Fedratinib (hydrochloride hydrate)_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fedratinib (hydrochloride hydrate) perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fedratinib (hydrochloride hydrate)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A 0.1287
SMOC1 SPARC related modular calcium binding 1 0.111521
ACTG1 actin gamma 1 0.109634
ENO1 enolase 1, (alpha) 0.107312
MCL1 myeloid cell leukemia 1 0.0987067
STC1 stanniocalcin 1 0.0957271
VGF VGF nerve growth factor inducible 0.0902968
MYH9 myosin, heavy chain 9, non-muscle 0.0847016
SNAP25 synaptosomal-associated protein, 25kDa 0.0782188
TPM3 tropomyosin 3 0.0751229
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0718659
PEG10 paternally expressed 10 0.0667401
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0602311
NDRG1 N-myc downstream regulated 1 0.0597905
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0581841
TENT5A terminal nucleotidyltransferase 5A 0.0568838
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0565224
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0539599
CHGB chromogranin B 0.0538241
LIFR leukemia inhibitory factor receptor alpha 0.050778
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0493122
MED13L mediator complex subunit 13-like 0.0491112
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0477927
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0476922
SFPQ splicing factor proline/glutamine-rich 0.047155
BIRC6 baculoviral IAP repeat containing 6 0.0460495
BZW1 basic leucine zipper and W2 domains 1 0.0459018
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.0458129
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0457067
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0453628
RORA RAR-related orphan receptor A 0.0452749
XPO1 exportin 1 0.0446659
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.044631
NALF1 NALCN channel auxiliary factor 1 0.0439629
TSPYL2 TSPY-like 2 0.0439125
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0438489
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0437315
ZNF292 zinc finger protein 292 0.0433831
CHD1 chromodomain helicase DNA binding protein 1 0.0432849
CPE carboxypeptidase E 0.0408344
AHR aryl hydrocarbon receptor 0.0406132
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0404709
WRN Werner syndrome, RecQ helicase-like 0.0399707
PTK2 protein tyrosine kinase 2 0.0398601
DOCK5 dedicator of cytokinesis 5 0.0397081
CAMTA1 calmodulin binding transcription activator 1 0.0394671
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0392291
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.0388269
INHBA inhibin, beta A 0.0385499
FAM13A family with sequence similarity 13, member A 0.0384341
POTEF POTE ankyrin domain family, member F 0.0381906
RPRD2 regulation of nuclear pre-mRNA domain containing 2 0.0375261
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0368034
MATR3 matrin 3 0.0365671
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0364655
DGKD diacylglycerol kinase, delta 130kDa 0.036198
PCBP3 poly(rC) binding protein 3 0.0361101
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0360661
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0359483
SIK3 SIK family kinase 3 0.0357145
CHD7 chromodomain helicase DNA binding protein 7 0.0351641
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0350167
MBNL2 muscleblind-like splicing regulator 2 0.0347899
GRB10 growth factor receptor-bound protein 10 0.0342454
PCBP2 poly(rC) binding protein 2 0.0338585
RB1CC1 RB1-inducible coiled-coil 1 0.0336631
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0334981
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0332594
PUM2 pumilio RNA-binding family member 2 0.0329701
ELP2 elongator acetyltransferase complex subunit 2 0.0326923
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0324369
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0319438
YTHDC1 YTH domain containing 1 0.0317067
DPYSL3 dihydropyrimidinase-like 3 0.0314945
MSN moesin 0.0305047
VMP1 vacuole membrane protein 1 0.0305001
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0303867
TRIO trio Rho guanine nucleotide exchange factor 0.0302364
ZCCHC7 zinc finger, CCHC domain containing 7 0.0301637
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.030147
TUFT1 tuftelin 1 0.0301278
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0300787
MAP2K1 mitogen-activated protein kinase kinase 1 0.0300126
NIPBL Nipped-B homolog (Drosophila) 0.0295042
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0294794
PCSK1 proprotein convertase subtilisin/kexin type 1 0.0292963
RPH3AL rabphilin 3A-like (without C2 domains) 0.029219
ANKHD1 ankyrin repeat and KH domain containing 1 0.0291755
ZMYM2 zinc finger, MYM-type 2 0.0291168
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.0290388
SSBP2 single-stranded DNA binding protein 2 0.029036
AKAP13 A kinase (PRKA) anchor protein 13 0.0289052
UBA2 ubiquitin-like modifier activating enzyme 2 0.0286336
CKAP5 cytoskeleton associated protein 5 0.0286097
COPA coatomer protein complex, subunit alpha 0.0285551
NBAS neuroblastoma amplified sequence 0.0282698
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0281829
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0278475
LDHA lactate dehydrogenase A 0.0278432
GATAD2B GATA zinc finger domain containing 2B 0.0274501

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.108036
FTL ferritin, light polypeptide -0.0841604
TENM1 teneurin transmembrane protein 1 -0.0807842
GRIK1 glutamate receptor, ionotropic, kainate 1 -0.0802194
PTMA prothymosin, alpha -0.0767875
RIMS2 regulating synaptic membrane exocytosis 2 -0.0701726
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 -0.0675454
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0536555
ADGRL2 adhesion G protein-coupled receptor L2 -0.0515139
TXNRD1 thioredoxin reductase 1 -0.0507106
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 -0.0427592
RPS21 ribosomal protein S21 -0.0406708
SNTG1 syntrophin, gamma 1 -0.0399089
RPLP1 ribosomal protein, large, P1 -0.0392643
NKAIN2 Na+/K+ transporting ATPase interacting 2 -0.0359242
TMSB10 thymosin beta 10 -0.0350668
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0340881
RPL35 ribosomal protein L35 -0.0336454
RPLP2 ribosomal protein, large, P2 -0.0317714
ZNF804A zinc finger protein 804A -0.031346
PDE4D phosphodiesterase 4D, cAMP-specific -0.0311369
RPS8 ribosomal protein S8 -0.0307071
FAM162A family with sequence similarity 162, member A -0.0303759
RPL34 ribosomal protein L34 -0.0296071
IFI6 interferon, alpha-inducible protein 6 -0.029589
RPL35A ribosomal protein L35a -0.0285847
RNF213 ring finger protein 213 -0.0281787
PHF14 PHD finger protein 14 -0.0278533
FTH1 ferritin, heavy polypeptide 1 -0.0273802
RPL38 ribosomal protein L38 -0.0271057
WWOX WW domain containing oxidoreductase -0.026634
RPL12 ribosomal protein L12 -0.0265391
FAAH2 fatty acid amide hydrolase 2 -0.0259269
HMGB1 high mobility group box 1 -0.0255369
NCKAP5 NCK-associated protein 5 -0.0254542
RPS6 ribosomal protein S6 -0.025297
TOX thymocyte selection-associated high mobility group box -0.0250064
WSB1 WD repeat and SOCS box containing 1 -0.0248882
S100A9 S100 calcium binding protein A9 -0.024833
SYT1 synaptotagmin I -0.0247493
ATP5F1E ATP synthase F1 subunit epsilon -0.0243047
ISG15 ISG15 ubiquitin-like modifier -0.0241798
RPS19 ribosomal protein S19 -0.0241751
RPS29 ribosomal protein S29 -0.0241172
GPC5 glypican 5 -0.0239772
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 -0.023956
RPS25 ribosomal protein S25 -0.0236442
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0234758
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0233466
PDE4B phosphodiesterase 4B, cAMP-specific -0.0229911
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0228285
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0225651
TUBB tubulin, beta class I -0.0223298
SCG2 secretogranin II -0.0220235
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0218383
PDIA3 protein disulfide isomerase family A, member 3 -0.0215046
RPS24 ribosomal protein S24 -0.021429
RPS27 ribosomal protein S27 -0.0211656
RACK1 receptor for activated C kinase 1 -0.0205216
PARK7 parkinson protein 7 -0.0202985
UBB ubiquitin B -0.0202923
RPS23 ribosomal protein S23 -0.0199904
RPS16 ribosomal protein S16 -0.019863
NLGN1 neuroligin 1 -0.0195407
SYT4 synaptotagmin IV -0.0192238
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 -0.0191384
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0189694
TPT1 tumor protein, translationally-controlled 1 -0.0184645
CHGA chromogranin A -0.0184449
KIAA0825 KIAA0825 -0.0180793
PCSK2 proprotein convertase subtilisin/kexin type 2 -0.0180328
CSMD3 CUB and Sushi multiple domains 3 -0.0179978
ZMAT4 zinc finger, matrin-type 4 -0.0179573
RPL5 ribosomal protein L5 -0.0178236
TUBB4B tubulin, beta 4B class IVb -0.0178231
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.017616
NOVA1 neuro-oncological ventral antigen 1 -0.0174569
NBEA neurobeachin -0.0172799
MARCHF1 membrane associated ring-CH-type finger 1 -0.0172595
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0172018
CHRM3 cholinergic receptor, muscarinic 3 -0.0171912
AKR1C2 aldo-keto reductase family 1, member C2 -0.0171058
KCNH7 potassium channel, voltage gated eag related subfamily H, member 7 -0.017067
RIT2 Ras-like without CAAX 2 -0.0170039
LRP1B low density lipoprotein receptor-related protein 1B -0.0169721
MAGEA10 melanoma antigen family A10 -0.016736
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0166859
RPL8 ribosomal protein L8 -0.0165813
RPL36 ribosomal protein L36 -0.0165719
H1-0 H1.0 linker histone -0.0165627
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0165504
RPL32 ribosomal protein L32 -0.0162762
EGR1 early growth response 1 -0.016151
PFN1 profilin 1 -0.0160788
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0160368
RPL23 ribosomal protein L23 -0.0160165
RPL6 ribosomal protein L6 -0.015966
RPS17 ribosomal protein S17 -0.0158084
RPL36AL ribosomal protein L36a-like -0.0156545
RALYL RALY RNA binding protein-like -0.0153999