Fenofibrate_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fenofibrate perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fenofibrate_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.203777
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.190978
BTBD9 BTB (POZ) domain containing 9 0.112008
ZMYND8 zinc finger, MYND-type containing 8 0.0973349
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0861835
MBNL2 muscleblind-like splicing regulator 2 0.0854013
CANX calnexin 0.0815784
B2M beta-2-microglobulin 0.0749941
CALR calreticulin 0.0677061
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0645223
RNF43 ring finger protein 43 0.0638889
TXNIP thioredoxin interacting protein 0.0635633
RUNX1 runt-related transcription factor 1 0.0631094
IFNGR1 interferon gamma receptor 1 0.0626967
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0609455
RNF149 ring finger protein 149 0.0604468
PDIA3 protein disulfide isomerase family A, member 3 0.0600753
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0565251
PTEN phosphatase and tensin homolog 0.0552266
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0549611
ZMYM2 zinc finger, MYM-type 2 0.0543208
UBC ubiquitin C 0.052385
PTBP3 polypyrimidine tract binding protein 3 0.0517023
ARGLU1 arginine and glutamate rich 1 0.0512948
SORBS1 sorbin and SH3 domain containing 1 0.0506865
DSPP dentin sialophosphoprotein 0.0499697
BCLAF1 BCL2-associated transcription factor 1 0.0490885
MCTP2 multiple C2 domains, transmembrane 2 0.0489021
NRIP1 nuclear receptor interacting protein 1 0.0486872
SREBF2 sterol regulatory element binding transcription factor 2 0.0484979
ABHD2 abhydrolase domain containing 2 0.0472596
PDIA4 protein disulfide isomerase family A, member 4 0.0469057
DSCAM Down syndrome cell adhesion molecule 0.046116
H1-0 H1.0 linker histone 0.0460955
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0459663
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0459567
SBF2 SET binding factor 2 0.0459529
FNDC3A fibronectin type III domain containing 3A 0.0442658
OGA O-GlcNAcase 0.0439201
AHI1 Abelson helper integration site 1 0.0437434
CD46 CD46 molecule, complement regulatory protein 0.0436743
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0434111
UBAC2 UBA domain containing 2 0.0433046
MYH9 myosin, heavy chain 9, non-muscle 0.0420707
EHF ets homologous factor 0.0419655
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0418168
DENND4C DENN/MADD domain containing 4C 0.0415217
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0412435
DIAPH3 diaphanous-related formin 3 0.0406569
PRELID2 PRELI domain containing 2 0.0395139
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0394415
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0392582
ERRFI1 ERBB receptor feedback inhibitor 1 0.0392302
USP3 ubiquitin specific peptidase 3 0.0389389
ESYT2 extended synaptotagmin-like protein 2 0.0381706
LDHA lactate dehydrogenase A 0.0378719
AFF1 AF4/FMR2 family, member 1 0.0377181
RBM26 RNA binding motif protein 26 0.0376894
MEIS2 Meis homeobox 2 0.0376708
SEC24D SEC24 family member D 0.036581
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0364403
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0363602
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0359837
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0356756
ZDHHC20 zinc finger, DHHC-type containing 20 0.0352898
RHOBTB3 Rho-related BTB domain containing 3 0.0348311
HDLBP high density lipoprotein binding protein 0.0347298
GRK3 G protein-coupled receptor kinase 3 0.0346542
RAB1A RAB1A, member RAS oncogene family 0.0342637
ENO1 enolase 1, (alpha) 0.0342385
ARRDC3 arrestin domain containing 3 0.0341416
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0337599
KMT2C lysine (K)-specific methyltransferase 2C 0.0336912
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0335457
TM9SF3 transmembrane 9 superfamily member 3 0.0332846
ARHGAP32 Rho GTPase activating protein 32 0.0331328
YEATS2 YEATS domain containing 2 0.0330472
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0326396
RBM39 RNA binding motif protein 39 0.0322654
FNDC3B fibronectin type III domain containing 3B 0.0318285
KDM3A lysine (K)-specific demethylase 3A 0.0316838
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0316396
PDIA6 protein disulfide isomerase family A, member 6 0.0311112
AOPEP aminopeptidase O (putative) 0.0310667
SUCO SUN domain containing ossification factor 0.030797
XPO1 exportin 1 0.0307413
ATXN1 ataxin 1 0.0306561
NEBL nebulette 0.0306117
GOLGA4 golgin A4 0.0306054
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0304138
AKAP9 A kinase (PRKA) anchor protein 9 0.0302111
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0301105
HYOU1 hypoxia up-regulated 1 0.0299806
HELZ helicase with zinc finger 0.0298939
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0295446
NAMPT nicotinamide phosphoribosyltransferase 0.0293334
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0291
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0290354
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0290295
MXI1 MAX interactor 1, dimerization protein 0.0289501

decreased expression

Symbol Name Standardized Value
INTS6 integrator complex subunit 6 -0.192959
ANXA2 annexin A2 -0.113563
EGR1 early growth response 1 -0.111968
RNF213 ring finger protein 213 -0.111213
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.105514
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0879525
PLSCR2 phospholipid scramblase 2 -0.0854977
RAB7A RAB7A, member RAS oncogene family -0.0842314
AREG amphiregulin -0.0808522
VCL vinculin -0.0789942
STS steroid sulfatase (microsomal), isozyme S -0.0768318
EPSTI1 epithelial stromal interaction 1 (breast) -0.0762151
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0750376
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0729962
LYZ lysozyme -0.0723499
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.0716454
RIGI RNA sensor RIG-I -0.0711277
LMO7 LIM domain 7 -0.0701225
SP100 SP100 nuclear antigen -0.0681136
TM4SF19 transmembrane 4 L six family member 19 -0.0592686
MX2 MX dynamin-like GTPase 2 -0.0577428
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0571023
MX1 MX dynamin-like GTPase 1 -0.0562038
MCL1 myeloid cell leukemia 1 -0.0495736
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0466567
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0466525
UBAP2 ubiquitin associated protein 2 -0.0466169
C6ORF132 chromosome 6 open reading frame 132 -0.045993
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0458029
TSHZ2 teashirt zinc finger homeobox 2 -0.0457679
NPSR1 neuropeptide S receptor 1 -0.0451886
NABP1 nucleic acid binding protein 1 -0.0449417
CATSPERB catsper channel auxiliary subunit beta -0.0444836
XAF1 XIAP associated factor 1 -0.0442052
TMC5 transmembrane channel-like 5 -0.0439308
TJP1 tight junction protein 1 -0.0437364
IGFBP3 insulin-like growth factor binding protein 3 -0.0436792
PLSCR1 phospholipid scramblase 1 -0.0436466
TNS4 tensin 4 -0.0429832
AKAP13 A kinase (PRKA) anchor protein 13 -0.0419946
POU2F2 POU class 2 homeobox 2 -0.0413649
ERBIN erbb2 interacting protein -0.0407022
MCTP1 multiple C2 domains, transmembrane 1 -0.0393327
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0389291
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0384846
POF1B premature ovarian failure, 1B -0.0370779
FBXO39 F-box protein 39 -0.0363806
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0354135
PERP PERP, TP53 apoptosis effector -0.0351535
LOC102724023 ES1 protein homolog, mitochondrial -0.0349259
ACTG1 actin gamma 1 -0.0347153
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0340461
FTL ferritin, light polypeptide -0.0339971
MAP7 microtubule-associated protein 7 -0.0338964
IFI6 interferon, alpha-inducible protein 6 -0.0337441
GMDS GDP-mannose 4,6-dehydratase -0.0326008
EXT1 exostosin glycosyltransferase 1 -0.0325814
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0320662
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0310309
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0306449
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.030637
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0306349
PMP22 peripheral myelin protein 22 -0.030511
EZR ezrin -0.0304939
TM4SF1 transmembrane 4 L six family member 1 -0.0301317
SQSTM1 sequestosome 1 -0.0300675
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0297379
MUC20 mucin 20, cell surface associated -0.0297328
MCU mitochondrial calcium uniporter -0.0291827
SMAD3 SMAD family member 3 -0.028325
RABGAP1L RAB GTPase activating protein 1-like -0.0283181
FOSL1 FOS-like antigen 1 -0.0280549
SIPA1L2 signal-induced proliferation-associated 1 like 2 -0.0280193
GCLC glutamate-cysteine ligase, catalytic subunit -0.0279905
MAML2 mastermind-like 2 (Drosophila) -0.0279771
TMSB10 thymosin beta 10 -0.0275835
EFNB2 ephrin-B2 -0.0273104
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0268861
LRRC8A leucine rich repeat containing 8 family, member A -0.0268145
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0267478
NCEH1 neutral cholesterol ester hydrolase 1 -0.0266801
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0264048
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0261005
BCL2L1 BCL2-like 1 -0.0260972
PDLIM5 PDZ and LIM domain 5 -0.0255255
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1 -0.0251602
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0248653
LAMA4 laminin, alpha 4 -0.024574
HOMER1 homer scaffolding protein 1 -0.0243013
ZHX2 zinc fingers and homeoboxes 2 -0.0242945
MYO1E myosin IE -0.0242575
KYNU kynureninase -0.0242123
LCN2 lipocalin 2 -0.0239106
TPT1 tumor protein, translationally-controlled 1 -0.0238366
MYH14 myosin, heavy chain 14, non-muscle -0.0237396
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0237206
IFI27 interferon, alpha-inducible protein 27 -0.0236417
HKDC1 hexokinase domain containing 1 -0.0234699
SDCBP syndecan binding protein (syntenin) -0.0232571
GK glycerol kinase -0.0231293