| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fedratinib (hydrochloride hydrate) perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Fedratinib (hydrochloride hydrate)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ACTG1 | actin gamma 1 | 0.200277 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.185884 |
| ASPH | aspartate beta-hydroxylase | 0.16646 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.149081 |
| LDHA | lactate dehydrogenase A | 0.142975 |
| EGFR | epidermal growth factor receptor | 0.139446 |
| LMO7 | LIM domain 7 | 0.125473 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.118051 |
| SDC4 | syndecan 4 | 0.109072 |
| PCBP2 | poly(rC) binding protein 2 | 0.106759 |
| ENO1 | enolase 1, (alpha) | 0.102029 |
| DSPP | dentin sialophosphoprotein | 0.0899819 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0898482 |
| LAMC2 | laminin, gamma 2 | 0.0871858 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0704727 |
| ARRDC3 | arrestin domain containing 3 | 0.069901 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0689194 |
| CPE | carboxypeptidase E | 0.0680514 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.067 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0654422 |
| HDLBP | high density lipoprotein binding protein | 0.0638254 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0635664 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0628309 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.0603197 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0590535 |
| AHNAK | AHNAK nucleoprotein | 0.0586007 |
| FAM13A | family with sequence similarity 13, member A | 0.0555299 |
| ANXA2 | annexin A2 | 0.0545771 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0539219 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0530347 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0518291 |
| OGA | O-GlcNAcase | 0.0515165 |
| PGK1 | phosphoglycerate kinase 1 | 0.0511889 |
| RPLP0 | ribosomal protein, large, P0 | 0.0511652 |
| LAMB3 | laminin, beta 3 | 0.0507822 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0507374 |
| B2M | beta-2-microglobulin | 0.0502365 |
| MCL1 | myeloid cell leukemia 1 | 0.0501939 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0486174 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0483807 |
| RPS4X | ribosomal protein S4, X-linked | 0.0479258 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0469741 |
| SPAG9 | sperm associated antigen 9 | 0.0469103 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0465417 |
| TPM3 | tropomyosin 3 | 0.0459072 |
| RAD21 | RAD21 homolog (S. pombe) | 0.044838 |
| CANX | calnexin | 0.0443122 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0436423 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0431414 |
| EGR1 | early growth response 1 | 0.0429992 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.042075 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0413461 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0407154 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0406556 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0406354 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.039925 |
| ANKRD17 | ankyrin repeat domain 17 | 0.039339 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0386019 |
| NPAS2 | neuronal PAS domain protein 2 | 0.038181 |
| DYNC2I1 | dynein 2 intermediate chain 1 | 0.0375076 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0374875 |
| POTEF | POTE ankyrin domain family, member F | 0.0374381 |
| SFTPA2 | surfactant protein A2 | 0.0374202 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0369632 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0365925 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0362682 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0351862 |
| ZNF638 | zinc finger protein 638 | 0.0351308 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0350909 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0350577 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.0347786 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | 0.0344973 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.034342 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0343207 |
| JUN | jun proto-oncogene | 0.0340211 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.034021 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0339616 |
| RBM25 | RNA binding motif protein 25 | 0.0337381 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0333812 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0333807 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.032486 |
| LAMA4 | laminin, alpha 4 | 0.0324054 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0323725 |
| VCL | vinculin | 0.032308 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0321706 |
| PTMA | prothymosin, alpha | 0.0321573 |
| RPL4 | ribosomal protein L4 | 0.0321001 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0320071 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0319976 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0317639 |
| CSNK1E | casein kinase 1, epsilon | 0.0316535 |
| RNF169 | ring finger protein 169 | 0.0316451 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0314751 |
| FNBP1L | formin binding protein 1-like | 0.0314441 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0310494 |
| RPL23 | ribosomal protein L23 | 0.0309194 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | 0.0307141 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0306798 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0306145 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0302173 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.132021 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.126239 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0914661 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.059715 |
| RPS2 | ribosomal protein S2 | -0.0519705 |
| RUNX1 | runt-related transcription factor 1 | -0.0517358 |
| SMAD3 | SMAD family member 3 | -0.050686 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0496265 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0480725 |
| SP100 | SP100 nuclear antigen | -0.0468864 |
| RPLP1 | ribosomal protein, large, P1 | -0.0437124 |
| GPHN | gephyrin | -0.0408212 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0392012 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0376202 |
| TXNRD1 | thioredoxin reductase 1 | -0.0371964 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.037089 |
| GPC6 | glypican 6 | -0.0368307 |
| RPS24 | ribosomal protein S24 | -0.0360146 |
| MYOF | myoferlin | -0.0358886 |
| DTNA | dystrobrevin, alpha | -0.0358574 |
| SEC61G | Sec61 gamma subunit | -0.0354994 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0344607 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0316116 |
| OSMR | oncostatin M receptor | -0.0312176 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0306907 |
| RPL37A | ribosomal protein L37a | -0.0293536 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0292769 |
| KYNU | kynureninase | -0.0280904 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0280175 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0267188 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0266871 |
| MORF4L2 | mortality factor 4 like 2 | -0.0261001 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0260101 |
| TENT2 | terminal nucleotidyltransferase 2 | -0.0256934 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0255909 |
| HELZ | helicase with zinc finger | -0.0250923 |
| CCNK | cyclin K | -0.0246356 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0245537 |
| TMEM165 | transmembrane protein 165 | -0.0244094 |
| SLMAP | sarcolemma associated protein | -0.0241184 |
| ANKRD37 | ankyrin repeat domain 37 | -0.024049 |
| BBX | bobby sox homolog (Drosophila) | -0.0239831 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | -0.023982 |
| PLSCR1 | phospholipid scramblase 1 | -0.0239245 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.023697 |
| MATR3 | matrin 3 | -0.0236943 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0235413 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0230818 |
| USP53 | ubiquitin specific peptidase 53 | -0.0229187 |
| RPS23 | ribosomal protein S23 | -0.0221938 |
| TNRC6A | trinucleotide repeat containing 6A | -0.0220021 |
| FTL | ferritin, light polypeptide | -0.0218537 |
| RPLP2 | ribosomal protein, large, P2 | -0.0218194 |
| NOP58 | NOP58 ribonucleoprotein | -0.0217317 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0215304 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.0213602 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0211117 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | -0.0208909 |
| BRD2 | bromodomain containing 2 | -0.0208642 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0208372 |
| H1-0 | H1.0 linker histone | -0.0208 |
| MXD1 | MAX dimerization protein 1 | -0.0206411 |
| EIF2A | eukaryotic translation initiation factor 2A, 65kDa | -0.0204933 |
| IER3 | immediate early response 3 | -0.0204215 |
| RPL6 | ribosomal protein L6 | -0.0202516 |
| SLC25A26 | solute carrier family 25 (S-adenosylmethionine carrier), member 26 | -0.0202398 |
| TMEM39A | transmembrane protein 39A | -0.0198985 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0197721 |
| GOLGA4 | golgin A4 | -0.0196938 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0195004 |
| KIAA1217 | KIAA1217 | -0.0193651 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.0192918 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0190774 |
| TFG | TRK-fused gene | -0.018908 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | -0.0188507 |
| RNF24 | ring finger protein 24 | -0.0187702 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | -0.0187537 |
| PPTC7 | PTC7 protein phosphatase homolog (S. cerevisiae) | -0.0186893 |
| UPP1 | uridine phosphorylase 1 | -0.0186699 |
| RNF145 | ring finger protein 145 | -0.0183844 |
| USP3 | ubiquitin specific peptidase 3 | -0.0183819 |
| GORASP2 | golgi reassembly stacking protein 2, 55kDa | -0.0182415 |
| ARL8B | ADP-ribosylation factor-like 8B | -0.0181939 |
| DMTF1 | cyclin D binding myb-like transcription factor 1 | -0.0181858 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0180564 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0180389 |
| KCMF1 | potassium channel modulatory factor 1 | -0.017809 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0177526 |
| SPPL3 | signal peptide peptidase like 3 | -0.0175098 |
| PTBP2 | polypyrimidine tract binding protein 2 | -0.0174367 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.0173774 |
| DENR | density-regulated protein | -0.0173469 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0173301 |
| RBM26 | RNA binding motif protein 26 | -0.017254 |
| RPS16 | ribosomal protein S16 | -0.0171387 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0170947 |
| AP3S1 | adaptor-related protein complex 3, sigma 1 subunit | -0.0169986 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0169499 |
| TMSB10 | thymosin beta 10 | -0.016662 |
| PMP22 | peripheral myelin protein 22 | -0.0161362 |
