| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fedratinib (hydrochloride hydrate) perturbation in HOP62 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Fedratinib (hydrochloride hydrate)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.209652 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.147464 |
| FN1 | fibronectin 1 | 0.126082 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.11118 |
| ACTG1 | actin gamma 1 | 0.106259 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0880405 |
| PDE10A | phosphodiesterase 10A | 0.0831697 |
| VIM | vimentin | 0.0812397 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0758343 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0735157 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0730404 |
| OGA | O-GlcNAcase | 0.0724046 |
| FNIP1 | folliculin interacting protein 1 | 0.0632777 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0616516 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0609227 |
| COL5A1 | collagen, type V, alpha 1 | 0.05874 |
| NGLY1 | N-glycanase 1 | 0.058362 |
| STC1 | stanniocalcin 1 | 0.0564668 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.054253 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0539822 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0535078 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.053109 |
| PCBP3 | poly(rC) binding protein 3 | 0.0517869 |
| FAM13A | family with sequence similarity 13, member A | 0.0515283 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0513857 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.051046 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0509363 |
| ARRDC3 | arrestin domain containing 3 | 0.0505838 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0480296 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0479424 |
| LOC112694756 | uncharaterized LOC112694756 | 0.046314 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.046083 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0454939 |
| COPA | coatomer protein complex, subunit alpha | 0.0449535 |
| RUNX1 | runt-related transcription factor 1 | 0.0435422 |
| HELZ | helicase with zinc finger | 0.0429292 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0424299 |
| CD109 | CD109 molecule | 0.0417623 |
| SDC4 | syndecan 4 | 0.0412373 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0406984 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0402469 |
| INSIG1 | insulin induced gene 1 | 0.0402268 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0397464 |
| MCL1 | myeloid cell leukemia 1 | 0.0397034 |
| CANX | calnexin | 0.0387934 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0373978 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0370413 |
| PCBP2 | poly(rC) binding protein 2 | 0.0370079 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0367269 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0367147 |
| SFTPA2 | surfactant protein A2 | 0.0357299 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0357211 |
| INHBA | inhibin, beta A | 0.035397 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0353803 |
| WDR45B | WD repeat domain 45B | 0.0353618 |
| RASA3 | RAS p21 protein activator 3 | 0.0352064 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0351928 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0348352 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0343238 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0341013 |
| HDLBP | high density lipoprotein binding protein | 0.0332854 |
| IL11 | interleukin 11 | 0.0331575 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0330502 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0327563 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0327311 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0326063 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0321603 |
| GOLGA2 | golgin A2 | 0.0320284 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0319325 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0318333 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | 0.0317758 |
| GOLGA4 | golgin A4 | 0.0316164 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0316028 |
| TNS1 | tensin 1 | 0.031541 |
| SETD5 | SET domain containing 5 | 0.0315292 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0312725 |
| USP34 | ubiquitin specific peptidase 34 | 0.030803 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0303643 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.030329 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0299579 |
| ZNF638 | zinc finger protein 638 | 0.0297873 |
| JUN | jun proto-oncogene | 0.0295418 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0288775 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0288572 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0288533 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0287965 |
| FNBP4 | formin binding protein 4 | 0.0285911 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.0284425 |
| TMEM165 | transmembrane protein 165 | 0.0281593 |
| ADM | adrenomedullin | 0.0277817 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0276284 |
| AFDN | afadin, adherens junction formation factor | 0.0276212 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0274058 |
| RARS1 | arginyl-tRNA synthetase 1 | 0.0272193 |
| HSPG2 | heparan sulfate proteoglycan 2 | 0.027203 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0271228 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | 0.0271091 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.027107 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0270693 |
| HPCAL1 | hippocalcin-like 1 | 0.0267691 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD44 | CD44 molecule (Indian blood group) | -0.210366 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.17455 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.153984 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.137578 |
| PTMA | prothymosin, alpha | -0.123418 |
| MT2A | metallothionein 2A | -0.114361 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.112708 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.0922359 |
| TMSB10 | thymosin beta 10 | -0.0892241 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.086641 |
| CCND1 | cyclin D1 | -0.0831285 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0696442 |
| CENPF | centromere protein F, 350/400kDa | -0.0692871 |
| GLIS3 | GLIS family zinc finger 3 | -0.0686154 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0665476 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0657526 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0647514 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0641112 |
| HMGA2 | high mobility group AT-hook 2 | -0.0639227 |
| CDCP1 | CUB domain containing protein 1 | -0.0630983 |
| RRBP1 | ribosome binding protein 1 | -0.0595176 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0579255 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0575435 |
| MAP1B | microtubule-associated protein 1B | -0.0555955 |
| TENM2 | teneurin transmembrane protein 2 | -0.053361 |
| DST | dystonin | -0.0506238 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0480688 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0479212 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0475568 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0474247 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0465012 |
| RPS2 | ribosomal protein S2 | -0.0418873 |
| NECTIN2 | nectin cell adhesion molecule 2 | -0.0416965 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0416211 |
| IER3 | immediate early response 3 | -0.0410177 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0403606 |
| TPX2 | TPX2, microtubule-associated | -0.0398229 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0390505 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0382644 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0373039 |
| RTN4 | reticulon 4 | -0.0365494 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0363179 |
| MKI67 | marker of proliferation Ki-67 | -0.0363129 |
| CAVIN1 | caveolae associated protein 1 | -0.0360567 |
| PKM | pyruvate kinase, muscle | -0.0345284 |
| RPL12 | ribosomal protein L12 | -0.0334843 |
| CLIC4 | chloride intracellular channel 4 | -0.0330614 |
| FTL | ferritin, light polypeptide | -0.0327903 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.0327154 |
| RPS24 | ribosomal protein S24 | -0.0327051 |
| RPS6 | ribosomal protein S6 | -0.0322516 |
| DIAPH2 | diaphanous-related formin 2 | -0.0315342 |
| RRM2 | ribonucleotide reductase M2 | -0.0314051 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0312118 |
| TUBB6 | tubulin, beta 6 class V | -0.0311349 |
| RAD51B | RAD51 paralog B | -0.0297412 |
| RPLP1 | ribosomal protein, large, P1 | -0.02954 |
| S100A10 | S100 calcium binding protein A10 | -0.02879 |
| SMAD3 | SMAD family member 3 | -0.0287137 |
| XPO1 | exportin 1 | -0.0287093 |
| TPI1 | triosephosphate isomerase 1 | -0.0280477 |
| H1-4 | H1.4 linker histone, cluster member | -0.0278411 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0275603 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.027489 |
| KIF5B | kinesin family member 5B | -0.0272873 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0265563 |
| RPS8 | ribosomal protein S8 | -0.026437 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.0262475 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0261897 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0256255 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0255401 |
| RPL38 | ribosomal protein L38 | -0.025527 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0254157 |
| DIAPH3 | diaphanous-related formin 3 | -0.0254098 |
| BPNT2 | 3'(2'), 5'-bisphosphate nucleotidase 2 | -0.0253467 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0249216 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0247405 |
| IGF2 | insulin-like growth factor 2 | -0.0247325 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0246193 |
| NAV1 | neuron navigator 1 | -0.024467 |
| KIF4A | kinesin family member 4A | -0.0243232 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0241738 |
| ANLN | anillin, actin binding protein | -0.0241275 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0237963 |
| COL1A1 | collagen, type I, alpha 1 | -0.0237803 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0232262 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0229316 |
| GNAI2 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | -0.0227924 |
| TRA2B | transformer 2 beta homolog (Drosophila) | -0.0226844 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0225887 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0225219 |
| MEF2A | myocyte enhancer factor 2A | -0.0224766 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0223923 |
| HMGB2 | high mobility group box 2 | -0.0222712 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0222315 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0220559 |
| YBX3 | Y box binding protein 3 | -0.0219603 |
| RPL6 | ribosomal protein L6 | -0.0219121 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0218483 |
| YBX1 | Y box binding protein 1 | -0.0217989 |
