Fedratinib (hydrochloride hydrate)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fedratinib (hydrochloride hydrate) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fedratinib (hydrochloride hydrate)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KDM2A lysine (K)-specific demethylase 2A 0.172458
PCBP2 poly(rC) binding protein 2 0.167197
AKAP12 A kinase (PRKA) anchor protein 12 0.160217
USP34 ubiquitin specific peptidase 34 0.125157
FNDC3B fibronectin type III domain containing 3B 0.118568
NAV2 neuron navigator 2 0.111352
GOLGA4 golgin A4 0.0997577
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0918867
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0866294
SMAD3 SMAD family member 3 0.0805656
TRIO trio Rho guanine nucleotide exchange factor 0.077992
VMP1 vacuole membrane protein 1 0.0778391
AKAP13 A kinase (PRKA) anchor protein 13 0.0756306
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0735268
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0707142
LOX lysyl oxidase 0.0684476
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0676603
FAM107B family with sequence similarity 107, member B 0.0676544
KMT2C lysine (K)-specific methyltransferase 2C 0.0658093
EFNA5 ephrin-A5 0.0641197
CD44 CD44 molecule (Indian blood group) 0.064082
RERE arginine-glutamic acid dipeptide (RE) repeats 0.063892
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0638453
DOCK5 dedicator of cytokinesis 5 0.0628017
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0625251
MAP2K1 mitogen-activated protein kinase kinase 1 0.0616149
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0605936
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0599185
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0581379
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0573282
FAM20C family with sequence similarity 20, member C 0.0566956
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0563197
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0557723
AKAP9 A kinase (PRKA) anchor protein 9 0.0555244
SEC23A Sec23 homolog A (S. cerevisiae) 0.0547725
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0546502
COPA coatomer protein complex, subunit alpha 0.0532091
SPAG9 sperm associated antigen 9 0.0524187
SEC31A SEC31 homolog A (S. cerevisiae) 0.0513997
UBA6 ubiquitin-like modifier activating enzyme 6 0.0510626
JMJD1C jumonji domain containing 1C 0.050907
ARHGAP5 Rho GTPase activating protein 5 0.050007
CANX calnexin 0.0492051
OGA O-GlcNAcase 0.0491228
EEF2 eukaryotic translation elongation factor 2 0.0488565
IQGAP1 IQ motif containing GTPase activating protein 1 0.0475114
DSCAM Down syndrome cell adhesion molecule 0.04718
RAB8B RAB8B, member RAS oncogene family 0.0469515
FNIP1 folliculin interacting protein 1 0.0468725
WWTR1 WW domain containing transcription regulator 1 0.0462488
SEC24A SEC24 family member A 0.0460429
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0459997
FBXL13 F-box and leucine-rich repeat protein 13 0.0456781
CALU calumenin 0.04475
SIK3 SIK family kinase 3 0.0444245
ITCH itchy E3 ubiquitin protein ligase 0.0444113
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0440648
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0437657
CLTC clathrin, heavy chain (Hc) 0.0437487
SDC4 syndecan 4 0.0436001
DENND4A DENN/MADD domain containing 4A 0.0429497
GRB10 growth factor receptor-bound protein 10 0.0429201
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0418918
RBM39 RNA binding motif protein 39 0.041872
ANKRD17 ankyrin repeat domain 17 0.0417448
MCL1 myeloid cell leukemia 1 0.0415025
NPC1 Niemann-Pick disease, type C1 0.041308
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0403364
SDK1 sidekick cell adhesion molecule 1 0.040144
CD109 CD109 molecule 0.0401221
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0398842
EGFR epidermal growth factor receptor 0.0389852
ARRDC3 arrestin domain containing 3 0.038945
RICTOR RPTOR independent companion of MTOR, complex 2 0.0388981
SBF2 SET binding factor 2 0.0387853
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0387512
COG5 component of oligomeric golgi complex 5 0.0381002
LDHA lactate dehydrogenase A 0.0380533
MON2 MON2 homolog (S. cerevisiae) 0.0380486
MACF1 microtubule-actin crosslinking factor 1 0.0376607
RAB1A RAB1A, member RAS oncogene family 0.0374472
FAM13A family with sequence similarity 13, member A 0.0373947
RUNX1 runt-related transcription factor 1 0.0372991
TTC3 tetratricopeptide repeat domain 3 0.0370622
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0368729
RAB5A RAB5A, member RAS oncogene family 0.0364584
FLNB filamin B, beta 0.0364449
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0363425
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0363195
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0361591
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0360647
BASP1 brain abundant, membrane attached signal protein 1 0.0360388
SOD2 superoxide dismutase 2, mitochondrial 0.036034
TGM2 transglutaminase 2 0.035727
BACE2 beta-site APP-cleaving enzyme 2 0.0356703
CTNND1 catenin (cadherin-associated protein), delta 1 0.0355328
TAOK1 TAO kinase 1 0.0354807
PICALM phosphatidylinositol binding clathrin assembly protein 0.0353893
APLP2 amyloid beta (A4) precursor-like protein 2 0.0353108
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.035109

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.131801
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.084819
FTL ferritin, light polypeptide -0.0831242
NRG1 neuregulin 1 -0.070842
PTMA prothymosin, alpha -0.0708311
RPL35A ribosomal protein L35a -0.0626528
RPLP1 ribosomal protein, large, P1 -0.0592762
TPT1 tumor protein, translationally-controlled 1 -0.0530962
IER3 immediate early response 3 -0.0463731
CDH13 cadherin 13 -0.0446143
RPL34 ribosomal protein L34 -0.0443219
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0442423
RPS19 ribosomal protein S19 -0.0425994
TFPI2 tissue factor pathway inhibitor 2 -0.0391388
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0383694
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0383687
FN1 fibronectin 1 -0.0361697
RPS24 ribosomal protein S24 -0.035977
RPL36 ribosomal protein L36 -0.0343674
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0342402
RPS21 ribosomal protein S21 -0.0339221
RPS6 ribosomal protein S6 -0.0336941
RPLP2 ribosomal protein, large, P2 -0.0327397
RPS29 ribosomal protein S29 -0.0323937
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0321783
VIM vimentin -0.0318242
WSB1 WD repeat and SOCS box containing 1 -0.0306873
RPL32 ribosomal protein L32 -0.030412
RPL37A ribosomal protein L37a -0.0297802
RPS8 ribosomal protein S8 -0.0297276
S100A9 S100 calcium binding protein A9 -0.0294055
HMGA1 high mobility group AT-hook 1 -0.0293439
RPL28 ribosomal protein L28 -0.0289394
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0283874
CLMP CXADR-like membrane protein -0.02751
RPS27 ribosomal protein S27 -0.0270416
RPL23 ribosomal protein L23 -0.0261198
RPL38 ribosomal protein L38 -0.0256002
RPL37 ribosomal protein L37 -0.0250949
HMGA2 high mobility group AT-hook 2 -0.024745
RPS16 ribosomal protein S16 -0.024293
FTH1 ferritin, heavy polypeptide 1 -0.0239366
MECOM MDS1 and EVI1 complex locus -0.0237064
RPS11 ribosomal protein S11 -0.0236596
DPYD dihydropyrimidine dehydrogenase -0.0235697
GLCCI1 glucocorticoid induced 1 -0.0235129
RPL35 ribosomal protein L35 -0.0231408
S100A6 S100 calcium binding protein A6 -0.0230136
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0226054
IFI6 interferon, alpha-inducible protein 6 -0.0225959
RPL19 ribosomal protein L19 -0.0222314
RPLP0 ribosomal protein, large, P0 -0.0219431
YBX1 Y box binding protein 1 -0.0217151
HLA-B major histocompatibility complex, class I, B -0.021552
LOC102724023 ES1 protein homolog, mitochondrial -0.021378
RPS23 ribosomal protein S23 -0.0211165
SP100 SP100 nuclear antigen -0.0207415
ENOSF1 enolase superfamily member 1 -0.0205801
RPL11 ribosomal protein L11 -0.0202158
RPS25 ribosomal protein S25 -0.0201563
NFE2L2 nuclear factor, erythroid 2-like 2 -0.020039
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0199839
IFITM3 interferon induced transmembrane protein 3 -0.0197381
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0196171
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0195732
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0194091
H1-0 H1.0 linker histone -0.0193176
IFI44L interferon-induced protein 44-like -0.019123
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0186901
GNAS GNAS complex locus -0.0186855
RPS14 ribosomal protein S14 -0.0185433
NAV3 neuron navigator 3 -0.0183977
NTN4 netrin 4 -0.0180267
S100A10 S100 calcium binding protein A10 -0.0179488
EGR1 early growth response 1 -0.0178524
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0173751
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0172748
SNX9 sorting nexin 9 -0.0172568
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0171873
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 -0.0171138
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0171084
RPS12 ribosomal protein S12 -0.0168443
SLC38A1 solute carrier family 38, member 1 -0.0168002
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0166726
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled -0.0165196
ZNFX1 zinc finger, NFX1-type containing 1 -0.01647
RPL31 ribosomal protein L31 -0.0163114
POLD4 polymerase (DNA-directed), delta 4, accessory subunit -0.0163112
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 -0.0161441
CP ceruloplasmin (ferroxidase) -0.0161378
NAP1L1 nucleosome assembly protein 1-like 1 -0.0160212
TRIM56 tripartite motif containing 56 -0.0159472
RPS13 ribosomal protein S13 -0.0159412
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0159328
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0159108
RPS15 ribosomal protein S15 -0.0157729
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0154282
RPS27A ribosomal protein S27a -0.0154101
ISG15 ISG15 ubiquitin-like modifier -0.015354
RPL5 ribosomal protein L5 -0.0152609