Fenofibrate_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fenofibrate perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fenofibrate_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYOF myoferlin 0.143083
FLNB filamin B, beta 0.14012
MEF2A myocyte enhancer factor 2A 0.136296
TRIO trio Rho guanine nucleotide exchange factor 0.12433
NAMPT nicotinamide phosphoribosyltransferase 0.105419
MYH9 myosin, heavy chain 9, non-muscle 0.103876
APLP2 amyloid beta (A4) precursor-like protein 2 0.0983088
MTSS1 metastasis suppressor 1 0.0839348
MSN moesin 0.0837909
ITGA6 integrin, alpha 6 0.0795146
KIAA1217 KIAA1217 0.0777604
OGA O-GlcNAcase 0.0767647
FNDC3B fibronectin type III domain containing 3B 0.076636
ENO1 enolase 1, (alpha) 0.074607
RICTOR RPTOR independent companion of MTOR, complex 2 0.0719622
PTK2 protein tyrosine kinase 2 0.0671924
RBM39 RNA binding motif protein 39 0.0655155
KRT17 keratin 17, type I 0.0649949
CUL4B cullin 4B 0.0643475
EZR ezrin 0.0631242
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0628297
KDM6A lysine (K)-specific demethylase 6A 0.0614542
ITCH itchy E3 ubiquitin protein ligase 0.0612994
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0607754
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0586495
ASPH aspartate beta-hydroxylase 0.0555289
EMP1 epithelial membrane protein 1 0.0541786
PGK1 phosphoglycerate kinase 1 0.0540045
CEMIP cell migration inducing protein, hyaluronan binding 0.053527
AHNAK AHNAK nucleoprotein 0.0526147
ZNF292 zinc finger protein 292 0.052224
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0517781
KMT2E lysine (K)-specific methyltransferase 2E 0.051745
PODXL podocalyxin-like 0.0498603
ESYT2 extended synaptotagmin-like protein 2 0.0492147
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0487439
MACF1 microtubule-actin crosslinking factor 1 0.0477982
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0476876
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0476234
TPM3 tropomyosin 3 0.0475635
YAP1 Yes-associated protein 1 0.0470124
APP amyloid beta (A4) precursor protein 0.045218
CANX calnexin 0.0447264
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0446297
PRELID2 PRELI domain containing 2 0.0442644
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0442417
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0440002
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0439684
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0432706
UBC ubiquitin C 0.0429695
KDM3A lysine (K)-specific demethylase 3A 0.0426977
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0424819
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0423698
RPL3 ribosomal protein L3 0.0422871
PLEC plectin 0.042195
TMSB4X thymosin beta 4, X-linked 0.041359
BLCAP bladder cancer associated protein 0.0411711
CTNND1 catenin (cadherin-associated protein), delta 1 0.0411485
NAV2 neuron navigator 2 0.0410093
H1-0 H1.0 linker histone 0.0409369
AKAP13 A kinase (PRKA) anchor protein 13 0.0405263
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0403835
ANLN anillin, actin binding protein 0.0403794
MYO10 myosin X 0.0402075
SPAG9 sperm associated antigen 9 0.0393381
RLF rearranged L-myc fusion 0.0391037
SMAD3 SMAD family member 3 0.0387093
SUCO SUN domain containing ossification factor 0.0385711
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.03797
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0379099
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0376304
FNIP1 folliculin interacting protein 1 0.0375769
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0372094
CSDE1 cold shock domain containing E1, RNA-binding 0.036942
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0367728
USP9X ubiquitin specific peptidase 9, X-linked 0.0367532
ARRDC3 arrestin domain containing 3 0.0364852
NCOR2 nuclear receptor corepressor 2 0.0355148
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0354245
DIDO1 death inducer-obliterator 1 0.035175
CD44 CD44 molecule (Indian blood group) 0.0350192
AFAP1 actin filament associated protein 1 0.0342592
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0341054
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0339611
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0337063
KDM5B lysine (K)-specific demethylase 5B 0.0336333
BHLHE40 basic helix-loop-helix family, member e40 0.0330493
CLU clusterin 0.0329771
SBF2 SET binding factor 2 0.0329009
GOLGA4 golgin A4 0.0328223
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0325354
MCL1 myeloid cell leukemia 1 0.0324439
TNIP1 TNFAIP3 interacting protein 1 0.0323503
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0319763
NBAS neuroblastoma amplified sequence 0.0319519
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0319058
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0318094
TOP1 topoisomerase (DNA) I 0.0317909
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0316577
SULF1 sulfatase 1 0.0316004

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.215122
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0976511
TIMP3 TIMP metallopeptidase inhibitor 3 -0.068247
PDLIM5 PDZ and LIM domain 5 -0.0631981
PALLD palladin, cytoskeletal associated protein -0.0515397
INTS6 integrator complex subunit 6 -0.0418425
ALCAM activated leukocyte cell adhesion molecule -0.0385451
HLA-B major histocompatibility complex, class I, B -0.0371903
TMSB10 thymosin beta 10 -0.0365858
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0362243
RPS21 ribosomal protein S21 -0.0359636
LMO7 LIM domain 7 -0.0346245
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0327975
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0315628
NDRG1 N-myc downstream regulated 1 -0.0313712
RPL35A ribosomal protein L35a -0.0303728
EGR1 early growth response 1 -0.0294256
MT2A metallothionein 2A -0.0290622
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0276572
IFITM3 interferon induced transmembrane protein 3 -0.027574
RASAL2 RAS protein activator like 2 -0.0271492
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0268986
HSPG2 heparan sulfate proteoglycan 2 -0.0263098
PRSS23 protease, serine, 23 -0.0259665
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.025692
DPYD dihydropyrimidine dehydrogenase -0.0252694
RPS6 ribosomal protein S6 -0.024728
IFITM1 interferon induced transmembrane protein 1 -0.0245123
RPS8 ribosomal protein S8 -0.0236904
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0229179
IFI6 interferon, alpha-inducible protein 6 -0.0229156
THBD thrombomodulin -0.0224197
FTL ferritin, light polypeptide -0.0211527
LOC112694756 uncharaterized LOC112694756 -0.0208011
HMGA2 high mobility group AT-hook 2 -0.019775
IGF2 insulin-like growth factor 2 -0.01976
IFI27 interferon, alpha-inducible protein 27 -0.0195297
WNT2B wingless-type MMTV integration site family, member 2B -0.0194754
FSCN1 fascin actin-bundling protein 1 -0.0193413
EXT1 exostosin glycosyltransferase 1 -0.0189027
CNTNAP3 contactin associated protein-like 3 -0.0186523
RPL11 ribosomal protein L11 -0.0180716
RPLP1 ribosomal protein, large, P1 -0.0180193
ASTN2 astrotactin 2 -0.0178699
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0178401
SOX7 SRY (sex determining region Y)-box 7 -0.0175144
CSTB cystatin B (stefin B) -0.0172518
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0172258
RABGAP1L RAB GTPase activating protein 1-like -0.0171246
EGFR epidermal growth factor receptor -0.0170251
RPL34 ribosomal protein L34 -0.0169705
AGO2 argonaute RISC catalytic component 2 -0.0169572
RPS25 ribosomal protein S25 -0.0168075
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0166929
S100A11 S100 calcium binding protein A11 -0.0165384
RPL39 ribosomal protein L39 -0.0163758
RPS19 ribosomal protein S19 -0.0163101
ITGB4 integrin, beta 4 -0.0162256
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -0.0160818
RPL36 ribosomal protein L36 -0.0160764
MT1E metallothionein 1E -0.0158827
VDAC1 voltage-dependent anion channel 1 -0.0158152
SAMD9 sterile alpha motif domain containing 9 -0.0156383
S100A9 S100 calcium binding protein A9 -0.0156289
CDK6 cyclin-dependent kinase 6 -0.0154715
ATF4 activating transcription factor 4 -0.0153816
RIGI RNA sensor RIG-I -0.0152279
RPS14 ribosomal protein S14 -0.01522
SETX senataxin -0.015182
FTH1 ferritin, heavy polypeptide 1 -0.0151798
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0151412
TBCA tubulin folding cofactor A -0.0149935
ABI3BP ABI family, member 3 (NESH) binding protein -0.0149488
TRIM56 tripartite motif containing 56 -0.0145105
RPLP0 ribosomal protein, large, P0 -0.0142021
RPL28 ribosomal protein L28 -0.0137535
TPT1 tumor protein, translationally-controlled 1 -0.013452
RPLP2 ribosomal protein, large, P2 -0.0134347
RPS13 ribosomal protein S13 -0.0133904
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0132415
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0132009
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.0132002
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0131921
HMGA1 high mobility group AT-hook 1 -0.0130502
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0129958
LMNA lamin A/C -0.0127448
RPL37A ribosomal protein L37a -0.0127308
ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein-like 2 -0.0127119
RPL8 ribosomal protein L8 -0.0126212
DGKH diacylglycerol kinase, eta -0.0126096
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0125279
SULF2 sulfatase 2 -0.0124845
RPS12 ribosomal protein S12 -0.012392
CNRIP1 cannabinoid receptor interacting protein 1 -0.0123526
PLTP phospholipid transfer protein -0.0123501
LRRC8A leucine rich repeat containing 8 family, member A -0.0123199
SHISA5 shisa family member 5 -0.0122521
ANKRD28 ankyrin repeat domain 28 -0.0121111
LOC102724023 ES1 protein homolog, mitochondrial -0.012097
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0120878