Felodipine Gene Set

Dataset HMDB Metabolites of Enzymes
Category physical interactions
Type metabolite
Description The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris. (Chemical Entities of Biological Interest Ontology, CHEBI_585948)
External Link http://www.hmdb.ca/metabolites/HMDB15158
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Genes

20 interacting proteins for the Felodipine metabolite from the curated HMDB Metabolites of Enzymes dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7
NR3C2 nuclear receptor subfamily 3, group C, member 2
PDE1A phosphodiesterase 1A, calmodulin-dependent
PDE1B phosphodiesterase 1B, calmodulin-dependent
TNNC1 troponin C type 1 (slow)
TNNC2 troponin C type 2 (fast)