Fenofibrate_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fenofibrate perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fenofibrate_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.298278
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.141535
FAM13A family with sequence similarity 13, member A 0.0953894
DSCAM Down syndrome cell adhesion molecule 0.092856
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0922392
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0914445
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0729
DSPP dentin sialophosphoprotein 0.0694899
ZFAND3 zinc finger, AN1-type domain 3 0.0691757
EREG epiregulin 0.0687961
VEGFA vascular endothelial growth factor A 0.0677924
GOLGA4 golgin A4 0.0676269
LMO7 LIM domain 7 0.0668074
FAT1 FAT atypical cadherin 1 0.0666233
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0646223
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0641128
KDM3A lysine (K)-specific demethylase 3A 0.0616666
MED13L mediator complex subunit 13-like 0.0564011
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0552634
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0540771
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0535174
MBNL2 muscleblind-like splicing regulator 2 0.0533416
ESYT2 extended synaptotagmin-like protein 2 0.0531572
OGA O-GlcNAcase 0.0518009
SEC31A SEC31 homolog A (S. cerevisiae) 0.0512818
CCNY cyclin Y 0.0512463
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0508638
RBM39 RNA binding motif protein 39 0.0498915
ANKRD11 ankyrin repeat domain 11 0.0497347
CALR calreticulin 0.0492709
CANX calnexin 0.0491888
RAB1A RAB1A, member RAS oncogene family 0.0479941
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.047913
WAC WW domain containing adaptor with coiled-coil 0.0468818
BTBD9 BTB (POZ) domain containing 9 0.0464406
FNDC3B fibronectin type III domain containing 3B 0.0463874
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0462867
FLNB filamin B, beta 0.0435738
PRELID2 PRELI domain containing 2 0.042822
UBC ubiquitin C 0.0420667
GRB10 growth factor receptor-bound protein 10 0.0420475
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0418489
RPL3 ribosomal protein L3 0.0400611
HDLBP high density lipoprotein binding protein 0.0398795
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0391374
IARS1 isoleucyl-tRNA synthetase 1 0.0387889
PUM2 pumilio RNA-binding family member 2 0.0380295
WDR45B WD repeat domain 45B 0.0377838
RNF145 ring finger protein 145 0.0377515
MYO5B myosin VB 0.0372668
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.037234
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0368749
TXNIP thioredoxin interacting protein 0.036702
NCOR1 nuclear receptor corepressor 1 0.0365063
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0359283
COPA coatomer protein complex, subunit alpha 0.0357286
EPS8 epidermal growth factor receptor pathway substrate 8 0.0354717
AHNAK AHNAK nucleoprotein 0.0353858
NBAS neuroblastoma amplified sequence 0.0351857
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.03487
PICALM phosphatidylinositol binding clathrin assembly protein 0.0348642
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0348515
FNBP1L formin binding protein 1-like 0.0347151
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0346165
COG5 component of oligomeric golgi complex 5 0.0344713
ZNF292 zinc finger protein 292 0.0341771
CD46 CD46 molecule, complement regulatory protein 0.0340802
UBA6 ubiquitin-like modifier activating enzyme 6 0.0339144
MXI1 MAX interactor 1, dimerization protein 0.0337003
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0333118
CSNK1A1 casein kinase 1, alpha 1 0.0331697
KMT2C lysine (K)-specific methyltransferase 2C 0.0331066
KDM6A lysine (K)-specific demethylase 6A 0.0330675
PDIA4 protein disulfide isomerase family A, member 4 0.0324717
RREB1 ras responsive element binding protein 1 0.0323425
KLF5 Kruppel-like factor 5 (intestinal) 0.0323014
AFDN afadin, adherens junction formation factor 0.0322048
CSDE1 cold shock domain containing E1, RNA-binding 0.0321421
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0320114
ATXN1 ataxin 1 0.0318161
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0317903
GARS1 glycyl-tRNA synthetase 1 0.0316825
ZC3H11A zinc finger CCCH-type containing 11A 0.0316574
TFG TRK-fused gene 0.0315649
GDF15 growth differentiation factor 15 0.0313804
KDM4C lysine (K)-specific demethylase 4C 0.0305249
SERINC5 serine incorporator 5 0.0303421
GSK3B glycogen synthase kinase 3 beta 0.0302849
PARD3 par-3 family cell polarity regulator 0.030209
SEC24D SEC24 family member D 0.0301611
HELZ helicase with zinc finger 0.0300354
PDIA6 protein disulfide isomerase family A, member 6 0.030024
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0298783
USP3 ubiquitin specific peptidase 3 0.0297712
ITGA6 integrin, alpha 6 0.0296785
ERRFI1 ERBB receptor feedback inhibitor 1 0.029374
EIF4A2 eukaryotic translation initiation factor 4A2 0.0292549
KMT2E lysine (K)-specific methyltransferase 2E 0.0292411
EXOC1 exocyst complex component 1 0.0290743
MACF1 microtubule-actin crosslinking factor 1 0.0288778

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.242418
TMSB10 thymosin beta 10 -0.170848
RPS6 ribosomal protein S6 -0.113661
MUC6 mucin 6, oligomeric mucus/gel-forming -0.106356
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0917905
RPL35A ribosomal protein L35a -0.0917816
RPS19 ribosomal protein S19 -0.0826949
MT2A metallothionein 2A -0.0677489
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0662974
PTMA prothymosin, alpha -0.0660983
FTL ferritin, light polypeptide -0.0660363
RPS8 ribosomal protein S8 -0.0609694
RPLP1 ribosomal protein, large, P1 -0.0592838
RPL36 ribosomal protein L36 -0.0589399
LOC102724023 ES1 protein homolog, mitochondrial -0.053136
TPT1 tumor protein, translationally-controlled 1 -0.0524299
RPLP2 ribosomal protein, large, P2 -0.0471007
S100A6 S100 calcium binding protein A6 -0.0459245
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0457233
RPL23 ribosomal protein L23 -0.0406927
RPL11 ribosomal protein L11 -0.0406718
RPL9 ribosomal protein L9 -0.0402389
RPL12 ribosomal protein L12 -0.0394575
POTEF POTE ankyrin domain family, member F -0.03817
EGR1 early growth response 1 -0.0378115
RPL34 ribosomal protein L34 -0.0374909
KRT19 keratin 19, type I -0.0363013
ACTG1 actin gamma 1 -0.0361676
GSTP1 glutathione S-transferase pi 1 -0.0361279
TUBB4B tubulin, beta 4B class IVb -0.0359712
HMGA1 high mobility group AT-hook 1 -0.0348047
RPLP0 ribosomal protein, large, P0 -0.0341232
RPL32 ribosomal protein L32 -0.0340694
TNS4 tensin 4 -0.0337413
RPS21 ribosomal protein S21 -0.0332093
LMNA lamin A/C -0.0329682
RPS23 ribosomal protein S23 -0.0326359
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0325934
RPL37A ribosomal protein L37a -0.0325344
RPS14 ribosomal protein S14 -0.0323071
PFN1 profilin 1 -0.0316707
HMGB1 high mobility group box 1 -0.031579
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0312136
ALCAM activated leukocyte cell adhesion molecule -0.0307439
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0302688
RPL28 ribosomal protein L28 -0.0290884
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0289095
RPS29 ribosomal protein S29 -0.0286623
S100A10 S100 calcium binding protein A10 -0.0285803
VDAC1 voltage-dependent anion channel 1 -0.0285589
MT1X metallothionein 1X -0.0280667
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0275445
RPS25 ribosomal protein S25 -0.0269354
RPL19 ribosomal protein L19 -0.0264169
CCND1 cyclin D1 -0.0263299
EIF5B eukaryotic translation initiation factor 5B -0.0261825
RPL8 ribosomal protein L8 -0.0254729
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -0.0252019
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0250955
MT1E metallothionein 1E -0.0249553
RPL31 ribosomal protein L31 -0.0247816
RPL36A ribosomal protein L36a -0.0246185
NALF1 NALCN channel auxiliary factor 1 -0.0241637
RPS11 ribosomal protein S11 -0.0238139
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0236258
RPL18 ribosomal protein L18 -0.0236004
NPSR1 neuropeptide S receptor 1 -0.0235871
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0235714
CADPS Ca++-dependent secretion activator -0.0230491
ATP5F1B ATP synthase F1 subunit beta -0.0228532
RPL5 ribosomal protein L5 -0.0226405
RPS15 ribosomal protein S15 -0.0218847
TUBA1B tubulin, alpha 1b -0.02179
ZFP36L2 ZFP36 ring finger protein-like 2 -0.021671
PRDX2 peroxiredoxin 2 -0.0214705
LOC112694756 uncharaterized LOC112694756 -0.0213596
RPL35 ribosomal protein L35 -0.0211358
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.020975
CYB5R3 cytochrome b5 reductase 3 -0.0207284
KLK10 kallikrein-related peptidase 10 -0.0203353
NDUFA4 NDUFA4, mitochondrial complex associated -0.0202925
RPS20 ribosomal protein S20 -0.0197578
S100A9 S100 calcium binding protein A9 -0.0195638
RPL7A ribosomal protein L7a -0.0194354
TFF3 trefoil factor 3 (intestinal) -0.0193323
ISG15 ISG15 ubiquitin-like modifier -0.0192978
SOX4 SRY (sex determining region Y)-box 4 -0.019264
RPS5 ribosomal protein S5 -0.0188102
ATF4 activating transcription factor 4 -0.0186845
RPS27 ribosomal protein S27 -0.0185824
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0184558
RPS13 ribosomal protein S13 -0.0183455
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0183159
PA2G4 proliferation-associated 2G4, 38kDa -0.0180575
RPL7 ribosomal protein L7 -0.0180569
CLDN4 claudin 4 -0.0180485
TBCA tubulin folding cofactor A -0.0178082
VIM vimentin -0.0177099
RPL27 ribosomal protein L27 -0.0177063
RPL30 ribosomal protein L30 -0.017699