| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fedratinib (hydrochloride hydrate) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Fedratinib (hydrochloride hydrate)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ACTG1 | actin gamma 1 | 0.11135 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.10355 |
| TPM3 | tropomyosin 3 | 0.0950742 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0879236 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0878087 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0861888 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0718352 |
| WDR43 | WD repeat domain 43 | 0.0588315 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0572964 |
| CCNL1 | cyclin L1 | 0.05519 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0519439 |
| SDC4 | syndecan 4 | 0.051561 |
| PCBP2 | poly(rC) binding protein 2 | 0.0503599 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | 0.0485721 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0483801 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0448624 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0446614 |
| RBM25 | RNA binding motif protein 25 | 0.044168 |
| RTN4 | reticulon 4 | 0.0421221 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0417511 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0417156 |
| YME1L1 | YME1-like 1 ATPase | 0.041484 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0403845 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.039532 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0390895 |
| NUP58 | nucleoporin 58 | 0.0386047 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0385603 |
| TPD52 | tumor protein D52 | 0.0385142 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0378192 |
| USP3 | ubiquitin specific peptidase 3 | 0.0375846 |
| APP | amyloid beta (A4) precursor protein | 0.0372006 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0370337 |
| RBM39 | RNA binding motif protein 39 | 0.0366241 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0358777 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.0358654 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.035761 |
| POTEF | POTE ankyrin domain family, member F | 0.0357403 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0356303 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0356042 |
| MATR3 | matrin 3 | 0.0350267 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0349801 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0345621 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0343544 |
| COPA | coatomer protein complex, subunit alpha | 0.0343522 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0337861 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0337516 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0337506 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.033459 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0330233 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0330226 |
| ZNF292 | zinc finger protein 292 | 0.0326336 |
| ANXA1 | annexin A1 | 0.032393 |
| EIF4A3 | eukaryotic translation initiation factor 4A3 | 0.0316241 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0313867 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0307095 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0300885 |
| RPL7 | ribosomal protein L7 | 0.0299186 |
| TFG | TRK-fused gene | 0.029584 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0291659 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.029148 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0291008 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0289337 |
| YTHDC1 | YTH domain containing 1 | 0.0287354 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0286896 |
| RLF | rearranged L-myc fusion | 0.0286718 |
| GOLT1B | golgi transport 1B | 0.0284873 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0279666 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0279075 |
| CDC73 | cell division cycle 73 | 0.0278726 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0276205 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0275232 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0274261 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0271165 |
| NOP58 | NOP58 ribonucleoprotein | 0.0270467 |
| GOLGA4 | golgin A4 | 0.027045 |
| FAM168A | family with sequence similarity 168, member A | 0.0266434 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0263957 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0262853 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0262349 |
| NUP153 | nucleoporin 153kDa | 0.0260978 |
| RAB18 | RAB18, member RAS oncogene family | 0.0260527 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0258286 |
| BRD2 | bromodomain containing 2 | 0.0255947 |
| SCAF4 | SR-related CTD-associated factor 4 | 0.0253766 |
| CASC3 | cancer susceptibility candidate 3 | 0.0251527 |
| MCL1 | myeloid cell leukemia 1 | 0.0251239 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.025118 |
| COG5 | component of oligomeric golgi complex 5 | 0.025075 |
| AFTPH | aftiphilin | 0.0247425 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.024646 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0245921 |
| SFTPA2 | surfactant protein A2 | 0.0245337 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0244896 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0244291 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0244171 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0243656 |
| PSMC6 | proteasome (prosome, macropain) 26S subunit, ATPase, 6 | 0.0243493 |
| IST1 | increased sodium tolerance 1 homolog (yeast) | 0.0243151 |
| CCNY | cyclin Y | 0.0242944 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0242449 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.241291 |
| PM20D1 | peptidase M20 domain containing 1 | -0.223567 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.19729 |
| GRAMD1B | GRAM domain containing 1B | -0.166363 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.160675 |
| MT2A | metallothionein 2A | -0.143772 |
| TMSB10 | thymosin beta 10 | -0.120881 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.114659 |
| BICC1 | BicC family RNA binding protein 1 | -0.0978646 |
| SVIL | supervillin | -0.0729598 |
| CMIP | c-Maf inducing protein | -0.0722644 |
| VIM | vimentin | -0.0709569 |
| KYNU | kynureninase | -0.0670413 |
| OSMR | oncostatin M receptor | -0.0626571 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0623348 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0619057 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0570252 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0555662 |
| IGF2 | insulin-like growth factor 2 | -0.0538361 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0503642 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0498697 |
| WWOX | WW domain containing oxidoreductase | -0.0491111 |
| EFNA5 | ephrin-A5 | -0.0488824 |
| GLIS3 | GLIS family zinc finger 3 | -0.0479791 |
| RAD51B | RAD51 paralog B | -0.0439557 |
| NNMT | nicotinamide N-methyltransferase | -0.0435144 |
| DST | dystonin | -0.0423212 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0422655 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0414993 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0396889 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0379438 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0369613 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0365244 |
| NEGR1 | neuronal growth regulator 1 | -0.0362442 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0361091 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0353063 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0352663 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0351082 |
| RPLP1 | ribosomal protein, large, P1 | -0.0339764 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0338435 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0334617 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0333511 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0326109 |
| TPM4 | tropomyosin 4 | -0.032525 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0321964 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0319752 |
| NTN4 | netrin 4 | -0.0313901 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0308359 |
| RSPO3 | R-spondin 3 | -0.0304755 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0303368 |
| FGB | fibrinogen beta chain | -0.0301005 |
| RPS19 | ribosomal protein S19 | -0.0300169 |
| HDAC9 | histone deacetylase 9 | -0.0297104 |
| EGR1 | early growth response 1 | -0.0296268 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0289877 |
| FAM107B | family with sequence similarity 107, member B | -0.028699 |
| UTRN | utrophin | -0.0284275 |
| RNF213 | ring finger protein 213 | -0.0281463 |
| EHBP1 | EH domain binding protein 1 | -0.0279233 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0276109 |
| RPL19 | ribosomal protein L19 | -0.0275773 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0273258 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0267336 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0267186 |
| RPL23 | ribosomal protein L23 | -0.026649 |
| NF1 | neurofibromin 1 | -0.0265779 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0259327 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0258539 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0258069 |
| RPL35A | ribosomal protein L35a | -0.0257721 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0257238 |
| AK1 | adenylate kinase 1 | -0.024945 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0246161 |
| ATXN1 | ataxin 1 | -0.0244586 |
| EGFR | epidermal growth factor receptor | -0.0243512 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0240243 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0234077 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0233512 |
| NHSL1 | NHS-like 1 | -0.0232039 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0229026 |
| RAB31 | RAB31, member RAS oncogene family | -0.0226711 |
| SLC35F3 | solute carrier family 35, member F3 | -0.022584 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0224903 |
| BMP5 | bone morphogenetic protein 5 | -0.0224509 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0223805 |
| PDE8A | phosphodiesterase 8A | -0.022255 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0222094 |
| RPS8 | ribosomal protein S8 | -0.0221209 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0220455 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0220278 |
| FHIT | fragile histidine triad | -0.0218788 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0218431 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0218096 |
| AHR | aryl hydrocarbon receptor | -0.0216916 |
| RPS25 | ribosomal protein S25 | -0.021604 |
| PDE10A | phosphodiesterase 10A | -0.0210517 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0210259 |
| CUX1 | cut-like homeobox 1 | -0.0208844 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0205857 |
| ZFHX3 | zinc finger homeobox 3 | -0.0205074 |
