Fenofibrate_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Fenofibrate perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Fenofibrate_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.282197
LAMC2 laminin, gamma 2 0.100621
UBC ubiquitin C 0.0859787
LMO7 LIM domain 7 0.0815145
TOP1 topoisomerase (DNA) I 0.0774053
CES1 carboxylesterase 1 0.0770328
PTPRM protein tyrosine phosphatase, receptor type, M 0.0748038
ANKRD10 ankyrin repeat domain 10 0.0679653
MCL1 myeloid cell leukemia 1 0.0647824
MYH9 myosin, heavy chain 9, non-muscle 0.0621884
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0561728
SLTM SAFB-like, transcription modulator 0.0561135
DSCAM Down syndrome cell adhesion molecule 0.0551682
ASPH aspartate beta-hydroxylase 0.0550681
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.053027
GCLC glutamate-cysteine ligase, catalytic subunit 0.0520268
SOD2 superoxide dismutase 2, mitochondrial 0.0503375
ARRDC3 arrestin domain containing 3 0.0480351
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0460788
RPL3 ribosomal protein L3 0.0458333
NAMPT nicotinamide phosphoribosyltransferase 0.0452913
TXNRD1 thioredoxin reductase 1 0.0448476
TBC1D22A TBC1 domain family, member 22A 0.0445741
GSK3B glycogen synthase kinase 3 beta 0.044477
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0439778
ARGLU1 arginine and glutamate rich 1 0.0428311
AKAP13 A kinase (PRKA) anchor protein 13 0.0427771
MACF1 microtubule-actin crosslinking factor 1 0.0426494
PLEC plectin 0.0420416
LAMB3 laminin, beta 3 0.0419634
ANKRD11 ankyrin repeat domain 11 0.0417589
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0395344
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0391392
DSPP dentin sialophosphoprotein 0.0388734
GRB10 growth factor receptor-bound protein 10 0.0387777
SAMD4A sterile alpha motif domain containing 4A 0.0383551
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0379549
GLS2 glutaminase 2 (liver, mitochondrial) 0.0361797
DOCK5 dedicator of cytokinesis 5 0.0361785
LDHA lactate dehydrogenase A 0.0361227
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0360465
PGK1 phosphoglycerate kinase 1 0.0358723
ANXA5 annexin A5 0.0357659
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0354293
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0352825
OSMR oncostatin M receptor 0.0351974
RUNX1 runt-related transcription factor 1 0.0350097
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0348232
CTTN cortactin 0.0347728
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0345486
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0343096
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0340792
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0339541
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0327567
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0324353
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0322115
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0319835
RPL4 ribosomal protein L4 0.0319466
SMAD3 SMAD family member 3 0.0318576
MYO5B myosin VB 0.0314267
ELL2 elongation factor, RNA polymerase II, 2 0.0312801
EFNA5 ephrin-A5 0.0311803
BCAR3 breast cancer anti-estrogen resistance 3 0.0311235
THSD4 thrombospondin, type I, domain containing 4 0.0309055
FAT1 FAT atypical cadherin 1 0.0305201
USP34 ubiquitin specific peptidase 34 0.0304337
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0302141
LGALS12 lectin, galactoside-binding, soluble, 12 0.029676
PDLIM5 PDZ and LIM domain 5 0.0295883
PDE4D phosphodiesterase 4D, cAMP-specific 0.0295077
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0294527
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0293451
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0291201
ADAM9 ADAM metallopeptidase domain 9 0.0290609
PTEN phosphatase and tensin homolog 0.0290458
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0289721
ENO1 enolase 1, (alpha) 0.0289071
DENND4A DENN/MADD domain containing 4A 0.0287557
ATP13A3 ATPase type 13A3 0.0287225
STAT1 signal transducer and activator of transcription 1, 91kDa 0.028571
MSN moesin 0.0283868
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0283295
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0279017
ANO6 anoctamin 6 0.0278445
CSDE1 cold shock domain containing E1, RNA-binding 0.0276072
TES testin LIM domain protein 0.0274851
EIF4A2 eukaryotic translation initiation factor 4A2 0.027421
EIF4B eukaryotic translation initiation factor 4B 0.0274185
APP amyloid beta (A4) precursor protein 0.0273529
HAPSTR1 HUWE1 associated protein modifying stress responses 0.027314
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0272198
ADAM17 ADAM metallopeptidase domain 17 0.0270375
NCKAP1 NCK-associated protein 1 0.0269677
ZFAND6 zinc finger, AN1-type domain 6 0.0269532
APLP2 amyloid beta (A4) precursor-like protein 2 0.0267961
CCNL1 cyclin L1 0.0262617
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0261203
CTNND1 catenin (cadherin-associated protein), delta 1 0.0255195
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0252419
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0251779

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.405926
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.179817
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.121582
MT2A metallothionein 2A -0.0896617
TMSB10 thymosin beta 10 -0.0826936
NDRG1 N-myc downstream regulated 1 -0.0770196
PTMA prothymosin, alpha -0.0723639
FTL ferritin, light polypeptide -0.0674799
TPT1 tumor protein, translationally-controlled 1 -0.0572989
RPL35A ribosomal protein L35a -0.0552943
S100A10 S100 calcium binding protein A10 -0.0457445
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0412004
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0376069
FAM13A family with sequence similarity 13, member A -0.035438
BTG1 B-cell translocation gene 1, anti-proliferative -0.0334024
RPLP1 ribosomal protein, large, P1 -0.033306
RPL12 ribosomal protein L12 -0.0331779
RPLP0 ribosomal protein, large, P0 -0.0316632
RPS8 ribosomal protein S8 -0.0314768
CSTB cystatin B (stefin B) -0.0310651
IER3 immediate early response 3 -0.030828
STC1 stanniocalcin 1 -0.0307148
ANKRD37 ankyrin repeat domain 37 -0.0296967
RPS6 ribosomal protein S6 -0.0296213
FTH1 ferritin, heavy polypeptide 1 -0.0287824
MT1X metallothionein 1X -0.0276393
SEC61G Sec61 gamma subunit -0.02751
CD163L1 CD163 molecule-like 1 -0.0274862
RPS25 ribosomal protein S25 -0.0270757
EIF1 eukaryotic translation initiation factor 1 -0.0262006
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0259738
CCNI cyclin I -0.0250232
HILPDA hypoxia inducible lipid droplet-associated -0.0245173
VDAC1 voltage-dependent anion channel 1 -0.024422
PDE8A phosphodiesterase 8A -0.0242988
C15ORF48 chromosome 15 open reading frame 48 -0.024005
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0238861
S100P S100 calcium binding protein P -0.0237289
MXI1 MAX interactor 1, dimerization protein -0.0230958
RPS19 ribosomal protein S19 -0.0227066
RPS24 ribosomal protein S24 -0.0209976
RPL34 ribosomal protein L34 -0.0209574
RPL36A ribosomal protein L36a -0.0208259
RPS21 ribosomal protein S21 -0.0198644
GM2A GM2 ganglioside activator -0.0194596
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0193658
HMGA1 high mobility group AT-hook 1 -0.0192097
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0187448
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0185813
RPL37A ribosomal protein L37a -0.0178093
CST3 cystatin C -0.0176889
RPS23 ribosomal protein S23 -0.0176275
ATF4 activating transcription factor 4 -0.0175991
YY1 YY1 transcription factor -0.0175649
RPL19 ribosomal protein L19 -0.0174357
GSTP1 glutathione S-transferase pi 1 -0.0171994
S100A9 S100 calcium binding protein A9 -0.0171351
HLA-B major histocompatibility complex, class I, B -0.0167813
AGR2 anterior gradient 2 -0.0166163
GNAS GNAS complex locus -0.0164486
H1-0 H1.0 linker histone -0.0164175
AKR1C1 aldo-keto reductase family 1, member C1 -0.0161542
RPL8 ribosomal protein L8 -0.0161168
CAV1 caveolin 1, caveolae protein, 22kDa -0.0156084
PDIA3 protein disulfide isomerase family A, member 3 -0.0154495
EGR1 early growth response 1 -0.0154133
LOC102724023 ES1 protein homolog, mitochondrial -0.0153111
RPL9 ribosomal protein L9 -0.0151914
ASTN2 astrotactin 2 -0.0150609
RPL32 ribosomal protein L32 -0.0150567
RPL36 ribosomal protein L36 -0.0147802
RPS20 ribosomal protein S20 -0.0143779
SERF2 small EDRK-rich factor 2 -0.0143405
NIPBL Nipped-B homolog (Drosophila) -0.0142581
UBE2B ubiquitin-conjugating enzyme E2B -0.014016
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0136825
ACTG1 actin gamma 1 -0.0135754
H3-3B H3.3 histone B -0.0135343
RPL23 ribosomal protein L23 -0.0131898
RPS14 ribosomal protein S14 -0.0130449
SRP54 signal recognition particle 54kDa -0.0129285
RPLP2 ribosomal protein, large, P2 -0.0128545
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0127669
LOC112694756 uncharaterized LOC112694756 -0.0127296
MLF1 myeloid leukemia factor 1 -0.0127261
RPL18 ribosomal protein L18 -0.012588
SEC24A SEC24 family member A -0.0125553
TBCA tubulin folding cofactor A -0.0125323
RPL11 ribosomal protein L11 -0.012275
KLHL24 kelch-like family member 24 -0.0121492
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0121278
RPS27A ribosomal protein S27a -0.0120326
IRF1 interferon regulatory factor 1 -0.0119612
IGFBP3 insulin-like growth factor binding protein 3 -0.0119511
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.011849
ZMYND8 zinc finger, MYND-type containing 8 -0.0118117
ATP5MG ATP synthase membrane subunit g -0.0117262
RPL5 ribosomal protein L5 -0.0116983
ADM adrenomedullin -0.0116868
KPNB1 karyopherin (importin) beta 1 -0.011525