Fenofibrate_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fenofibrate perturbation in A-172 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Fenofibrate_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.267739
AKAP12 A kinase (PRKA) anchor protein 12 0.189111
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.177647
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.15328
TRIO trio Rho guanine nucleotide exchange factor 0.146846
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.146588
FBN1 fibrillin 1 0.146134
AHNAK AHNAK nucleoprotein 0.10834
UBC ubiquitin C 0.0960599
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0882326
COL3A1 collagen, type III, alpha 1 0.0819002
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0794434
COL5A2 collagen, type V, alpha 2 0.0788877
FNDC3B fibronectin type III domain containing 3B 0.0766411
CALR calreticulin 0.0759701
DLG1 discs, large homolog 1 (Drosophila) 0.0751696
CANX calnexin 0.0742082
OGA O-GlcNAcase 0.0741889
NAV1 neuron navigator 1 0.0725734
DST dystonin 0.0725475
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0718037
IQGAP1 IQ motif containing GTPase activating protein 1 0.071664
LDHA lactate dehydrogenase A 0.0713573
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0701056
NAV2 neuron navigator 2 0.0677041
AUTS2 autism susceptibility candidate 2 0.065777
LOXL2 lysyl oxidase-like 2 0.0657222
SBF2 SET binding factor 2 0.0654083
SOD2 superoxide dismutase 2, mitochondrial 0.0647337
LOX lysyl oxidase 0.063427
FLNB filamin B, beta 0.0623401
PODXL podocalyxin-like 0.0602918
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.05994
APP amyloid beta (A4) precursor protein 0.0597657
MYOF myoferlin 0.0594746
COL8A1 collagen, type VIII, alpha 1 0.0590695
SEPTIN9 septin 9 0.0589311
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0576105
THBS2 thrombospondin 2 0.0557939
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0545605
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0541791
CD44 CD44 molecule (Indian blood group) 0.0517391
PSD3 pleckstrin and Sec7 domain containing 3 0.0510194
PGK1 phosphoglycerate kinase 1 0.0497606
ATP13A3 ATPase type 13A3 0.0495045
ZEB1 zinc finger E-box binding homeobox 1 0.0479066
COL1A2 collagen, type I, alpha 2 0.046767
MYH9 myosin, heavy chain 9, non-muscle 0.0464812
FBXL7 F-box and leucine-rich repeat protein 7 0.0460563
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0442253
KDM3A lysine (K)-specific demethylase 3A 0.0438422
ZBTB20 zinc finger and BTB domain containing 20 0.0436801
FNIP1 folliculin interacting protein 1 0.043367
GPC6 glypican 6 0.0423289
MAP4 microtubule-associated protein 4 0.0419058
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0418613
PLAT plasminogen activator, tissue 0.0415755
ZNF292 zinc finger protein 292 0.0414535
ANKRD36 ankyrin repeat domain 36 0.0413438
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0406152
NAP1L1 nucleosome assembly protein 1-like 1 0.0404889
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0396341
RAI14 retinoic acid induced 14 0.0393431
SQSTM1 sequestosome 1 0.0390731
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.038972
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0389693
TNIP1 TNFAIP3 interacting protein 1 0.0389131
PICALM phosphatidylinositol binding clathrin assembly protein 0.0386305
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0384554
RUNX1 runt-related transcription factor 1 0.0384445
BHLHE40 basic helix-loop-helix family, member e40 0.0378158
TMSB4X thymosin beta 4, X-linked 0.0374004
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0365396
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0363685
DPYSL2 dihydropyrimidinase-like 2 0.0359401
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.03591
CYLD cylindromatosis (turban tumor syndrome) 0.0356137
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0352958
GLS2 glutaminase 2 (liver, mitochondrial) 0.0352628
COL5A1 collagen, type V, alpha 1 0.0340222
DPYSL3 dihydropyrimidinase-like 3 0.0339345
YEATS2 YEATS domain containing 2 0.0339271
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0335857
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0335477
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0334908
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0329714
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0328753
MXI1 MAX interactor 1, dimerization protein 0.0326273
PRELID2 PRELI domain containing 2 0.0323591
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0322879
ELL2 elongation factor, RNA polymerase II, 2 0.0322519
ZEB2 zinc finger E-box binding homeobox 2 0.0320063
SPAG9 sperm associated antigen 9 0.0318377
DENND5A DENN/MADD domain containing 5A 0.03179
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0316357
SETD5 SET domain containing 5 0.0312223
ABI1 abl-interactor 1 0.0308648
PDIA6 protein disulfide isomerase family A, member 6 0.0305698
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0303134
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0302724

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0928464
TMSB10 thymosin beta 10 -0.0911185
MT2A metallothionein 2A -0.0755827
IGFBP3 insulin-like growth factor binding protein 3 -0.0619262
NDRG1 N-myc downstream regulated 1 -0.0438411
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0400964
VIM vimentin -0.0377113
FTL ferritin, light polypeptide -0.0318438
IFITM3 interferon induced transmembrane protein 3 -0.0286651
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0270112
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0261721
RPL35A ribosomal protein L35a -0.0240269
RPLP1 ribosomal protein, large, P1 -0.0213954
PFN1 profilin 1 -0.0208444
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0202592
ABI3BP ABI family, member 3 (NESH) binding protein -0.0199005
RPL28 ribosomal protein L28 -0.0198511
EIF1 eukaryotic translation initiation factor 1 -0.0197022
RPL36 ribosomal protein L36 -0.0194834
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.0194563
CD81 CD81 molecule -0.0193816
HLA-B major histocompatibility complex, class I, B -0.0189643
HLA-C major histocompatibility complex, class I, C -0.0179874
RPLP2 ribosomal protein, large, P2 -0.0178174
FN1 fibronectin 1 -0.0175348
RPS6 ribosomal protein S6 -0.0164835
MT1X metallothionein 1X -0.0160673
BSG basigin (Ok blood group) -0.0159294
S100A11 S100 calcium binding protein A11 -0.0157444
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0156555
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0155646
MYADM myeloid-associated differentiation marker -0.0155323
MTDH metadherin -0.0151316
TBCA tubulin folding cofactor A -0.0150996
IFITM1 interferon induced transmembrane protein 1 -0.0148308
SEC61G Sec61 gamma subunit -0.0148056
RPL9 ribosomal protein L9 -0.0146899
RPS19 ribosomal protein S19 -0.0146774
RPS14 ribosomal protein S14 -0.0143684
ISG15 ISG15 ubiquitin-like modifier -0.0143237
LMNA lamin A/C -0.0142773
CYB5R3 cytochrome b5 reductase 3 -0.0142284
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0141237
ATF4 activating transcription factor 4 -0.013873
RPL37A ribosomal protein L37a -0.0138482
NABP1 nucleic acid binding protein 1 -0.0136348
EIF5B eukaryotic translation initiation factor 5B -0.013578
MRC2 mannose receptor, C type 2 -0.013135
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0131138
LOC102724023 ES1 protein homolog, mitochondrial -0.012785
DGKG diacylglycerol kinase, gamma 90kDa -0.0127054
FOSL1 FOS-like antigen 1 -0.0124853
CTSD cathepsin D -0.0123627
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0122182
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0120472
HLA-A major histocompatibility complex, class I, A -0.012038
RPL32 ribosomal protein L32 -0.0119022
PLXNA2 plexin A2 -0.0118685
EGR1 early growth response 1 -0.0117133
RPS15 ribosomal protein S15 -0.011525
RPS12 ribosomal protein S12 -0.0113635
IFI27 interferon, alpha-inducible protein 27 -0.0113111
POTEF POTE ankyrin domain family, member F -0.0112343
UGCG UDP-glucose ceramide glucosyltransferase -0.011145
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0109323
RPL35 ribosomal protein L35 -0.0108196
MRPS6 mitochondrial ribosomal protein S6 -0.0105381
UBE2B ubiquitin-conjugating enzyme E2B -0.010535
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0104922
RPL11 ribosomal protein L11 -0.0104042
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -0.010285
GNAS GNAS complex locus -0.010132
RAD23A RAD23 homolog A (S. cerevisiae) -0.00995874
NUPR1 nuclear protein, transcriptional regulator, 1 -0.00995302
UBL5 ubiquitin-like 5 -0.00992773
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.00991413
FLT1 fms-related tyrosine kinase 1 -0.00990946
TMEM165 transmembrane protein 165 -0.00990685
RPS20 ribosomal protein S20 -0.00975283
RPS8 ribosomal protein S8 -0.00974121
RPS21 ribosomal protein S21 -0.00965171
TTYH3 tweety family member 3 -0.009642
S100A4 S100 calcium binding protein A4 -0.00960134
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.00955965
ENO2 enolase 2 (gamma, neuronal) -0.00940249
TXNIP thioredoxin interacting protein -0.00938432
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -0.00936672
CST3 cystatin C -0.00933067
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.00923218
DSTN destrin (actin depolymerizing factor) -0.00920419
RPS23 ribosomal protein S23 -0.00909388
INTS6 integrator complex subunit 6 -0.00909132
GUK1 guanylate kinase 1 -0.00895178
RPS27 ribosomal protein S27 -0.00893642
RPS3 ribosomal protein S3 -0.00884662
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.00884609
IL7R interleukin 7 receptor -0.00883114
FMN2 formin 2 -0.00873688
TOR4A torsin family 4, member A -0.00873077
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.00870498