Fenofibrate_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fenofibrate perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fenofibrate_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.119243
MEF2A myocyte enhancer factor 2A 0.0916548
FAM13A family with sequence similarity 13, member A 0.0895049
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0830107
FNDC3B fibronectin type III domain containing 3B 0.0740003
AKAP12 A kinase (PRKA) anchor protein 12 0.072097
SEPTIN9 septin 9 0.0719857
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0717562
SOS1 son of sevenless homolog 1 (Drosophila) 0.0696763
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0660256
DSCAM Down syndrome cell adhesion molecule 0.060478
VEGFA vascular endothelial growth factor A 0.0588816
LIMCH1 LIM and calponin homology domains 1 0.0576913
PSD3 pleckstrin and Sec7 domain containing 3 0.0550999
NRG1 neuregulin 1 0.0526265
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0515521
FMN1 formin 1 0.0514006
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0509525
TRIO trio Rho guanine nucleotide exchange factor 0.050691
RPL4 ribosomal protein L4 0.0468725
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0454813
SEC31A SEC31 homolog A (S. cerevisiae) 0.0431396
HELZ helicase with zinc finger 0.0426604
CSDE1 cold shock domain containing E1, RNA-binding 0.0416849
NREP neuronal regeneration related protein 0.0376655
TENT5A terminal nucleotidyltransferase 5A 0.0371686
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0346266
CD46 CD46 molecule, complement regulatory protein 0.0344617
YEATS2 YEATS domain containing 2 0.0342882
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0334677
ADGRG6 adhesion G protein-coupled receptor G6 0.0331849
EXT1 exostosin glycosyltransferase 1 0.0322914
HSPA8 heat shock 70kDa protein 8 0.0316716
SMAD3 SMAD family member 3 0.0312546
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.030625
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0305927
MARCHF6 membrane associated ring-CH-type finger 6 0.0295415
NRIP1 nuclear receptor interacting protein 1 0.0292042
IGFBP4 insulin-like growth factor binding protein 4 0.0291017
IGF1R insulin-like growth factor 1 receptor 0.0287651
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.0286889
ESYT2 extended synaptotagmin-like protein 2 0.028617
ATL2 atlastin GTPase 2 0.02855
SSBP3 single stranded DNA binding protein 3 0.0282479
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0281586
THSD4 thrombospondin, type I, domain containing 4 0.0280964
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0279279
RLIM ring finger protein, LIM domain interacting 0.0279059
SUCO SUN domain containing ossification factor 0.027867
DPH6 diphthamine biosynthesis 6 0.0274825
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0272346
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0271999
MEIS2 Meis homeobox 2 0.027161
UBA6 ubiquitin-like modifier activating enzyme 6 0.0271282
WAC WW domain containing adaptor with coiled-coil 0.0269844
NCOR1 nuclear receptor corepressor 1 0.0267036
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0266691
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0260491
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.026037
RUNX1 runt-related transcription factor 1 0.0256364
ANTXR1 anthrax toxin receptor 1 0.0253117
SBF2 SET binding factor 2 0.025043
RAB1A RAB1A, member RAS oncogene family 0.0249739
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0249684
SNX13 sorting nexin 13 0.0249631
FXR1 fragile X mental retardation, autosomal homolog 1 0.0247725
PPARG peroxisome proliferator-activated receptor gamma 0.0246782
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.024513
BIRC2 baculoviral IAP repeat containing 2 0.0244994
MSI2 musashi RNA-binding protein 2 0.0244039
RPL3 ribosomal protein L3 0.0242892
PANK3 pantothenate kinase 3 0.0241101
MXI1 MAX interactor 1, dimerization protein 0.0236854
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0236405
PDE8A phosphodiesterase 8A 0.0234071
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0233238
NBAS neuroblastoma amplified sequence 0.023308
ANGPT1 angiopoietin 1 0.0232879
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0232783
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0231969
ASCC3 activating signal cointegrator 1 complex subunit 3 0.023012
ERRFI1 ERBB receptor feedback inhibitor 1 0.0229939
MACF1 microtubule-actin crosslinking factor 1 0.0229911
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0228965
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0227516
ADARB1 adenosine deaminase, RNA-specific, B1 0.0227246
SMYD3 SET and MYND domain containing 3 0.0226632
USP15 ubiquitin specific peptidase 15 0.0225954
NF1 neurofibromin 1 0.022473
TET2 tet methylcytosine dioxygenase 2 0.0224449
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 0.0223982
PRKD1 protein kinase D1 0.0223529
EWSR1 EWS RNA-binding protein 1 0.022317
ARHGAP32 Rho GTPase activating protein 32 0.0221241
TCERG1 transcription elongation regulator 1 0.0220999
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0220037
CALR calreticulin 0.0219391
OGA O-GlcNAcase 0.0219289
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0219254
ZNF292 zinc finger protein 292 0.0217038

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.352513
IGF2 insulin-like growth factor 2 -0.307806
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.232659
VIM vimentin -0.155221
PCBP2 poly(rC) binding protein 2 -0.0890354
RPL23 ribosomal protein L23 -0.0819091
SYT1 synaptotagmin I -0.0679673
PTPRD protein tyrosine phosphatase, receptor type, D -0.0666586
COL1A1 collagen, type I, alpha 1 -0.0657666
VCL vinculin -0.0654468
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.065043
AHNAK AHNAK nucleoprotein -0.0634587
EEF2 eukaryotic translation elongation factor 2 -0.0541582
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.052259
SLIT2 slit homolog 2 (Drosophila) -0.0488921
BPTF bromodomain PHD finger transcription factor -0.044544
TRIB2 tribbles pseudokinase 2 -0.0443064
RPS27A ribosomal protein S27a -0.044301
NALF1 NALCN channel auxiliary factor 1 -0.0438854
TMSB10 thymosin beta 10 -0.0412634
RPS6 ribosomal protein S6 -0.0407076
GNAS GNAS complex locus -0.0401854
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0372947
RPL35A ribosomal protein L35a -0.0367175
MAP1B microtubule-associated protein 1B -0.0360737
TLE4 transducin-like enhancer of split 4 -0.0358996
NRP1 neuropilin 1 -0.0348281
GLG1 golgi glycoprotein 1 -0.0337237
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) -0.0335157
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0332932
FBXL20 F-box and leucine-rich repeat protein 20 -0.0326008
ZNF609 zinc finger protein 609 -0.031776
EIF1 eukaryotic translation initiation factor 1 -0.0309244
ITGAV integrin, alpha V -0.0307828
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0303436
RPS19 ribosomal protein S19 -0.0302915
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0302559
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0301384
RPLP1 ribosomal protein, large, P1 -0.0294323
GATA3 GATA binding protein 3 -0.0293867
GLCCI1 glucocorticoid induced 1 -0.0288605
CELF1 CUGBP, Elav-like family member 1 -0.0287195
AUTS2 autism susceptibility candidate 2 -0.0278967
PDIA3 protein disulfide isomerase family A, member 3 -0.0278718
VDAC1 voltage-dependent anion channel 1 -0.02752
LPIN1 lipin 1 -0.0269537
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0269464
RPL9 ribosomal protein L9 -0.0268111
RPL11 ribosomal protein L11 -0.0267464
PTMA prothymosin, alpha -0.0261986
DSTN destrin (actin depolymerizing factor) -0.0261329
RACK1 receptor for activated C kinase 1 -0.0260897
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0259392
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0257051
DLC1 DLC1 Rho GTPase activating protein -0.0256441
GREM2 gremlin 2, DAN family BMP antagonist -0.0256205
UBC ubiquitin C -0.0255643
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0255183
PLPP1 phospholipid phosphatase 1 -0.0254029
POTEF POTE ankyrin domain family, member F -0.0253635
ZC3H15 zinc finger CCCH-type containing 15 -0.0251204
DCAF10 DDB1 and CUL4 associated factor 10 -0.0249642
NDRG1 N-myc downstream regulated 1 -0.0246963
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0246263
RPL12 ribosomal protein L12 -0.0245141
RPL36 ribosomal protein L36 -0.0245088
THBS1 thrombospondin 1 -0.0244753
BICD1 bicaudal D homolog 1 (Drosophila) -0.024305
RPS16 ribosomal protein S16 -0.0242725
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0242074
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0241518
RPL5 ribosomal protein L5 -0.0239178
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0238508
RPL32 ribosomal protein L32 -0.0237684
PAWR PRKC, apoptosis, WT1, regulator -0.0237249
UBE2B ubiquitin-conjugating enzyme E2B -0.0236639
MCL1 myeloid cell leukemia 1 -0.0235468
RPS12 ribosomal protein S12 -0.0233964
RPL31 ribosomal protein L31 -0.0226791
RPL34 ribosomal protein L34 -0.0226495
TRIP12 thyroid hormone receptor interactor 12 -0.0224267
KTN1 kinectin 1 (kinesin receptor) -0.0221677
GLI3 GLI family zinc finger 3 -0.0220909
RPS25 ribosomal protein S25 -0.02195
MED13L mediator complex subunit 13-like -0.0219344
ANXA2 annexin A2 -0.0218642
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0217506
RPS23 ribosomal protein S23 -0.0217439
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0216576
CCNI cyclin I -0.0213513
LOC112694756 uncharaterized LOC112694756 -0.0211331
EXOC4 exocyst complex component 4 -0.0210867
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0210171
RPL28 ribosomal protein L28 -0.0206428
ASTN2 astrotactin 2 -0.0204851
FERMT2 fermitin family member 2 -0.0202787
SERBP1 SERPINE1 mRNA binding protein 1 -0.0201027
FTL ferritin, light polypeptide -0.0200069
FAM193A family with sequence similarity 193, member A -0.019943
TENM4 teneurin transmembrane protein 4 -0.0198269