| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fedratinib (hydrochloride hydrate) perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Fedratinib (hydrochloride hydrate)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ACTG1 | actin gamma 1 | 0.404954 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.252085 |
| POTEF | POTE ankyrin domain family, member F | 0.233657 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.13805 |
| FTL | ferritin, light polypeptide | 0.123348 |
| SDC4 | syndecan 4 | 0.11135 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.069067 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0615471 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0591858 |
| CCNL1 | cyclin L1 | 0.0500566 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0438179 |
| LDHA | lactate dehydrogenase A | 0.0433454 |
| DSTN | destrin (actin depolymerizing factor) | 0.04308 |
| RPS6 | ribosomal protein S6 | 0.0415884 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0411079 |
| PCBP2 | poly(rC) binding protein 2 | 0.0380725 |
| RPL35A | ribosomal protein L35a | 0.0370273 |
| MSN | moesin | 0.0363826 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0341177 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0326702 |
| S100A6 | S100 calcium binding protein A6 | 0.0322276 |
| TPM3 | tropomyosin 3 | 0.0305667 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0289436 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0285724 |
| RPLP0 | ribosomal protein, large, P0 | 0.0282661 |
| ARRDC3 | arrestin domain containing 3 | 0.028162 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0279534 |
| GOLGA4 | golgin A4 | 0.0276388 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0273131 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0269041 |
| KRT8 | keratin 8, type II | 0.0267165 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0267125 |
| ASPH | aspartate beta-hydroxylase | 0.0260961 |
| MSMO1 | methylsterol monooxygenase 1 | 0.0257473 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0256904 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0255704 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0253856 |
| DTNA | dystrobrevin, alpha | 0.0248876 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.024287 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0241527 |
| DSPP | dentin sialophosphoprotein | 0.023696 |
| CNN3 | calponin 3, acidic | 0.0233389 |
| AREG | amphiregulin | 0.0232484 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0231195 |
| TMF1 | TATA element modulatory factor 1 | 0.0230252 |
| DUSP10 | dual specificity phosphatase 10 | 0.022982 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | 0.022939 |
| RPL7 | ribosomal protein L7 | 0.0225754 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0224985 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0222911 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0221327 |
| RBM25 | RNA binding motif protein 25 | 0.0219852 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0215851 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0209311 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0205539 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.0203008 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.020165 |
| NDRG1 | N-myc downstream regulated 1 | 0.0198558 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.019761 |
| MLEC | malectin | 0.0197002 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0195372 |
| VEGFA | vascular endothelial growth factor A | 0.0193156 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0191311 |
| CRABP2 | cellular retinoic acid binding protein 2 | 0.0191252 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0186702 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0179582 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.017918 |
| RPS12 | ribosomal protein S12 | 0.0174956 |
| SET | SET nuclear proto-oncogene | 0.0174903 |
| RPS3 | ribosomal protein S3 | 0.0174286 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0173906 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0172802 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.016992 |
| BRD2 | bromodomain containing 2 | 0.0169272 |
| MT2A | metallothionein 2A | 0.016839 |
| ANKRD37 | ankyrin repeat domain 37 | 0.0167094 |
| CLDN4 | claudin 4 | 0.0166385 |
| RNF145 | ring finger protein 145 | 0.016613 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.0163076 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0162316 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 0.0160474 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0159262 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0158937 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0157357 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 0.0156424 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0154659 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0154002 |
| RAP2B | RAP2B, member of RAS oncogene family | 0.0153758 |
| GPX4 | glutathione peroxidase 4 | 0.0149601 |
| TRIM33 | tripartite motif containing 33 | 0.0147103 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | 0.0147018 |
| EGR1 | early growth response 1 | 0.0145916 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | 0.0145508 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0145111 |
| IPO7 | importin 7 | 0.0144242 |
| RPL4 | ribosomal protein L4 | 0.0143728 |
| RPS14 | ribosomal protein S14 | 0.0142855 |
| ATP6V1A | ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A | 0.0142268 |
| TMSB4X | thymosin beta 4, X-linked | 0.0141883 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0141069 |
| Symbol | Name | Standardized Value |
|---|---|---|
| UBC | ubiquitin C | -0.197362 |
| TMSB10 | thymosin beta 10 | -0.13778 |
| FN1 | fibronectin 1 | -0.107376 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0923199 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0858005 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0851799 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0802592 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0799203 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0757314 |
| LAMC2 | laminin, gamma 2 | -0.0700625 |
| AHNAK | AHNAK nucleoprotein | -0.0634277 |
| NAV2 | neuron navigator 2 | -0.0580046 |
| FBXO32 | F-box protein 32 | -0.0561271 |
| S100A10 | S100 calcium binding protein A10 | -0.0555867 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0547923 |
| RPS27A | ribosomal protein S27a | -0.0537857 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0535901 |
| LAMB3 | laminin, beta 3 | -0.0527521 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0496126 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0482907 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0450346 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0450329 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.044346 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0422903 |
| MX1 | MX dynamin-like GTPase 1 | -0.0422898 |
| KRT7 | keratin 7, type II | -0.040432 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0398579 |
| TXNRD1 | thioredoxin reductase 1 | -0.0398005 |
| LMO7 | LIM domain 7 | -0.0384337 |
| SP100 | SP100 nuclear antigen | -0.0369243 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0368153 |
| ENO1 | enolase 1, (alpha) | -0.0367616 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0362844 |
| FLNB | filamin B, beta | -0.0362344 |
| PLSCR1 | phospholipid scramblase 1 | -0.0361402 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0360855 |
| ERBIN | erbb2 interacting protein | -0.0359835 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0348283 |
| SMAD3 | SMAD family member 3 | -0.0343036 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.033624 |
| CCND1 | cyclin D1 | -0.0333669 |
| PLEC | plectin | -0.0325815 |
| CD2AP | CD2-associated protein | -0.032399 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0322827 |
| EFNA5 | ephrin-A5 | -0.0321794 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0318374 |
| RNF213 | ring finger protein 213 | -0.0313585 |
| TMEM263 | transmembrane protein 263 | -0.030954 |
| MAP4 | microtubule-associated protein 4 | -0.0307658 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0306322 |
| OSMR | oncostatin M receptor | -0.0306247 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0304835 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0303983 |
| RRBP1 | ribosome binding protein 1 | -0.0302572 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0300297 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.029876 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0298171 |
| FLNA | filamin A, alpha | -0.0297425 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.029409 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0291058 |
| ATXN1 | ataxin 1 | -0.0285395 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0282514 |
| FHIT | fragile histidine triad | -0.0282414 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.027599 |
| PARP12 | poly (ADP-ribose) polymerase family, member 12 | -0.0275394 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0270666 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | -0.0270512 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0269699 |
| EPCAM | epithelial cell adhesion molecule | -0.026796 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0267554 |
| RPS24 | ribosomal protein S24 | -0.0261699 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0261641 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0259141 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0257689 |
| NF1 | neurofibromin 1 | -0.0256285 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0255498 |
| EXT1 | exostosin glycosyltransferase 1 | -0.025337 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0249625 |
| ESRP1 | epithelial splicing regulatory protein 1 | -0.024735 |
| TFG | TRK-fused gene | -0.0245094 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0245013 |
| MX2 | MX dynamin-like GTPase 2 | -0.0244638 |
| CAB39 | calcium binding protein 39 | -0.0242804 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0240028 |
| IFI44L | interferon-induced protein 44-like | -0.0236289 |
| ATP11A | ATPase, class VI, type 11A | -0.0235817 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.023558 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0231797 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0230439 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0228853 |
| RUNX1 | runt-related transcription factor 1 | -0.0228691 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0219383 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0218928 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.0213283 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0212472 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0212424 |
| FBXO34 | F-box protein 34 | -0.0210033 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0208312 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0207982 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0207752 |
