagy related 7 | -0.0301539 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0288456 |
| H1-0 | H1.0 linker histone | -0.0288007 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0280034 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0273301 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0267323 |
| FLNA | filamin A, alpha | -0.0262966 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0261637 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0258423 |
| HNRNPAB | heterogeneous nuclear ribonucleoprotein A/B | -0.02579 |
| NDUFAF2 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 | -0.0256969 |
| TRA2B | transformer 2 beta homolog (Drosophila) | -0.0256765 |
| POU5F1 | POU class 5 homeobox 1 | -0.0256509 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0256268 |
| DENND1A | DENN/MADD domain containing 1A | -0.0255001 |
| PPIA | peptidylprolyl isomerase A (cyclophilin A) | -0.0254036 |
| RPS15 | ribosomal protein S15 | -0.0251362 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.025135 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0251004 |
| RPL32 | ribosomal protein L32 | -0.0249019 |
| GLIS3 | GLIS family zinc finger 3 | -0.0248932 |
| RPL31 | ribosomal protein L31 | -0.0242887 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.0242197 |
| RPS21 | ribosomal protein S21 | -0.0239528 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0238718 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0238622 |
| TGFA | transforming growth factor, alpha | -0.0238174 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0237445 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0235024 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0234765 |
| HLA-C | major histocompatibility complex, class I, C | -0.0234395 |
| CAPRIN1 | cell cycle associated protein 1 | -0.0233124 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0231199 |
| WWC1 | WW and C2 domain containing 1 | -0.0228165 |
| MSI2 | musashi RNA-binding protein 2 | -0.0227756 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0226688 |
| KLF6 | Kruppel-like factor 6 | -0.0226347 |
| ANKLE2 | ankyrin repeat and LEM domain containing 2 | -0.0226312 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0225228 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0223226 |
| GPR39 | G protein-coupled receptor 39 | -0.0223052 |
| RPL18 | ribosomal protein L18 | -0.0222369 |
| NPR2 | natriuretic peptide receptor 2 | -0.0220409 |
| FOSL1 | FOS-like antigen 1 | -0.0218965 |
| HMGA2 | high mobility group AT-hook 2 | -0.0218854 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0218127 |
| TKT | transketolase | -0.0216937 |
| RPL26 | ribosomal protein L26 | -0.0215658 |
