| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fedratinib (hydrochloride hydrate) perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Fedratinib (hydrochloride hydrate)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.216809 |
| NDRG1 | N-myc downstream regulated 1 | 0.208909 |
| VEGFA | vascular endothelial growth factor A | 0.114871 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.111934 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.10032 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0918405 |
| ACTG1 | actin gamma 1 | 0.0822862 |
| GOLGA4 | golgin A4 | 0.072292 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0671137 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0609432 |
| LDHA | lactate dehydrogenase A | 0.0578878 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0571505 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0546641 |
| ARRDC3 | arrestin domain containing 3 | 0.0498494 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0429345 |
| FTL | ferritin, light polypeptide | 0.0398848 |
| ENO1 | enolase 1, (alpha) | 0.03953 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0367542 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0363914 |
| LOXL2 | lysyl oxidase-like 2 | 0.0362616 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0362287 |
| INSIG1 | insulin induced gene 1 | 0.0355988 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0353166 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0350967 |
| TMEM165 | transmembrane protein 165 | 0.0347985 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0341013 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0340946 |
| NAV2 | neuron navigator 2 | 0.0337451 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0332361 |
| ADM | adrenomedullin | 0.0332031 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0329868 |
| RPS6 | ribosomal protein S6 | 0.03292 |
| SQSTM1 | sequestosome 1 | 0.032787 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0321334 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0318935 |
| POTEF | POTE ankyrin domain family, member F | 0.0293367 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0282827 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0280948 |
| OGA | O-GlcNAcase | 0.0278435 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0270098 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0269354 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0263866 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0260243 |
| RARS1 | arginyl-tRNA synthetase 1 | 0.0258304 |
| PCBP2 | poly(rC) binding protein 2 | 0.0258088 |
| ATP13A3 | ATPase type 13A3 | 0.0257718 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0257295 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0256497 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0255281 |
| SDC4 | syndecan 4 | 0.0254093 |
| NGLY1 | N-glycanase 1 | 0.0247577 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0246545 |
| NOTCH2 | notch 2 | 0.0246124 |
| WASF2 | WAS protein family, member 2 | 0.024399 |
| FOXJ3 | forkhead box J3 | 0.0243824 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0242534 |
| CALU | calumenin | 0.0241362 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0240306 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0239658 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0238702 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0238234 |
| CANX | calnexin | 0.0238062 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.023519 |
| RPL35A | ribosomal protein L35a | 0.0233787 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0233563 |
| FNIP1 | folliculin interacting protein 1 | 0.0232623 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.023083 |
| TPM3 | tropomyosin 3 | 0.0228181 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0227811 |
| GOLGB1 | golgin B1 | 0.0227716 |
| RPL8 | ribosomal protein L8 | 0.0227064 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.022488 |
| ANXA1 | annexin A1 | 0.0224816 |
| SFTPA2 | surfactant protein A2 | 0.0224252 |
| GOLGA2 | golgin A2 | 0.0223993 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0222305 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0220773 |
| SRP54 | signal recognition particle 54kDa | 0.0219296 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0215232 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0214975 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.021393 |
| PGM3 | phosphoglucomutase 3 | 0.0213143 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0213084 |
| ASPH | aspartate beta-hydroxylase | 0.0209376 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0208655 |
| CTSB | cathepsin B | 0.0207286 |
| NKTR | natural killer cell triggering receptor | 0.0202975 |
| MTDH | metadherin | 0.0202648 |
| CCNL1 | cyclin L1 | 0.0202621 |
| TMEM41B | transmembrane protein 41B | 0.0201773 |
| TMF1 | TATA element modulatory factor 1 | 0.0201645 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0199851 |
| FBXO42 | F-box protein 42 | 0.019629 |
| APP | amyloid beta (A4) precursor protein | 0.0195258 |
| RPLP0 | ribosomal protein, large, P0 | 0.01943 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0193801 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0192934 |
| PTMA | prothymosin, alpha | 0.0190679 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.0190518 |
| FOSL1 | FOS-like antigen 1 | 0.018876 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.345069 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.123244 |
| HMGA2 | high mobility group AT-hook 2 | -0.118128 |
| CD44 | CD44 molecule (Indian blood group) | -0.105962 |
| COL1A1 | collagen, type I, alpha 1 | -0.10464 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0972459 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0854242 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0798383 |
| GLIS3 | GLIS family zinc finger 3 | -0.0763549 |
| CDH13 | cadherin 13 | -0.0713148 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0692993 |
| OSMR | oncostatin M receptor | -0.0667163 |
| RIGI | RNA sensor RIG-I | -0.0649701 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0633759 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0587092 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0554637 |
| TMSB10 | thymosin beta 10 | -0.0554318 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0527582 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0501319 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0487753 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0482551 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0475035 |
| PALLD | palladin, cytoskeletal associated protein | -0.0472886 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0462784 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0452615 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0451418 |
| FBN1 | fibrillin 1 | -0.0448268 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0444084 |
| CALD1 | caldesmon 1 | -0.0438031 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0435089 |
| SP100 | SP100 nuclear antigen | -0.0434123 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0424397 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.0407772 |
| VCL | vinculin | -0.0407004 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0389445 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0386086 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0382173 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0380879 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0376073 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0370877 |
| CNTN5 | contactin 5 | -0.0370641 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0361925 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0359318 |
| AHNAK | AHNAK nucleoprotein | -0.0359197 |
| DST | dystonin | -0.0357929 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0357135 |
| IL6ST | interleukin 6 signal transducer | -0.0355997 |
| JAK2 | Janus kinase 2 | -0.0353926 |
| PRELID2 | PRELI domain containing 2 | -0.0351742 |
| MAP1B | microtubule-associated protein 1B | -0.0348599 |
| MX2 | MX dynamin-like GTPase 2 | -0.0348419 |
| VCAN | versican | -0.0339923 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0337744 |
| PLSCR1 | phospholipid scramblase 1 | -0.0335319 |
| VEGFC | vascular endothelial growth factor C | -0.0335284 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0327982 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0324001 |
| EBF1 | early B-cell factor 1 | -0.0315536 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.031518 |
| LOX | lysyl oxidase | -0.0311716 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0309074 |
| IER3 | immediate early response 3 | -0.0306727 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.03061 |
| KIAA1217 | KIAA1217 | -0.0304709 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0301036 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0297541 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0292686 |
| CPQ | carboxypeptidase Q | -0.0290582 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0287592 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.028265 |
| AOPEP | aminopeptidase O (putative) | -0.0282219 |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | -0.0280487 |
| NREP | neuronal regeneration related protein | -0.028035 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0276981 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0270797 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0266172 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0259108 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0256523 |
| INHBA | inhibin, beta A | -0.0249811 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0244596 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0243685 |
| FAT1 | FAT atypical cadherin 1 | -0.024329 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0241908 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0238469 |
| CAVIN1 | caveolae associated protein 1 | -0.0234408 |
| SVIL | supervillin | -0.0234133 |
| UBC | ubiquitin C | -0.0229384 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0224522 |
| KLF6 | Kruppel-like factor 6 | -0.0219317 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.0218777 |
| HMCN1 | hemicentin 1 | -0.0216912 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0215945 |
| NF1 | neurofibromin 1 | -0.0214969 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | -0.0214012 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0212624 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0212541 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0212451 |
| GBP1 | guanylate binding protein 1, interferon-inducible | -0.0210852 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0209829 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.020924 |
