| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fedratinib (hydrochloride hydrate) perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Fedratinib (hydrochloride hydrate)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.231221 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.214981 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.209881 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.12557 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.102551 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0989807 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0979455 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0933289 |
| YBX3 | Y box binding protein 3 | 0.0816151 |
| OGA | O-GlcNAcase | 0.0790415 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0767638 |
| TPM3 | tropomyosin 3 | 0.076677 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0723933 |
| XPO1 | exportin 1 | 0.0707012 |
| RTN4 | reticulon 4 | 0.0674533 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0666604 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0664335 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.063798 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0615529 |
| ACTG1 | actin gamma 1 | 0.0567715 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0556641 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0549938 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0544214 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0539879 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0533524 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.052792 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0525731 |
| ENO1 | enolase 1, (alpha) | 0.0515944 |
| PCBP2 | poly(rC) binding protein 2 | 0.0514378 |
| PGK1 | phosphoglycerate kinase 1 | 0.0506035 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0503319 |
| ADAR | adenosine deaminase, RNA-specific | 0.0500338 |
| TPI1 | triosephosphate isomerase 1 | 0.0473311 |
| PHIP | pleckstrin homology domain interacting protein | 0.0471111 |
| JMJD1C | jumonji domain containing 1C | 0.0462558 |
| CCNL1 | cyclin L1 | 0.0459134 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0456123 |
| COPA | coatomer protein complex, subunit alpha | 0.0454583 |
| CLTC | clathrin, heavy chain (Hc) | 0.043831 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0435874 |
| IPO7 | importin 7 | 0.0435101 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0431979 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0426588 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0426072 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0413257 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0411136 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.040973 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0407334 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0405221 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0396318 |
| GPHN | gephyrin | 0.0389983 |
| ANO6 | anoctamin 6 | 0.0388129 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0386079 |
| ATXN2 | ataxin 2 | 0.0383732 |
| KIF5B | kinesin family member 5B | 0.0382171 |
| GRAMD1B | GRAM domain containing 1B | 0.0375198 |
| VMP1 | vacuole membrane protein 1 | 0.0369409 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.0361298 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.036017 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0358666 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.0354058 |
| NCKAP1 | NCK-associated protein 1 | 0.034857 |
| CTTNBP2NL | CTTNBP2 N-terminal like | 0.0347099 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0345212 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.0342567 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0342146 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0341597 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.033956 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0337205 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0331582 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0331242 |
| MATR3 | matrin 3 | 0.0328949 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0328771 |
| SET | SET nuclear proto-oncogene | 0.0327418 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0325062 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0324594 |
| RAB10 | RAB10, member RAS oncogene family | 0.0320201 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0319878 |
| ZNF638 | zinc finger protein 638 | 0.031803 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0317843 |
| RRM2 | ribonucleotide reductase M2 | 0.0315189 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0314458 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0314326 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | 0.0313471 |
| RLF | rearranged L-myc fusion | 0.031336 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0312944 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0305704 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0303533 |
| GOLGA4 | golgin A4 | 0.0301945 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0301543 |
| WDR45B | WD repeat domain 45B | 0.030132 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | 0.0301257 |
| ZNF292 | zinc finger protein 292 | 0.0298412 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0296463 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0295934 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0295733 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0294107 |
| CEP192 | centrosomal protein 192kDa | 0.0293268 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0290262 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0290192 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.0849313 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0752405 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0669137 |
| PTMA | prothymosin, alpha | -0.0642579 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0565244 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.047674 |
| RPL35A | ribosomal protein L35a | -0.0457169 |
| HLA-B | major histocompatibility complex, class I, B | -0.0426124 |
| HMGA2 | high mobility group AT-hook 2 | -0.0423034 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0414835 |
| PDE10A | phosphodiesterase 10A | -0.039327 |
| RYR3 | ryanodine receptor 3 | -0.0384219 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0381305 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0366708 |
| RPS29 | ribosomal protein S29 | -0.0362347 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0360741 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0359003 |
| NCOA7 | nuclear receptor coactivator 7 | -0.033995 |
| RPS8 | ribosomal protein S8 | -0.0332739 |
| RPL34 | ribosomal protein L34 | -0.0330116 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0317149 |
| ATXN1 | ataxin 1 | -0.0315884 |
| AEBP2 | AE binding protein 2 | -0.0311404 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0310398 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.029071 |
| RPS19 | ribosomal protein S19 | -0.0280994 |
| RPL36 | ribosomal protein L36 | -0.028092 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0276528 |
| VIM | vimentin | -0.0274013 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0239296 |
| OSMR | oncostatin M receptor | -0.0233827 |
| S100A10 | S100 calcium binding protein A10 | -0.0228504 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0226132 |
| CUX1 | cut-like homeobox 1 | -0.0224348 |
| RPL38 | ribosomal protein L38 | -0.022324 |
| RPLP1 | ribosomal protein, large, P1 | -0.0216915 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.021657 |
| RPL37A | ribosomal protein L37a | -0.0215037 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0213781 |
| RPL31 | ribosomal protein L31 | -0.0211068 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | -0.0210297 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0209685 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0207553 |
| CALR | calreticulin | -0.0205628 |
| IER3 | immediate early response 3 | -0.0203531 |
| WWOX | WW domain containing oxidoreductase | -0.0203178 |
| NEK10 | NIMA-related kinase 10 | -0.0203119 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.020229 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0201454 |
| INTS6 | integrator complex subunit 6 | -0.0197747 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0193922 |
| PDLIM5 | PDZ and LIM domain 5 | -0.019173 |
| RPS27 | ribosomal protein S27 | -0.0190121 |
| RPS3 | ribosomal protein S3 | -0.0186145 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0182365 |
| RPS24 | ribosomal protein S24 | -0.0181925 |
| RPLP2 | ribosomal protein, large, P2 | -0.0181783 |
| LOXL2 | lysyl oxidase-like 2 | -0.0181495 |
| LRRC23 | leucine rich repeat containing 23 | -0.017897 |
| RPS15 | ribosomal protein S15 | -0.0178662 |
| RPS17 | ribosomal protein S17 | -0.0178416 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0176427 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0171494 |
| RPS10 | ribosomal protein S10 | -0.0169375 |
| PRKCE | protein kinase C, epsilon | -0.0167808 |
| RPS13 | ribosomal protein S13 | -0.0167583 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0163299 |
| FHIT | fragile histidine triad | -0.0162294 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.015989 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0159464 |
| NLGN1 | neuroligin 1 | -0.0159176 |
| RPS21 | ribosomal protein S21 | -0.0158946 |
| TRIM59 | tripartite motif containing 59 | -0.0156302 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0155568 |
| MAGT1 | magnesium transporter 1 | -0.0154285 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0154106 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | -0.0153215 |
| TPM1 | tropomyosin 1 (alpha) | -0.0152987 |
| STYK1 | serine/threonine/tyrosine kinase 1 | -0.0152897 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0151823 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | -0.0151646 |
| FARS2 | phenylalanyl-tRNA synthetase 2, mitochondrial | -0.0151588 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.015052 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0149723 |
| RPS25 | ribosomal protein S25 | -0.0149286 |
| RSU1 | Ras suppressor protein 1 | -0.0147916 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0147186 |
| DOCK1 | dedicator of cytokinesis 1 | -0.0145351 |
| TPM2 | tropomyosin 2 (beta) | -0.0144623 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0143682 |
| RPS27A | ribosomal protein S27a | -0.0142792 |
| RPL28 | ribosomal protein L28 | -0.0142729 |
| PCNX4 | pecanex 4 | -0.0142052 |
| RPL9 | ribosomal protein L9 | -0.0138569 |
| RPS14 | ribosomal protein S14 | -0.0138496 |
| GPC6 | glypican 6 | -0.0138355 |
| EGFR | epidermal growth factor receptor | -0.0136554 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0133137 |
| PRELID2 | PRELI domain containing 2 | -0.0133102 |
| SCFD2 | sec1 family domain containing 2 | -0.0132616 |
