| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fedratinib (hydrochloride hydrate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Fedratinib (hydrochloride hydrate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SDC4 | syndecan 4 | 0.206989 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.19044 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.187235 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.15833 |
| DSPP | dentin sialophosphoprotein | 0.155529 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.12989 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.129683 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.11901 |
| C3 | complement component 3 | 0.0937112 |
| AFDN | afadin, adherens junction formation factor | 0.0898796 |
| ASPH | aspartate beta-hydroxylase | 0.0822113 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0734641 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0704548 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0700836 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0699564 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0681563 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0678693 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0662658 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0654431 |
| LDHA | lactate dehydrogenase A | 0.0629706 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0614338 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0583435 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0570857 |
| PCBP2 | poly(rC) binding protein 2 | 0.0559064 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.055588 |
| TF | transferrin | 0.0543014 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0534928 |
| ENO1 | enolase 1, (alpha) | 0.0532073 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0527252 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0520931 |
| VEGFA | vascular endothelial growth factor A | 0.0507709 |
| DIAPH1 | diaphanous-related formin 1 | 0.0502298 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0490372 |
| FLNB | filamin B, beta | 0.0487625 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0471632 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0470501 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0466042 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0463406 |
| ACTG1 | actin gamma 1 | 0.0440781 |
| VCL | vinculin | 0.0420076 |
| CPE | carboxypeptidase E | 0.0409382 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.040022 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.0399493 |
| TNS1 | tensin 1 | 0.0397198 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0392497 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0391448 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0388293 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0376553 |
| KIF1B | kinesin family member 1B | 0.0371274 |
| SVIL | supervillin | 0.0371151 |
| GOLGA4 | golgin A4 | 0.0366713 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.0362295 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0361311 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0354017 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.035104 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0350547 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0348258 |
| JAG1 | jagged 1 | 0.0346237 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0344279 |
| MYO6 | myosin VI | 0.0342773 |
| PLIN2 | perilipin 2 | 0.0340829 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0334339 |
| TCIM | transcriptional and immune response regulator | 0.0331547 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0331311 |
| BCL2L1 | BCL2-like 1 | 0.0330968 |
| CANX | calnexin | 0.0329881 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0329395 |
| DST | dystonin | 0.0328951 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0323882 |
| CCNY | cyclin Y | 0.0317994 |
| FAT1 | FAT atypical cadherin 1 | 0.0316434 |
| FOXO1 | forkhead box O1 | 0.031181 |
| CLIC4 | chloride intracellular channel 4 | 0.0310747 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0307998 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0305385 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0304679 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0304541 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.029948 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0297301 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0292201 |
| CYTH1 | cytohesin 1 | 0.029116 |
| ITGAV | integrin, alpha V | 0.0290911 |
| SET | SET nuclear proto-oncogene | 0.0289155 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0285057 |
| ARFGEF3 | ARFGEF family member 3 | 0.0282566 |
| FMNL2 | formin-like 2 | 0.0280061 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0279938 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0278787 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0277994 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.027361 |
| TPM3 | tropomyosin 3 | 0.0271371 |
| GRB10 | growth factor receptor-bound protein 10 | 0.02712 |
| RPL3 | ribosomal protein L3 | 0.0269225 |
| MAPK6 | mitogen-activated protein kinase 6 | 0.0267411 |
| SMAD3 | SMAD family member 3 | 0.0263575 |
| CCNL1 | cyclin L1 | 0.0262768 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0262707 |
| LRRC1 | leucine rich repeat containing 1 | 0.0261753 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0261411 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0260577 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GPC3 | glypican 3 | -0.105383 |
| FTL | ferritin, light polypeptide | -0.0816478 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0728234 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0686417 |
| TMSB10 | thymosin beta 10 | -0.0652866 |
| RPS24 | ribosomal protein S24 | -0.0637282 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0632975 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0618253 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0585511 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0543843 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0543685 |
| APOA2 | apolipoprotein A-II | -0.0540004 |
| IGF2 | insulin-like growth factor 2 | -0.0524259 |
| A2M | alpha-2-macroglobulin | -0.0494763 |
| GPC6 | glypican 6 | -0.0489965 |
| RPLP1 | ribosomal protein, large, P1 | -0.0468464 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0456797 |
| RPL35A | ribosomal protein L35a | -0.0449803 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0446657 |
| RPL34 | ribosomal protein L34 | -0.0444684 |
| RPS8 | ribosomal protein S8 | -0.0438054 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0408854 |
| PTCHD4 | patched domain containing 4 | -0.0406587 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0396392 |
| RRBP1 | ribosome binding protein 1 | -0.0380668 |
| APOE | apolipoprotein E | -0.0378279 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0376572 |
| MT2A | metallothionein 2A | -0.0369252 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0351654 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0340146 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0336475 |
| SYN3 | synapsin III | -0.0335337 |
| RPL31 | ribosomal protein L31 | -0.0333176 |
| RACK1 | receptor for activated C kinase 1 | -0.0329679 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0326183 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0308559 |
| RPS21 | ribosomal protein S21 | -0.0306569 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0305954 |
| FABP1 | fatty acid binding protein 1, liver | -0.0304692 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0291755 |
| RPS23 | ribosomal protein S23 | -0.0289523 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0289131 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0287805 |
| RPL12 | ribosomal protein L12 | -0.0284453 |
| RPS6 | ribosomal protein S6 | -0.0278428 |
| RPL11 | ribosomal protein L11 | -0.0269989 |
| KRT23 | keratin 23, type I | -0.0269213 |
| RPL38 | ribosomal protein L38 | -0.0265125 |
| RPL28 | ribosomal protein L28 | -0.0260289 |
| ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) | -0.0258396 |
| TMEM123 | transmembrane protein 123 | -0.025319 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0250616 |
| RPS19 | ribosomal protein S19 | -0.0250285 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.024653 |
| TBCK | TBC1 domain containing kinase | -0.0246093 |
| RPL32 | ribosomal protein L32 | -0.0242091 |
| CDK6 | cyclin-dependent kinase 6 | -0.0240742 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0239946 |
| ACTN4 | actinin, alpha 4 | -0.0239439 |
| NPAS2 | neuronal PAS domain protein 2 | -0.023501 |
| RPL27A | ribosomal protein L27a | -0.0231603 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0228609 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.022852 |
| PHF14 | PHD finger protein 14 | -0.0225692 |
| MBNL3 | muscleblind-like splicing regulator 3 | -0.0225464 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0222945 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.0222766 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.022143 |
| GNAS | GNAS complex locus | -0.0221321 |
| OSMR | oncostatin M receptor | -0.021976 |
| NPR2 | natriuretic peptide receptor 2 | -0.0219077 |
| RPL37A | ribosomal protein L37a | -0.0216163 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.0211652 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.0211453 |
| CST3 | cystatin C | -0.0211254 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0209919 |
| RPL13A | ribosomal protein L13a | -0.0208471 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0205422 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.020464 |
| CP | ceruloplasmin (ferroxidase) | -0.0204328 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0204315 |
| H1-0 | H1.0 linker histone | -0.0203465 |
| RPLP2 | ribosomal protein, large, P2 | -0.0202393 |
| RPL10A | ribosomal protein L10a | -0.0201792 |
| IER3 | immediate early response 3 | -0.0201306 |
| CCND1 | cyclin D1 | -0.0198013 |
| S100A10 | S100 calcium binding protein A10 | -0.0196419 |
| ARID3A | AT rich interactive domain 3A (BRIGHT-like) | -0.0196333 |
| RPS11 | ribosomal protein S11 | -0.0196286 |
| RPL27 | ribosomal protein L27 | -0.0196269 |
| RPS25 | ribosomal protein S25 | -0.0194786 |
| ARL5A | ADP-ribosylation factor-like 5A | -0.0194721 |
| RPS14 | ribosomal protein S14 | -0.0192517 |
| TBCA | tubulin folding cofactor A | -0.0191074 |
| RPS5 | ribosomal protein S5 | -0.0190041 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | -0.0189445 |
| TLK1 | tousled-like kinase 1 | -0.0189161 |
| RPS29 | ribosomal protein S29 | -0.0189134 |
| NFIA | nuclear factor I/A | -0.018833 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0185741 |
