Fedratinib (hydrochloride hydrate)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fedratinib (hydrochloride hydrate) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fedratinib (hydrochloride hydrate)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 0.151539
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.143535
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.11025
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.102462
ACTG1 actin gamma 1 0.100326
LDHA lactate dehydrogenase A 0.0992933
PCBP2 poly(rC) binding protein 2 0.0885851
PDGFA platelet-derived growth factor alpha polypeptide 0.0872213
ENO1 enolase 1, (alpha) 0.0834569
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0807464
PGK1 phosphoglycerate kinase 1 0.0764868
DSPP dentin sialophosphoprotein 0.0758655
AKAP12 A kinase (PRKA) anchor protein 12 0.0748176
TXNIP thioredoxin interacting protein 0.0703248
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0696254
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0677933
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0665816
EEF2 eukaryotic translation elongation factor 2 0.0626944
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0597459
KRT8 keratin 8, type II 0.0545531
ITGA6 integrin, alpha 6 0.0543857
KRT18 keratin 18, type I 0.0531341
NAV2 neuron navigator 2 0.051527
AKAP9 A kinase (PRKA) anchor protein 9 0.0509073
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0502242
MACF1 microtubule-actin crosslinking factor 1 0.046778
OGA O-GlcNAcase 0.0460452
TTC3 tetratricopeptide repeat domain 3 0.0450955
KIZ kizuna centrosomal protein 0.044798
ESYT2 extended synaptotagmin-like protein 2 0.0439239
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0411006
ASPH aspartate beta-hydroxylase 0.0410278
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0402814
ITPRID2 ITPR interacting domain containing 2 0.0399938
DUSP6 dual specificity phosphatase 6 0.0396453
AKAP13 A kinase (PRKA) anchor protein 13 0.0391525
SYT1 synaptotagmin I 0.0390203
FNIP1 folliculin interacting protein 1 0.0381035
MSN moesin 0.0380244
GLG1 golgi glycoprotein 1 0.0377198
N4BP2L2 NEDD4 binding protein 2-like 2 0.0375182
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0373724
EIF4B eukaryotic translation initiation factor 4B 0.0372028
UTRN utrophin 0.0359368
MYH9 myosin, heavy chain 9, non-muscle 0.0354686
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0353748
MAN1A1 mannosidase, alpha, class 1A, member 1 0.035374
USP34 ubiquitin specific peptidase 34 0.0345654
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0339226
APLP2 amyloid beta (A4) precursor-like protein 2 0.033908
SESN3 sestrin 3 0.0329421
SDC4 syndecan 4 0.0324806
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0317626
POTEF POTE ankyrin domain family, member F 0.0313674
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0313283
ZSWIM6 zinc finger, SWIM-type containing 6 0.0308637
SMC4 structural maintenance of chromosomes 4 0.030833
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.030484
DNM3 dynamin 3 0.0292501
KMT2C lysine (K)-specific methyltransferase 2C 0.0290418
ARHGAP26 Rho GTPase activating protein 26 0.0286379
UBA6 ubiquitin-like modifier activating enzyme 6 0.0279976
KTN1 kinectin 1 (kinesin receptor) 0.0277029
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0276785
ANLN anillin, actin binding protein 0.0276773
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0275421
TPM3 tropomyosin 3 0.0270879
CANX calnexin 0.0270555
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0270481
MT2A metallothionein 2A 0.0270142
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0269559
TMF1 TATA element modulatory factor 1 0.0265916
CKAP5 cytoskeleton associated protein 5 0.0265354
SFTPA2 surfactant protein A2 0.0264938
KDM4C lysine (K)-specific demethylase 4C 0.0264111
DST dystonin 0.0261441
SFPQ splicing factor proline/glutamine-rich 0.0260847
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 0.0258622
ADARB1 adenosine deaminase, RNA-specific, B1 0.0257412
ZFP36L1 ZFP36 ring finger protein-like 1 0.0256548
TOP2A topoisomerase (DNA) II alpha 170kDa 0.025412
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0253818
UBC ubiquitin C 0.025347
MKI67 marker of proliferation Ki-67 0.0252365
SERINC3 serine incorporator 3 0.0250807
SLC35F5 solute carrier family 35, member F5 0.0249207
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0249096
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.0247197
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0246762
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0245197
KDM7A lysine (K)-specific demethylase 7A 0.0242784
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0237344
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 0.0236319
PTEN phosphatase and tensin homolog 0.0236185
FXR1 fragile X mental retardation, autosomal homolog 1 0.0235205
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0234163
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0233646
ABHD2 abhydrolase domain containing 2 0.0233322
EIF4A2 eukaryotic translation initiation factor 4A2 0.0229132
NDRG1 N-myc downstream regulated 1 0.0227626

decreased expression

Symbol Name Standardized Value
NKD1 naked cuticle homolog 1 (Drosophila) -0.1029
RPL35A ribosomal protein L35a -0.0945936
PTMA prothymosin, alpha -0.0795482
CDH13 cadherin 13 -0.0793237
TMSB10 thymosin beta 10 -0.0785
RPS6 ribosomal protein S6 -0.0653575
RPS24 ribosomal protein S24 -0.0592299
CDK6 cyclin-dependent kinase 6 -0.0569841
RPL23 ribosomal protein L23 -0.0539989
RPLP1 ribosomal protein, large, P1 -0.052464
RPS19 ribosomal protein S19 -0.0510611
ADGRL2 adhesion G protein-coupled receptor L2 -0.0510385
VCL vinculin -0.0499489
SPATA13 spermatogenesis associated 13 -0.0498481
HMGB1 high mobility group box 1 -0.0492886
PDE4D phosphodiesterase 4D, cAMP-specific -0.048808
RPL37A ribosomal protein L37a -0.0481297
CCND1 cyclin D1 -0.0468652
RPL26 ribosomal protein L26 -0.0457144
RUNX1 runt-related transcription factor 1 -0.0445931
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0418341
GMDS GDP-mannose 4,6-dehydratase -0.041533
TNS3 tensin 3 -0.0413857
IARS1 isoleucyl-tRNA synthetase 1 -0.0411821
NCEH1 neutral cholesterol ester hydrolase 1 -0.0399305
RPS8 ribosomal protein S8 -0.0391847
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0376414
RPL38 ribosomal protein L38 -0.0370692
RPLP2 ribosomal protein, large, P2 -0.0368941
RPS25 ribosomal protein S25 -0.0358864
RPL34 ribosomal protein L34 -0.035743
TRIO trio Rho guanine nucleotide exchange factor -0.0348416
GARS1 glycyl-tRNA synthetase 1 -0.0345114
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0341092
RPL36A ribosomal protein L36a -0.0323776
LPP LIM domain containing preferred translocation partner in lipoma -0.0321475
ANKRD28 ankyrin repeat domain 28 -0.0316389
PCDH9 protocadherin 9 -0.0316228
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0314274
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0312014
FHIT fragile histidine triad -0.0308781
RPL12 ribosomal protein L12 -0.0303863
RBM39 RNA binding motif protein 39 -0.0303724
RPS23 ribosomal protein S23 -0.0301997
S100A10 S100 calcium binding protein A10 -0.030089
RAD51B RAD51 paralog B -0.0300108
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0298601
RPL35 ribosomal protein L35 -0.0289362
RPL32 ribosomal protein L32 -0.0286057
NAP1L1 nucleosome assembly protein 1-like 1 -0.028527
DIAPH2 diaphanous-related formin 2 -0.0282508
RPS29 ribosomal protein S29 -0.0279483
LRMDA leucine rich melanocyte differentiation associated -0.0277094
RPS21 ribosomal protein S21 -0.0272832
NACA nascent polypeptide-associated complex alpha subunit -0.0268818
COBL cordon-bleu WH2 repeat protein -0.0268096
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0262022
ANXA2 annexin A2 -0.0261265
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0256737
RPS12 ribosomal protein S12 -0.0255734
EIF5B eukaryotic translation initiation factor 5B -0.0252979
RPL19 ribosomal protein L19 -0.024678
RPL5 ribosomal protein L5 -0.0246156
RPL6 ribosomal protein L6 -0.0244015
ACTN4 actinin, alpha 4 -0.0238899
NOP58 NOP58 ribonucleoprotein -0.0238434
NOP56 NOP56 ribonucleoprotein -0.0236054
AOPEP aminopeptidase O (putative) -0.0234515
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0233747
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0232335
BCAS3 breast carcinoma amplified sequence 3 -0.023199
SKAP1 src kinase associated phosphoprotein 1 -0.0228608
SLC38A2 solute carrier family 38, member 2 -0.0228201
PERP PERP, TP53 apoptosis effector -0.0225895
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0224577
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0224104
IER3 immediate early response 3 -0.022054
GNAS GNAS complex locus -0.0220529
POU2F1 POU class 2 homeobox 1 -0.0219931
RPL36 ribosomal protein L36 -0.0219563
MTAP methylthioadenosine phosphorylase -0.0218689
TMEM123 transmembrane protein 123 -0.0216563
MAP4 microtubule-associated protein 4 -0.0216242
RPS16 ribosomal protein S16 -0.0213139
TUBB tubulin, beta class I -0.0210788
TOP1 topoisomerase (DNA) I -0.02103
RPL9 ribosomal protein L9 -0.0208819
RPL11 ribosomal protein L11 -0.0208218
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0207119
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0206083
MATR3 matrin 3 -0.0205111
RPL28 ribosomal protein L28 -0.0204532
PRRC2C proline-rich coiled-coil 2C -0.0204066
TRA2A transformer 2 alpha homolog (Drosophila) -0.020301
RPS27A ribosomal protein S27a -0.0202772
MAML2 mastermind-like 2 (Drosophila) -0.0202626
FUS FUS RNA binding protein -0.0201584
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0201354
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.0200982
MSI2 musashi RNA-binding protein 2 -0.020075