Fedratinib (hydrochloride hydrate)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fedratinib (hydrochloride hydrate) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fedratinib (hydrochloride hydrate)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ACTG1 actin gamma 1 0.136339
DTNA dystrobrevin, alpha 0.106988
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0911019
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0763942
KDM3A lysine (K)-specific demethylase 3A 0.0707094
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0705896
DST dystonin 0.0690381
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0668501
SPAG9 sperm associated antigen 9 0.0665905
EXT1 exostosin glycosyltransferase 1 0.066185
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0627106
ATP13A3 ATPase type 13A3 0.0621566
JMJD1C jumonji domain containing 1C 0.0616286
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0615814
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0613044
APP amyloid beta (A4) precursor protein 0.0604934
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0591221
PICALM phosphatidylinositol binding clathrin assembly protein 0.0556929
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0554652
MED13L mediator complex subunit 13-like 0.0551541
MMP12 matrix metallopeptidase 12 0.0547313
CD109 CD109 molecule 0.0540394
LDHA lactate dehydrogenase A 0.0536141
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0515746
MCTP1 multiple C2 domains, transmembrane 1 0.051486
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0500476
PTPRG protein tyrosine phosphatase, receptor type, G 0.0471104
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0463405
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0462349
NUP58 nucleoporin 58 0.0457554
WDR43 WD repeat domain 43 0.0456469
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0432657
ZNF292 zinc finger protein 292 0.0431521
RTN4 reticulon 4 0.0425092
OSBPL8 oxysterol binding protein-like 8 0.042493
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0421596
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0418986
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0412335
KMT2C lysine (K)-specific methyltransferase 2C 0.0411039
NAMPT nicotinamide phosphoribosyltransferase 0.040727
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.04029
FUBP1 far upstream element (FUSE) binding protein 1 0.0392847
YBX3 Y box binding protein 3 0.039263
HELZ helicase with zinc finger 0.0392103
MARCHF6 membrane associated ring-CH-type finger 6 0.0387785
HDAC9 histone deacetylase 9 0.0387603
GLS2 glutaminase 2 (liver, mitochondrial) 0.0386331
PGK1 phosphoglycerate kinase 1 0.0384618
RLF rearranged L-myc fusion 0.0381809
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0381305
CALD1 caldesmon 1 0.0380918
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0373994
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0373915
PUM2 pumilio RNA-binding family member 2 0.0368717
EFNA5 ephrin-A5 0.0363877
OGA O-GlcNAcase 0.0361702
ZMYM2 zinc finger, MYM-type 2 0.0359792
YEATS2 YEATS domain containing 2 0.0355876
RBM39 RNA binding motif protein 39 0.0355232
ADAM9 ADAM metallopeptidase domain 9 0.0354958
FRMD6 FERM domain containing 6 0.0354147
PAWR PRKC, apoptosis, WT1, regulator 0.0350273
ABI1 abl-interactor 1 0.0349115
NCKAP1 NCK-associated protein 1 0.0348061
MSN moesin 0.0344761
ERRFI1 ERBB receptor feedback inhibitor 1 0.0340456
TPM3 tropomyosin 3 0.0339252
KMT2E lysine (K)-specific methyltransferase 2E 0.0338523
ASPH aspartate beta-hydroxylase 0.0337311
RAD21 RAD21 homolog (S. pombe) 0.0336836
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0336804
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0336401
BIRC6 baculoviral IAP repeat containing 6 0.0334078
ELL2 elongation factor, RNA polymerase II, 2 0.0331392
YAP1 Yes-associated protein 1 0.032946
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0328699
WDR45B WD repeat domain 45B 0.0326818
USP34 ubiquitin specific peptidase 34 0.0324517
ZFAND3 zinc finger, AN1-type domain 3 0.03234
SFPQ splicing factor proline/glutamine-rich 0.0322218
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 0.0321944
EIF4B eukaryotic translation initiation factor 4B 0.0318418
BZW1 basic leucine zipper and W2 domains 1 0.0317106
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0313984
KLF7 Kruppel-like factor 7 (ubiquitous) 0.031391
SPRED1 sprouty-related, EVH1 domain containing 1 0.0313367
RND3 Rho family GTPase 3 0.0312671
WAC WW domain containing adaptor with coiled-coil 0.0311681
JARID2 jumonji, AT rich interactive domain 2 0.0311384
PCBP2 poly(rC) binding protein 2 0.0311078
ZEB1 zinc finger E-box binding homeobox 1 0.0309152
MYH9 myosin, heavy chain 9, non-muscle 0.0308219
SETD5 SET domain containing 5 0.0306644
RASA2 RAS p21 protein activator 2 0.0306052
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0304433
PBX3 pre-B-cell leukemia homeobox 3 0.030182
TEX10 testis expressed 10 0.0301637
QKI QKI, KH domain containing, RNA binding 0.030001
NEK7 NIMA-related kinase 7 0.0299974
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0299644

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.245223
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.24442
TMSB10 thymosin beta 10 -0.152221
RPS6 ribosomal protein S6 -0.148768
FTL ferritin, light polypeptide -0.0794638
PTMA prothymosin, alpha -0.0772003
RPLP1 ribosomal protein, large, P1 -0.0744105
RPL23 ribosomal protein L23 -0.0734936
RPL35A ribosomal protein L35a -0.0730131
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0680722
RPS19 ribosomal protein S19 -0.065885
RPS8 ribosomal protein S8 -0.062368
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0608725
RPL37A ribosomal protein L37a -0.0587804
RPS25 ribosomal protein S25 -0.0518356
RPLP2 ribosomal protein, large, P2 -0.0517699
RPS12 ribosomal protein S12 -0.050575
HMGA1 high mobility group AT-hook 1 -0.0483655
TPT1 tumor protein, translationally-controlled 1 -0.0477387
RPL12 ribosomal protein L12 -0.0469398
RPS17 ribosomal protein S17 -0.0425008
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0422671
EGR1 early growth response 1 -0.0418117
RPS3 ribosomal protein S3 -0.0414074
SAMD3 sterile alpha motif domain containing 3 -0.0407476
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.040322
CDH13 cadherin 13 -0.0395007
AKAP12 A kinase (PRKA) anchor protein 12 -0.0392544
MT2A metallothionein 2A -0.0391669
RPL28 ribosomal protein L28 -0.0388124
RPL8 ribosomal protein L8 -0.0383787
RPS23 ribosomal protein S23 -0.038123
PHACTR1 phosphatase and actin regulator 1 -0.0376875
RPS24 ribosomal protein S24 -0.0367414
RPL36 ribosomal protein L36 -0.0356368
RPL19 ribosomal protein L19 -0.0343361
RPL34 ribosomal protein L34 -0.0338934
RPL35 ribosomal protein L35 -0.0323833
RPS14 ribosomal protein S14 -0.0323633
RPL11 ribosomal protein L11 -0.0319778
RPL31 ribosomal protein L31 -0.0319048
RPLP0 ribosomal protein, large, P0 -0.0313022
RPL30 ribosomal protein L30 -0.0308392
RACK1 receptor for activated C kinase 1 -0.0298899
RPL9 ribosomal protein L9 -0.029418
RPS16 ribosomal protein S16 -0.0288613
RPS20 ribosomal protein S20 -0.0288601
RPS29 ribosomal protein S29 -0.0286781
RPS27A ribosomal protein S27a -0.0286456
NAV1 neuron navigator 1 -0.0279489
RPS27 ribosomal protein S27 -0.0264951
PTCHD4 patched domain containing 4 -0.0263735
SDCCAG8 serologically defined colon cancer antigen 8 -0.0263292
RPL18 ribosomal protein L18 -0.0253955
NTM neurotrimin -0.0249733
RPS2 ribosomal protein S2 -0.0249627
GNAS GNAS complex locus -0.0247135
LDHB lactate dehydrogenase B -0.0242693
RPL7A ribosomal protein L7a -0.0242358
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0241629
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0241016
RPL38 ribosomal protein L38 -0.0237799
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0232183
RPS10 ribosomal protein S10 -0.0228358
RPL13A ribosomal protein L13a -0.022813
NDRG1 N-myc downstream regulated 1 -0.0227018
RPL32 ribosomal protein L32 -0.0224857
CSTB cystatin B (stefin B) -0.0222821
RPS13 ribosomal protein S13 -0.0221982
HMGB1 high mobility group box 1 -0.021694
RPL27A ribosomal protein L27a -0.0216282
ASTN2 astrotactin 2 -0.0216035
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0214068
RPL36A ribosomal protein L36a -0.0213484
EEF1G eukaryotic translation elongation factor 1 gamma -0.0209868
S100A10 S100 calcium binding protein A10 -0.0209148
PDE4D phosphodiesterase 4D, cAMP-specific -0.0205352
PKM pyruvate kinase, muscle -0.0203054
CAVIN1 caveolae associated protein 1 -0.0197511
RPS21 ribosomal protein S21 -0.0195013
C2CD2 C2 calcium-dependent domain containing 2 -0.0193874
RPS15 ribosomal protein S15 -0.0193376
CALR calreticulin -0.0192126
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0189682
PCDH11X protocadherin 11 X-linked -0.0188667
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.018413
RPL27 ribosomal protein L27 -0.0182892
RPL5 ribosomal protein L5 -0.0180583
S100A9 S100 calcium binding protein A9 -0.0178294
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0174647
PFN1 profilin 1 -0.0174356
RPL21 ribosomal protein L21 -0.0166901
RPL37 ribosomal protein L37 -0.0166476
RPS11 ribosomal protein S11 -0.0165869
SP100 SP100 nuclear antigen -0.0164732
TENM2 teneurin transmembrane protein 2 -0.016428
CUX1 cut-like homeobox 1 -0.016412
RABGAP1L RAB GTPase activating protein 1-like -0.0162747
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0161075
RPL26 ribosomal protein L26 -0.0160945