Fenofibrate_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fenofibrate perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fenofibrate_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.245139
FGFR2 fibroblast growth factor receptor 2 0.230883
FNDC3B fibronectin type III domain containing 3B 0.115043
HYOU1 hypoxia up-regulated 1 0.0900297
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0791353
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0683879
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0646327
ARHGAP32 Rho GTPase activating protein 32 0.0637073
GMDS GDP-mannose 4,6-dehydratase 0.0636593
ZFAND3 zinc finger, AN1-type domain 3 0.0612892
CEMIP cell migration inducing protein, hyaluronan binding 0.0611301
SPTBN1 spectrin, beta, non-erythrocytic 1 0.060955
ATXN1 ataxin 1 0.0601525
KMT2C lysine (K)-specific methyltransferase 2C 0.0590439
DSPP dentin sialophosphoprotein 0.0547542
ZNF292 zinc finger protein 292 0.0546921
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0536794
GOLGA4 golgin A4 0.0534206
PDIA4 protein disulfide isomerase family A, member 4 0.0531227
TXNRD1 thioredoxin reductase 1 0.0522918
CTNND1 catenin (cadherin-associated protein), delta 1 0.0493566
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0479659
ANKRD11 ankyrin repeat domain 11 0.0473916
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0470277
SNX13 sorting nexin 13 0.0467022
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0464804
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0462074
H1-0 H1.0 linker histone 0.0460735
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0460142
TES testin LIM domain protein 0.0459381
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0456153
SEPTIN9 septin 9 0.0445865
AKAP13 A kinase (PRKA) anchor protein 13 0.0433596
COG5 component of oligomeric golgi complex 5 0.0431821
MBNL2 muscleblind-like splicing regulator 2 0.0430945
GARS1 glycyl-tRNA synthetase 1 0.0427941
ESRP1 epithelial splicing regulatory protein 1 0.0420217
CEMIP2 cell migration inducing hyaluronidase 2 0.0414065
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0413447
ESYT2 extended synaptotagmin-like protein 2 0.0412508
OGA O-GlcNAcase 0.0411895
ADAM9 ADAM metallopeptidase domain 9 0.0408967
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0399098
CLTC clathrin, heavy chain (Hc) 0.0397934
PDIA6 protein disulfide isomerase family A, member 6 0.0395858
PTK2 protein tyrosine kinase 2 0.039323
PICALM phosphatidylinositol binding clathrin assembly protein 0.0393025
MYH9 myosin, heavy chain 9, non-muscle 0.0390969
ASPH aspartate beta-hydroxylase 0.0385963
RAB1A RAB1A, member RAS oncogene family 0.0381443
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0380272
AKAP9 A kinase (PRKA) anchor protein 9 0.0380179
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0377897
ITGA6 integrin, alpha 6 0.0371384
BIRC6 baculoviral IAP repeat containing 6 0.036923
AHNAK AHNAK nucleoprotein 0.0368002
YAP1 Yes-associated protein 1 0.036629
AVL9 AVL9 homolog (S. cerevisiase) 0.0365602
ARGLU1 arginine and glutamate rich 1 0.0359288
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0358663
LMO7 LIM domain 7 0.0355467
PTEN phosphatase and tensin homolog 0.035367
DSCAM Down syndrome cell adhesion molecule 0.0352019
SEC24D SEC24 family member D 0.0348717
TRIM2 tripartite motif containing 2 0.0348464
RBM39 RNA binding motif protein 39 0.0341584
PRSS3 protease, serine, 3 0.033798
FAT1 FAT atypical cadherin 1 0.0336382
BCL2L1 BCL2-like 1 0.0335885
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0334527
KDM3A lysine (K)-specific demethylase 3A 0.0334446
STK24 serine/threonine kinase 24 0.0333853
NBAS neuroblastoma amplified sequence 0.0331969
ZCCHC7 zinc finger, CCHC domain containing 7 0.0331441
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.03266
GSK3B glycogen synthase kinase 3 beta 0.0324504
MED13 mediator complex subunit 13 0.0323123
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0320806
HDLBP high density lipoprotein binding protein 0.0316294
KDM6A lysine (K)-specific demethylase 6A 0.0315811
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0315715
ANLN anillin, actin binding protein 0.0312649
USP9X ubiquitin specific peptidase 9, X-linked 0.0310658
HELZ helicase with zinc finger 0.0310022
MGAM2 maltase-glucoamylase 2 (putative) 0.0308021
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0307807
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.0305923
VMP1 vacuole membrane protein 1 0.0305266
NFE2L1 nuclear factor, erythroid 2-like 1 0.0305019
MACF1 microtubule-actin crosslinking factor 1 0.0304446
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0303874
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0302495
SEC23B Sec23 homolog B (S. cerevisiae) 0.0300604
FNDC3A fibronectin type III domain containing 3A 0.0299305
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0298796
NCKAP1 NCK-associated protein 1 0.02936
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.0292975
XPO1 exportin 1 0.0292047
EIF4A2 eukaryotic translation initiation factor 4A2 0.0290445
GOLGB1 golgin B1 0.0288536

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.155952
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.109155
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0963995
TPT1 tumor protein, translationally-controlled 1 -0.0953476
RPL35A ribosomal protein L35a -0.0853203
PTMA prothymosin, alpha -0.0822349
RPS6 ribosomal protein S6 -0.0753784
EIF1 eukaryotic translation initiation factor 1 -0.0692811
FTL ferritin, light polypeptide -0.0682489
RPLP1 ribosomal protein, large, P1 -0.0622073
RPS25 ribosomal protein S25 -0.0549728
S100A6 S100 calcium binding protein A6 -0.0530031
RPS19 ribosomal protein S19 -0.0495556
RPL23 ribosomal protein L23 -0.0461457
S100A10 S100 calcium binding protein A10 -0.0438979
MAML2 mastermind-like 2 (Drosophila) -0.0423359
AGR2 anterior gradient 2 -0.0423156
GNAS GNAS complex locus -0.0411226
IFI6 interferon, alpha-inducible protein 6 -0.040989
IFI27 interferon, alpha-inducible protein 27 -0.0401299
ACTG1 actin gamma 1 -0.0400766
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.0400594
ATF5 activating transcription factor 5 -0.0391468
S100A9 S100 calcium binding protein A9 -0.0390969
RPS8 ribosomal protein S8 -0.038533
RPS16 ribosomal protein S16 -0.0383293
RPL11 ribosomal protein L11 -0.0373648
LMNA lamin A/C -0.0372263
RPS20 ribosomal protein S20 -0.0368987
HLA-A major histocompatibility complex, class I, A -0.0363955
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.036362
LOC102724023 ES1 protein homolog, mitochondrial -0.035917
RPS12 ribosomal protein S12 -0.0358535
RPS3 ribosomal protein S3 -0.0357939
RPL12 ribosomal protein L12 -0.0356872
B2M beta-2-microglobulin -0.0354535
RPLP0 ribosomal protein, large, P0 -0.0353508
RPS21 ribosomal protein S21 -0.0351442
RPL37A ribosomal protein L37a -0.0346228
RPL19 ribosomal protein L19 -0.0345641
CDK6 cyclin-dependent kinase 6 -0.0338217
AREG amphiregulin -0.033815
RPL9 ribosomal protein L9 -0.0338125
GSTP1 glutathione S-transferase pi 1 -0.0327116
RPS29 ribosomal protein S29 -0.0323867
SOX4 SRY (sex determining region Y)-box 4 -0.0322486
RPL34 ribosomal protein L34 -0.0317437
RPL8 ribosomal protein L8 -0.030911
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0299966
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0293049
INTS6 integrator complex subunit 6 -0.0292794
RPS27A ribosomal protein S27a -0.0288199
RPL26 ribosomal protein L26 -0.0286118
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0284344
LCN2 lipocalin 2 -0.0279091
RPL28 ribosomal protein L28 -0.0273499
NDRG1 N-myc downstream regulated 1 -0.0271319
CCND1 cyclin D1 -0.0266579
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.026332
RPS24 ribosomal protein S24 -0.026319
KLF6 Kruppel-like factor 6 -0.0262087
S100A11 S100 calcium binding protein A11 -0.0261977
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0260792
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0256983
RPLP2 ribosomal protein, large, P2 -0.0254421
H3-3B H3.3 histone B -0.0250709
NPSR1 neuropeptide S receptor 1 -0.0246735
RPL39 ribosomal protein L39 -0.0245065
RPL5 ribosomal protein L5 -0.0242313
NDUFA4 NDUFA4, mitochondrial complex associated -0.0240413
HMGB1 high mobility group box 1 -0.0237265
CATSPERB catsper channel auxiliary subunit beta -0.0237257
RPL36A ribosomal protein L36a -0.0234769
RPL18 ribosomal protein L18 -0.0233579
IFITM3 interferon induced transmembrane protein 3 -0.0230881
PFN1 profilin 1 -0.0227181
SLC38A1 solute carrier family 38, member 1 -0.0227102
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0226455
HLA-C major histocompatibility complex, class I, C -0.0224568
RPS5 ribosomal protein S5 -0.0223786
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0219649
IFITM1 interferon induced transmembrane protein 1 -0.021954
LOC112694756 uncharaterized LOC112694756 -0.021885
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0217812
RPS13 ribosomal protein S13 -0.0217719
COTL1 coactosin-like F-actin binding protein 1 -0.0216284
S100P S100 calcium binding protein P -0.0212098
RPL7A ribosomal protein L7a -0.0210318
CLDN4 claudin 4 -0.0207641
UBB ubiquitin B -0.0205969
RPS11 ribosomal protein S11 -0.0204899
HLA-B major histocompatibility complex, class I, B -0.0204494
RPL31 ribosomal protein L31 -0.0203946
MDK midkine (neurite growth-promoting factor 2) -0.0203013
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0202081
RPL27 ribosomal protein L27 -0.0201072
TFF2 trefoil factor 2 -0.0199467
RPL38 ribosomal protein L38 -0.0198969
POF1B premature ovarian failure, 1B -0.0198411
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0198307