| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fedratinib (hydrochloride hydrate) perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Fedratinib (hydrochloride hydrate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MCL1 | myeloid cell leukemia 1 | 0.173626 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.110149 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.103293 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.101485 |
| EFNA5 | ephrin-A5 | 0.0976866 |
| STC1 | stanniocalcin 1 | 0.0953018 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.093807 |
| FN1 | fibronectin 1 | 0.0903274 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0849286 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0728372 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0707599 |
| CANX | calnexin | 0.0701094 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0682175 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0681629 |
| FNDC3A | fibronectin type III domain containing 3A | 0.067171 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0614956 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0608118 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0599897 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0567781 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0517654 |
| FLNB | filamin B, beta | 0.0510042 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0509537 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0506986 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0506538 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0505224 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0501974 |
| NBEAL1 | neurobeachin-like 1 | 0.0493951 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0483833 |
| FMNL2 | formin-like 2 | 0.0478082 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0469794 |
| COPA | coatomer protein complex, subunit alpha | 0.0465507 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.0457956 |
| GDA | guanine deaminase | 0.0455205 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0454485 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.045308 |
| USP34 | ubiquitin specific peptidase 34 | 0.0452529 |
| GRAMD1B | GRAM domain containing 1B | 0.0452373 |
| DNER | delta/notch-like EGF repeat containing | 0.0448609 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.044574 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0444763 |
| FNIP1 | folliculin interacting protein 1 | 0.0443716 |
| ACTG1 | actin gamma 1 | 0.04424 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.043958 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0439427 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0423761 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0423342 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0408223 |
| ANXA1 | annexin A1 | 0.0405814 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0400042 |
| PGK1 | phosphoglycerate kinase 1 | 0.0398372 |
| LDHA | lactate dehydrogenase A | 0.0396837 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0386871 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0386104 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0377199 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0376336 |
| PCBP2 | poly(rC) binding protein 2 | 0.0371564 |
| ARRDC3 | arrestin domain containing 3 | 0.0365851 |
| MSN | moesin | 0.0362275 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0361222 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0358817 |
| PCBP3 | poly(rC) binding protein 3 | 0.0357188 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0354591 |
| ATP13A3 | ATPase type 13A3 | 0.0353122 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0350147 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.034672 |
| INHBA | inhibin, beta A | 0.034481 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0343866 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0340049 |
| NBAS | neuroblastoma amplified sequence | 0.0337262 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0333805 |
| FAM13A | family with sequence similarity 13, member A | 0.0331679 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0329064 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0319305 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.030884 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0307239 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0305127 |
| VMP1 | vacuole membrane protein 1 | 0.0303863 |
| PYGL | phosphorylase, glycogen, liver | 0.0302394 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0299947 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0291001 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0287225 |
| COL4A6 | collagen, type IV, alpha 6 | 0.0287219 |
| ZNF638 | zinc finger protein 638 | 0.0283606 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0282262 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0281564 |
| JMJD1C | jumonji domain containing 1C | 0.0280496 |
| DST | dystonin | 0.0276125 |
| CD44 | CD44 molecule (Indian blood group) | 0.0274492 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0273736 |
| NDRG1 | N-myc downstream regulated 1 | 0.0273321 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0270928 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0266651 |
| RGS2 | regulator of G-protein signaling 2 | 0.0265442 |
| AUTS2 | autism susceptibility candidate 2 | 0.0265374 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0263778 |
| IL1RAP | interleukin 1 receptor accessory protein | 0.0263409 |
| GPC6 | glypican 6 | 0.0263071 |
| ENO1 | enolase 1, (alpha) | 0.0261659 |
| CTBP2 | C-terminal binding protein 2 | 0.0260009 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0253634 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.287455 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.11286 |
| COL5A2 | collagen, type V, alpha 2 | -0.110266 |
| TMSB10 | thymosin beta 10 | -0.106359 |
| PTMA | prothymosin, alpha | -0.0980634 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0876542 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0842396 |
| RPLP1 | ribosomal protein, large, P1 | -0.0733989 |
| RPS24 | ribosomal protein S24 | -0.0706594 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0702322 |
| RPL35A | ribosomal protein L35a | -0.0660102 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0639792 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0637126 |
| TXNRD1 | thioredoxin reductase 1 | -0.0635313 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0633535 |
| RPS6 | ribosomal protein S6 | -0.0627529 |
| RPL26 | ribosomal protein L26 | -0.0622741 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0621799 |
| SMYD3 | SET and MYND domain containing 3 | -0.0617416 |
| PDE10A | phosphodiesterase 10A | -0.0590582 |
| FTL | ferritin, light polypeptide | -0.0585951 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.0563675 |
| RPL37A | ribosomal protein L37a | -0.0559941 |
| RPS19 | ribosomal protein S19 | -0.0554458 |
| RPL23 | ribosomal protein L23 | -0.0552345 |
| RPS8 | ribosomal protein S8 | -0.0544345 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0541658 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0507304 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0506168 |
| RPL34 | ribosomal protein L34 | -0.0473758 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0470844 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.04603 |
| RPL19 | ribosomal protein L19 | -0.0457711 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.045651 |
| GNAS | GNAS complex locus | -0.0451407 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0443695 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0419055 |
| RPL12 | ribosomal protein L12 | -0.0406543 |
| RPLP2 | ribosomal protein, large, P2 | -0.0404953 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0393733 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0388288 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0385563 |
| RPL36 | ribosomal protein L36 | -0.0385146 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0382664 |
| PALLD | palladin, cytoskeletal associated protein | -0.0378295 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0373074 |
| RPS3 | ribosomal protein S3 | -0.0372957 |
| RPL9 | ribosomal protein L9 | -0.037256 |
| RPS12 | ribosomal protein S12 | -0.0363303 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0348923 |
| NEK7 | NIMA-related kinase 7 | -0.0337084 |
| CENPF | centromere protein F, 350/400kDa | -0.0335332 |
| RPS21 | ribosomal protein S21 | -0.0327077 |
| KIAA0825 | KIAA0825 | -0.0322387 |
| RPS29 | ribosomal protein S29 | -0.031661 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0313317 |
| RPL13A | ribosomal protein L13a | -0.0312743 |
| RPL11 | ribosomal protein L11 | -0.0312606 |
| RPL38 | ribosomal protein L38 | -0.0305517 |
| RPS25 | ribosomal protein S25 | -0.0303947 |
| RPS27A | ribosomal protein S27a | -0.0292466 |
| RPL35 | ribosomal protein L35 | -0.0288486 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0287545 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.028523 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0284531 |
| NOP58 | NOP58 ribonucleoprotein | -0.0283893 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.028318 |
| RPS16 | ribosomal protein S16 | -0.0281101 |
| RPS2 | ribosomal protein S2 | -0.0279578 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0279145 |
| YBX1 | Y box binding protein 1 | -0.027526 |
| RPL36A | ribosomal protein L36a | -0.0270384 |
| RPL7A | ribosomal protein L7a | -0.026857 |
| CDH13 | cadherin 13 | -0.0267061 |
| PRDX1 | peroxiredoxin 1 | -0.0265184 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | -0.0264929 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0263776 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | -0.0259219 |
| RACK1 | receptor for activated C kinase 1 | -0.0257505 |
| RPS23 | ribosomal protein S23 | -0.0256857 |
| HMGB1 | high mobility group box 1 | -0.025029 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0250049 |
| S100A10 | S100 calcium binding protein A10 | -0.0248894 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0243251 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0241826 |
| PDE1A | phosphodiesterase 1A, calmodulin-dependent | -0.0240277 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0233947 |
| RPS17 | ribosomal protein S17 | -0.0230391 |
| RPL5 | ribosomal protein L5 | -0.0229382 |
| AOPEP | aminopeptidase O (putative) | -0.0221983 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0221628 |
| CADM2 | cell adhesion molecule 2 | -0.0220881 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0220399 |
| RPL37 | ribosomal protein L37 | -0.0216586 |
| GREM2 | gremlin 2, DAN family BMP antagonist | -0.0215738 |
| RPS14 | ribosomal protein S14 | -0.0215189 |
| PDE7B | phosphodiesterase 7B | -0.0212923 |
| RPS5 | ribosomal protein S5 | -0.0211454 |
| RPL28 | ribosomal protein L28 | -0.0211322 |
| RPS27 | ribosomal protein S27 | -0.0208276 |
