Fedratinib (hydrochloride hydrate)_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fedratinib (hydrochloride hydrate) perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fedratinib (hydrochloride hydrate)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.244459
FBL fibrillarin 0.167038
ACTG1 actin gamma 1 0.16209
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.133609
PABPC1 poly(A) binding protein, cytoplasmic 1 0.125267
VCL vinculin 0.104955
ERRFI1 ERBB receptor feedback inhibitor 1 0.0996698
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0954041
JMJD1C jumonji domain containing 1C 0.0924361
SFTPA2 surfactant protein A2 0.082977
ZCCHC7 zinc finger, CCHC domain containing 7 0.0796221
ASPH aspartate beta-hydroxylase 0.074754
MYH9 myosin, heavy chain 9, non-muscle 0.0736258
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0729043
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0727705
ARRDC3 arrestin domain containing 3 0.0701172
SAMD4B sterile alpha motif domain containing 4B 0.0664318
WWTR1 WW domain containing transcription regulator 1 0.0655754
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0639878
VMP1 vacuole membrane protein 1 0.0620636
DST dystonin 0.0611858
ACTN4 actinin, alpha 4 0.0594931
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0586549
TMEM41B transmembrane protein 41B 0.0577208
SEPTIN9 septin 9 0.0570653
PCBP2 poly(rC) binding protein 2 0.0555641
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0554776
APLP2 amyloid beta (A4) precursor-like protein 2 0.0546791
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0542868
USP34 ubiquitin specific peptidase 34 0.0530286
CDK19 cyclin-dependent kinase 19 0.0529466
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0524538
IPO7 importin 7 0.0515265
OGA O-GlcNAcase 0.0504979
DSCAM Down syndrome cell adhesion molecule 0.0492297
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0491473
APP amyloid beta (A4) precursor protein 0.0485101
MCL1 myeloid cell leukemia 1 0.0476264
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0470643
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0441784
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0437432
NPAS2 neuronal PAS domain protein 2 0.0431056
CSNK1A1 casein kinase 1, alpha 1 0.0428724
PDE10A phosphodiesterase 10A 0.0428121
MACF1 microtubule-actin crosslinking factor 1 0.0425596
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0425156
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.0422035
LDHA lactate dehydrogenase A 0.0418041
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0417143
SMYD3 SET and MYND domain containing 3 0.0413749
TPM3 tropomyosin 3 0.0406755
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0405467
AFDN afadin, adherens junction formation factor 0.0403149
ANGPTL4 angiopoietin-like 4 0.0394107
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0389936
BIRC6 baculoviral IAP repeat containing 6 0.0389583
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0388733
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0388635
CDK13 cyclin-dependent kinase 13 0.0388049
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0383608
PTK2 protein tyrosine kinase 2 0.0382497
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0379222
AKAP13 A kinase (PRKA) anchor protein 13 0.0376661
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0371293
SMAD3 SMAD family member 3 0.0369225
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0367368
ENO1 enolase 1, (alpha) 0.0365907
SEC14L1 SEC14-like 1 (S. cerevisiae) 0.0357355
SBF2 SET binding factor 2 0.0356852
EFNA5 ephrin-A5 0.0350657
PICALM phosphatidylinositol binding clathrin assembly protein 0.0349891
DGKD diacylglycerol kinase, delta 130kDa 0.0348652
TRIP12 thyroid hormone receptor interactor 12 0.034806
PUM2 pumilio RNA-binding family member 2 0.0347207
ATP13A3 ATPase type 13A3 0.0340542
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0338376
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0335939
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0335361
KDM2A lysine (K)-specific demethylase 2A 0.0333569
FNDC3B fibronectin type III domain containing 3B 0.033161
FNIP1 folliculin interacting protein 1 0.0330441
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0327293
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0323651
EIF4B eukaryotic translation initiation factor 4B 0.032187
EIF4A2 eukaryotic translation initiation factor 4A2 0.0318006
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 0.0317247
ZNF146 zinc finger protein 146 0.0317001
ZNF638 zinc finger protein 638 0.0309406
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0299869
MSN moesin 0.0299603
RTN4 reticulon 4 0.0299172
CANX calnexin 0.0298069
YAP1 Yes-associated protein 1 0.029803
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0297423
AKAP9 A kinase (PRKA) anchor protein 9 0.0295942
TTC17 tetratricopeptide repeat domain 17 0.0295332
ARHGAP29 Rho GTPase activating protein 29 0.0294415
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0287799
SPRED2 sprouty-related, EVH1 domain containing 2 0.0287062
GIGYF2 GRB10 interacting GYF protein 2 0.0285391

decreased expression

Symbol Name Standardized Value
RPS16 ribosomal protein S16 -0.195554
VIM vimentin -0.158643
TMSB10 thymosin beta 10 -0.143976
PTMA prothymosin, alpha -0.137161
RPL35A ribosomal protein L35a -0.0980266
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0795495
RPLP2 ribosomal protein, large, P2 -0.0766202
RPS24 ribosomal protein S24 -0.0692576
RPLP1 ribosomal protein, large, P1 -0.0585043
FTL ferritin, light polypeptide -0.054165
RPS8 ribosomal protein S8 -0.0483543
MT2A metallothionein 2A -0.0421142
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0411033
S100A10 S100 calcium binding protein A10 -0.0372103
HMGA1 high mobility group AT-hook 1 -0.0371113
RPS25 ribosomal protein S25 -0.0367768
RPL34 ribosomal protein L34 -0.0365484
RPS23 ribosomal protein S23 -0.0351731
CD44 CD44 molecule (Indian blood group) -0.0349471
IFITM3 interferon induced transmembrane protein 3 -0.0346981
RPL37A ribosomal protein L37a -0.0318926
HMGB1 high mobility group box 1 -0.031058
RPL38 ribosomal protein L38 -0.0308129
RPL28 ribosomal protein L28 -0.0305592
RPS17 ribosomal protein S17 -0.029847
RPL12 ribosomal protein L12 -0.029707
RPS19 ribosomal protein S19 -0.0284597
RPS5 ribosomal protein S5 -0.0272881
RAP1B RAP1B, member of RAS oncogene family -0.0269089
RPS14 ribosomal protein S14 -0.0268687
RPS21 ribosomal protein S21 -0.0266742
S100A9 S100 calcium binding protein A9 -0.0247029
TPT1 tumor protein, translationally-controlled 1 -0.0243544
TUBB tubulin, beta class I -0.024297
RPS6 ribosomal protein S6 -0.0237969
RPL9 ribosomal protein L9 -0.0231911
PFN1 profilin 1 -0.0229438
EIF3K eukaryotic translation initiation factor 3, subunit K -0.0228131
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -0.0224548
SERF2 small EDRK-rich factor 2 -0.0223628
RPS3 ribosomal protein S3 -0.0222164
CNRIP1 cannabinoid receptor interacting protein 1 -0.0219892
RPL11 ribosomal protein L11 -0.0215267
RPL35 ribosomal protein L35 -0.0215257
YBX1 Y box binding protein 1 -0.0212651
RPL36A ribosomal protein L36a -0.020747
RPS27A ribosomal protein S27a -0.0207399
RPL32 ribosomal protein L32 -0.0202862
RPS12 ribosomal protein S12 -0.0201178
WSB1 WD repeat and SOCS box containing 1 -0.0195299
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0194759
RPS13 ribosomal protein S13 -0.0193805
H1-0 H1.0 linker histone -0.0192053
RPS15 ribosomal protein S15 -0.0189667
GNAS GNAS complex locus -0.0189099
RPL36 ribosomal protein L36 -0.0187216
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0187144
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0186538
RPL31 ribosomal protein L31 -0.0186096
CTSD cathepsin D -0.0182236
TPI1 triosephosphate isomerase 1 -0.018204
IER3 immediate early response 3 -0.0178647
RPS10 ribosomal protein S10 -0.0176457
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0175577
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -0.0174916
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0173164
ATP5MG ATP synthase membrane subunit g -0.0172528
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0170073
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0168278
RNF220 ring finger protein 220 -0.0166106
C15ORF48 chromosome 15 open reading frame 48 -0.0161343
RPL30 ribosomal protein L30 -0.0161106
RPS20 ribosomal protein S20 -0.0160458
RPL8 ribosomal protein L8 -0.0160434
RPS29 ribosomal protein S29 -0.0159554
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -0.0158797
NOP58 NOP58 ribonucleoprotein -0.0157346
PARK7 parkinson protein 7 -0.0153909
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -0.0152679
ATP5F1E ATP synthase F1 subunit epsilon -0.0152564
HSPG2 heparan sulfate proteoglycan 2 -0.0146131
LMNA lamin A/C -0.0145979
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.0142116
UBB ubiquitin B -0.0141855
TMEM123 transmembrane protein 123 -0.0140985
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0140639
FUS FUS RNA binding protein -0.0139841
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0138983
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast) -0.0136462
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0135487
SEC61G Sec61 gamma subunit -0.0135344
PDCD5 programmed cell death 5 -0.0135211
ATP5F1B ATP synthase F1 subunit beta -0.0134159
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0131243
RPL23 ribosomal protein L23 -0.0131122
NDUFA4 NDUFA4, mitochondrial complex associated -0.0129754
RPS27 ribosomal protein S27 -0.0129666
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0129394
ELOB elongin B -0.0126428
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0124536