| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fedratinib (hydrochloride hydrate) perturbation in LoVo cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Fedratinib (hydrochloride hydrate)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ACTG1 | actin gamma 1 | 0.119333 |
| INTS6 | integrator complex subunit 6 | 0.0914757 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0907668 |
| DSPP | dentin sialophosphoprotein | 0.0898718 |
| LMO7 | LIM domain 7 | 0.0863387 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0770124 |
| POTEF | POTE ankyrin domain family, member F | 0.0641134 |
| LDHA | lactate dehydrogenase A | 0.0620933 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0611747 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0589241 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0524826 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | 0.0524215 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0509161 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0498427 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0477094 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0464598 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0454462 |
| PCBP2 | poly(rC) binding protein 2 | 0.0450779 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.0445194 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0444082 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0433735 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0423295 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0416997 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0415186 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0389167 |
| SQSTM1 | sequestosome 1 | 0.0375252 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0373151 |
| ASPH | aspartate beta-hydroxylase | 0.0372616 |
| CALB1 | calbindin 1, 28kDa | 0.0363066 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0356585 |
| FRMD5 | FERM domain containing 5 | 0.0354183 |
| NABP1 | nucleic acid binding protein 1 | 0.0352422 |
| CANX | calnexin | 0.0345799 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0343416 |
| LRRC23 | leucine rich repeat containing 23 | 0.0337513 |
| MYO1E | myosin IE | 0.0337354 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0326535 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0316906 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.0316301 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0311836 |
| KRT8 | keratin 8, type II | 0.0307189 |
| VMP1 | vacuole membrane protein 1 | 0.0293747 |
| RCOR1 | REST corepressor 1 | 0.0292459 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0288322 |
| UBAP2 | ubiquitin associated protein 2 | 0.028503 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0283048 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0280317 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0279968 |
| FNIP1 | folliculin interacting protein 1 | 0.0276529 |
| EZR | ezrin | 0.0275074 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | 0.0274691 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0273143 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0266589 |
| CCNYL1 | cyclin Y-like 1 | 0.0259658 |
| ADIPOR2 | adiponectin receptor 2 | 0.0258558 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0256563 |
| TMF1 | TATA element modulatory factor 1 | 0.025597 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0255385 |
| PLK2 | polo-like kinase 2 | 0.0253727 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0250122 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.0247003 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.024645 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0245611 |
| SKP1 | S-phase kinase-associated protein 1 | 0.0244964 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | 0.024285 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0240568 |
| MYO5B | myosin VB | 0.0238562 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0238143 |
| UBC | ubiquitin C | 0.0236855 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0235514 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0233413 |
| AEBP2 | AE binding protein 2 | 0.0227491 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0226455 |
| MYH14 | myosin, heavy chain 14, non-muscle | 0.0221346 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | 0.0220679 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0219618 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0216358 |
| FBXO11 | F-box protein 11 | 0.0213948 |
| LARP1B | La ribonucleoprotein domain family, member 1B | 0.0213522 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0213231 |
| SNX14 | sorting nexin 14 | 0.0211443 |
| IRF1 | interferon regulatory factor 1 | 0.0209297 |
| ENO1 | enolase 1, (alpha) | 0.0209008 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0208832 |
| PGM3 | phosphoglucomutase 3 | 0.0208827 |
| MLEC | malectin | 0.0208047 |
| BRD2 | bromodomain containing 2 | 0.0208035 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0207283 |
| MCL1 | myeloid cell leukemia 1 | 0.0203842 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0202643 |
| HDLBP | high density lipoprotein binding protein | 0.0198623 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0197405 |
| ATF3 | activating transcription factor 3 | 0.0196258 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0193979 |
| MSH4 | mutS homolog 4 | 0.0193653 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0192866 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0192719 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0192526 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0189339 |
| ARRDC3 | arrestin domain containing 3 | 0.0188879 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPLP1 | ribosomal protein, large, P1 | -0.11065 |
| PKP2 | plakophilin 2 | -0.0757747 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0750821 |
| TMSB10 | thymosin beta 10 | -0.0740583 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.073448 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0708816 |
| PRSS3 | protease, serine, 3 | -0.0676858 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.0666221 |
| TXNRD1 | thioredoxin reductase 1 | -0.0622829 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0612301 |
| WWC1 | WW and C2 domain containing 1 | -0.0566666 |
| FOXO1 | forkhead box O1 | -0.0566663 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0537073 |
| FLNB | filamin B, beta | -0.0487705 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.0477879 |
| FOXP1 | forkhead box P1 | -0.0464503 |
| ABHD17C | abhydrolase domain containing 17C | -0.0456601 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.045248 |
| RRBP1 | ribosome binding protein 1 | -0.0445855 |
| PLAC8 | placenta-specific 8 | -0.0437816 |
| PCDHB16 | protocadherin beta 16 | -0.0403824 |
| SH3RF2 | SH3 domain containing ring finger 2 | -0.0398112 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0392968 |
| RPS19 | ribosomal protein S19 | -0.0391744 |
| RPS24 | ribosomal protein S24 | -0.0389268 |
| TRIM2 | tripartite motif containing 2 | -0.0371757 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0369147 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0366671 |
| SHROOM3 | shroom family member 3 | -0.0361789 |
| ETV6 | ets variant 6 | -0.0360293 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0353269 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | -0.0352961 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0349027 |
| RPLP2 | ribosomal protein, large, P2 | -0.034432 |
| ATP10B | ATPase, class V, type 10B | -0.0343508 |
| PDE8A | phosphodiesterase 8A | -0.034293 |
| TNRC18 | trinucleotide repeat containing 18 | -0.0338924 |
| RIGI | RNA sensor RIG-I | -0.0338199 |
| RPL34 | ribosomal protein L34 | -0.0334297 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | -0.0333202 |
| RPS6 | ribosomal protein S6 | -0.0327486 |
| ANXA11 | annexin A11 | -0.0326203 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.0325213 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | -0.0322423 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0320394 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0319489 |
| RPS21 | ribosomal protein S21 | -0.0319057 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0307331 |
| MX2 | MX dynamin-like GTPase 2 | -0.0305347 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0301846 |
| PRELID2 | PRELI domain containing 2 | -0.0301014 |
| RFX7 | regulatory factor X, 7 | -0.0299269 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0295165 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0293302 |
| VPS37B | vacuolar protein sorting 37 homolog B (S. cerevisiae) | -0.0292397 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0291828 |
| FERMT1 | fermitin family member 1 | -0.0291747 |
| BCL2L1 | BCL2-like 1 | -0.0288291 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.0287562 |
| RPS23 | ribosomal protein S23 | -0.028744 |
| NF1 | neurofibromin 1 | -0.0286433 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0283886 |
| TLN2 | talin 2 | -0.0282388 |
| TCF12 | transcription factor 12 | -0.0277964 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.0274668 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0272195 |
| ETNK1 | ethanolamine kinase 1 | -0.0271973 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.0271334 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0270873 |
| PTEN | phosphatase and tensin homolog | -0.0260587 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.026033 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0257692 |
| RHPN2 | rhophilin, Rho GTPase binding protein 2 | -0.0256836 |
| TSPAN8 | tetraspanin 8 | -0.0256704 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | -0.0256413 |
| RNF213 | ring finger protein 213 | -0.0255562 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0254995 |
| MX1 | MX dynamin-like GTPase 1 | -0.0251471 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0250217 |
| MYO1D | myosin ID | -0.0249629 |
| RNF145 | ring finger protein 145 | -0.0243346 |
| CARD16 | caspase recruitment domain family, member 16 | -0.023869 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0238155 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.023393 |
| FAT1 | FAT atypical cadherin 1 | -0.0231978 |
| AOPEP | aminopeptidase O (putative) | -0.0230875 |
| PLSCR1 | phospholipid scramblase 1 | -0.0229616 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0228892 |
| RPL37A | ribosomal protein L37a | -0.0228342 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0225602 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.022524 |
| RPL35A | ribosomal protein L35a | -0.0224783 |
| SH3RF1 | SH3 domain containing ring finger 1 | -0.0222683 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.022041 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0219054 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0218792 |
| DSG4 | desmoglein 4 | -0.0218138 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0217671 |
| RBM47 | RNA binding motif protein 47 | -0.0216331 |
| MKI67 | marker of proliferation Ki-67 | -0.0216178 |
