Fedratinib (hydrochloride hydrate)_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fedratinib (hydrochloride hydrate) perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fedratinib (hydrochloride hydrate)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.199094
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.16313
ATP13A3 ATPase type 13A3 0.113842
ZNF841 zinc finger protein 841 0.1088
MYH9 myosin, heavy chain 9, non-muscle 0.0963901
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0910967
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0877414
TRIO trio Rho guanine nucleotide exchange factor 0.0767213
UBA6 ubiquitin-like modifier activating enzyme 6 0.0749533
SDC4 syndecan 4 0.0714477
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0682349
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0677257
IGFBP3 insulin-like growth factor binding protein 3 0.0644817
PICALM phosphatidylinositol binding clathrin assembly protein 0.0628352
FLNB filamin B, beta 0.0585161
AKAP12 A kinase (PRKA) anchor protein 12 0.0576017
CANX calnexin 0.054022
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0529719
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0524845
ANXA1 annexin A1 0.0510704
TPM3 tropomyosin 3 0.0500108
FN1 fibronectin 1 0.0498492
DTNA dystrobrevin, alpha 0.0488387
ARRDC3 arrestin domain containing 3 0.0471859
SMAD3 SMAD family member 3 0.0463094
MSN moesin 0.045751
UGCG UDP-glucose ceramide glucosyltransferase 0.0454956
NDRG1 N-myc downstream regulated 1 0.0442261
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0419488
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0416743
KDM2A lysine (K)-specific demethylase 2A 0.0413078
CCNL1 cyclin L1 0.041074
NAV2 neuron navigator 2 0.0409623
ACTG1 actin gamma 1 0.0405849
ITCH itchy E3 ubiquitin protein ligase 0.0401105
LOX lysyl oxidase 0.0393363
ERBIN erbb2 interacting protein 0.0390255
BZW1 basic leucine zipper and W2 domains 1 0.0380086
LIMCH1 LIM and calponin homology domains 1 0.0375471
FNIP1 folliculin interacting protein 1 0.0373943
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0364052
PCBP2 poly(rC) binding protein 2 0.035676
FNDC3B fibronectin type III domain containing 3B 0.0348223
COL5A1 collagen, type V, alpha 1 0.034642
CD44 CD44 molecule (Indian blood group) 0.034604
ADAM9 ADAM metallopeptidase domain 9 0.0343396
AHNAK AHNAK nucleoprotein 0.0342472
FAR1 fatty acyl CoA reductase 1 0.0337477
NUP58 nucleoporin 58 0.033472
CLIC4 chloride intracellular channel 4 0.0328372
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0327667
POTEF POTE ankyrin domain family, member F 0.0326192
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0325784
GLS2 glutaminase 2 (liver, mitochondrial) 0.0318154
SEC23A Sec23 homolog A (S. cerevisiae) 0.0316134
ADARB1 adenosine deaminase, RNA-specific, B1 0.0313616
UBXN7 UBX domain protein 7 0.0309475
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0304188
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0300224
TMEM41B transmembrane protein 41B 0.0296048
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.029403
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0286426
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0280056
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0278832
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0277517
TMSB4X thymosin beta 4, X-linked 0.0272539
PHACTR1 phosphatase and actin regulator 1 0.027199
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0271427
RASA2 RAS p21 protein activator 2 0.0270525
EIF4A2 eukaryotic translation initiation factor 4A2 0.0267056
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0264912
NCOR2 nuclear receptor corepressor 2 0.0264828
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0264785
EGFR epidermal growth factor receptor 0.0264554
DST dystonin 0.0264292
MARCHF6 membrane associated ring-CH-type finger 6 0.0263385
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0263015
PDE10A phosphodiesterase 10A 0.0261277
FAM120A family with sequence similarity 120A 0.026011
SRP54 signal recognition particle 54kDa 0.0260021
SUCO SUN domain containing ossification factor 0.0258703
ARF4 ADP-ribosylation factor 4 0.0254484
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.025339
SEPTIN9 septin 9 0.025177
PLPP6 phospholipid phosphatase 6 0.0251318
WWTR1 WW domain containing transcription regulator 1 0.0251065
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0249939
ELL2 elongation factor, RNA polymerase II, 2 0.0249285
LDHA lactate dehydrogenase A 0.0248844
VEGFA vascular endothelial growth factor A 0.0247758
GOLGA2 golgin A2 0.0247173
HPS3 Hermansky-Pudlak syndrome 3 0.0245515
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0245067
CXCL8 chemokine (C-X-C motif) ligand 8 0.0244513
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0242588
CALU calumenin 0.0242116
IQGAP1 IQ motif containing GTPase activating protein 1 0.0241735
AFF4 AF4/FMR2 family, member 4 0.0239662
VMP1 vacuole membrane protein 1 0.0238946
STK4 serine/threonine kinase 4 0.0238507

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.312215
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.159567
HLA-B major histocompatibility complex, class I, B -0.125739
MT2A metallothionein 2A -0.107715
RPS6 ribosomal protein S6 -0.0953802
MARCKS myristoylated alanine-rich protein kinase C substrate -0.094665
RPL35A ribosomal protein L35a -0.0942435
TMSB10 thymosin beta 10 -0.0903774
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0883388
TPT1 tumor protein, translationally-controlled 1 -0.0868404
FTH1 ferritin, heavy polypeptide 1 -0.0793587
HMGB1 high mobility group box 1 -0.074774
RPLP2 ribosomal protein, large, P2 -0.0714703
S100A10 S100 calcium binding protein A10 -0.066941
TXNRD1 thioredoxin reductase 1 -0.0639549
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0639419
DEK DEK proto-oncogene -0.0638442
PTMA prothymosin, alpha -0.0618824
RPL12 ribosomal protein L12 -0.0579149
RPS8 ribosomal protein S8 -0.0556438
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0551032
RPLP1 ribosomal protein, large, P1 -0.0525498
IFITM3 interferon induced transmembrane protein 3 -0.0512238
RPL35 ribosomal protein L35 -0.0506171
RPL23 ribosomal protein L23 -0.0489659
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0470152
KRT7 keratin 7, type II -0.0456387
TUBB tubulin, beta class I -0.0452171
RPS24 ribosomal protein S24 -0.0450888
PFN1 profilin 1 -0.0449197
PLCB4 phospholipase C, beta 4 -0.0433044
IFI6 interferon, alpha-inducible protein 6 -0.0430547
GNAS GNAS complex locus -0.0427303
RPS19 ribosomal protein S19 -0.0423361
RPS3 ribosomal protein S3 -0.040983
VIM vimentin -0.0402202
RPS13 ribosomal protein S13 -0.0394663
RPL28 ribosomal protein L28 -0.039392
RPL34 ribosomal protein L34 -0.0390677
S100A6 S100 calcium binding protein A6 -0.0389872
RPL37 ribosomal protein L37 -0.0379091
NALF1 NALCN channel auxiliary factor 1 -0.0371924
IER3 immediate early response 3 -0.0364745
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0357109
PKM pyruvate kinase, muscle -0.0354123
RPL37A ribosomal protein L37a -0.0350426
RPL26 ribosomal protein L26 -0.0346506
TPM1 tropomyosin 1 (alpha) -0.0346242
TUBB4B tubulin, beta 4B class IVb -0.033987
RPS20 ribosomal protein S20 -0.0334504
RPL8 ribosomal protein L8 -0.0330314
GLIS3 GLIS family zinc finger 3 -0.0329273
RPS16 ribosomal protein S16 -0.0320761
RPL32 ribosomal protein L32 -0.0320356
RPS21 ribosomal protein S21 -0.0315605
RPL36A ribosomal protein L36a -0.0313775
ANXA2 annexin A2 -0.0309256
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.030905
RPL7A ribosomal protein L7a -0.0302947
TPI1 triosephosphate isomerase 1 -0.0295827
RPL36 ribosomal protein L36 -0.029334
YBX1 Y box binding protein 1 -0.0292035
RPL11 ribosomal protein L11 -0.0291656
RHOBTB3 Rho-related BTB domain containing 3 -0.0289683
RPL27A ribosomal protein L27a -0.0287985
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.028135
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0281004
EIF5B eukaryotic translation initiation factor 5B -0.0280466
RPS25 ribosomal protein S25 -0.0278777
CTSD cathepsin D -0.0274447
IFI27 interferon, alpha-inducible protein 27 -0.0272184
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0270723
RPL18 ribosomal protein L18 -0.0269199
RPS12 ribosomal protein S12 -0.0266475
DYNLRB1 dynein, light chain, roadblock-type 1 -0.0261454
SERF2 small EDRK-rich factor 2 -0.0261145
CAVIN1 caveolae associated protein 1 -0.0256093
IFITM1 interferon induced transmembrane protein 1 -0.0254936
RACK1 receptor for activated C kinase 1 -0.0253337
LMNA lamin A/C -0.0250021
NOP58 NOP58 ribonucleoprotein -0.0246693
RPS17 ribosomal protein S17 -0.0244749
RPL31 ribosomal protein L31 -0.0243149
S100A9 S100 calcium binding protein A9 -0.0241933
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0241871
DIAPH3 diaphanous-related formin 3 -0.0239756
RPL30 ribosomal protein L30 -0.0238877
UBB ubiquitin B -0.0237953
MAP1B microtubule-associated protein 1B -0.0236255
RPS27 ribosomal protein S27 -0.0235278
S100A11 S100 calcium binding protein A11 -0.0234824
KRT18 keratin 18, type I -0.0232922
RRBP1 ribosome binding protein 1 -0.022971
SEPTIN7 septin 7 -0.0228608
RPL19 ribosomal protein L19 -0.0228316
PARD3B par-3 family cell polarity regulator beta -0.02279
CHD4 chromodomain helicase DNA binding protein 4 -0.0227748
TKT transketolase -0.0226822
SEC61G Sec61 gamma subunit -0.0225778
PRDX1 peroxiredoxin 1 -0.0225569