| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fedratinib (hydrochloride hydrate) perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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175 genes differentially expressed following the Fedratinib (hydrochloride hydrate)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.225001 |
| WAC | WW domain containing adaptor with coiled-coil | 0.138234 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.125733 |
| JMJD1C | jumonji domain containing 1C | 0.116616 |
| ACTG1 | actin gamma 1 | 0.108921 |
| PTMA | prothymosin, alpha | 0.103385 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0986828 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0985953 |
| RPS3 | ribosomal protein S3 | 0.0958601 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0899212 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0894325 |
| RPL35A | ribosomal protein L35a | 0.0894251 |
| ZNF292 | zinc finger protein 292 | 0.0864641 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0799539 |
| PTK2 | protein tyrosine kinase 2 | 0.0776169 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0754293 |
| POTEF | POTE ankyrin domain family, member F | 0.0734018 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0711595 |
| ATXN1 | ataxin 1 | 0.0646456 |
| MEF2A | myocyte enhancer factor 2A | 0.0602709 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.059703 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.059344 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0592513 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0580259 |
| NAV2 | neuron navigator 2 | 0.0567092 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0516862 |
| RPS12 | ribosomal protein S12 | 0.0516681 |
| RBM39 | RNA binding motif protein 39 | 0.0500599 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0482626 |
| TMEM123 | transmembrane protein 123 | 0.0477263 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0462123 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0451696 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.043895 |
| RPS6 | ribosomal protein S6 | 0.0417382 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0416719 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0403979 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0399291 |
| LDHA | lactate dehydrogenase A | 0.0393959 |
| FTL | ferritin, light polypeptide | 0.0389979 |
| TXNRD1 | thioredoxin reductase 1 | 0.0389706 |
| B2M | beta-2-microglobulin | 0.0387954 |
| SPAG9 | sperm associated antigen 9 | 0.0380273 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0376624 |
| ERBIN | erbb2 interacting protein | 0.0367631 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0366546 |
| SMAD3 | SMAD family member 3 | 0.0344898 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0334991 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0330452 |
| SEPTIN9 | septin 9 | 0.0316379 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0289757 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0285759 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.028211 |
| RPS8 | ribosomal protein S8 | 0.0277755 |
| SH3D19 | SH3 domain containing 19 | 0.0264004 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0247884 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0236291 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0226379 |
| RLF | rearranged L-myc fusion | 0.0211282 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0203777 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0193519 |
| RPS25 | ribosomal protein S25 | 0.0165349 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0162064 |
| MCL1 | myeloid cell leukemia 1 | 0.0154662 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0154293 |
| RPL26 | ribosomal protein L26 | 0.0150331 |
| RPL12 | ribosomal protein L12 | 0.0140327 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0135898 |
| DIAPH2 | diaphanous-related formin 2 | 0.0128182 |
| SRPK2 | SRSF protein kinase 2 | 0.0107407 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0106065 |
| MED13L | mediator complex subunit 13-like | 0.0100321 |
| MATR3 | matrin 3 | 0.00976691 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.00972015 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.00941769 |
| AOPEP | aminopeptidase O (putative) | 0.00911497 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.00847408 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.00722504 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.00708402 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.00683962 |
| BBX | bobby sox homolog (Drosophila) | 0.00634478 |
| SMYD3 | SET and MYND domain containing 3 | 0.00625065 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0049317 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.00492442 |
| CERS6 | ceramide synthase 6 | 0.00439338 |
| DST | dystonin | 0.00232366 |
| PARD3 | par-3 family cell polarity regulator | 0.00185857 |
| CANX | calnexin | 0.00115631 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 8.23873E-4 |
| PDE10A | phosphodiesterase 10A | 1.59809E-4 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.251813 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.163868 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.12782 |
| EXT1 | exostosin glycosyltransferase 1 | -0.123607 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.108263 |
| CDH13 | cadherin 13 | -0.107265 |
| FN1 | fibronectin 1 | -0.103255 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0965969 |
| EFNA5 | ephrin-A5 | -0.0912686 |
| HMGA2 | high mobility group AT-hook 2 | -0.0865075 |
| VIM | vimentin | -0.0815581 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0812321 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0716838 |
| STC1 | stanniocalcin 1 | -0.0697663 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0633616 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0628674 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0600352 |
| SLTM | SAFB-like, transcription modulator | -0.0589488 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0572591 |
| TMSB10 | thymosin beta 10 | -0.05575 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0550703 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.054095 |
| FLNB | filamin B, beta | -0.0534398 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0528578 |
| LAMB3 | laminin, beta 3 | -0.052705 |
| VCL | vinculin | -0.0524159 |
| NDRG1 | N-myc downstream regulated 1 | -0.0512146 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0502316 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.048948 |
| SETD5 | SET domain containing 5 | -0.0488533 |
| RORA | RAR-related orphan receptor A | -0.0482506 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0465012 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0458422 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0456857 |
| RPL23 | ribosomal protein L23 | -0.0456161 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.045602 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.043992 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.04374 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | -0.0421977 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0417888 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0403678 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0401691 |
| ATP9B | ATPase, class II, type 9B | -0.0396498 |
| EGFR | epidermal growth factor receptor | -0.0393367 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0390657 |
| ENO1 | enolase 1, (alpha) | -0.0377048 |
| MYO1E | myosin IE | -0.0373497 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0372284 |
| PRKCA | protein kinase C, alpha | -0.0338171 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0335455 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0332163 |
| MT2A | metallothionein 2A | -0.0302751 |
| GOLGA4 | golgin A4 | -0.0298018 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0291509 |
| PKM | pyruvate kinase, muscle | -0.0272153 |
| RPS19 | ribosomal protein S19 | -0.0269616 |
| RUNX1 | runt-related transcription factor 1 | -0.0262129 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0251591 |
| ANXA2 | annexin A2 | -0.0234987 |
| RPLP1 | ribosomal protein, large, P1 | -0.0234028 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0232658 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0211923 |
| NBEAL1 | neurobeachin-like 1 | -0.0209895 |
| RPL34 | ribosomal protein L34 | -0.0188954 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0184887 |
| COL5A1 | collagen, type V, alpha 1 | -0.0183247 |
| TCF12 | transcription factor 12 | -0.0149951 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.014921 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0143448 |
| TOP1 | topoisomerase (DNA) I | -0.0124844 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0100787 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.00945471 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0082944 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.00587344 |
| ASPH | aspartate beta-hydroxylase | -0.00563653 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0051302 |
| PGK1 | phosphoglycerate kinase 1 | -0.00496471 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.00436825 |
| ELOVL5 | ELOVL fatty acid elongase 5 | -0.00381242 |
| RPL37A | ribosomal protein L37a | -0.00324483 |
| RPLP2 | ribosomal protein, large, P2 | -0.00255212 |
| IL6ST | interleukin 6 signal transducer | -0.00253156 |
| OGA | O-GlcNAcase | -0.00210487 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.00163254 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -4.8181E-4 |
| APP | amyloid beta (A4) precursor protein | -4.11286E-4 |
