| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fedratinib (hydrochloride hydrate) perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Fedratinib (hydrochloride hydrate)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.163156 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.132191 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.112656 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.111651 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.106288 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.105807 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.101093 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0930861 |
| RPS6 | ribosomal protein S6 | 0.0862616 |
| QKI | QKI, KH domain containing, RNA binding | 0.0826381 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0776777 |
| CANX | calnexin | 0.0769311 |
| ZNF292 | zinc finger protein 292 | 0.0763264 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.075998 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0755393 |
| RTN4 | reticulon 4 | 0.0748721 |
| WDR45B | WD repeat domain 45B | 0.0703583 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0703473 |
| RHEB | Ras homolog enriched in brain | 0.0680452 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0680405 |
| S100A6 | S100 calcium binding protein A6 | 0.0675194 |
| COG5 | component of oligomeric golgi complex 5 | 0.0659703 |
| PCBP2 | poly(rC) binding protein 2 | 0.0658087 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0653259 |
| HELZ | helicase with zinc finger | 0.0652504 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0623704 |
| MATR3 | matrin 3 | 0.0599425 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0589041 |
| HMGA1 | high mobility group AT-hook 1 | 0.0582889 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0580882 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0577709 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0575473 |
| COL5A2 | collagen, type V, alpha 2 | 0.0575246 |
| USP15 | ubiquitin specific peptidase 15 | 0.054678 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0540976 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0531762 |
| GOLGA4 | golgin A4 | 0.0528476 |
| FAM162A | family with sequence similarity 162, member A | 0.0527806 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | 0.0515455 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.0515247 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0514597 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0512837 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0509614 |
| FN1 | fibronectin 1 | 0.0503164 |
| RPS12 | ribosomal protein S12 | 0.0497973 |
| NAV1 | neuron navigator 1 | 0.0492901 |
| SET | SET nuclear proto-oncogene | 0.0488171 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0484759 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0484372 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0475817 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0475519 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0472292 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.047151 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0469985 |
| RPS27A | ribosomal protein S27a | 0.0469632 |
| ASPH | aspartate beta-hydroxylase | 0.0468279 |
| YBX3 | Y box binding protein 3 | 0.046577 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0465507 |
| NUP58 | nucleoporin 58 | 0.046359 |
| ENAH | enabled homolog (Drosophila) | 0.0463221 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0460201 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.045807 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0457681 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0457253 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0453711 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0453064 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0442947 |
| RLF | rearranged L-myc fusion | 0.0442609 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0442045 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0440282 |
| SEC63 | SEC63 homolog (S. cerevisiae) | 0.0437736 |
| MORF4L1 | mortality factor 4 like 1 | 0.0437052 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0436418 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0433346 |
| PIAS1 | protein inhibitor of activated STAT, 1 | 0.0427288 |
| RNF145 | ring finger protein 145 | 0.0422953 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | 0.0419031 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0414862 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0412547 |
| KIF5B | kinesin family member 5B | 0.0412478 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0411587 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0410932 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0403258 |
| RPL8 | ribosomal protein L8 | 0.040099 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0398806 |
| ARRDC3 | arrestin domain containing 3 | 0.0397337 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0396179 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0393428 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0391553 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0387095 |
| RORA | RAR-related orphan receptor A | 0.0385574 |
| ANO6 | anoctamin 6 | 0.0384939 |
| POTEF | POTE ankyrin domain family, member F | 0.0384831 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0381433 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0379136 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0375922 |
| DST | dystonin | 0.0370993 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0370768 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0370043 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0369775 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | -0.123713 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.104626 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.103699 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0877792 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0827297 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0814638 |
| EGFR | epidermal growth factor receptor | -0.0811826 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0755173 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0739696 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0686594 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0678791 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0670473 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0627743 |
| MUC16 | mucin 16, cell surface associated | -0.0623592 |
| KIF13B | kinesin family member 13B | -0.0610275 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0609503 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0603622 |
| AK1 | adenylate kinase 1 | -0.0601606 |
| METTL15 | methyltransferase like 15 | -0.0600955 |
| TMEM165 | transmembrane protein 165 | -0.0598379 |
| INTS6 | integrator complex subunit 6 | -0.0588736 |
| VIM | vimentin | -0.0576996 |
| ZNF638 | zinc finger protein 638 | -0.056375 |
| WASF2 | WAS protein family, member 2 | -0.0554158 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0548389 |
| IGF2 | insulin-like growth factor 2 | -0.0548088 |
| PRKCA | protein kinase C, alpha | -0.054587 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0531804 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.052757 |
| TMPRSS4 | transmembrane protease, serine 4 | -0.0524296 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0521445 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0516292 |
| SVIL | supervillin | -0.0515635 |
| MUC13 | mucin 13, cell surface associated | -0.0515519 |
| MYO1E | myosin IE | -0.0500466 |
| CDCP1 | CUB domain containing protein 1 | -0.0494658 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0492285 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0485125 |
| RIGI | RNA sensor RIG-I | -0.0479141 |
| LAMB3 | laminin, beta 3 | -0.0476524 |
| KYNU | kynureninase | -0.0475507 |
| PARD3 | par-3 family cell polarity regulator | -0.0473943 |
| ABHD17C | abhydrolase domain containing 17C | -0.0471086 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0466109 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0455376 |
| SLMAP | sarcolemma associated protein | -0.0452493 |
| BPTF | bromodomain PHD finger transcription factor | -0.0451294 |
| SLTM | SAFB-like, transcription modulator | -0.0449435 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0447958 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0446986 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0446938 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.043699 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0436962 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0436255 |
| CSTB | cystatin B (stefin B) | -0.0427281 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0427196 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0421888 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0418361 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0418157 |
| HLA-B | major histocompatibility complex, class I, B | -0.0417991 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0411809 |
| SSH2 | slingshot protein phosphatase 2 | -0.0403795 |
| CRADD | CASP2 and RIPK1 domain containing adaptor with death domain | -0.0400865 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0400174 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0399942 |
| DENND1A | DENN/MADD domain containing 1A | -0.0399462 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0398595 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0396907 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0392353 |
| SPNS2 | spinster homolog 2 (Drosophila) | -0.0388864 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0387602 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0385963 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0380332 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0379973 |
| BBX | bobby sox homolog (Drosophila) | -0.0379662 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.037734 |
| CNKSR3 | CNKSR family member 3 | -0.0372752 |
| MCU | mitochondrial calcium uniporter | -0.0370161 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0369868 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0369422 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0369274 |
| ATOSA | atos homolog A | -0.0366481 |
| MAP7 | microtubule-associated protein 7 | -0.0352258 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0344942 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0343061 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0341266 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0341238 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0332694 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0330427 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.032908 |
| PKP4 | plakophilin 4 | -0.0329012 |
| LAMC2 | laminin, gamma 2 | -0.0328024 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0327065 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0326571 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0324435 |
| ATXN1 | ataxin 1 | -0.0320291 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0315992 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.031407 |
| NDRG1 | N-myc downstream regulated 1 | -0.0313314 |
| CDK5RAP2 | CDK5 regulatory subunit associated protein 2 | -0.0313042 |
