| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fedratinib (hydrochloride hydrate) perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Fedratinib (hydrochloride hydrate)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.181844 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.139414 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.120687 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0953329 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0884811 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0877283 |
| POTEF | POTE ankyrin domain family, member F | 0.0771368 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0738957 |
| PCBP2 | poly(rC) binding protein 2 | 0.0626462 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0613999 |
| TPM3 | tropomyosin 3 | 0.0593893 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0566884 |
| TMSB4X | thymosin beta 4, X-linked | 0.0539324 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0491899 |
| THBS1 | thrombospondin 1 | 0.0481786 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0481407 |
| ACTG1 | actin gamma 1 | 0.0478225 |
| ZNF292 | zinc finger protein 292 | 0.0475684 |
| PTMA | prothymosin, alpha | 0.0453165 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0448864 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0448555 |
| WDR43 | WD repeat domain 43 | 0.0437422 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0432623 |
| RBM39 | RNA binding motif protein 39 | 0.0429031 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0427929 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0423309 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.04009 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0400871 |
| ANXA2 | annexin A2 | 0.0398656 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.039506 |
| SET | SET nuclear proto-oncogene | 0.0387267 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0372006 |
| MATR3 | matrin 3 | 0.0370568 |
| CALR | calreticulin | 0.0369365 |
| YBX1 | Y box binding protein 1 | 0.0365805 |
| QKI | QKI, KH domain containing, RNA binding | 0.0360076 |
| PFN1 | profilin 1 | 0.0358781 |
| CANX | calnexin | 0.0358424 |
| GOLGA4 | golgin A4 | 0.0348785 |
| TPR | translocated promoter region, nuclear basket protein | 0.0345464 |
| PEG10 | paternally expressed 10 | 0.0343227 |
| HMGB2 | high mobility group box 2 | 0.0340395 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0339983 |
| EIF5AL1 | eukaryotic translation initiation factor 5A-like 1 | 0.0338074 |
| NCKAP1 | NCK-associated protein 1 | 0.0334581 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0333714 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0333258 |
| ENAH | enabled homolog (Drosophila) | 0.0332332 |
| RBM25 | RNA binding motif protein 25 | 0.0331841 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0328898 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0319906 |
| CENPF | centromere protein F, 350/400kDa | 0.0317177 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0316143 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0309408 |
| RHEB | Ras homolog enriched in brain | 0.0306737 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0303468 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0300681 |
| NOP58 | NOP58 ribonucleoprotein | 0.0300468 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0299978 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0298263 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0292939 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0291683 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0289306 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0288559 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0287768 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0285694 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0285074 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0283821 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0282544 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0282053 |
| SRP54 | signal recognition particle 54kDa | 0.0274126 |
| MEMO1 | mediator of cell motility 1 | 0.0273355 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | 0.0270485 |
| SFRP4 | secreted frizzled-related protein 4 | 0.0269932 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0268448 |
| RLF | rearranged L-myc fusion | 0.0268351 |
| CCNL1 | cyclin L1 | 0.0267875 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0267622 |
| TBC1D12 | TBC1 domain family, member 12 | 0.0265706 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0265006 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0262248 |
| USP3 | ubiquitin specific peptidase 3 | 0.0262041 |
| YAP1 | Yes-associated protein 1 | 0.0260929 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0260675 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0259402 |
| FNBP1L | formin binding protein 1-like | 0.0255835 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0254991 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0254106 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | 0.0253781 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0253338 |
| RTN4 | reticulon 4 | 0.0253222 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0251529 |
| RPL3 | ribosomal protein L3 | 0.0247338 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | 0.0247307 |
| CCN2 | cellular communication network factor 2 | 0.0247276 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0246496 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.024386 |
| MTF2 | metal response element binding transcription factor 2 | 0.024372 |
| FBXO11 | F-box protein 11 | 0.0241741 |
| PSMA6 | proteasome (prosome, macropain) subunit, alpha type, 6 | 0.0240352 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CADM2 | cell adhesion molecule 2 | -0.196376 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.196015 |
| COL11A1 | collagen, type XI, alpha 1 | -0.183982 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.154892 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.142865 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.133524 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.124598 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.120394 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.111022 |
| PCDH9 | protocadherin 9 | -0.109114 |
| VIM | vimentin | -0.100859 |
| GPC3 | glypican 3 | -0.0895429 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0886676 |
| TENM3 | teneurin transmembrane protein 3 | -0.0815498 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.079592 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0789944 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.0773624 |
| COL3A1 | collagen, type III, alpha 1 | -0.0701429 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0637517 |
| TMSB10 | thymosin beta 10 | -0.0594051 |
| LRRC4C | leucine rich repeat containing 4C | -0.0593365 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0569857 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0558787 |
| COL1A2 | collagen, type I, alpha 2 | -0.0528453 |
| MEIS2 | Meis homeobox 2 | -0.0513745 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0481212 |
| NPAS3 | neuronal PAS domain protein 3 | -0.0464565 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0460884 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0452561 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0424414 |
| PRELID2 | PRELI domain containing 2 | -0.0416947 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0403771 |
| RAD51B | RAD51 paralog B | -0.0399208 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0386042 |
| HMCN1 | hemicentin 1 | -0.0377079 |
| PHIP | pleckstrin homology domain interacting protein | -0.0376261 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0375477 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | -0.0366669 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.036259 |
| GSE1 | Gse1 coiled-coil protein | -0.0330762 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0329076 |
| TOX | thymocyte selection-associated high mobility group box | -0.0322341 |
| PCDH7 | protocadherin 7 | -0.0315342 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0312791 |
| H1-0 | H1.0 linker histone | -0.0308098 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0306998 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0296719 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.029651 |
| USH2A | Usher syndrome 2A (autosomal recessive, mild) | -0.0296125 |
| MED12L | mediator complex subunit 12-like | -0.0284561 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0283753 |
| TENM2 | teneurin transmembrane protein 2 | -0.0279608 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0278411 |
| CDH19 | cadherin 19, type 2 | -0.0277533 |
| PRKD1 | protein kinase D1 | -0.0276923 |
| ZC3H12B | zinc finger CCCH-type containing 12B | -0.0273223 |
| KLHL5 | kelch-like family member 5 | -0.027292 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.027226 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0272219 |
| NEBL | nebulette | -0.0269803 |
| PLPP1 | phospholipid phosphatase 1 | -0.0268265 |
| KCTD16 | potassium channel tetramerization domain containing 16 | -0.0263352 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.026323 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0260143 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0259942 |
| DMD | dystrophin | -0.0257459 |
| FRY | furry homolog (Drosophila) | -0.0257097 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0254068 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0250122 |
| CCDC102B | coiled-coil domain containing 102B | -0.0249004 |
| PLEKHG1 | pleckstrin homology domain containing, family G (with RhoGef domain) member 1 | -0.0248128 |
| ARHGAP15 | Rho GTPase activating protein 15 | -0.024414 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0242535 |
| ARHGAP24 | Rho GTPase activating protein 24 | -0.0233898 |
| CUX1 | cut-like homeobox 1 | -0.0232885 |
| USP25 | ubiquitin specific peptidase 25 | -0.0232778 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0230411 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0228567 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0228534 |
| LYST | lysosomal trafficking regulator | -0.0227378 |
| MEF2C | myocyte enhancer factor 2C | -0.0222732 |
| RASAL2 | RAS protein activator like 2 | -0.0219541 |
| HMGA2 | high mobility group AT-hook 2 | -0.0218876 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0217878 |
| NHSL1 | NHS-like 1 | -0.0216361 |
| RPS8 | ribosomal protein S8 | -0.0215783 |
| LPIN2 | lipin 2 | -0.021417 |
| ZNF385D | zinc finger protein 385D | -0.0213888 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0213886 |
| SIK2 | salt-inducible kinase 2 | -0.021355 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0212171 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0210475 |
| APOE | apolipoprotein E | -0.0209898 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0208678 |
| DENND5B | DENN/MADD domain containing 5B | -0.020831 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0207656 |
| PALLD | palladin, cytoskeletal associated protein | -0.0207464 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0207151 |
| MPG | N-methylpurine-DNA glycosylase | -0.0206813 |
| EPHA5 | EPH receptor A5 | -0.0206493 |
