| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Fedratinib (hydrochloride hydrate) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Fedratinib (hydrochloride hydrate)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.208193 |
| NRG3 | neuregulin 3 | 0.179495 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.158836 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.145027 |
| NLGN1 | neuroligin 1 | 0.129124 |
| LDHA | lactate dehydrogenase A | 0.115279 |
| ENO1 | enolase 1, (alpha) | 0.114154 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.110641 |
| ACTG1 | actin gamma 1 | 0.102308 |
| VIM | vimentin | 0.0847605 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0816877 |
| PGK1 | phosphoglycerate kinase 1 | 0.0816301 |
| ANGPTL4 | angiopoietin-like 4 | 0.0802734 |
| SFTPA2 | surfactant protein A2 | 0.07731 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0747989 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0723305 |
| SQSTM1 | sequestosome 1 | 0.0670905 |
| POTEF | POTE ankyrin domain family, member F | 0.0640052 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0617331 |
| ASPH | aspartate beta-hydroxylase | 0.0614037 |
| PCBP2 | poly(rC) binding protein 2 | 0.0599783 |
| MSI2 | musashi RNA-binding protein 2 | 0.0590826 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0586208 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.057522 |
| RAD51B | RAD51 paralog B | 0.0568262 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0564623 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0550271 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0544374 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0539541 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0539476 |
| CNIH3 | cornichon family AMPA receptor auxiliary protein 3 | 0.0538922 |
| CANX | calnexin | 0.0532728 |
| TPM3 | tropomyosin 3 | 0.0522473 |
| NOTCH2 | notch 2 | 0.0521839 |
| FN1 | fibronectin 1 | 0.050264 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0495391 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.0490167 |
| ATXN1 | ataxin 1 | 0.047698 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0470581 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0470425 |
| FMNL2 | formin-like 2 | 0.0459474 |
| OGA | O-GlcNAcase | 0.0455019 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0449401 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0444763 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0436005 |
| CADM1 | cell adhesion molecule 1 | 0.0433068 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0426301 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.0421282 |
| G3BP2 | GTPase activating protein (SH3 domain) binding protein 2 | 0.0420464 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0411614 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.0411319 |
| LAMP2 | lysosomal-associated membrane protein 2 | 0.0406777 |
| TNIK | TRAF2 and NCK interacting kinase | 0.0399607 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0398497 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.0397495 |
| WDR45B | WD repeat domain 45B | 0.0394713 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0394324 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0393476 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0391941 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0391326 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0381764 |
| JMJD1C | jumonji domain containing 1C | 0.0376447 |
| MSN | moesin | 0.0373646 |
| CALU | calumenin | 0.037235 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0369159 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0365689 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0362804 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0360938 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.036059 |
| INPP5F | inositol polyphosphate-5-phosphatase F | 0.0359222 |
| DIAPH1 | diaphanous-related formin 1 | 0.0355666 |
| EHBP1 | EH domain binding protein 1 | 0.0350499 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0349397 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0348163 |
| EXT1 | exostosin glycosyltransferase 1 | 0.034758 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0333046 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0332902 |
| USP22 | ubiquitin specific peptidase 22 | 0.0332237 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0327825 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0327057 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 0.0324589 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0316744 |
| CENPF | centromere protein F, 350/400kDa | 0.0316421 |
| LSAMP | limbic system-associated membrane protein | 0.0314743 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0312974 |
| SMYD3 | SET and MYND domain containing 3 | 0.0306062 |
| ARRDC3 | arrestin domain containing 3 | 0.0301869 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0298001 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0297071 |
| CTSB | cathepsin B | 0.0295964 |
| PMEL | premelanosome protein | 0.0295279 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.02939 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0292716 |
| GPHN | gephyrin | 0.0291455 |
| SDC4 | syndecan 4 | 0.0290214 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0289852 |
| FAM13A | family with sequence similarity 13, member A | 0.0289614 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0288277 |
| YEATS2 | YEATS domain containing 2 | 0.0284137 |
| CDK19 | cyclin-dependent kinase 19 | 0.0284083 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.115537 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.101217 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.092919 |
| FMN1 | formin 1 | -0.0855011 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0712902 |
| CCND1 | cyclin D1 | -0.0691963 |
| TXNRD1 | thioredoxin reductase 1 | -0.0511707 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0491918 |
| MAP4 | microtubule-associated protein 4 | -0.0485841 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0480163 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0456598 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0436487 |
| PLSCR1 | phospholipid scramblase 1 | -0.0435582 |
| RUNX1 | runt-related transcription factor 1 | -0.0434677 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0430338 |
| TMSB10 | thymosin beta 10 | -0.0406185 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0388413 |
| OXSR1 | oxidative stress responsive 1 | -0.0385721 |
| SP100 | SP100 nuclear antigen | -0.0375145 |
| RBM39 | RNA binding motif protein 39 | -0.0363898 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0362584 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0361953 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.032817 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0322942 |
| CD44 | CD44 molecule (Indian blood group) | -0.0321257 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0316529 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0316196 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0314473 |
| FRMD5 | FERM domain containing 5 | -0.0307591 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0305356 |
| RPLP1 | ribosomal protein, large, P1 | -0.0303503 |
| NAA50 | N(alpha)-acetyltransferase 50, NatE catalytic subunit | -0.0276495 |
| RASA2 | RAS p21 protein activator 2 | -0.0265218 |
| FTL | ferritin, light polypeptide | -0.0258628 |
| ERBIN | erbb2 interacting protein | -0.0256953 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0256363 |
| RPL38 | ribosomal protein L38 | -0.0251484 |
| RPL32 | ribosomal protein L32 | -0.0245876 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0245324 |
| TCF20 | transcription factor 20 (AR1) | -0.0240039 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0237364 |
| HDAC9 | histone deacetylase 9 | -0.0235743 |
| RPS2 | ribosomal protein S2 | -0.0232783 |
| MARCHF1 | membrane associated ring-CH-type finger 1 | -0.0230461 |
| TFG | TRK-fused gene | -0.0230001 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.022836 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.0223323 |
| RPS24 | ribosomal protein S24 | -0.022021 |
| HLA-B | major histocompatibility complex, class I, B | -0.0219878 |
| RIGI | RNA sensor RIG-I | -0.0219127 |
| RPS23 | ribosomal protein S23 | -0.0216966 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0214579 |
| USP32 | ubiquitin specific peptidase 32 | -0.0212354 |
| LAP3 | leucine aminopeptidase 3 | -0.0211646 |
| RPLP2 | ribosomal protein, large, P2 | -0.0211528 |
| TPTEP2-CSNK1E | TPTEP2-CSNK1E readthrough | -0.0210341 |
| NPR2 | natriuretic peptide receptor 2 | -0.0206004 |
| WDR43 | WD repeat domain 43 | -0.0205461 |
| GNAS | GNAS complex locus | -0.020497 |
| RNF213 | ring finger protein 213 | -0.0201184 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0200775 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0200259 |
| NKTR | natural killer cell triggering receptor | -0.0199599 |
| NF1 | neurofibromin 1 | -0.0199432 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.0199325 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.0199083 |
| IFI44L | interferon-induced protein 44-like | -0.0198069 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0196795 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0194433 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0194068 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0193808 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0193003 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0192794 |
| NUP153 | nucleoporin 153kDa | -0.0190914 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0189523 |
| N4BP1 | NEDD4 binding protein 1 | -0.0188191 |
| XAF1 | XIAP associated factor 1 | -0.018809 |
| IER3 | immediate early response 3 | -0.0187775 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0187204 |
| RPS5 | ribosomal protein S5 | -0.0186737 |
| SNX9 | sorting nexin 9 | -0.0185565 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0185498 |
| SERINC1 | serine incorporator 1 | -0.0182682 |
| RPS6 | ribosomal protein S6 | -0.0182325 |
| RTN4 | reticulon 4 | -0.0181215 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.018045 |
| RPL34 | ribosomal protein L34 | -0.0180314 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0178727 |
| GNS | glucosamine (N-acetyl)-6-sulfatase | -0.0177746 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0176748 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0176707 |
| SEC62 | SEC62 homolog (S. cerevisiae) | -0.0176606 |
| NOP58 | NOP58 ribonucleoprotein | -0.0176486 |
| RNF145 | ring finger protein 145 | -0.0175743 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | -0.0173354 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | -0.0173267 |
| WDR1 | WD repeat domain 1 | -0.0173207 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0170597 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0169801 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0166209 |
