| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fedratinib (hydrochloride hydrate) perturbation in HT-29 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Fedratinib (hydrochloride hydrate)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.16762 |
| ACTG1 | actin gamma 1 | 0.157475 |
| DSCAM | Down syndrome cell adhesion molecule | 0.139643 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.137833 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.117737 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.105062 |
| LDHA | lactate dehydrogenase A | 0.0991139 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0963941 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0946005 |
| NDRG1 | N-myc downstream regulated 1 | 0.0874883 |
| KRT8 | keratin 8, type II | 0.0757401 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0745434 |
| TXNRD1 | thioredoxin reductase 1 | 0.0735511 |
| ATXN1 | ataxin 1 | 0.0715626 |
| KRT20 | keratin 20, type I | 0.070499 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0694587 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0690798 |
| TJP1 | tight junction protein 1 | 0.0688144 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0641226 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0604974 |
| GOLGA4 | golgin A4 | 0.0581704 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0574958 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0558336 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0556411 |
| FAM91A1 | family with sequence similarity 91, member A1 | 0.0552596 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0547206 |
| ENO1 | enolase 1, (alpha) | 0.0538852 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0534425 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0520724 |
| DSPP | dentin sialophosphoprotein | 0.0512014 |
| LOC112694756 | uncharaterized LOC112694756 | 0.050756 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0501841 |
| TMEM65 | transmembrane protein 65 | 0.0491515 |
| GOLGB1 | golgin B1 | 0.0491287 |
| VEGFA | vascular endothelial growth factor A | 0.0481292 |
| SPAG9 | sperm associated antigen 9 | 0.0478085 |
| HYOU1 | hypoxia up-regulated 1 | 0.0477976 |
| MYO6 | myosin VI | 0.0474459 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0467401 |
| POTEF | POTE ankyrin domain family, member F | 0.0467154 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0461818 |
| VMP1 | vacuole membrane protein 1 | 0.0457984 |
| SET | SET nuclear proto-oncogene | 0.0457824 |
| OGA | O-GlcNAcase | 0.0449436 |
| HDLBP | high density lipoprotein binding protein | 0.044299 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0438434 |
| CANX | calnexin | 0.0436239 |
| HKDC1 | hexokinase domain containing 1 | 0.0433965 |
| ZNF292 | zinc finger protein 292 | 0.0433934 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0424189 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0422591 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0416873 |
| SQSTM1 | sequestosome 1 | 0.0414751 |
| JMJD1C | jumonji domain containing 1C | 0.0414565 |
| TPM3 | tropomyosin 3 | 0.0413457 |
| CALU | calumenin | 0.0411527 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.04054 |
| FNIP1 | folliculin interacting protein 1 | 0.0400127 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0399654 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0396586 |
| PCBP2 | poly(rC) binding protein 2 | 0.0395674 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0394781 |
| ANXA1 | annexin A1 | 0.0393725 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.039305 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0388056 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0381841 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.037931 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0373489 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0371736 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | 0.0370649 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0370149 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0369283 |
| AFDN | afadin, adherens junction formation factor | 0.0366433 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0364289 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0358267 |
| SMAD3 | SMAD family member 3 | 0.0355324 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.035319 |
| SDC4 | syndecan 4 | 0.0352531 |
| INSIG1 | insulin induced gene 1 | 0.0348372 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | 0.0347339 |
| EXPH5 | exophilin 5 | 0.0342121 |
| IPO7 | importin 7 | 0.0340278 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0337945 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0337631 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0334766 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0333304 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0332752 |
| CCNL1 | cyclin L1 | 0.0332623 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0331793 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0331563 |
| PTEN | phosphatase and tensin homolog | 0.0329733 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0321373 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0320583 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0319137 |
| AREG | amphiregulin | 0.0316616 |
| GOLGA2 | golgin A2 | 0.0316026 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0314712 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0314337 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0312175 |
| RTN3 | reticulon 3 | 0.0310742 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.0947618 |
| TMSB10 | thymosin beta 10 | -0.0890804 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.080125 |
| RPLP1 | ribosomal protein, large, P1 | -0.0697845 |
| RPS24 | ribosomal protein S24 | -0.065339 |
| RPL35A | ribosomal protein L35a | -0.0620433 |
| PTMA | prothymosin, alpha | -0.0597005 |
| S100A10 | S100 calcium binding protein A10 | -0.0568486 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0558717 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0528675 |
| RPL34 | ribosomal protein L34 | -0.0501135 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0464171 |
| HMGB1 | high mobility group box 1 | -0.043047 |
| RPS19 | ribosomal protein S19 | -0.0427588 |
| RPS8 | ribosomal protein S8 | -0.0422372 |
| RPS25 | ribosomal protein S25 | -0.0411194 |
| H1-0 | H1.0 linker histone | -0.0408253 |
| RPL23 | ribosomal protein L23 | -0.0407926 |
| TMEM123 | transmembrane protein 123 | -0.0403736 |
| RPLP2 | ribosomal protein, large, P2 | -0.0397143 |
| FTL | ferritin, light polypeptide | -0.0370572 |
| SLC45A4 | solute carrier family 45, member 4 | -0.0367802 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0339742 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0338089 |
| RPS23 | ribosomal protein S23 | -0.0314243 |
| RRBP1 | ribosome binding protein 1 | -0.0312807 |
| RPL12 | ribosomal protein L12 | -0.0309442 |
| RPL37A | ribosomal protein L37a | -0.0304067 |
| RPS21 | ribosomal protein S21 | -0.030118 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0287943 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.02811 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0280223 |
| DIAPH2 | diaphanous-related formin 2 | -0.027932 |
| RPS14 | ribosomal protein S14 | -0.0277806 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0275218 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.0271207 |
| MMP7 | matrix metallopeptidase 7 | -0.0263854 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0262588 |
| RPL28 | ribosomal protein L28 | -0.0262361 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.0258403 |
| TCF12 | transcription factor 12 | -0.0253537 |
| RPS5 | ribosomal protein S5 | -0.0252733 |
| RPL35 | ribosomal protein L35 | -0.0250491 |
| EGR1 | early growth response 1 | -0.0250488 |
| NPR2 | natriuretic peptide receptor 2 | -0.0249934 |
| GNAS | GNAS complex locus | -0.0249592 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0248516 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.024515 |
| ITGA1 | integrin, alpha 1 | -0.0237167 |
| RPS29 | ribosomal protein S29 | -0.0236945 |
| RPL26 | ribosomal protein L26 | -0.0234952 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0227716 |
| CTTNBP2NL | CTTNBP2 N-terminal like | -0.0221197 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0217224 |
| LAMA4 | laminin, alpha 4 | -0.0217061 |
| S100A6 | S100 calcium binding protein A6 | -0.0214453 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0212095 |
| RPL31 | ribosomal protein L31 | -0.0208372 |
| ABLIM1 | actin binding LIM protein 1 | -0.0206991 |
| RPS6 | ribosomal protein S6 | -0.0205787 |
| RPL38 | ribosomal protein L38 | -0.0204414 |
| HMGA1 | high mobility group AT-hook 1 | -0.0203805 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0202519 |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | -0.0201833 |
| LMNA | lamin A/C | -0.0198245 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0196933 |
| LYZ | lysozyme | -0.0191184 |
| RPL32 | ribosomal protein L32 | -0.0188842 |
| SKAP1 | src kinase associated phosphoprotein 1 | -0.0188582 |
| RPL36A | ribosomal protein L36a | -0.0188047 |
| RPL19 | ribosomal protein L19 | -0.0187875 |
| NIBAN2 | niban apoptosis regulator 2 | -0.0186926 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0186603 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0185516 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0184798 |
| VIM | vimentin | -0.0184592 |
| JUP | junction plakoglobin | -0.0184282 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0183012 |
| NFIA | nuclear factor I/A | -0.0181313 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0179231 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0178913 |
| IER3 | immediate early response 3 | -0.0175819 |
| GSE1 | Gse1 coiled-coil protein | -0.0174899 |
| TNS3 | tensin 3 | -0.0174006 |
| MECOM | MDS1 and EVI1 complex locus | -0.0172733 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0171852 |
| ACTN4 | actinin, alpha 4 | -0.017174 |
| FOSL1 | FOS-like antigen 1 | -0.0168322 |
| RPL6 | ribosomal protein L6 | -0.0167016 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0165721 |
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | -0.0165056 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0163568 |
| LRP8 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor | -0.0163469 |
| LITAF | lipopolysaccharide-induced TNF factor | -0.0163115 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.016174 |
| TNS4 | tensin 4 | -0.0160935 |
| MKI67 | marker of proliferation Ki-67 | -0.0160927 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0160439 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0157624 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.015731 |
