Fedratinib Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/16722836
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Genes

199 proteins with high or low expression in Fedratinib relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
PAH phenylalanine hydroxylase 4.38
APOB apolipoprotein B 4.11
LAPTM4A lysosomal protein transmembrane 4 alpha 3.93
TMEM59 transmembrane protein 59 3.88
NDFIP1 Nedd4 family interacting protein 1 3.84
DHRS2 dehydrogenase/reductase (SDR family) member 2 3.79
NR4A2 nuclear receptor subfamily 4, group A, member 2 3.57
ITM2B integral membrane protein 2B 3.54
NDFIP2 Nedd4 family interacting protein 2 3.43
NR4A1 nuclear receptor subfamily 4, group A, member 1 3.37
NCOA4 nuclear receptor coactivator 4 3.34
NBR1 neighbor of BRCA1 gene 1 3.25
APLP2 amyloid beta (A4) precursor-like protein 2 3.16
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 3.13
ITM2C integral membrane protein 2C 3.03
ANKRD22 ankyrin repeat domain 22 2.97
MAP1LC3B2 microtubule-associated protein 1 light chain 3 beta 2 2.94
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 2.91
IFNGR1 interferon gamma receptor 1 2.73
ABTB1 ankyrin repeat and BTB (POZ) domain containing 1 2.64
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 2.59
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2.57
GINM1 glycoprotein integral membrane 1 2.53
APOE apolipoprotein E 2.5
LRP10 low density lipoprotein receptor-related protein 10 2.5
RNF149 ring finger protein 149 2.49
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 2.41
SERINC1 serine incorporator 1 2.19
SERINC3 serine incorporator 3 2.15
ACVR2A activin A receptor, type IIA 2.11
UNC5B unc-5 homolog B (C. elegans) 2.11
VASN vasorin 2.11
APP amyloid beta (A4) precursor protein 2.11
SQSTM1 sequestosome 1 2.1
FDFT1 farnesyl-diphosphate farnesyltransferase 1 2.1
PLD3 phospholipase D family, member 3 2.1
IDI1 isopentenyl-diphosphate delta isomerase 1 2.1
MFAP3 microfibrillar-associated protein 3 2.08
MFGE8 milk fat globule-EGF factor 8 protein 2.08
SERINC5 serine incorporator 5 2.04
SDCBP syndecan binding protein (syntenin) 1.98
LRP12 low density lipoprotein receptor-related protein 12 1.97
UGCG UDP-glucose ceramide glucosyltransferase 1.97
MAP2 microtubule-associated protein 2 1.92
SPINT2 serine peptidase inhibitor, Kunitz type, 2 1.91
LDLR low density lipoprotein receptor 1.87
ULK1 unc-51 like autophagy activating kinase 1 1.87
TPPP tubulin polymerization promoting protein 1.82
SORBS1 sorbin and SH3 domain containing 1 1.81
TSPAN3 tetraspanin 3 1.81
GRN granulin 1.78
PCSK9 proprotein convertase subtilisin/kexin type 9 1.77
CLK1 CDC-like kinase 1 1.77
NKD2 naked cuticle homolog 2 (Drosophila) 1.76
TMEM248 transmembrane protein 248 1.75
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 1.74
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 1.73
F2RL1 coagulation factor II (thrombin) receptor-like 1 1.72
CALCOCO2 calcium binding and coiled-coil domain 2 1.71
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.7
AREG amphiregulin 1.68
UBL3 ubiquitin-like 3 1.68
CARHSP1 calcium regulated heat stable protein 1, 24kDa 1.67
IL13RA1 interleukin 13 receptor, alpha 1 1.65
SQLE squalene epoxidase 1.64
CLU clusterin 1.64
ESPN espin 1.63
F5 coagulation factor V (proaccelerin, labile factor) 1.61
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.6
IL10RB interleukin 10 receptor, beta 1.59
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.58
PNPLA2 patatin-like phospholipase domain containing 2 1.58
ZER1 zyg-11 related, cell cycle regulator 1.58
SARAF store-operated calcium entry-associated regulatory factor 1.53
SLC49A4 solute carrier family 49 member 4 1.53
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 1.52
GABARAPL1 GABA(A) receptor-associated protein like 1 1.51
PTPRS protein tyrosine phosphatase, receptor type, S 1.51
FGFR4 fibroblast growth factor receptor 4 1.5
H1FX H1 histone family, member X 1.5
ZDHHC12 zinc finger, DHHC-type containing 12 1.49
CASTOR2 cytosolic arginine sensor for mTORC1 subunit 2 1.49
MSMO1 methylsterol monooxygenase 1 1.48
IL6ST interleukin 6 signal transducer 1.48
CD81 CD81 molecule 1.46
FAT1 FAT atypical cadherin 1 1.43
CBARP CACN subunit beta associated regulatory protein 1.43
ACVR1B activin A receptor, type IB 1.43
FBXL20 F-box and leucine-rich repeat protein 20 1.42
OPTN optineurin 1.41
ZCCHC24 zinc finger, CCHC domain containing 24 1.4
SLC38A2 solute carrier family 38, member 2 1.4
RNF13 ring finger protein 13 1.4
IRS2 insulin receptor substrate 2 1.39
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 1.39
GABARAPL2 GABA(A) receptor-associated protein-like 2 1.38
HGFAC HGF activator 1.38
FAM171B family with sequence similarity 171, member B 1.37
JAK1 Janus kinase 1 1.37

low expression

Symbol Name Standardized Value
SYTL3 synaptotagmin-like 3 -4.21
CDC25A cell division cycle 25A -4.0
EPN3 epsin 3 -3.72
PCLAF PCNA clamp associated factor -2.92
C14ORF93 chromosome 14 open reading frame 93 -2.82
TNS4 tensin 4 -2.76
WDR76 WD repeat domain 76 -2.7
CCNA2 cyclin A2 -2.59
MCM10 minichromosome maintenance complex component 10 -2.55
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like -2.44
TRIB1 tribbles pseudokinase 1 -2.42
RRM2 ribonucleotide reductase M2 -2.4
PTTG1 pituitary tumor-transforming 1 -2.37
UBE2C ubiquitin-conjugating enzyme E2C -2.27
AEN apoptosis enhancing nuclease -2.25
SGO1 shugoshin 1 -2.16
DUOX1 dual oxidase 1 -2.15
FBXO5 F-box protein 5 -2.15
MELK maternal embryonic leucine zipper kinase -2.1
EHF ets homologous factor -2.09
CDC25B cell division cycle 25B -2.04
CCNA1 cyclin A1 -2.04
MLPH melanophilin -2.03
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 -2.01
SCARA3 scavenger receptor class A, member 3 -1.99
CLSPN claspin -1.98
DONSON downstream neighbor of SON -1.97
SLF1 SMC5-SMC6 complex localization factor 1 -1.96
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -1.95
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -1.95
CDC20 cell division cycle 20 -1.94
KIF22 kinesin family member 22 -1.94
E2F7 E2F transcription factor 7 -1.93
TPX2 TPX2, microtubule-associated -1.92
CDC6 cell division cycle 6 -1.91
RAD51 RAD51 recombinase -1.91
GMNN geminin, DNA replication inhibitor -1.91
E2F8 E2F transcription factor 8 -1.9
DDN dendrin -1.89
ANLN anillin, actin binding protein -1.88
ZGRF1 zinc finger, GRF-type containing 1 -1.88
HOXB8 homeobox B8 -1.85
CDCA7 cell division cycle associated 7 -1.84
PLEKHG4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 -1.82
HOXB4 homeobox B4 -1.82
TRAF5 TNF receptor-associated factor 5 -1.82
KIF18A kinesin family member 18A -1.82
CCNB1 cyclin B1 -1.8
EXO1 exonuclease 1 -1.78
NFE2L3 nuclear factor, erythroid 2-like 3 -1.76
CUEDC2 CUE domain containing 2 -1.75
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 -1.75
ERRFI1 ERBB receptor feedback inhibitor 1 -1.74
ARHGAP19 Rho GTPase activating protein 19 -1.73
RAD51AP1 RAD51 associated protein 1 -1.73
AURKA aurora kinase A -1.72
TPGS2 tubulin polyglutamylase complex subunit 2 -1.66
TK1 thymidine kinase 1, soluble -1.64
CDCA5 cell division cycle associated 5 -1.64
ZMYND19 zinc finger, MYND-type containing 19 -1.63
HELLS helicase, lymphoid-specific -1.63
FOSL2 FOS-like antigen 2 -1.62
PIMREG PICALM interacting mitotic regulator -1.62
MCPH1 microcephalin 1 -1.6
TCF3 transcription factor 3 -1.6
FUCA2 fucosidase, alpha-L- 2, plasma -1.59
C12ORF57 chromosome 12 open reading frame 57 -1.59
NEIL3 nei endonuclease VIII-like 3 (E. coli) -1.59
UHRF1 ubiquitin-like with PHD and ring finger domains 1 -1.57
KIF18B kinesin family member 18B -1.56
SDC1 syndecan 1 -1.56
CENPF centromere protein F, 350/400kDa -1.55
WEE1 WEE1 G2 checkpoint kinase -1.54
BORA bora, aurora kinase A activator -1.52
PITX1 paired-like homeodomain 1 -1.51
KIFC1 kinesin family member C1 -1.51
OBI1 ORC ubiquitin ligase 1 -1.51
CC2D2A coiled-coil and C2 domain containing 2A -1.5
SOCS6 suppressor of cytokine signaling 6 -1.5
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) -1.5
CDT1 chromatin licensing and DNA replication factor 1 -1.5
FKTN fukutin -1.49
ZNF507 zinc finger protein 507 -1.49
FOXM1 forkhead box M1 -1.49
PLK1 polo-like kinase 1 -1.49
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -1.47
MYC v-myc avian myelocytomatosis viral oncogene homolog -1.47
HOXB7 homeobox B7 -1.46
CASP4 caspase 4, apoptosis-related cysteine peptidase -1.46
PLIN2 perilipin 2 -1.45
PHF19 PHD finger protein 19 -1.45
KDM4D lysine (K)-specific demethylase 4D -1.44
NUSAP1 nucleolar and spindle associated protein 1 -1.44
PRC1 protein regulator of cytokinesis 1 -1.43
TCTEX1D2 Tctex1 domain containing 2 -1.42
ZNF584 zinc finger protein 584 -1.42
NR1D2 nuclear receptor subfamily 1, group D, member 2 -1.42
SLBP stem-loop binding protein -1.41
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -1.41
RARA retinoic acid receptor, alpha -1.41