| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fedratinib (hydrochloride hydrate) perturbation in RKO cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Fedratinib (hydrochloride hydrate)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ACTG1 | actin gamma 1 | 0.157297 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.139178 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.11372 |
| LAMB3 | laminin, beta 3 | 0.0809469 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0801239 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.079769 |
| NUP58 | nucleoporin 58 | 0.0746008 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0685515 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0674297 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0668387 |
| OGA | O-GlcNAcase | 0.065144 |
| JMJD1C | jumonji domain containing 1C | 0.0618194 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0618108 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0603824 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0601891 |
| RLF | rearranged L-myc fusion | 0.0585999 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0572894 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0564201 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0556869 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0544927 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0543843 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0516206 |
| USP3 | ubiquitin specific peptidase 3 | 0.0491643 |
| ZNF292 | zinc finger protein 292 | 0.0486761 |
| PTK2 | protein tyrosine kinase 2 | 0.0481426 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0473147 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0460406 |
| TXNRD1 | thioredoxin reductase 1 | 0.0455157 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0450865 |
| SET | SET nuclear proto-oncogene | 0.044288 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0441633 |
| ATP13A3 | ATPase type 13A3 | 0.0438915 |
| CANX | calnexin | 0.0431421 |
| TPD52 | tumor protein D52 | 0.0431024 |
| RBM39 | RNA binding motif protein 39 | 0.0423631 |
| RASA2 | RAS p21 protein activator 2 | 0.0417462 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.041163 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0410773 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0409526 |
| CALU | calumenin | 0.0407142 |
| YTHDC1 | YTH domain containing 1 | 0.040501 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.040259 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0401125 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0400519 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0399453 |
| GOLGA4 | golgin A4 | 0.0394744 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0393955 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0389612 |
| RTN4 | reticulon 4 | 0.0385721 |
| NCKAP1 | NCK-associated protein 1 | 0.0384968 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0380642 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0368501 |
| WDR45B | WD repeat domain 45B | 0.0368319 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0366838 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.036674 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0366594 |
| SBF2 | SET binding factor 2 | 0.0363126 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0362372 |
| PCBP2 | poly(rC) binding protein 2 | 0.0359419 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0358541 |
| STC1 | stanniocalcin 1 | 0.0354515 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0353253 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0347943 |
| CCNL1 | cyclin L1 | 0.0345235 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0344232 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0338331 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0338321 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0337623 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0337123 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0334547 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0330003 |
| SPAG9 | sperm associated antigen 9 | 0.0329188 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0328194 |
| FOXJ3 | forkhead box J3 | 0.032671 |
| ANXA5 | annexin A5 | 0.0326709 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0324651 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0320298 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.0319159 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0317553 |
| ZNF654 | zinc finger protein 654 | 0.0314696 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0314667 |
| FOXO3 | forkhead box O3 | 0.0312852 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.03124 |
| UBXN7 | UBX domain protein 7 | 0.0309588 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0308365 |
| ARFGEF3 | ARFGEF family member 3 | 0.0307662 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0304509 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0304248 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0303541 |
| RBM33 | RNA binding motif protein 33 | 0.0300147 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0296352 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | 0.0294315 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0294251 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0293791 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0292758 |
| HMGB2 | high mobility group box 2 | 0.0290475 |
| RNF145 | ring finger protein 145 | 0.0289621 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0289133 |
| CRY1 | cryptochrome circadian clock 1 | 0.0288903 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0287642 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZNF438 | zinc finger protein 438 | -0.151964 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.150508 |
| MT2A | metallothionein 2A | -0.135542 |
| HMGA2 | high mobility group AT-hook 2 | -0.0935686 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.0851236 |
| FRMD6 | FERM domain containing 6 | -0.0789869 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0788409 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0726787 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0714964 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.069179 |
| FLNB | filamin B, beta | -0.0676975 |
| BNC2 | basonuclin 2 | -0.0646584 |
| TMSB10 | thymosin beta 10 | -0.0621801 |
| NABP1 | nucleic acid binding protein 1 | -0.0609554 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0576107 |
| RAD51B | RAD51 paralog B | -0.0558386 |
| SP100 | SP100 nuclear antigen | -0.0552853 |
| MTAP | methylthioadenosine phosphorylase | -0.0550808 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0545292 |
| RPL9 | ribosomal protein L9 | -0.0530735 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0501465 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0492055 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.049197 |
| RPS6 | ribosomal protein S6 | -0.0490491 |
| RPL35A | ribosomal protein L35a | -0.048578 |
| RPS24 | ribosomal protein S24 | -0.0473775 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0470069 |
| RPLP1 | ribosomal protein, large, P1 | -0.0457387 |
| FTL | ferritin, light polypeptide | -0.0431305 |
| NAV3 | neuron navigator 3 | -0.0425632 |
| FHIT | fragile histidine triad | -0.0421305 |
| RPS8 | ribosomal protein S8 | -0.039377 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | -0.0364814 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0363987 |
| RPL12 | ribosomal protein L12 | -0.0361405 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0358608 |
| RPL31 | ribosomal protein L31 | -0.0358129 |
| EFNB2 | ephrin-B2 | -0.0356246 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0348896 |
| EXOC4 | exocyst complex component 4 | -0.0347015 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0346016 |
| RIGI | RNA sensor RIG-I | -0.0341947 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0338895 |
| TCF12 | transcription factor 12 | -0.0337293 |
| RPS21 | ribosomal protein S21 | -0.0331771 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.032945 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0319977 |
| HMGA1 | high mobility group AT-hook 1 | -0.0315759 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | -0.0315537 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0308046 |
| RPL11 | ribosomal protein L11 | -0.0304556 |
| RPS23 | ribosomal protein S23 | -0.0298559 |
| CAST | calpastatin | -0.0295966 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0293447 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0293226 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0291343 |
| RPS15 | ribosomal protein S15 | -0.0291168 |
| RPS19 | ribosomal protein S19 | -0.0286321 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0280779 |
| RPS29 | ribosomal protein S29 | -0.0280565 |
| PHF14 | PHD finger protein 14 | -0.0278468 |
| CUX1 | cut-like homeobox 1 | -0.0278102 |
| FRMD4A | FERM domain containing 4A | -0.0275948 |
| PLSCR1 | phospholipid scramblase 1 | -0.027149 |
| RPL7A | ribosomal protein L7a | -0.0271469 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0266756 |
| RPLP2 | ribosomal protein, large, P2 | -0.0264467 |
| ASPH | aspartate beta-hydroxylase | -0.0263243 |
| RPL37A | ribosomal protein L37a | -0.0262944 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0262037 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0260828 |
| MX1 | MX dynamin-like GTPase 1 | -0.025899 |
| GPHN | gephyrin | -0.0258318 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.025822 |
| WWOX | WW domain containing oxidoreductase | -0.0257875 |
| RASAL2 | RAS protein activator like 2 | -0.0257348 |
| RAB3IP | RAB3A interacting protein | -0.0256199 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0256121 |
| RPS17 | ribosomal protein S17 | -0.0254651 |
| RPS25 | ribosomal protein S25 | -0.0253477 |
| RPS13 | ribosomal protein S13 | -0.0249245 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0247428 |
| PCNX4 | pecanex 4 | -0.0246385 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0246182 |
| NOP56 | NOP56 ribonucleoprotein | -0.0246016 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.0238589 |
| RPL34 | ribosomal protein L34 | -0.0237164 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.0235313 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0232772 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | -0.0230783 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0229413 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0228933 |
| ANK2 | ankyrin 2, neuronal | -0.0226982 |
| RPL30 | ribosomal protein L30 | -0.0222473 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0221433 |
| PFN1 | profilin 1 | -0.0221383 |
| RPS27A | ribosomal protein S27a | -0.0220175 |
| EGR1 | early growth response 1 | -0.021971 |
| MX2 | MX dynamin-like GTPase 2 | -0.0218253 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0216622 |
