Fenofibrate_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fenofibrate perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fenofibrate_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLC38A2 solute carrier family 38, member 2 0.223619
FN1 fibronectin 1 0.212948
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.200441
FNDC3B fibronectin type III domain containing 3B 0.190699
C3 complement component 3 0.170983
LRMDA leucine rich melanocyte differentiation associated 0.158632
AKAP12 A kinase (PRKA) anchor protein 12 0.149145
ENO1 enolase 1, (alpha) 0.127116
MAML2 mastermind-like 2 (Drosophila) 0.120933
GPC3 glypican 3 0.110137
DSPP dentin sialophosphoprotein 0.108003
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.104351
SPTBN1 spectrin, beta, non-erythrocytic 1 0.102246
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0847986
SAMD4A sterile alpha motif domain containing 4A 0.0820463
ATXN1 ataxin 1 0.0767633
TM4SF1 transmembrane 4 L six family member 1 0.0762429
VEGFA vascular endothelial growth factor A 0.0738011
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0733039
EHBP1 EH domain binding protein 1 0.0714161
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0682652
TF transferrin 0.0678876
SESTD1 SEC14 and spectrin domains 1 0.0638038
ASPH aspartate beta-hydroxylase 0.0624255
DST dystonin 0.0613346
TNS1 tensin 1 0.0590677
VCL vinculin 0.0562127
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0555593
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0544413
PEG3 paternally expressed 3 0.0532857
LPP LIM domain containing preferred translocation partner in lipoma 0.0527871
UBC ubiquitin C 0.0525913
DLC1 DLC1 Rho GTPase activating protein 0.0520891
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0512735
FAT1 FAT atypical cadherin 1 0.0512725
NKD1 naked cuticle homolog 1 (Drosophila) 0.051007
FRMD5 FERM domain containing 5 0.0492734
DTNA dystrobrevin, alpha 0.049242
TRIO trio Rho guanine nucleotide exchange factor 0.0484981
MSI2 musashi RNA-binding protein 2 0.0474421
GPC6 glypican 6 0.0459198
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0455135
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0452931
STAT1 signal transducer and activator of transcription 1, 91kDa 0.045064
GMDS GDP-mannose 4,6-dehydratase 0.0443508
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 0.0423283
EXT1 exostosin glycosyltransferase 1 0.0418394
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0415677
ERRFI1 ERBB receptor feedback inhibitor 1 0.0415455
MYH9 myosin, heavy chain 9, non-muscle 0.0414689
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0406596
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0398865
RPL3 ribosomal protein L3 0.0394818
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0390712
PLIN2 perilipin 2 0.0386229
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0385775
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.038474
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0382055
CEMIP2 cell migration inducing hyaluronidase 2 0.0378989
DOCK4 dedicator of cytokinesis 4 0.0378552
CP ceruloplasmin (ferroxidase) 0.0377836
AFDN afadin, adherens junction formation factor 0.0373863
PTK2 protein tyrosine kinase 2 0.0369039
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0368133
SBF2 SET binding factor 2 0.0362744
FMNL2 formin-like 2 0.0362493
ELL2 elongation factor, RNA polymerase II, 2 0.0361548
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0361141
DSCAM Down syndrome cell adhesion molecule 0.0358997
PDIA6 protein disulfide isomerase family A, member 6 0.035822
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0350107
KRT8 keratin 8, type II 0.0346694
RNF213 ring finger protein 213 0.0345439
OSMR oncostatin M receptor 0.0344989
RUNX1 runt-related transcription factor 1 0.0343437
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0343014
FLNB filamin B, beta 0.0341282
LDHA lactate dehydrogenase A 0.0336661
EEF2 eukaryotic translation elongation factor 2 0.0331864
KIAA1217 KIAA1217 0.0329374
ADAM9 ADAM metallopeptidase domain 9 0.0328455
RAD51B RAD51 paralog B 0.0328384
ZBTB20 zinc finger and BTB domain containing 20 0.0322318
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0320913
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0320688
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0317997
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0315757
NPAS2 neuronal PAS domain protein 2 0.0314234
OSBPL10 oxysterol binding protein-like 10 0.031203
AHR aryl hydrocarbon receptor 0.0311657
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0311065
CTNND1 catenin (cadherin-associated protein), delta 1 0.0308372
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0306684
BIRC3 baculoviral IAP repeat containing 3 0.0304774
MALRD1 MAM and LDL receptor class A domain containing 1 0.0299715
CANX calnexin 0.0298429
ATP10A ATPase, class V, type 10A 0.0297607
MALT1 MALT1 paracaspase 0.029699
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0295662
RTN4 reticulon 4 0.0295588

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.277384
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0969756
RPL11 ribosomal protein L11 -0.0933264
RPS6 ribosomal protein S6 -0.0856463
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0804745
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0710964
NAP1L1 nucleosome assembly protein 1-like 1 -0.0523487
RPS8 ribosomal protein S8 -0.0517595
RPS12 ribosomal protein S12 -0.0492635
MT2A metallothionein 2A -0.0478073
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0472667
FTL ferritin, light polypeptide -0.0445376
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.0442209
APOE apolipoprotein E -0.042163
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0411686
RPL5 ribosomal protein L5 -0.0410688
RPS19 ribosomal protein S19 -0.0402677
RPS2 ribosomal protein S2 -0.0397706
RPL37A ribosomal protein L37a -0.0396464
RPL7 ribosomal protein L7 -0.0384611
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0384398
TPT1 tumor protein, translationally-controlled 1 -0.0382953
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.0379839
RPS21 ribosomal protein S21 -0.0371508
RPL9 ribosomal protein L9 -0.035552
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0346686
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0345302
FOXP1 forkhead box P1 -0.0330043
RPL31 ribosomal protein L31 -0.0324337
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0318328
JMJD1C jumonji domain containing 1C -0.0314035
RPLP0 ribosomal protein, large, P0 -0.0313996
RPL35A ribosomal protein L35a -0.0313263
MATR3 matrin 3 -0.0291924
AHSG alpha-2-HS-glycoprotein -0.0290365
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0287632
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0282579
PRRC2C proline-rich coiled-coil 2C -0.0281059
RRBP1 ribosome binding protein 1 -0.0278338
RPL10A ribosomal protein L10a -0.0273632
RPLP1 ribosomal protein, large, P1 -0.0270034
ZC3H15 zinc finger CCCH-type containing 15 -0.0266454
LCN2 lipocalin 2 -0.0264236
PTMA prothymosin, alpha -0.0262212
RPLP2 ribosomal protein, large, P2 -0.026108
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.025931
RPL26 ribosomal protein L26 -0.0255358
IGFBP1 insulin-like growth factor binding protein 1 -0.0254308
RPL12 ribosomal protein L12 -0.0251749
RPS5 ribosomal protein S5 -0.0249415
NIPBL Nipped-B homolog (Drosophila) -0.0248723
RPL28 ribosomal protein L28 -0.0246809
FOXK2 forkhead box K2 -0.0246583
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0245987
MARCKS myristoylated alanine-rich protein kinase C substrate -0.023793
RPS20 ribosomal protein S20 -0.0237852
MED13L mediator complex subunit 13-like -0.0237697
DDIT4 DNA-damage-inducible transcript 4 -0.0236487
NKTR natural killer cell triggering receptor -0.0236318
RPL7A ribosomal protein L7a -0.0232023
RPL34 ribosomal protein L34 -0.0230819
SVIL supervillin -0.0230446
FAM162A family with sequence similarity 162, member A -0.0225589
EIF1 eukaryotic translation initiation factor 1 -0.0225397
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0218169
EIF5B eukaryotic translation initiation factor 5B -0.021774
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0216835
WDR45B WD repeat domain 45B -0.0216284
ZFR zinc finger RNA binding protein -0.0214677
RPS25 ribosomal protein S25 -0.0213615
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0212435
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0211838
PTBP3 polypyrimidine tract binding protein 3 -0.021101
PCBP2 poly(rC) binding protein 2 -0.020989
LITAF lipopolysaccharide-induced TNF factor -0.0208141
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0207281
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0207004
RACK1 receptor for activated C kinase 1 -0.02066
RBM39 RNA binding motif protein 39 -0.0204704
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0203633
SBNO1 strawberry notch homolog 1 (Drosophila) -0.0202564
ARID3A AT rich interactive domain 3A (BRIGHT-like) -0.0201644
RPS16 ribosomal protein S16 -0.0198368
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0196925
H3-3B H3.3 histone B -0.0195379
MAPK8 mitogen-activated protein kinase 8 -0.0194207
CDC27 cell division cycle 27 -0.019245
RPS15 ribosomal protein S15 -0.0191445
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0188639
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0188384
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0187612
RPL8 ribosomal protein L8 -0.0187273
CLU clusterin -0.0186379
NAMPT nicotinamide phosphoribosyltransferase -0.018529
MTDH metadherin -0.0184542
RPS24 ribosomal protein S24 -0.0183939
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0180843
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0180311
RPS23 ribosomal protein S23 -0.0179767
JAK1 Janus kinase 1 -0.0179435